niaid commitment to influenza research and preparedness

NIAID Commitment to Influenza Research and

Preparedness

F. Gray Handley

Associate Director for

International Research Affairs

National Institute of Allergy and

Infectious Diseases

National Institutes of Health

January 28-31, 2007

U.S. Department of Health and Human Services

U.S. Department of Health and Human Services

Administration forChildren and Families

(ACF)

Food and DrugAdministration

(FDA)

Health Resourcesand Services

Administration(HRSA)

TheSecretary

Deputy Secretary

Administration onAging(AoA)

Centers for Medicare and

Medicaid Services (CMS)

Indian HealthServices

(IHS)

Centers for Disease Controland Prevention

(CDC)

Substance Abuse andMental Health Services

Administration(SAMHSA)

Program SupportCenter(PSC)

Agency for ToxicSubstances andDisease Registry

(ATSDR)

Agency for Health Care Policy

and Research(AHCPR)

National Institutesof Health

(NIH)

Office of the Director

National Instituteo Alcohol Abuseand Alcoholism

National Instituteof Arthritis andMusculoskeletal

and Skin Diseases

National CancerInstitute

National Instituteof Diabetes andDigestive and

Kidney Diseases

National Instituteof Dental andCraniofacial

Research

National Instituteon Drug Abuse

National Instituteof Environmental Health Sciences

National Instituteon Aging

National Instituteof Child Health

and HumanDevelopment

National Institute onDeafness and Other

CommunicationDisorders

National EyeInstitute

National HumanGenome Research

Institute

National Heart,Lung, and Blood

Institute

National Instituteof Mental Health

National Instituteof NeurologicalDisorders and

Stroke

National Instituteof General

Medical Sciences

National Instituteof Nursing Research

National Libraryof Medicine

Center for InformationTechnology

Center for Scientific Review

National Centerfor Complementary

and AlternativeMedicine

National Instituteof Allergy and

Infectious Diseases

National Centerfor ResearchResources

Clinical Center

National Center on Minority Health andHealth Disparities

National Institute of Biomedical Imagingand Bioengineering

FogartyInternational

Center

National Institutes of Health

NIAID Basic Research on Influenza

Viral replication and evolution Host-virus interactions Mechanisms and sites that stimulate immune

response Immune correlates of protection related to

seasonal influenza vaccination Modeling the dynamics of influenza

transmission in large human populations Sequence analysis of the 1918 pandemic

virus and its impact on human immune response

http://www.niaid.nih.gov/dmid/genomes/mscs/influenza.htm

NIAID Influenza Reagent Repository Managed by BEI Resources Makes reagents available to all registered

researchers (including international) at no charge (shipping and handling fees only)

Influenza reagents currently available: Purified H and N proteins Poly and monoclonal antibodies Influenza virus isolates Peptide arrays designed for epitope mapping Antiserum including human serum from H5

vaccinees

Register at: www.beiresources.gov

H5 Influenza Plans Underway in SE AsiaH5 Influenza Plans Underway in SE Asia

Increase training for investigators in SE Asia in areas related to clinical research and data management

Support seroprevalence H5N1 studies in China and Vietnam through NIAID’s CIPRA program and in collaboration with AFRIMS.

Develop research studies to examine cross-reactivity of H5N1 strains and molecular characterization of strains.

Funding in FY06: $18 Million.

Increase training for investigators in SE Asia in areas related to clinical research and data management

Support seroprevalence H5N1 studies in China and Vietnam through NIAID’s CIPRA program and in collaboration with AFRIMS.

Develop research studies to examine cross-reactivity of H5N1 strains and molecular characterization of strains.

Funding in FY06: $18 Million.

Opportunities for Expanded Research Cooperation

Global networks focused on basic, translational, therapeutic, vaccine research

Viral characterization and ecology studies (human and animal)

Training in all areas Seroprevalence studies Cooperative sequencing of strains Bioinformatics to facilitate access to

sequence data and analysis tools globally and equitably

Key Funding Links

Collaborative projects involving investigators and institutions from international sites and the U.S. are particularly encouraged.

NIAID has a long-standing interest in and commitment to global health and international research.

Topics of interest for this program are limited to research on infectious diseases, including emerging infections that are of the greatest public health significance within the overseas country (e.g. tuberculosis; malaria; HIV/AIDS; sexually transmitted diseases; diarrheal, respiratory, and enteric diseases; viral hemorrhagic fevers; viral encephalitides; parasitic diseases; and vector-borne diseases).

Development of immunological, microbiological, biostatistical, epidemiological, and clinical research capacity is encouraged. Studies may be proposed on any aspect of infectious diseases (except clinical trials), including but not limited to: the epidemiology, pathogenesis, immunopathogenesis of infectious diseases; epidemiologic studies to define the incidence, clinical presentations, and outcomes of diseases; identification of resistance patterns; characterization of susceptible cohorts for a particular pathogen; pilot and feasibility studies in preparation for larger studies.

http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-06-041.html http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html

For further information contact Karen Lacourciere: lacourcierek@niaid.nih.gov