evaluation of chest pain in outpatient clinic crystal wiley cené, md, mph
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Evaluation of Chest PainIn Outpatient Clinic
Crystal Wiley Cené, MD, MPH
A Chest Pain Case
A 65 year-old man with a past medical history significant for hypertension and dyslipidemia presents to clinic after 2 episodes of chest pain in past couple days. What do you want to know and do?
Clinical classification of chest pain
• Typical angina (definite)1) Substernal chest discomfort with a characteristic
quality & duration that is 2) provoked by exertion or stress and 3) relieved by NTG or rest
• Atypical angina (probable)– Meets 2 of above characteristics
• Noncardiac chest pain– Meets 1 or none of typical anginal characteristics
#1 Goal
EXCLUDE Coronary artery disease and other life-threatening conditions
So, what are those?
• Acute Coronary Syndrome/Myocardial infarction
• Pulmonary embolus
• Aortic dissection
• Tension Pneumothorax
*All of these could lead to sudden death*
History• “PQRST”
– Provocative/palliative factors
– Quality: character, duration, frequency, associated sxs
– Radiation
–Severity–Timing
• Risk factors: age, tobacco use, family history, DM/HTN/Lipids, cocaine; other- DVT/PE, Marfans/Pregnancy, ETOH, NSAIDS
• PMHx: prior CV w/u & Rx, GI history
Provocation and Palliation• Postprandial? GI or cardiac
disease
• Exertion? Angina or esophageal pain
• Cold, emotional stress, sexual intercourse can promote ischemic pain
• Worse with swallowing? Esophageal origin
• Body position, movement, deep breathing? Musculoskeletal origin
• Antacids or food? Gastro-esophageal origin
• Sublingual nitro? Esophageal or cardiac
• “GI Cocktail” (viscous lidocaine and antacid)? GI or cardiac
• Cessation of activity/rest? Ischemic origin
• Sitting up and leaning forward? Pericarditis
Evaluation• Region or location:
– Radiation to neck, throat, lower jaw, teeth, upper extremity, or shoulder• Radiation to arms is useful and stronger predictor of acute MI• Between scapulae think aortic dissection
– Larger areas of discomfort more likely ischemic etiology
• Severity: not useful predictor for presence of CAD
• Timing:– Abrupt onset with greatest intensity in beginning: PTX, dissection,
acute PE– Gradual with increasing onset over time: ischemic – Crescendo pattern: esophageal disease– Lasts for seconds or constant over weeks ≠ ischemic– Circadian rhythm (morning>afternoon) correlating with increase
sympathetic tome- more likely myocardial ischemia
Associated Symptoms• Belching, bad taste in mouth, dysphagia or odynaphagia
esophageal disease
• Vomiting Transmural MI, GI problems
• Diaphoresis MI> esphoageal disease
• Syncope dissection, PE, critical AS, ruptured AAA
• Presyncope myocardia ischemia
• Palpitations in setting of new A. Fib + chest pain PE
• Fatigue can be presenting complaint of MI esp. in elderly
Any exam findings that might help distinguish cardiac from non cardiac
chest pain?• General Appearance
– may suggest seriousness of symptoms.
• Vital signs – marked difference in blood
pressure between arms suggests aortic dissection
• Palpate the chest wall – Hyperesthesia may be due
to herpes zoster
• Complete cardiac examination– pericardial rub– signs of acute AI or AS – Ischemia may result in MI
murmur, S4 or S3
• Determine if breath sounds are symmetric and if wheezes, crackles or evidence of consolidation
Ancillary Studies• EKG
– “Normal” reduces probability chest pain is due to AMI, but does NOT exclude serious cardiac etiology (i.e. Unstable Angina)
– ST elevation, ST depression, or new Q waves- important predictor of Acute Coronary Syndrome (AMI or UA)
– “Nonspecific” ST and T wave changes is common- may or may not indicate heart disease
• CXR– Useful in acute setting to avoid missing dangerous diagnoses
(e.g. PTX, Aortic dissection, Pneumomediastinum)
“Likelihood Ratio”
• Likelihood ratio expresses the odds that a given level of a diagnostic test result would be expected in a patient with (as opposed to without) the target disorder
Sacket, et al. Clinical Epidemiology
Features Increasing Likelihood of AMI
Clinical Feature Likelihood Ratio (95% CI)Pain in chest or left arm 2.7
Chest pain radiation
Right Shoulder 2.9 (1.4-6.0)
Left arm 2.3 (1.7-3.1)
Both left and right arm 7.1 (3.6-14.2)
Chest pain most important symptom 2.0
History of MI 1.5-3.0
Nausea or vomiting 1.9 (1.7-2.3)
Diaphoresis 2.0 (1.9-2.2)
Third heart sound 3.2 (1.6-6.5)
Hypotension (SBP<80) 3.1 (1.8-5.2)
Pulmonary rales on exam 2.1 (1.4-3.1)
Features Decreasing Likelihood of AMI
Clinical Feature Likelihood Ratio (95% CI)Pleuritic chest pain 0.2 (0.2-0.3)
Chest pain sharp or stabbing 0.3 (0.2-0.5)
Positional chest pain 0.3 (0.2-0.4)
Chest pain reproduced with palpation
0.2-0.4
Panju, et al. JAMA 1998;280:14:1256-1263
ECG Findings Increasing Likelihood of AMI
Panju, et al. JAMA 1998;280:14:1256-1263
High likelihood of ACS • Worsening frequency, intensity, duration, timing (e.g.
nocturnal pain, rest pain) of prior angina• New onset SOB, nausea, sweating, extreme fatigue in
patient with known h/o CVD• Onset of typical anginal symptoms in pt without h/o
CVD• New murmur (or worsening of previously noted
murmur), hypotension, diaphoresis, rales, pulmonary edema
• Transient ST deviation (≥ 1mm) or TWI in multiple precordial leads
Case
• A 57 year old male comes in to the ER with sudden onset of “tearing chest pain” that radiates to his back. – What is your differential?– What exam findings might you look for?– What tests could you do and why?– What are the treatments for the most likely
diagnoses?
What exam findings might you look for?
• Acute MI • Hypotension in one extremity• Aortic murmur• Neurologic deficits, including paraplegia, stroke,
or decreased consciousness• Syncope, tamponade, and sudden death due to
rupture of the aorta into the pericardial space• Shock, hemothorax, and exsanguination• Acute lower extremity ischemia
Wrestler with Chest Pain
18 yo high school wrestler develops right-sided chest pain while pinning his opponent.
Physical exam reveal decreased breath sounds on right
Final Thoughts
• Nitro response is not diagnostic of UA• Post-prandial pain may be ischemic• Discomfort thresholds vary• Patient histrionics may influence you• “Atypical” is typical of something• Value of careful history and physical
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