dictionary- & model-based methods (in quantitative mri … · 2019. 10. 18. · 32 x 16 echoes,...

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Dictionary- & Model-based methods (in quantitative MRI reconstruction)

Mariya DonevaPhilips Research, Hamburg

14.10.2019

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Outline

• Brief introduction to MRI

• Image reconstruction as an inverse problem

• Model-based reconstruction for MR parameter mapping

• Dictionary-based methods

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A very brief introduction to MRI

PolarizationPut a person in a strong magnetic field B0

ExcitationApply an RF pulse B1 to flip the magnetization in the transverse plane

Spatial encodingApply a magnetic field gradients

Acquisition„Listen“ to the signal using RF coils

ReconstructionDecode the measured signal to obtain an image

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MRI data acquisition

Pulse sequence k-space

Spin echo

RF

Greadout

Gphase

Scan Time = TR × (No. phase encodes) ×(No. averages)

Data in k-space are acquired sequentially

TR

image space

Data acquisition is just a small portion of the MR scan

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• Assumption: The measured signal is a Fourier transform of the image

Standard MRI reconstruction

• In many cases this model is too simplified

k-space image space

iFFT

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Which factors influence the MR images?

T1 T2 PD

B0B1+/-

Diffusion

Perfusion

Chemical shift(Tissue composition)

Physiological motion

MRI signal strength is a function of the tissue parameters, system parameters, and sequence parameters

Magnetic susceptibility

TR TETI

…

Magnetization transfer

radial spiral

randomrosette lissajous

propeller

Many ways to sample the k-spacePrecise knowledge of gradient waveforms becomes important

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Model-based Reconstruction

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Forward model:

• 𝑦 measured data

• 𝐹 forward transform (linear or non-linear)

• 𝑥 image (T1W, T2W, parameter map,…)

• 𝑛 noise

Image reconstruction as an inverse problem

𝒚 = 𝑭𝒙 + 𝒏

Reconstruction problem: Recover 𝑥 based on the measurements 𝑦

Cause(parameter, unknown)

Effect(observation,

data)

inverse problem

forward problem

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Well-posed/ill-posed inverse problems

Well-posed problem

• A solution exists

• The solution is unique

• The inverse mapping 𝒚 → 𝒙 is well conditioned

Image reconstruction in MRI is always an ill-posed inverse problem

• No exact solution (data inconsistencies, noise)

• Solution is not unique (incomplete data)

• Sometimes the problem is ill-conditioned (noise amplification)

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• 𝑭𝒙 = 𝒚 has no exact solution

Least squares solution

• Solution is not unique, many choices of 𝒙 lead to the same 𝒚

Minimum norm solution

The Moore-Penrose pseudoinverse gives the minimum L2 norm solution

Solving ill-posed inverse problems

𝒙 = argmin 𝑭𝒙 − 𝒚 𝟐𝟐

minimize 𝒙subject to 𝑭𝒙 = 𝒚

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• Ill-conditioned problem: add regularization

Regularized inverse problem

• Regularization adds prior knowledge to stabilize the solution

Regularization

𝒙 = argmin𝒙

𝑭𝒙 − 𝒚 𝟐𝟐 + 𝜆𝑅(𝒙)

data consistency regularization

Examples:

• L2 norm 𝑅 𝒙 = 𝒙 𝟐𝟐

• Total Variation 𝑅 𝒙 = Δ𝒙

• L1 norm 𝑅 𝒙 = 𝒙Propagated data error

Approximation error

𝝀

Total error

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Modelling signal and system properties

• Ignoring many things, the measured signal in MRI is:

