heavy ion tumor therapy michael scholz gsi darmstadt
Post on 25-Dec-2015
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Introduction
Advantage of ion beams for therapy:
Physical aspects:• Inverted depth dose profile• Defined penetration depth• Reduced lateral scattering
Biological aspects:• Increased effectiveness• Reduced oxygen effect
Increased effectiveness depends on many parameters like e.g.dose, Z, LET, or depth, which have to be taken into account fortreatment planning
Die höhere Wirkung schwerer Ionen
Die RBE hängt ab von:
• Dosis
• Strahlenergie
• Ionensorte
• Reparaturvermögen
der Zelle
Heavy ion induced foci
Cell Nucleus
CDKN1A/p21: greenDNA: red
Tracks in CR39
p21 response
Pb-ions, 3.1 MeV/u, 3x106/cm2
Ca-ions, 10.1 MeV/u, 2x106/cm2
Heavy Ion Therapy
• Carbon: advantage of RBE• 3 Blocks / 4 weeks per year• 10…15 Patients / Block• 140 Patients total since Dec. 1997
2/3 carbon alone
1/3 photons + carbon boost
• Tumors: head and neck, few pelvic• chordoma, chondrosarcoma, ACC, meningeoma
Heavy Ion Therapy: Technical Aspects
• Horizontal fixed beam• Active magnetic scanning + energy variation
– 250 energies, 7 focus steps, 15 intensity steps
• 2-4 fields per patient and treatment day• Typical treatment time: 45 min• Typical irradiation time/field: 5…10min• Verification of distal field edge by PET using 11C
Current Activities
• Moving targets
• Installation of patient chair
• PET with protons (FZ Rossendorf, W. Enghardt et al.)
• Preparation of the dedicated clinical facility at Heidelberg
Schedule for Heidelberg Facility
2002 Call for tenderRefine specificationsPrepare Component manufacturingBuilding construction documentation
2003 Component manufacturingConstruction work
2004 Component manufacturingComponent acceptance trials
Begin 2005 SystemtestsMid 2005 CommissioningMid 2006 Pre-clinical operationsEnd 2006 Clinical operation
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