disruptive innovation - moving beyond the talk

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Disruptive Innovation:Moving Beyond the Talk

Thomas KrohnEli Lilly & Company

Case for Disruptive Innovation

Source: FDA.gov

Productivity Down, Costs Up Future revenues under pressure

Unsustainable Business Model

The Far Sideby Gary Larson

Drug Development

$- $50 $100 $150 $200 $250 $300

Mill

ions

US$

Typical Cost/NME/Phase

Precompetitive Competitivepatent

Innovation Process

3 Challenges

• Incremental vs. Disruptive• Precompetitive vs. Competitive• Closed vs. Open

Incremental Improvement

Clinical Research Improvement

Outsourcing

BPMCritical ChaineDC

Investigator Portal

Good, but not sufficient

Disruptive Innovation

to S1'

to S2

S1

Time

Performance

DisruptiveChange

Simpler, Faster, Cheaper?

Who is being disrupted?

Precompetitive vs. Competitive

Precompetitive Competitive

Collaboration should and can exist across model

patent

Closed vs. Open

Trial Planning & Design Example

Reality• Distant from practice• Small number• Slow and expensive• Naïve

Today’s Closed Fortress Model:• Internal product teams• Advisors• Third party organizations• Competitive = Secret

Time to explore other models

Experiment Portfolio

• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

Open Clinical Intelligence Network

Commons Licensing

3. Curate

4. Connect1. Collect

ClinicalKnowledgeGeneration

2. Consume

Uncurated Data

Curated Data

Crowd

Public Data

Motivation

Technology

Worldbank

ROAR

Open Clinical Intelligence Network

Knowledge Generating System

Krohn & Crist Whitepaper

TrialSite

PublicationDrug

DiseaseRegulatory

TimelineGeographic

Network DiagramScatter Plot

ExportAPI

Search/FilterAnnotateCorrect

Cross LinkAPI

Social ShareCollaborate

External DataGamification

Commons Licensing

3. Curate

4. Connect1. Collect

ClinicalKnowledgeGeneration

2. Consume

Uncurated Data

Curated Data

Crowd

Public Data

From data to insights

Experiment Portfolio

• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

• Protocol Design– Crowd-based feedback

Protocol Design

Experiment Portfolio

• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

• Protocol Design– Crowd-based feedback

• Site Training & Experience– Credentials, Training, Historical Trials

• Predictive Analytics– Kaggle style enrollment projections

Predictive Analytics

We’re making data science a sport.™

Experiment Portfolio

• Open Clinical Intelligence Network– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

• Protocol Design– Crowd-based feedback

• Site Training & Experience– Credentials, Training, Historical Trials

• Predictive Analytics– Kaggle style enrollment projections

• Q&A Forum– Site to site sharing, clinical research topics

Q&A Forum

So What?

If...– Incremental improvement is a slow death,– Competitive mindset is stopping collaboration, and,– Closed model is part of the problem…

Then…check your assumptions:– Incremental vs. Disruptive– Precompetitive vs. Competitive– Closed vs. Open

Time to Engage!

Tide is rising for disruptive change.

Are you on board?

The case is clearThe opportunities are manyThe question is leadership

Thanks

Thomas Krohnkrohnta@lilly.comEli Lilly and Companywww.lillycoi.com