sensing the swell by aoife morrin

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Sensing the Swell

Aoife Morrin Dublin City University

Responsive materials

Formats amenable to

electrochemical control and sensing

Tissue Hydration Skin

Patch

Gas Sensor Skin Tattoo

Protein Mining in Skin ISF

• Non-invasive• Early detection of

eczema flare-ups

• Non-invasive• Detection of acetone

as a marker for occult liver pathology

• Minimally-invasive• Melanoma biomarker

extraction from ISF

Conformable, conducting materials for skin electronics

Conformable, responsive materials for skin gas sensing

Smart nanomaterials for protein capture in

skin

Gorey, B., Smyth, M.R., White, B., Morrin, A. (2014). Journal of Materials Chemistry C, 2(30):6004-6009.

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Semi-wet and typically inert – host-network Ability to control diffusional behaviour of

molecules Responsive swelling

Hydrogels

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Responsive swelling

pH responsive hydrogel O

OO

O

NH2

OO

NH2+

O

OO

OH

NHO

ONH

OH

OO

O

PEGDGE Jeffamine EDR 148

Epoxy-amine network

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Conformable electrode substrate

Bare

1 coating

2 coatings

Tracking biospecific swelling using impedance

Z' /ohm

0 2000 4000 6000 8000 10000 12000 14000 16000 18000

- Z

'' / o

hm

0

5000

10000

15000

20000

25000

30000

35000

Water 1 uM glucose5 uM glucose10 uM glucose50 uM glucose100 uM glucose1 mM glucose3 mM glucose4 mM glucose 6 mM glucose10 mM glucose

1 mM glucose

10 mM glucose

….at least a 1000-fold improvement in LOD

MacKenna, N., Calvert, P., Morrin, A. (2015). Analyst. DOI: 10.1039/C4AN02252A

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MO

rGO

MO

Controlled release – electro-stimulation

MacKenna, N., Calvert, P., Morrin, A., Wallace, G.G., Moulton, S. (2015). J. Mater. Chem. B, 3:2530-2537.

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Time (min)

0 100 200 300 400

Sw

elli

ng

Rat

io

0

5

10

15

20

Increasing [acid]

Low pH(~ pH 3-

4)

O

OO

OH

NHO

ONH

OH

OO

O

High pH

Controlled release – pH-stimulation

Response times

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Disk Thick film

Not radically improved

Superporous

Aim to completely eliminate diffusional barrier

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Inducing superporosity Limitation on polymerisation using CO2 gas generation Oxygen gas generation via hydrogen peroxide catalysis

on Ag NPs

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Superporous hydrogels

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Response Times

Bulk Gel200-500 min

Superporous Gel20-40 s

Following On…..

Tissue Hydration Skin

Patch

Gas Sensor Skin Tattoo

Protein Mining in Skin ISF

• Non-invasive• Early detection of

eczema flare-ups

• Non-invasive• Detection of acetone

as a marker for occult liver pathology

• Minimally-invasive• Melanoma biomarker

extraction from ISF

Conformable, conducting materials for skin electronics

Conformable, responsive materials for skin gas sensing

Smart nanomaterials for protein capture in

skin

Thanks!To my group and my collaborators:

Esp: Nicky MacKenna Prof. Paul Calvert Prof. Simon Moulton Prof. Gordon Wallace

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aoife.morrin@dcu.ie