dubravka Šipuš, 2nd year 2013/2014 mentor: a. Žmegač horvat
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Dubravka Šipuš, 2nd year2013/2014
Mentor: A. Žmegač Horvat
Hemostasis – prevention of blood loss
Mechanisms:
1)Vascular constriction
2)Formation of a platelet plug
3)Formation of a blood clot
4)Growth of fibrous tissue
Fast process
Procoagulants and anticoagulants
Complex cascade of chemical reactions
Blood coagulation factors
Formation of prothrombin activator
Extrinsic pathway
Intrinsic pathway
Endothelial surface factors (smoothness, glycocalyx, thrombomodulin)
Antithrombin III - heparin cofactor
Coumarin (warfarin)
Citrate ion, oxalate
Vitamin K deficiency
Diseases of the liver
Hemophilia
Thrombocytopenia
Guyton, Hall: Textbook of Medical Physiology
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