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Mentoring for Startups

ReviveMedUnlocking the Value of Metabolomics

Leila Pirhaji, Ph.D.Founder and CEO

lpirhaji@revive-med.com

Presentation Overview

• ReviveMed’s Summary

• My Journey

• The role of my mentors in my journey

New Use of Existing Drugs Could Save Millions of Lives

Non-Alcoholic Fatty Liver has no Treatments

10,000s of Existing Drugs,>$1 Trillion of R&D

ReviveMed Solves the Puzzle Using Metabolomics

Existing AI/Machine-LearningLast decade

Metabolites>40,000 Small Molecules

ProteinDNA RNA

ReviveMedNow!

ReviveMed’s Pioneering Machine-Learning Algorithm

Developed at MIT Our patent-pending technology

was published at:

Because of tremendous diversity of metabolites, current platforms can only detect 500-700 of them (<5%)

Metabolomics had been Underutilized, Until Now!

ReviveMed Enables Leveraging Metabolomics

Reduces the need for costly and slow processes to identify large-set of metabolites

Proprietary Database Machine-

Learning

ReviveMed Revolutionizes Discovering New Treatments

Therapeutic Insights

Pre-clinically validatedReviveMed

Tissue Serum

Hospitals/Disease Associations

CROs

Whitehead/Harvard Metabolomic Facilities

I. Disease PathwaysII. Therapeutic TargetsIII. Existing (pre-, post-, no-

patent) drug CandidatesIV. Serum Biomarkers

Saving 100s of Millions and Years from Discovery to Clinic

ReviveMed Creates Value for Patients and Pharma

$55 B

Market Opportunity

Technology FitUniquely leveraging data

from 1000s of metabolites

The Next Breakout

Biotech Market

Market Size> 60M Americans

>$35B by 2025

ReviveMed Platform

Therapeutics for metabolic diseases

1st Therapeutic Focus

Therapeutics for non-alcoholic fatty liver

It wouldn’t be possible without Boston's Biotech Ecosystem

Boston’s Biotech

Ecosystem

Mentors

Academic research

Investment capital

Talent

Government

Industry

Boston is the Hollywood for Biotech Entrepreneurs

Legendary Stars Legendary Startups

My Entrepreneurial Journey – Academic Phase

Catching the entrepreneurial virus

Learning entrepreneurship

Practicing entrepreneurship

My Entrepreneurial Journey – Beyond Academia

Most Important Part of these Programs are Mentorships

Always Seeking for Mentors

The Power of Mentorships

Leveraging Mentors’ Professional Network

Foster Mentorship

Moving Beyond Mentor-Mentee Relationships

ReviveMed’s World-Class Team & Advisors

Prof. Ernest FraenkelCo-founder & Board

Member

Associate Professor of at MIT

Dr. Andrey Zarur

Board Member

CEO at GreenLightBiosciences

Lecturer at MIT Sloan

Prof. Clary ClishScientific Advisor

Director of Metabolomics Broad Institute

Prof. Matthew Vander Heiden

Scientific advisor

Associate Professor of Biology at MIT

Scientific advisor

Director of Data Sciences Fortune 500 Pharma

No public disclosures

Leila Pirhaji, Ph.D.Founder & CEO

Inventor of the technologyPhD in Bioengineering at MIT

ReviveMed: An Award-Winning Start-Up Company>$50 K in Cash Prize $50 K of Lab Space $200 K in Cloud Computing Credits

Machine-learning CompetitionTop 10 finalists

Analytic PrizeTop 26 Winners of 2017

22

www.revive-med.com

617.955.6425

info@revive-med.com

@Revive_Med

ReviveMedTransforming Metabolomics Data into

the Right Therapeutics for the Right Patients