kapita selekta mikrobiologi mikroskop ‣ anton van leeuwenhoek. ‣ pembesaran sampai 300x. ‣ era...
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Mengapa belajar mikrobiologi?
Berperan dalam kesehatan manusia
The Triumph of Death by Pieter Brueghel
Mikroorganisme sangat berguna dalam dunia riset
‣ Struktur yang sederhana pemodelan proses kehidupan.
‣ Cost-benefit.
‣ Reproduksi sangat cepat.
Sejarah Mikrobiologi
‣ Bangsa Yunani kuno, Romawi, dan Yahudi berkontribusi pada pemahaman awal tentang penyebaran penyakit.
‣ Sanitasi, isolasi, agen penyakit.
Wabah Bubonic (Black Death)
‣ 1347-1351.
‣ 25 juta jiwa tewas ~ 1/4 populasi eropa saat itu.
‣ Ketidakmampuan.
Sedlec OssuaryThe Triumph of Death by Pieter Brueghel
Penemuan Mikroskop‣ Anton van Leeuwenhoek.
‣ Pembesaran sampai 300x.
‣ Era observasi mikroorganisme dimulai.
‣ ‘‘For my part I judge, from myself (howbeit I clean my mouth like I’ve already said), that all the people living in our United Netherlands are not as many as the living animals that I carry in my own mouth this very day.’’
Anton van Leeuwenhoek (1632–1723).
The Germ Theory of Disease
‣ mikroorganisme dapat menyerang organisme lain dan menyebabkan penyakit.
‣ Fase studi awal, Pasteur, Koch, Pengendalian infeksi.
Fase Studi Awal
‣ Penyangkalan “Spontaneous Generation Theory” (Abad 17 -19)
‣ Francesco Redi, Lazzaro Spallanzani, Schwann.
‣ Louis Pasteur, John Tyndall.
Robert Koch
‣ Identifikasi penyebab antrax, tuberkulosis dan kolera.
‣ Kultur murni bakteri
‣ Postulat Koch Robert Koch dan istri
Infection Control
‣ Ignaz Philipp Semmelweis ; pentingnya mencuci tangan
‣ Joseph Lister; teknik aseptik sebelum pembedahan
Because of the wealth of prior knowledge, it is likely that you will learn more about microbiology in a single
course than many pioneers learned in a lifetime.
Current and Future Microbiology
‣ AIDS
‣ Post-Antibiotic Era (Phage Therapy?)
‣ Bioengineering
‣ Gene-therapy
‣ Bioterroism
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