𝑦(𝑡) = 𝜌(𝑟)𝑒−2𝜋𝑖𝑘 𝑡 ∙𝑟 ⅆ𝑟

𝑦(𝑡) = 𝑒−𝑅2 𝑟 𝑡𝜌(𝑟) 𝑒−2𝜋𝑖𝑘 𝑡 ∙𝑟 ⅆ𝑟

𝑦(𝑡) = 𝑒𝑖Δ𝐵0 𝑟 𝑡𝜌(𝑟)𝑒−2𝜋𝑖𝑘 𝑡 ∙𝑟 ⅆ𝑟

• Include T2 relaxation

• Include off-resonance

• Include CSM 𝑦𝑗(𝑡) = 𝑐𝑗 𝑟 𝜌(𝑟)𝑒−2𝜋𝑖𝑘 𝑡 ∙𝑟 ⅆ𝑟

• Other effects: chemical shift, motion, flow, diffusion, …

• More accurate, more complete description of the measurements

• Allows estimating additional physical properties from the data

Model-based reconstruction for quantitative MR parameter mapping

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Quantitative MRI• Improved tissue contrast

• Robust tissue segmentation

• Detection of diffuse disease

• Improved data consistency and comparability

• Synthetic MRI/ Single protocol exam

T2W FLAIR T1W

T1 map T2 map PD map

WM GM CSF

segmentation synthetic MRI

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Generalized View on Quantitative MRI

• Collect multiple images for different acquisition parameters, each of which is “weighted” by a specific tissue property

• Use a model to extract the value of the tissue property from the weighted images

𝑠

𝑝

Parameter Map

Challenge: we need to acquire multiple images

Acquisition parameter 𝑝 𝑠 = 𝑓(𝑝, Θ) Θ

Solution: undersample the data (and use model-based reconstruction)

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Model-based reconstruction for MR parameter mapping

Generalized signal model

𝑥 = 𝑓(𝑝, Θ)

k-p measurements

Acqusition parameters

Sampling operator

Θ = argmin1

2

𝑝

Φ𝑝𝑥𝑝(Θ) − 𝑦𝑝 2

2

Tissue parameters

Model-based reconstruction problem

Obtain the parameter maps directly from the undersampled data, solving a non-linear (and possibly non-convex) problem

Model-based reconstruction for MR parameter mapping

Θ = argmin1

2

𝑝

Φ𝑝𝑥𝑝 Θ − 𝑦𝑝 2

2+

𝑖

𝜆𝑖𝑅𝑖 𝑥𝑝, Θ

Add regularization

𝜌 𝑇2

= argmin1

2 𝑐 𝑇𝐸𝑗

𝑀𝑇𝐸𝑗ℱ𝐶𝑐𝜌 𝑟 𝑒−

𝑇𝐸𝑗

𝑇2 𝑟 − 𝑦𝑇𝐸𝑗,𝑐 2

2

+ 𝑖 𝜆𝑖𝑅𝑖 𝑥𝑝, Θ

Example: T2 mapping

Block KT et al. IEEE Trans Med Imaging 28 (2009): 1759-1769Sumpf TJ et al. JMRI 2011

Proton density R2 relaxivity

Radial 2D FSE sequence

32 x 16 echoes, ∆TE = 10 ms, TR = 7000 ms, 224 x 224 pixels (acceleration R=11)

Model based T2 mapping

Block KT et al. IEEE Trans Med Imaging 28 (2009): 1759-1769

Optimization performed with non-linear CG algorithm (CG-DESCENT)

Slide Courtesy of Dr. T Block

Proton density R2 relaxivity

Radial 2D FSE sequence

32 x 16 echoes, ∆TE = 10 ms, TR = 7000 ms, 224 x 224 pixels (acceleration R=11)

Model based T2 mapping

Block KT et al. IEEE Trans Med Imaging 28 (2009): 1759-1769

Optimization performed with non-linear CG algorithm (CG-DESCENT)

Slide Courtesy of Dr. T Block

Provides quantitative T2 & PD map from single radial FSE dataset

Radial Projections Consistent Model ResultModelMagnetization Preparation

&Look-Locker Acquisition

Termination

Criterion

n Single Projections

n Complete k-Spaces

Pixel-wise

Model Fit

Reinsert

Projections

Repeat Iteratively

Reconstruction Scheme[2]

[1] Tran-Gia, MRM 2013. [2]According to Doneva, MRM 2010. [3] Tran-Gia, PLOS ONE 2015.

