dna repair. cell cycle checkpoint activation dna repair: base excision repair nucleotide excision...
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DNA Repair
Cell Cycle Checkpoint activation
DNA Repair:
Base Excision Repair
Nucleotide excision repair
Mismatch repair
DSB repair
SENESCENCE/
APOPTOSIS
CANCER
Source of Damage
Endogenous: Replication Errors Reactive Oxygen Species
Exogenous: UV radiation, IR.. Mutagenic chemicals
Type of Damage- Endogenous
Oxidation of bases Methylation of bases Hydrolysis of bases Mismatch of bases
Damage mostly on DNA bases, causing point mutations:
Type of Damage- Exogenous
UV light- pyrimidine dimers IR- Breaks in DNA strands Chemicals (found in smoke, soot and tar)-
diversity of DNA damages including crosslinking of DNA.
Damage mostly on helix structure:
DNA MutationDNA Damage ≠
The cellular DNA damage response
Transducers
Mediators
Sensors
EffectorsCell cycle arrest
DNA repair ApoptosisDNA repair
DNA damage
DNA Repair Mechanisms
DNA Mismatch repair
Base Excision Repair
Nucleotide excision repair
Nucleotide Excision Repair in Eukaryotes
Xeroderma Pigmentosum
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