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GlycobiologyNutritional Glycobiology

Essential Nutrients!

CarbohydratesFatsProteins

VitaminsMineralsWater

Definition of terms Glycans is the scientific term used by researchers to describe carbohydrate structures. (sugars)

Glycomics or glycobiology is the study of glycans.

These nutrients are categorized in the “sugar” family but these are the

BENEFICIALnot the

HARMFUL SUGARS

Glycobiology

The study ofBiological Sugar Chains(Essential Carbohydrates)

INFORMATIONAL SOURCE: ROBERT K MURRAY, MD, PHD

Technology

“Glycomcs is one of the top 10 technologies that will change the world.”

MIT’s Technology Review: Feb 2003

Technology

National Academy of Sciences Report:

Transforming Glycoscience:A Roadmap for the future: “Glycoscience Focus Recommended”

Oct 2012

Transforming Glycoscience: A roadmap to the Future.National Academy of Sciences (NAS) Oct 2012

“Every living cell on the planet is covered with a dense and complex arrayof glycans.”

Technology

Technology

“Every disease that affects humans significantly involvesglycans.”

Transforming Glycoscience: A roadmap to the Future.National Academy of Sciences (NAS) Oct 2012

“Glycans aresugar moleculesthat coat thesurface of everyliving cell. Once thought to be relatively unimportant, scientist now recognize that glycans play critical roles in cell regulation, human health and disease progression.”

UGA News Service Sept 6, 2013

"The tide is starting to turn,and researchers are beginning to appreciate how important thesesugar molecules are."

NCBG principal investigatorand member of UGA's Complex Carbohydrate Research Center.

Michael Pierce

8 Essential Biological Sugars

Glucose(from table Sugar)

Galactose(from milk products)

Typically, only these two are found in our modern diet.

Mannose

Xylose

Fucose

N-Acetylglucosamine

N-Acetylgalactosamine

N-Acetylneuraminic acid“Glycans”

GlycomicsDo Glycans make a difference?

They can mean the difference between life and death!“Blood Types”The only

difference between

TYPE A (GalNAc)

and

TYPE B (Gal)

is one sugar, but it can make a life/death difference in a transfusion

Red Blood Cell

N-Acetylgalactosamine

N-Acetylglucosamine

Fucose

Galactose

O

A

B

AB

GlycomicsDo Glycans make a difference?

They can mean the difference between life and death!Universal

DonorThe only difference between

TYPE A (GalNAc)

and

TYPE B (Gal)

is one sugar, but it can make a life/death difference in a transfusion

Red Blood Cell

N-Acetylgalactosamine

N-Acetylglucosamine

Fucose

Galactose

O

A

B

AB

GlycomicsDo Glycans make a difference?

They can mean the difference between life and death!

UniversalReceiver

The only difference between

TYPE A (GalNAc)

and

TYPE B (Gal)

is one sugar, but it can make a life/death difference in a transfusion

Red Blood Cell

N-Acetylgalactosamine

N-Acetylglucosamine

Fucose

Galactose

O

A

B

AB

Technology

“Glycans play roles in almost every biological process and are involved inevery majordisease.”Transforming Glycoscience: A roadmap to the Future.

National Academy of Sciences (NAS) Oct 2012

Technology

“Elimination of any single major class of glycans from an organismresults in death.”

Transforming Glycoscience: A roadmap to the Future.National Academy of Sciences (NAS) Oct 2012

Technology“Altered glycosylation is a universal feature of cancer and contributes to pathogenesisand progression.”

Transforming Glycoscience: A roadmap to the Future.National Academy of Sciences (NAS) Oct 2012

Technology

“From seasonal flu to cancer, scientists know that glycans are involved in the development of many disease, and they are constantly discovering more.”

UGA News Service Sept 6, 2013

SUMMARYCell surface sugar structures in glycoproteins and glycolipids are necessary for the proper recognition and function of every cell.

Immune system cells read these cell surface sugar structures on other cells to determine if they are healthy, need repair, or need to be destroyed.

SUMMARYWhen cells turn against the body as in degenerative or autoimmune functions, research has shown that in some cases sugars are missing from their glycoprotein structures.

“Removing a sugar [from its cell surface structures] turns protective antibodies [immune cells] into attackers” Rockefeller University, July 23, 2007

SUMMARYSince 2011, there are now several published studies using the combination of glyconutrients conducted in human trials which document improvements in immune system, cognitive, memory, concentration, attentiveness, mood, irritability, digestive, and cellular communication function.

Old Theory: Scientists once believed it was not possible to influence the body’s production of cell surface sugar structures through dietary intervention.

New Evidence: Science has now shown that the ingestion of glyconutrients can induce statistically significant changes in cell surface sugar structures like glycoproteins with no adverse effects

Latest research published in the European Journal of Clinical Nutrition (2011) 65,648-656

These nutrients do no cure, treat or mitigate disease and we make no claims regarding the personal outcome you may have by incorporating these special sugars into your diet.

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