eating disorders - medicine for psychiatrists · 2017-05-30 · epiphyses, advised to lose weight...
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EATING DISORDERSMedical Assessment & Management
Dr Raewyn Gavin
Dr Louise Webster
Auckland - March 2015
Review Definition and Epidemiology
Medical Complications
Medical Risk Assessment
Children vs Adults
Psychiatric Comorbidity
Cases
OVERVIEW
Persistent restriction of energy intake leading
to significantly low body weight.
Intense fear of gaining weight or persistent
behaviour that interferes with weight gain.
Disturbance in the way one's body weight or
shape is experienced
Subtypes:
- Restricting type
- Binge-eating/purging type
DSM V - AN
Recurrent episodes of binge eating.
Recurrent inappropriate compensatory behaviour to prevent weight gain (self-induced vomiting, laxative abuse, diuretics, enemas, exercise etc.)
Behaviours both occur, on average, at least once a week for three months.
Self-evaluation is unduly influenced by body shape and weight.
The disturbance does not occur exclusively during episodes of Anorexia Nervosa.
DSM V - BN
Disordered eating behaviour which does not
meet all criteria for AN or BN
Not less severe
Biggest group
EDNOS
AN 0.3% (0.4% teenage girls)
Lifetime 1.4 – 2.2%
~33% will receive care for AN
BN 1%
Lifetime 4 - 7%
~6% will receive care for BN
EDNOS 2.3% of young females
PREVALENCE (UK)
Re-feeding syndrome
Renal
Haematological
Cardiac
GI
Bones
Gynaecological
Endocrine
Cognitive & psychological
Other
MEDICAL COMPLICATIONS AN
Starvation:
↓ carbohydrate intake
↓ insulin secretion
Energy from fat & protein catabolism
Intracellular loss of electrolytes
Intracellular phosphate can be low despite normal serum phosphate
Re-feeding:
Shift to carbohydrate metabolism
↑ insulin secretion
Phosphate moves from serum into cells
Can cause rapid ↓ serum phosphate
RE-FEEDING SYNDROME
Phosphate needed for crucial phosphorylation reactions – e.g. generating ATP from ADP etc.
Early signs often subtle
Occurs within 4-7 days re-feeding
As well as low phosphate may get:
↓ magnesium
↓ potassium
↓ glucose (most likely if long periods between meals)
RE-FEEDING SYNDROME
Rhabdomyolysis
Oedema
Respiratory failure
Cardiac failure
Arrhythmias
Hypotension
Delirium
Seizures
Coma
Sudden death
EFFECTS OF SEVERE ↓PO4
Prophylactic phosphate supplement if planning to significantly increase intake(Phosphate sandoz – one tablet twice daily)
Reintroduce feeds at approximately half expected daily requirement
Monitor bloods closely in 1st week
Can increase feeds quickly to 100% if monitoring closely (beware under-feeding)
Consider thiamine 50 mg bd (or multivitamin containing thiamine) if long history
PREVENTING RE-FEEDING SYNDROME
Dehydration → pre-renal
Nephrocalcinosis (risk of kidney stones)
Polyuria (↓ ability to concentrate urine)
Usually resolve with improved nutrition
NB: Expect creatinine to be low because of ↓ muscle mass
RENAL COMPLICATIONS
Haematological: Anaemia (often macrocytic)
Neutropenia – 25%
Thrombocytopenia - 5%
Due to bone marrow atrophy with deposition of gelatinous material.
Cardiac: Arrhythmia due to electrolyte imbalance
Bradycardia
Prolonged QT interval
↓ ventricular mass
Mitral valve prolapse
COMPLICATIONS
CTR 35%
Constipation (very common) – supervised treatment
Intestinal dilatation & delayed gastric emptying (↓ gut motility) – feeling of gastric fullness very common.
Abnormal liver function (AST, ALT)
Gall stones
Pancreatitis
GI COMPLICATIONS
↓ bone density 2° to:
↓ oestrogen
↑ cortisol
malnutrition
1/3 bone mass achieved during puberty
↑ risk osteoporosis later – esp if delayed recovery
30-50% have osteopenia >10 years later despite full recovery
BONE HEALTH
Total Body
Lumbar Spine
Z score
Osteopenia = -1.0 - -2.5
Osteoporosis = <-2.5
Body Composition
(% body fat)
BONE DENSITY SCAN
Z score -2.9
Important to aim for recovery by age 18 -20, the
years of maximal bone density accrual.
Best treatment of low bone density in younger
age group is weight restoration (body fat)
Remember Vitamin D
Hormone supplements controversial
Nutritional improvement preferred
Variable response in bone density
BONE HEALTH CONTD;
Gynae / Fertility:
Delayed menarche
2° amenorrhoea (regular menses never return in ~25%)
↑ risk pregnancy complications (miscarriage, LBW, etc.)
↓ response to fertility treatment
Endocrine:
↑ Cortisol
Sick euthyroid with low T3
Abnormal insulin secretion
COMPLICATIONS
Cognitive: Cortical atrophy & ↑ ventricle size
Significant long term deficits if remain amenorrhoeic
Weight & oestrogen have independent effects on brain.
