lymphoma / leukaemia biobanks · lymphomas - released material to help support projects in...

Lymphoma / Leukaemia Biobanks

Melanie Oates

• 2 diseases • 1 issue: collect material involved in disease

Circulating within the blood Lymphatic tissues

Leukaemia/Lymphoma Biobanking

in Liverpool

University of Liverpool

Leukaemia Bank

LLR funded

2005-15

Leukaemia Biobanking in Liverpool

2005

2002

1988 No formal Biobank, samples were collected by PIs for their own research group

University of Liverpool

Leukaemia Bank

The coordinated collection of lymphoproliferative disorders was started with clinical annotation

2013

University of Liverpool Leukaemia Bank

•Purpose: Local & LLR funded Researchers

•Disease(s): Leukaemias and Lymphomas

•Collection: Local cohort

•Samples: cryopreserved PBMCs, plasma,

germline DNA

•Run to local and HTA standards

Leukaemia Biobanking in Liverpool

Leukaemia Biobanking in Liverpool

University of Liverpool Leukaemia Bank

- > 32,640 vials of patient material

- Data/ material from more than 600 CLL patients

- Material/data from 151 other leukaemias and lymphomas

- Released material to help support projects in

Newcastle University Hull Royal Marsden Manchester Royal Inf.

Birmingham University Oxford University

Leukaemia Biobanking in Liverpool

UK CLL Trials Biobank (2008)

• Purpose: National sample repository

• Disease: CLL

• Collection: patients entering national clinical trials

• Samples: PBMCs, plasma, serum, germline DNA

• Run to GCP for Laboratories and HTA standards

LIVERPOOL

GCLP

Leukaemia Biobanking in Liverpool

UK CLL Trials Biobank

• Has historical clinical trial material transferred

CLL201, CLL202, CLL206, CLL4

Trials Phase I Phase II Phase III

Closed RESPeCT

Closed to recruitment

AdMIRE ARCTIC

Open CLEAR, CLL210, COSMIC, CHOP-OR CyCLLe

RIAltO

Lymphoma Biobanking in Liverpool

PACIFICO Phase III trial (2009)

• Purpose: Research sample collection

• Disease: Follicular Lymphoma

• Collection: Patients entering national clinical trials

• Samples: PBMCs, plasma, serum, germline DNA &

FFPE tissue blocks

• Run to GCP for Laboratories standards and HTA

Purine-Alkylator Combination In Follicular lymphoma Immuno-Chemotherapy for

Older patients: a phase III comparison of R-CVP versus R-FC

LIVERPOOL

GCLP

Lymphoma Biobanking in Liverpool

PACIFICO Phase III (2009)

• Recruitment -680 patients

• 226 patients, given 352 blood samples for PBMCs,

plasma & serum

• 178 FFPE blocks from 136 patients

• Supporting research within Liverpool and nationally

University of Liverpool

Leukaemia Bank

•Lymphoma research groups

are expanding

•Different material required

•Logistical problems

Liverpool Tissue Bank

•Expertise in solid tissue

collection

•Collects material from other

sites

Leukaemia/Lymphoma Biobanking

in Liverpool

• To build on the lymphoma collection with LTB to include freshly isolated cells from tissue

• Support the national collection of Mantle Cell Lymphoma

The Future for Leukaemia/

Lymphoma Biobanking in Liverpool