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↔ T1 map[3]

Slide Courtesy of Dr. Johannes Tran-Gia

MAP (Model-based Acceleration of Parameter mapping)

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Model-based Regularization and Dictionaries

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Model-based sparsity constraint in a compressed sensing reconstruction

1. Create a training data set using the model2. Learn a sparsifying transform from the training data 3. Use the constraint in the reconstruction

f(p;θ1)

p

f(p;θ2)

p

f(p;θ3)

p

f(p;θn)

p

s1 s2 s3 sn

Training dataset S = [s1, s2, s3,... sn]

Discrete vector of sampling locations p

Set of parameter values {θ1 ,...,θn}

Data modelf(p;θ1)

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Data adapted sparse representations: Dictionaries

Dictionary Dx

s

= .

Each atom is a basic unit that is used to compose larger units atoms

0.6

0.4

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Model-based sparsity constraint: Orthogonal transform

𝑥 = argmin1

2

𝑐

𝑝

𝑀𝑝ℱ𝐶𝑐𝑥𝑝 − 𝑦𝑝,𝑐 2

2+ 𝜆1 𝑈𝐻𝑥 1

𝑅 = 𝑆𝑆𝐻 = 𝑈Σ𝑈𝐻

𝑧 = 𝑈𝐻𝑥

• 𝑈𝐻 is a linear sparsifying transform for the measurements 𝑥

• Include the data model in the regularization term

• PCA-based constraint

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Model-based subspace projection (REPCOM, T2 shuffling)

𝑥 = argmin1

2

𝑐

𝑝

𝑀𝑝ℱ𝐶𝑐𝑈𝑅𝑧𝑝 − 𝑦𝑇𝐸𝑗,𝑐 2

2

𝑅 = 𝑆𝑆𝐻 = 𝑈Σ𝑈𝐻

𝑧 = 𝑈𝑅𝐻𝑥

• 𝑈𝑅𝐻 projection to the subspace of the first R principal components

• Reconstruct the compressed image series

• PCA-based constraint

1) Huang et al MRM 2012 2) Tamir et al MRM 2017

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Model-based sparsity constraint: Over-complete dictionary

• Improve the sparsity: use over-complete dictionary

Obtain overcomplete dictionary by training (K-SVD2)

basis Dx

=

s

.

Dictionary Dx

s

= .

1) Doneva et al MRM 2010 2) Aharon M et. al, IEEE Trans Signal Process 2006

Orthogonal transform(e.g. PCA)

Over-complete dictionary

minimize 𝑥 − 𝐷𝑠 2, s. t. 𝑠 0 ≤ 𝐾

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Model-based sparsity constraint

Generate signal prototypes from

model

Dictionary training (K-SVD)

Apply dictionary in CS reconstruction

Original 2 Atoms 10 Atoms

Doneva et al MRM 2010

𝒙 = argmin𝒙

𝑭𝒙 − 𝒚 𝟐𝟐 + 𝝀 𝒙 − 𝑫𝒔 𝟐

𝟐,

s. t. 𝒔 0 ≤ 𝐾

Reconstruction

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Undersampled T1 mapping (CS)

multi-echo IR brain data TE = 1.9ms, TR = 3.8ms, α = 10°, FOV = 250 mm, 224×224 matrix, 40 images

0.055 0.086 0.106 0.131

0.051 0.062 0.083 0.113

NRMSE

NRMSE

1x 2x 4x 6x 8x

Doneva et al MRM 2010

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Dictionaries for higher dimensional signals

• Dictionaries for 2D image representation

– 2D image patches

Ravishankar S et al IEEE Trans Med Imag 2011; 30(5): 1028-41Caballero J et al. ISMRM 2014 #1560Katscher U et al ISMRM2017 #3641

minimize 𝑅𝑖𝑗𝑥 − 𝐷𝑠𝑖𝑗 2, s. t. 𝑠𝑖𝑗 0

≤ 𝐾

• Reconstruction

𝑅𝑖𝑗 - operator that extracts a patch centered at position i,j

Each atom in the dictionary is a 2D patch Image patch based dictionary

• Spatiotemporal dictionaries

– Spatio-temporal blocks (3D, 4D)