Short term memory, focus and attention, spatial skills & cognitive flexibility
Are they fit to drive?
Psychological: 50-75% depression or low mood
60% anxiety
- ? secondary to weight loss (reverses with weight gain)
- ? pre-existing
Loss of ‘personality’ & sense of humour
COMPLICATIONS
Hair Loss – non-essential use of protein
Lanugo hair
Dry skin
Carotenaemia
Hypercholesterolaemia
Patulous eustachian tube
Parotid swelling (purging)
Dental erosions (purging)
OTHER
Average duration of illness = 5-6 years
~50% full recovery (all ages). Up to 80% adolescents
Adolescents with AN (US study)
At 3.5 years :
75% excellent or much improved
Mean weight = 94% IBW
79% females menstruating
Most = good social & educational functioning
PROGNOSIS AN
Mortality ~5%
Highest mortality of all psychiatric disorders
Predictors of mortality (adults) BMI < 13 (BMI < 11 = risk)
Prolonged QT interval
Low serum albumin
Long duration illness
Poor social adjustment
↑ risk suicide (22% make at least one attempt)
~50% from medical complications
~50% suicide
Death is usually sudden, can look well
MORTALITY
Higher risk rapid medical deterioration
Risk of potentially irreversible effects on
physical and emotional development
BMI less useful, can be normal
Linear Growth
Pubertal Delay
Better prognosis (unless onset < 10 years)
CHILDREN vs ADULTS
Ideal weight is a
moving target.
Especially if still
growing but even if
not.
BMI naturally
increases with age .
GROWTH
Weight
Height BMI
Eating Disorder symptoms and behaviour
Weight information
Medical parameters
Bloods
Re-feeding risk
Ongoing risk monitoring
Long term risk
32
MEDICAL RISK ASSESSMENT
Good information - weight & growth history
Calculator and BMI centile chart
Good clear communication with GP who will
be monitoring your patient.
33
WHAT YOU NEED
Medical Risk Increased if:
Low weight and purging
Multiple forms of purging (laxatives and diuretics)
Excessive exercise
Look for inconsistency between history and objective evidence
34
ED SYMPTOMS AND BEHAVIOUR
Medical Risk Increased if :
Rapid weight loss > 4kg in 6 weeks
Loss 15-20% of body weight in 3 months,
regardless of BMI
<2nd percentile BMI,<80% wt for ht
Lower BMI usually means more risk but depends
on rapidity of loss and other medical factors
Height gain but no weight increase
35
WEIGHT INFORMATION
Weight/height/BMI
Blood pressure lying and then standing
Pulse rate lying and standing
Temperature
Hydration
Muscle strength
Duration of amenorrhoea
36
MEDICAL PARAMETERS
Hypotension: BP less than 80mmHg systolic < than 75mmHg (adults)
Postural drop in blood pressure > 20mmHg (take BP lying and then after standing for 2 min)
Bradycardia = HR < 50 beats per minute < 40/min (adults)
Increased heart rate of more than 20-30 beats per minute on standing after lying down
37
BLOOD PRESSURE AND PULSE
Arrhythmia/palpitations
Fainting
Dizziness
Chest pain
Consider ECG if bradycardic or other cardiac
symptoms. Check QTc and PR interval. If ECG
abnormal needs medical review
Helpful tips about ECGs can be found online at ‘ECGpedia’ http://en.ecgpedia.org/wiki/Main_Page
38
OTHER CARDIAC SYMPTOMS
Hypothermia: body temperature taken orally less than 35.5 C
less than 35.0 (adults)
Severe dehydration – dry lips, mouth, skin,
sunken eyes, difficulty taking blood
Inability to rise from chair or squatting
position without use of hands (or SUSS test)
39
TEMPERATURE, HYDRATION, MUSCLE
STRENGTH
41
Full blood count
Electrolytes: Na, K, Mg, Phosphate, Calcium, bicarbonate
Kidney function tests, creatinine and urea
Glucose
Liver function tests including albumin
Thyroid function tests
Hormonal levels (oestradiol most useful)
Iron, Vit B12 and red cell folate
Vitamin D
INITIAL BLOOD TESTS
Potassium (K+) low due to vomiting and laxative use.
If below 3.0 mmol/l need urgent medical review
If below 2.5 mmol/l especially with ECG changes; can be life threatening.
42
POTASSIUM
Low sodium can indicate water loading
Low Magnesium - risk of arrhythmias
If Mg low - always indicates deficiency. Often due to
vomiting, laxative/diuretic use.
Low Phosphate – indicator of re-feeding syndrome,
need to treat and consider hospital referral.
