malaysian healthy ageing society...e. laconi, s. doratiotto, p. vineis, the microenvironments of...

Organised by:

Malaysian Healthy Ageing Society

Co-Sponsored:

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Nutritional Therapy for

Cancer

Dato’ Steve Yap

Fellowship, Integrative Cancer Therapies

(USA)

Fellowship, Anti-Aging Regenerative

Medicine (USA)

DSY Wellness & Longevity Center

&

Mohamad Roji Sarmidi

Living Active, Wellness Centre

Universiti Teknologi Malaysia

22 March 2012 ■ FIRST WORLD CONGRESS ON HEALTY AGEING ■ Kualal Lumpur

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Presentation

Introduction: Halmarks of Cancer

Hypoxia, Mitochondria & Metabolism

Nutrients

Figure 1

Source: Cell , Volume 144, Issue 5, Pages 646-674 (DOI:10.1016/j.cell.2011.02.013)

Copyright © 2011 Elsevier Inc. Terms and Conditions

Hallmarks of Cancer

Hanahan, D, & Weinberg RA (2011). Hallmarks of cancer:the next generation

.

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Hallmarks of cancer

Increased glucose consumption and high rates of glycolysis

Resistance to the toxicity of local acidification

Evasion of anoikis

Cancer-associated inflammation

Hallmarks of Cancer

R.A. Gatenby, R.J. Gillies, A microenvironmental model of carcinogenesis, Nat Rev Cancer 8 (2008) 56-61. F. Colotta, P. Allavena, A. Sica, C. Garlanda, A. Mantovani, Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability, Carcinogenesis (2009).

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Why cancer cells do what they do

Hostile cellular environment

Adaptation & survival

Switch to default primitive state

J.S. Fang, R.D. Gillies, R.A. Gatenby, Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression, Semin Cancer Biol 18 (2008) 330-337. E. Laconi, S. Doratiotto, P. Vineis, The microenvironments of multistage carcinogenesis, Semin Cancer Biol 18 (2008) 322-329.

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Cellular Hypoxia

Vladimir Gogvadze, Sten Orrenius and Boris Zhivotovsky, Mitochondria in cancer cells: what is so special about them?Trends in Cell Biology Vol.18 No.4 [J.F. De Los Santos, G.M. Thomas, Anemia correction in malignancy management: threat or opportunity?, Gynecol Oncol 105 (2007) 517-529.

O2 O2 O2

Microcapillar

y

Expression of HIF-1 in human cancer: causes and consequences.

Vaupel P The Oncologist 2004;9:10-17

©2004 by AlphaMed Press

HIF-1-mediated switch from aerobic to anaerobic metabolism in hypoxic tumors for energy

preservation.

Vaupel P The Oncologist 2004;9:10-17

©2004 by AlphaMed Press

Schematic displaying the vicious circle of tumor hypoxia and malignant progression [6].

Vaupel P The Oncologist 2004;9:10-17

©2004 by AlphaMed Press

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Nutritional Therapy Strategy

Nutritional Therapy Strategy

Enhance overall health

Restore homeostasis

Optimize metabolism

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Raising Metabolism

Reduce Oxidation &

Inflammation

Optimize Basal Body

Temperature 97.8-98.3 oF

Normalize Thyroid

Function

Nutrient Dense & Low

GI Foods

Raising Metabolism

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Cell Membranes nutrients

Linoleic Acid (LA)

Alpha-Linolenic Acid (ALA)

Eicosapentanoic Acid (EPA; 20:5)

Docosahexanoic Acid (DHA; 22:6)

Phosphatidylcholine (PC)

Phosphatidylserine (PS)

Cell Membranes Nutrients

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Mitochondrial Nutrients

Mitochodrial Nutrients

Acetyl-L-Carnitine

Coenzyme-Q10

Alpha-Lipoic acid

Linoleic acid

Biotin

Nicotinamide

Riboflavin

Pyridoxine Pyrroloquinoline Quinone (PQQ)

Jiankang Liu a,f,⁎, Weili Shen b, Baolu Zhao c, Ying Wang d, Karin Wertz d, Peter Weber d, Peifang Zhang e, Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity : Hope from natural mitochondrial nutrients, Advanced Drug Delivery Reviews 61 (2009) 1343–1352

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Mitochondrial Toxin

Mitochondrial Toxins

Arsenite

Cynide

Fluoride

Oligomycin

Carbon monoxide

Sodium benzoate

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Sodium-Potassium Pumps

Magnesium

Potassium

SCFA enhances the absorption of Mg, K and Na in colon

Na+/K+ - ATPase

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Liver Nutrients

Vit C

Mg

Arginine

Tumeric

Silybum marianum

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Collagen Synthesis

Vit C

Lysine

Proline

Glycine

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Anti-inflammatory Nutrients

EPA

Papain

Quercetin

Anthocyanins

Curcumin

Methylsulphonylmethane (MSM)

Gamma-linolenic acid, VCO

Bromelain

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EGCG

Green tea (-)-epigallocatechin-3-gallate (EGCG)

Inhibit hypoxia-induced HIF-1a

Reduce vascular endothelial growth factor (VEGF)

Limit angiogenesis

Qunzhou Zhang, Xudong Tang, QingYi Lu, et al. Green tea extract and (−)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1 α protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells

Mol Cancer Ther 2006;5:1227-1238. Published online May 26, 2006.

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