potential biomarker for cancer diagnosis identified and cancer linked

Potential Biomarker for Cancer Diagnosis Identified and Cancer-Linked FAM190A Gene Found to Regulate Cell Division

Manuela Rincón Muñoz3rd semester

UPB

Cancer is a pathology very common nowdays, this is why researchers are constantly studying the causes.

Genes and some biomarkers have helped the process of understanding this illness .

It is extremely important for medicine students and profesionals to be updated with this information.

INTRODUCTION

In mitosis one set of chromosomes goes to each daughter cell, but for some reason, the chromosomes sometimes are not divided evenly, with one cell receiving an extra set and the other cell coming up short. Micronuclei appear at a higher frequency in cancer cells.

Potential Biomarker for Cancer Diagnosis Identified

Disrupted micronuclei, which can trigger massive DNA damage on chromosomes, might play an even more active role in carcinogenesis than previously thought.

Potential Biomarker for Cancer Diagnosis Identified

 "We identified disrupted micronuclei in two major subtypes of

human non-small cell lung cancer, which suggests that they could be a valuable

tool for cancer diagnosis.“

Potential Biomarker for Cancer Diagnosis Identified

Defects in: nuclear lamina, filaments that provide support and stability to the cell's nucleus, cause the nuclear envelope surrounding micronuclei to catastrophically collapse leading to the loss of basic nuclear functions such as replication, transcription, and DNA damage recognition and repair.

Potential Biomarker for Cancer Diagnosis Identified

It is fundamental for a correct diagnosis to understand how pathology is evolving, also this is a very important evidence of the advances molecular biology has acquired, I consider the cure for cancer is not far away.

OPINION

Cancer-Linked FAM190A Gene Found to Regulate Cell Division

knocking down expression of FAM190A disrupts mitosis. It shows a difficulty to separate creating cells with two or more nuclei.

 Professor of oncology and pathology at Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "The next time they try to divide, all the nuclei come together, and they try to make four cells instead of two. Subsequently, they try to make eight cells, and so on." 

Cancer-Linked FAM190A Gene Found to Regulate Cell Division

Deletions in the FAM190A gene could be found in nearly 40 percent of human cancers.

Cancer-Linked FAM190A Gene Found to Regulate Cell Division

Damage in FAM190A may cause chromosomal imbalances commonly seen in cancers. Multipolar mitosis is one of the most common functional defects reported in human cancers90 percent of human cancers have abnormal numbers of chromosomes.

Cancer-Linked FAM190A Gene Found to Regulate Cell Division

This is something very important that can lead to a suspicion on developing a cancer helping with the diagnosis. It is very interesting to know the illness that affects a big percentage of the world is multicausal and can be determined stuying genes.

OPINION

Cancer is one of the most common deseases on the earth. It’s extremely important to understand where it comes from and what it does.

MEDICAL UTILITY

Genetic information is highly related with cancer. It determines the way a cell acts, this is why is a target for actual medicine.

MEDICAL UTILITY

Mitosis plays a big role in carcinogenesis, cancer cells can go on dividing indefinitely which is why this is another determinating factor of pathology.

MEDICAL UTILITY

 "We identified disrupted micronuclei in two major subtypes of human non-small cell lung cancer, which suggests that they could be a valuable tool for cancer diagnosis.“ says Martin Hetzer

With this identification micronuclei is very important for several diagnosis, one of them is cancer, a very common famous illness.

MEDICAL UTILITY

Martínez S, Lina María. Biología molecular. 5 ed. Medellín : UPB . Facultad de medicina.

3ScienceDaily. Retrieved July 8 2013, from http://www.sciencedaily.com/releases/2013/07/130708200014.htm

3ScienceDaily. Retrieved July 3 2013, from http://www.sciencedaily.com/releases/2013/07/130703160357.htm

BIBLIOGRAPHY

GRACIAS…