43
SODIUM, MAGNESIUM, PHOSPHATE
Significantly elevated levels of bicarbonate
(more than 35 mmol/l) are often correlated
with purging
Monitor potassium closely if bicarbonate
elevated and vomiting or laxative use
suspected
44
BICARBONATE
45
Quick Reference Table (<18 years)
Body
System
Test or measure Warning
Parameter
Intervention if Within the Warning Parameter
Circulation Systolic BP (top number) <80 Monitor, check postural drop, assess hydration
Postural drop (lying-stand) >20 Check hydration, consider admission
Pulse rate <50 bpm get ECG and consider hospital admission
Temperature Oral if possible < 35.5
degrees
Need to keep warm, and increase food intake, restrict activity levels
and outings
Blood result Potassium <3.0
<2.5
Ask about vomiting and laxative use, ECG, medical review
Urgent medical review, hospital admission needed
Sodium < 135 Check for potential water loading, ask parents to monitor this
Magnesium < 0.75 Ask about vomiting or laxative use, needs treatment
Bicarbonate >31mmol Check for purging especially if > 35
Phosphate <0.7 Treat. Monitor regularly, if refeeding may need daily checks, refer
Creatinine Upper range of
normal or
>90
Suggests renal impairment, dehydration and/or muscle
wasting/weight loss
Quick Reference
Guide (Adults)
Assess ED behaviour change weekly
Assess weight weekly - if dropping need to check bloods (frequency depends on rate of loss and BMI%)
If at high risk of re-feeding consider hospital admission for medical stabilisation
Check medical monitoring is occurring and providing the information you need
Think about – should they be at school, playing sport, driving, travelling overseas?
47
ONGOING MONITORING
WHAT FACTORS CAN OBSCURE AN EATING
DISORDER?
Prior obesity with rapid weight loss
Other comorbid psychiatric disorders
Other comorbid medical disorders
Family and patient denial
14 YEAR OLD
Presented with a history of:
40 kg weight loss over 2 years
Restricted food intake
Excessive exercising
Low irritable mood.
Secondary amenorrhea for 1 year
Medically unstable:
Pulse rate below 38/min
Hypotensive
Peripherally shut down
Weight = 63 kg
PAST 3 YEARS
2012 aged 12 years, surgery for slipped femoral
epiphyses, advised to lose weight (weight = 103 kg)
Multiple appointments for myringoplasties
Recurrent presentations 2013 to GP with collapses
Investigated by Cardiology Service 2014 after a
collapse, heart rate down to 38/min on Holter
monitor
Diagnosed Fe deficiency and Vasovagal syncope
(weight = 78 kg)
WEIGHT PERCENTILE FOR AGE
HEIGHT PERCENTILE FOR AGE
BMI PERCENTILE FOR AGE
PSYCHIATRIC COMORBIDITY
Depression
Anxiety
Borderline Personality Disorder
Drug and alcohol abuse
Somatoform disorders
18 YEAR OLD
Long history of low mood, social phobia, mood
instability and deliberate self harm
Trials of SSRIs, CBT, attending a DBT group
Presented after seeing GP for a chest infection and
GP noted weight loss
No record of weights in treating mental health
services.
Disclosed 2-3 year history of vomiting and food
restriction, initially as part of attempted affect
regulation
13 year old girl
Identical twin
Born prematurely
Onset of symptoms 12yrs
Teased about pre-adolescent chubbiness
Healthy eating
Rep netball team
School council
Twin issues
CASE PRESENTATION - LS
Weight 1 year prior = 68kg
As weight ↓, more & more driven and obsessed by weight.
Last 4 months low mood, low energy, anxious
Weight loss 23.5 kg in 1 year (35% of body wt)
No periods last 2 months (?more)
Exercising 1-2 hours per day
No purging
Fluid restricting
LS
GROWTH CHART - WEIGHT
GROWTH CHART - HEIGHT
GROWTH CHART - BMI
OBSERVATIONS
Temp = 35.4
Heart Rate = 38/min
BP lying = 138/92
BP standing = 96/55
Dehydrated
ELECTROLYTES
FULL BLOOD COUNT
16 years old
Age 9 meningitis → chronic headaches
(Topiramate)
Last 2 years – chronic abdominal pain
Extensive investigation
Seen by several specialists
GP prescribed multiple alternative therapies
Tried various exclusion diets
Weight loss of 20kg in 1 year
HC
2 admissions to hospital
Evidence of laxative abuse
3rd admission Xmas Eve
Pitting oedema to knees
Heart Rate = 33/min
BP and temp normal
Rapid fluctuations in weight
Hyponatraemia
Abnormal liver function tests
HC
Nutritional supplements
Alternative therapies
Liquorice tea!
Athletes
BE AWARE OF:
SUPPLEMENTS
Is there any side effects?
Garcinia Cambogia is very well tolerated by the body.
CDC Weight, height and BMI centile charts
http://www.cdc.gov/growthcharts/clinical_charts.htm#Set2
Starship Clinical Guidelines
https://www.starship.org.nz/for -health-professionals/starship -cl inical -guidel ines/a/anorexia /
Marsipan Guidelines (UK – 2nd edition Oct 2014)
http://www.rcpsych.ac.uk/pdf/CR189_a.pdf
Junior Marsipan Guideline
http://www.rcpsych.ac.uk/files/pdfversion/CR168nov14.pdf
73
ONLINE RESOURCES
“FOOD IS AN IMPORTANT PART OF A
BALANCED DIET”- FRAN LEBOWITZ
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