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5PerkoGIPATHMWHH.tl PANCREAS GALLBLADDER 20

INfkmni.fifnIiInininirerngiseaseWilsonDisease

1 VIRALHEPATITIS HepaB c carcinoma

Asymptomatic or symptomaticd

i acute la ffinoesis1failure2 chronic3 fulminant failure

A B CTransmission fecal oral body fluid bo id

needles needles

1ChronicHep 751 7851carcinoma t t

Etc 750 syors vaccine newdrugsBottomline benign mostrecorer BADalmost

11110kjaundice acuteyellow skin due to TbilirubinCONJUGATED HB UNCONVUGATED HBdeliverexcretion hepatitis T production eamnoethitia

bile flow tumorblockage tuptake hepatitiscirrhosis chronicfibrotic nodular liverCAUSES

alcoholismhepatitis

leads to portal htht liver failIn risk ofcarcinoma

portal hypertension bloodflow through liverCAUSE consequences of pnthcirrhosisSYMPTOMS

ascitesvenousshuntsvarices hemorrhoidscongestivesplenomegalyhepaticencephalopathy

liverfailure endpt of diseaseCAUSES

fulminanthepatitiscirrhosisoverdose ascites

SYMPTOMSjaundiceedemableedinghyperammonemia

multipleorgansyst failure oral manifestationshepatic encephalopathy hematomaslgingbleedinghepatorenal Syst jaundicedmucosa

glossitist healingaftersurgery

2 ALCOHOLIC INERDHEAIE steatosis cirrhosis HepatitisAbstinence 5yrs 901

continuing syrs 50 660

endstage alcoholismCAUSE of DEATH

liver failureGl bleedinfection

3 HIRED HEMOCHROMATON nepawrenal synaAutosomal recessive pre

hepatocellularcarcinoma

mutation in hemochromatosis genecirrhosisskin pigmentation bronzingliver carcinomaearlydetection e tx phlebotomy chelators

4 WILSON DHEAff Autosomalrecessive Tcumutation ingene regulating a excretionSYMPTOMS

acute chronic liverdiseaseneuropsychiatric manifKayser Fleisherrings TO

TX cu onelationtherapy

5 HEPATO CARCINOMA strong assoc wt Hep Btc chronic liverdiseaseSYMPTOMS e attatoxinsrapid T liver sizePascitesfevert pain metastatic carcinomaPpp fetoprotein Irl gmostcommon livermalignancysurvivalrate p mo multiple lesions

GALLBLADDERuniichnoiteithsitani's

1 CHANTHIAN commonCholesterolStones COMPLICATIONS

fefantate cholecystitisfertile empyemaforty perforation

pigmentedstones a fistulaObstruction

theimathytic anemia pancreatitisbilirubin infections

PANCREA fmri Peaatifnaimitais

EXOCRINE ENDOCRINEdigestionenzymes insulin glucagon hormonesdiseases oo diseases

pancreatitis diabetescystic fibrosis tumorstumors

1 ACUTE PANCREATITIS acute inflammation reversible destructionSYMPTOMS

radiating pain abdomen backCAUSES

alcoholismgallstones

Labs T serum amylase lipase

2 CHRONIC PANCREATITIS long irreversible destructionmostly alcohol relatedSYMTOMS

I jiamutnaicelpain bouts5501 mortality20yrs

3 CARCINOMA 4Mleading cause of cancer usbiggest factor smokingHIGHLYINVASIVEsilent until late v highmortality 5yrs 51

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