neurotransmitter receptors in the amygdala receptors in the amygdala amygdala basomedial nucleus...
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Neurotransmitter Receptors in the AmygdalaAmygdala
Basomedial Nucleus(Accessory Basal)
Cortical Nucleus
Basolateral Nucleus
Medial Nucleus
Central Nucleus
Lateral Nucleus
Coronal Brain Section
Amygdala
The Amygdala (Greek for “almond-shaped”) is a nuclear complex found in the medial temporal lobe. It was initially described in the fi rst-half of
the 19th century by the German physician Karl Burdach, who also co-coined the term “morphology”. The amygdala suff ers from both a lack of
consensus regarding its anatomical structure, and the relationships of its structures (or nuclei) to adjacent brain areas. Here, we consider the
central and medial nuclei to be a phylogenetically “old” complex that has an association with olfaction, and the lateral and basolateral nuclei to
be phylogenetically “new” with connections to the cerebral cortex. In general, glutamatergic inputs target the lateral nucleus. The terminals can
end on amygdaloid glutamatergic projection neurons that further project to the basolateral and centromedial nuclei. These nuclei may
contribute additional intra-amygdaloid connections, or impact neurons in the central nucleus which typically transmit inhibitory signals to
neurons in autonomic centers. Alternatively, glutamatergic inputs to the lateral nucleus may end on lateral nucleus GABA neurons. This activates
GABA neurons, which subsequently inhibit lateral nucleus projection neurons, creating a feed forward inhibition pathway. In addition,
glutamatergic lateral nucleus neurons can act on adjacent GABAergic neurons, generating an inhibitory signal in a feedback inhibition pathway.
This schematic depicts potential neuronal processes, their interactions, and associated neurotransmitter receptors. R&D Systems currently off ers
antibodies to all labeled molecules.
PM_09.11_amygdala_OCT
NOTE: This poster conveys a general overview and should be considered neither comprehensive nor defi nitive. The details of the process are understood to be subject to interpretation. © R&D Systems, Inc. 2011 R&D Systems, Inc., 1-800-343-7475, www.RnDSystems.com/Neuroscience
PYRAMIDAL NEURON
(CaMK+)
ACCESSORY OLFACTORY BULB
GLUTAMATERGIC AFFERENT
GABAergic NEURON
(Estrogen Receptor +,
Parvalbumin+)
mGluR8
mGluR7
mGluR2
Glutamate Vesicles
mGluR2/R3
PERIAMYGDALOID CORTEX
GAD67+
GAD65+
PYRAMIDAL NEURON(CaMK+)
GLUTAMATERGIC AFFERENTGABAergic NEURON
(Parvalbumin+)
GABAergic NEURON(Cholecystokinin+)
(Vasointestinal Peptide+)
GABAergic NEURON(Cholecystokinin+)
mGluR3
GluR2 GluR3
mGluR5
mGluR2
mGluR7 GluR2GluR3
GluR1
mGluR1a
GABA Vesicles
GABA Vesicles
GABA Vesicles
GABAAR ( 3) GABA
AR ( 3)
Glutamate Vesicles
GABABR1
GABABR2
CannabinoidReceptor 1Kv3.1
K+ Channel
NPY R1
Kv2.2K+ Channel
Leptin R (Ob R)
mGluR3Glutamate Vesicles
BASOLATERAL NUCLEUS
GLUTAMATERGIC AFFERENT
NMDAR(NR2C)
GABAAR
( 1, 2+3)
GABAAR
( 1, 2+3)
GABA Vesicles
GABA Vesicles
PYRAMIDAL NEURON(CaMK+)
GABAergic NEURON(Parvalbumin+)
GABAergic NEURON
DOPAMINERGIC AFFERENTfrom VENTRAL TEGMENTAL AREA
NMDAR (NR1,NR2B)
NMDAR (NR2C)
GABABR1
TRPV1
Cannabinoid Receptor 1
GABABR2
Dopamine Transporter
Glutamate Vesicles
Glutamate Vesicles
Dopamine Vesicles
GLUTAMATERGIC AFFERENT
mGluR5
mGluR1a
NMDAR (NR1,NR2A)
GluR (2,3)
NMDAR (NR1,NR2A)
LATERAL NUCLEUS
PYRAMIDAL NEURON(CaMK+)
GABAergic PROJECTION NEURON
(Vasointestinal Peptide+,Somatostatin+)
NMDAR (NR1,NR2A)
GABAAR
( 2, 1, 2)
Corticotropin-releasing Hormone Receptor 1
Corticotropin-releasing Hormone Receptor 1 Glycine R ( 1, )
Somatostatin Receptor 2
GABAAR
( 2, 3, 1)
GLUTAMATERGIC AFFERENT
INTERCALATED CELL MASSES AFFERENT
BED NUCLEUS OF THESTRIA TERMINALS AFFERENT
TrkB
mGluR5
GAD67+
mGluR1a
GABA Vesicles
GABA Vesicles
GABAAR ( 2, 1)
Glutamate Vesicles
Vasointestinal Peptide Receptor 2
CENTRAL NUCLEUS
GABAergic NEURON(Neuropeptide Y+)
Glucagon-like Peptide Receptor 1
MEDIAL NUCLEUS
Nogo-C
GABAB R1 BSRP-A
Vanilloid R1
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