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Chapter 6 DNA Replication, Repair, and
Recombination
Essential Cell Biology
Third Edition
Copyright © Garland Science 2010
Figure 6-2 Essential Cell Biology (© Garland Science 2010)
Figure 6-3 Essential Cell Biology (© Garland Science 2010)
Figure 6-4 Essential Cell Biology (© Garland Science 2010)
Figure 6-5 Essential Cell Biology (© Garland Science 2010)
Figure 6-6 Essential Cell Biology (© Garland Science 2010)
Figure 6-7 Essential Cell Biology (© Garland Science 2010)
Figure 6-8 Essential Cell Biology (© Garland Science 2010)
Figure 6-9 Essential Cell Biology (© Garland Science 2010)
Figure 6-10 Essential Cell Biology (© Garland Science 2010)
Figure 6-11 Essential Cell Biology (© Garland Science 2010)
Figure 6-12 Essential Cell Biology (© Garland Science 2010)
Figure 6-13 Essential Cell Biology (© Garland Science 2010)
Incorrectly inserted nucleotides are removed by DNA Pol 5’-> 3’ editing activity
Figure 6-14 Essential Cell Biology (© Garland Science 2010)
With proofreading, error rate is 1 error in 107 bases
Figure 6-16 Essential Cell Biology (© Garland Science 2010)
The replacement of RNA in DNA requires three enzymes
Nuclease, DNA polymerase
DNA ligase
Figure 6-17a Essential Cell Biology (© Garland Science 2010)
Figure 6-17b Essential Cell Biology (© Garland Science 2010)
Figure 6-18 Essential Cell Biology (© Garland Science 2010)
Figure 6-19 Essential Cell Biology (© Garland Science 2010)
Single base-pair changes in DNA give rise to many diseases
Also……
Hun$ngton’s Disease
Hemacrhomatosis
Cys$c fibrosis
Muscular Dystrophy
Haemophilia A & B
Achonroplasia
And many others!
~1013 - 1014 cells in human body
Figure 6-20 Essential Cell Biology (© Garland Science 2010)
Accumula+on of muta+ons increases cancer risk
Figure 6-21c Essential Cell Biology (© Garland Science 2010)
Figure 6-22 Essential Cell Biology (© Garland Science 2010)
The efficient synthesis of DNA has enabled synthesis of microbial genomes
See interview on “60 Minutes”
Figure 6-23 Essential Cell Biology (© Garland Science 2010)
Wear a hat with a wide brim
Figure 6-24 Essential Cell Biology (© Garland Science 2010)
Figure 6-25a Essential Cell Biology (© Garland Science 2010)
Deaminda+on of Cytosine Yields Uracil and a permanent G-‐>A muta+on
Figure 6-25b Essential Cell Biology (© Garland Science 2010)
Depurina+on results in base-‐pair dele+on
Figure 6-26 Essential Cell Biology (© Garland Science 2010)
Figure 6-30 Essential Cell Biology (© Garland Science 2010)
Figure 6-37 Essential Cell Biology (© Garland Science 2010)
Figure 6-36 Essential Cell Biology (© Garland Science 2010)
Figure 6-38 Essential Cell Biology (© Garland Science 2010)
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