𝒙 = argmin𝒙

𝑭𝒙 − 𝒚 𝟐𝟐 + 𝝀

𝒊𝒋

𝑅𝑖𝑗𝑥 − 𝐷𝑠𝑖𝑗 𝟐

𝟐, s. t. 𝑠𝑖𝑗 0

≤ 𝐾

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More Dictionary-based techniques(extremely sparse representation)

“In a dictionary with infinitely many atoms, the signal can be ultimately represented by a single atom. This is equivalent to fitting the signal to the model”

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T2 mapping: model-based reconstruction with EMC

0

50

100

150

[ms]

22 min

Cartesian

Multi Spin-Echo Acquisitions

a e g

Single Spin-Echo

Cartesian

b f hT 2

Re

laxa

tio

n

Map

s

c

d 3:10 min

[Exponential fit] [EMC fit][Exponential fit]

Ben-Eliezer etl al, Magn Reson Med (2015) 73(2): 809-17.

Note: Parameter maps are discretized

0 2 4 6 8 10 12 140

5

10

15

20

25

30Echo train modulation

T2 = 30:2:55; 73:2:103

Echo train length = 13

29 simulations• The Echo Modulation Curve (EMC) Algorithm

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• Compute signal evolution using Bloch simulations

Echo-modulation curves database EMC (T2, B1, …)

𝑦(𝑡) = 𝐸𝑀𝐶(𝐵1, 𝑇2)𝜌(𝑟) 𝑒−2𝜋𝑖𝑘 𝑡 ∙𝑟 ⅆ𝑟

• Fit experimental decay curve to simulated EMC database

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Magnetic Resonance Fingerprinting

time (ms)

sign

al in

ten

sity

B0 map

M0 map

T2 map

T1 map

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Magnetic Resonance Fingerprinting

full sampling undersamplingspiral read-out

Is the dictionary matching in MRF the same as model-based reconstruction for MR parameter mapping?

• Direct matching in MRF seems to work quite well, but it is only the first iteration of an iterative model-based reconstruction

• For long sequences and VD spiral sampling 1 iteration might be enough

• In the general case, iterative reconstruction is needed

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Model-based reconstruction for MRF

• Davies M et al. A Compressed Sensing Framework for Magnetic Resonance Fingerprinting SIAM J. Imaging Sci., 2014, 7(4), 2623–2656.

• Pierre E et al. Multiscale Reconstruction for MR Fingerprinting MagnReson Med. 2016 Jun;75(6):2481-92

• Zhao B, et al. Maximum Likelihood Reconstruction for Magnetic resonance Fingerprinting IEEE Trans Med Imaging. 2016 Aug;35(8):1812-23. doi:10.1109/TMI.2016.2531640

• Doneva M et al. Matrix Completion-based reconstruction for undersampled magnetic resonance fingerprinting data Magn ResonImaging. 2017 Mar 3 doi:10.1016/j.mri.2017.02.007

• Assländer J et al. Low rank alternating direction method of multipliers reconstruction for MR fingerprinting Magn Reson Med. 2017 Mar 5. doi: 10.1002/mrm.26639.

direct matching iterative recon

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MR-STATmulti-parametric model-based reconstruction (non-linear inversion)

Time-data Signal model

Slide Courtesy of Dr. Alessandro. Sbrizzi

T1

T2

True Recon

|B1+|

ΔB0

P.D.

Tx/Rxphase

True Recon

• Large scale non-linear inverse problem for all relevant tissue and system parameters

– Computationally very intensive

– Careful initialization is required

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Summary

• Model-based reconstruction

– Generalized framework for MR reconstruction

– Modelling of physical properties, reduced artifacts, QMRI

– Insert prior knowledge as regularization

• Dictionaries

– Provide sparse(r) signal representation

– Convert a non-linear inverse problem to a linear search

– Can be learned from training data

• Examples in MR Parameter mapping

Acknowledgements

• Tobias Block

• Johannes Tran-Gia

• Noam Ben-Eliezer

• Alessandro Sbrizzi