isr'obot mona lisa product presentation- june 2016

iSR’obot TM Mona Lisa

ZICOM GROUP

• Founded in 1978

• Listed on the ASX.

• Global Workforce > 700

• Presence in Singapore (HQ), Australia, Indonesia, Thailand, China, USA

• Enterprise 50

• Singapore 1000

• ISO 13485 & 9001

Key Information

Marine, Oil & Gas ConstructionPrecision Engineering & Technologies (PET)

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(ASX: ZGL)

• Sales • R&D• Manufacturing

• Australia-Wide Service Support

Overview of iSR’obotTM Mona Lisa

The iSR’obot Mona Lisa is a

Robotic Assisted System .

• Transperineal Prostate Biopsy

• Automated Biopsy Positioning

• Unrestricted Dual Cone Coverage

• MRI-Ultrasound Fusion Capability

• HSA, CE, FDA and TGA Approved

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Automated Robotic Positioning from 3D Biopsy Plan

• Biopsy Planning on Real-time Ultrasound Transverse

Images

• Review of Biopsy Plan on 3D Ultrasound Model

• Automated Robotic Arm Guides Biopsy Needle to Each

Planned Biopsy Core via Perennial Skin

• Ease of MRI Cognitive Planning

• Consistent and Repeatable Biopsy Precision

Automated Needle Trajectory

Automated Needle Depth

Biopsy Planning on Real-time Ultrasound

Biopsy Plan Review on 3D Model

Automated Robotic Needle Positioning based on Biopsy Plan

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Unrestricted Dual Conical Coverage

Horizontal rotational movement (top view)

Vertical rotational movement (side view)

• Absence of a Grid Template to Restrict Biopsy

Sampling

• Good access to Prostate Apex and Anterior

• Minimal Skin Puncture

• Avoids Urethra

• Minimize Pubic Arch Interference

Prostate

Pivot Points Perineal skin

Intervention angles

2 Puncture Points on Perineum Skin

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MRI-US Fusion with Automated Robotic Guided Biopsy

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� Elastic MRI-Ultrasound 3D Model Registration

� Fusion-Guided Biopsy Planning

� Robotic Lesion Targeted Biopsy

Fused 3D Model with Marked Lesion

Automated Robotic Needle Positioning to Targeted

Tumor

Lesion Marked MRI Model

Real-time Ultrasound Model

Workflow - MRI-US Fusion Targeted Biopsy

Operative - Urologist

US Scan with Robot

patient3D US image

Prostate Modeling

US prostatemodel

Import MRI Data

Fusion Guidedbiopsy

Biopsy Execution

BiopsyReport

MRI Scan Prostate Modeling

Pre-operative – Radiologist/UrologistLesion Marking

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Minimal Prostate Movement with Probe Sheath

PZCZ

TS

AFZProstate

Probe Sheath

The Probe Sheath supports the Prostate during biopsy.

This Minimizes Prostate Movement, enabling Accurate Biopsy Targeting

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Journals & Conference Presentations

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AUA 16-21 st May 2014 The Journal of Urology, Vol. 191, No. 4S

Supplement

Conference Presentations

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34th SIU 12-14th October 2015 AUA 15-19 th May 2015

Conference & Preliminary Studies

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Patients:

55 men with only one non-palpable suspicious lesion in multi-parametric magnetic resonance imaging (mpMRI) after prior negative 12-core transrectal ultrasound-guided biopsy

Results :

• 34 out of 55 patients (61.8%) were diagnosed with Prostate Cancer .

• 29 out of 34 (85.3%) Prostate Cancer were clinically significant intermediate- or high-risk cancers.

69th USANZ 16-19th April 2016 Results from Preliminary Study from Clinical Partners

in Germany

In the News

SINGAPORE

GERMANY

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Worldwide

Singapore

Singapore General Hospital

- Prof. Christopher Cheng

National University Hospital

Germany

Universitätsklinikum Tuebingen

- Prof. Arnulf Stenzl

Universitätsklinikum Freiburg

Australia

Epworth Hospital, Melbourne

USA

NYU Langone Medical Center

- Prof. Samir Taneja

United Kingdom

Charing Cross Hospital, Imperial College Healthcare

Italy (Clinical Demos)

Arcispedale Santa Maria Nuova, Reggio Emilia

Ospedale San Lazzaro, Alba

Ospedale San Bortolo, Vicenza

Hesperia Hospital, Modena

Ospedale Maggiore S Giovanni, Torino

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