soal farmakokinetika
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Plot data berikut pada 2 jenis kertas (Semilog & Standar Rectangular)
a
t (jam) c (mg) Ln C
10 9 !"# b
20 $9 !"!9
!0 % !"29
0 #% !"0!90 ! "# c
120 10 2"0
10 2"# 0"92
d
Slope b '0"%$22$ k
ntercept a 10!"21 C0
R 0"99
a" paka* penurunan jumla* obat mengikuti protes orde nol atau orde 1+
b" ,erapa tetapan keceapatan (-)
c" ,erapa t 1"2+d" ,erapa jumla* obat .ang diekstrapolasikan pada sumbu / 0
e" Co+
" ,agaimana persamaan garis dan armakokinetikan.a+
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S33R4 56P6
5rde 7ol
Regression Statistics
' k 6 80 3ultiple R 0.99998
9-/10810!"21 R Suare 0"9999#2
k0 0"$21 jam djusted R 0"9999!
Standard : 0"2$9%2t1;2 0"#/0 5bser
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gnicance F
$"9:'010
oer 9!"#$$er 9!"oer 9!%& $$er 9!%&"
10"$#1 10#"12! 10"$#1 10#"12!'0"%9#2$ '0"%%$$9 '0"%9#2$ '0"%%$$9
PR5,,L64 56P6
Percentile 96
$" 2"#
2# 10
!1"% !#$" #%
%# %
91"% $9
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0
'0"!
'0"20
0"2
0"!
10
Residuals#
10
96
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Suatu larutan 5bat .ang dibuat segar pada konsentrasi #0 mg;ml" Setela* 0 *ari pa
1 Bika diasumsikan orde 1A kapan obat akan berkurang menjadi setenga* dari
2 Pertan.aan .ang sama dengan aA tetapi diasumsikan prosesn.a orde nol
log 'k;2"0/t8log 0 5rde 1 61;2 0"9;k 5de 0 0"#/0;k0
t1;2 0"9 1"# *ari 2! jam
log %#'k ; 2"0 / 08 log #01"$%#'2"#!!'k;2"0"0
0"0#1 *ari
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a 6 2#@A konsentrasi #0 mg;ml" -onsentrasi obat di dalam laruan menjadi %# mg;
konsentrasi asal+ t1;2
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l+
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pabila t 1;2 penguraian obat adala* ! jamA berapa lama aktu .ang diperlukan untuk
?ik
61;2 ! jam
0 12# mg
?it
6
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menguraikan 0@ dari 12# mg obat (asumsi orde 1)
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5bat dengan dosis #00 mgA = 0 lA - :l 0"2;*rA diberikan secara oral
,erapa konsentrasi obat dalam plasma 2 jam dan ! jam setala* pemberian
Baab
?osis #00 mg
= 0 l- el 0"2
61 2 jam
6 2 ! jam
CpCp0/e>'kel"t
Cp0 dose;<
#00;0 l
1" mg;l
Pada 2 jam e'k"t
0"%0/1"
11"1
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Ditung parameter armakokinetik - :lA dan = apabila
Cp 2 jam !"# mg;l
Cp jam "% mg;l
?osis !00 mg
kel ln "% ' ln !"#;'2'0"0!$%#
'0"0!
ln Cp 2 jamln Cp0 ' kel"t
ln !"#ln Cp0'0"0!$9/2
ln Cp21"#0!80"09$1"02
Cp0 !"9?ose;g
=?ose;Cp0!00"!"9$0" lt
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?ik -l (0"1% per jam) & = 2# l
,erapa dosis .ang diperlukan untuk obat ini melalui i< bolus agar mencapai konsentra
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i plasma 2"! mcg;ml (! mg;l) pada 2 jam
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Studi -asus
6 (jam) C (mg;ml) ln C
0"%# "!9 1"2# R 0"99
1 "2# 1"1$ a 1"!#$$%2 intercept
2 2"! 0"90 b '0"2%9$%# slope
1"$ 0"2! 1"! 0"!
# 1"0 0"0 1"2! '-"0"%# 8 ln 1"!#
0"$ '0"22 k"0"%# 1"!# ' 1"2!
% 0"1 '0"!9 0"%# 0"21
$ 0"! '0"%$ k 0"2$
10 0"2 '1"#
12 0"1# '1"90 kel '0"2$ Slope terbaa* 6 1;2 0"
?itan.a 6 1;2 2"1
1" - :lA t1;2A =dA uCA Cl+ =d ?osis ; Cp
2" Persamaan Earmakokinetik" pabila obat din.atakan tidak eekti *ingga konsentrasi 0" mcg;ml berapa lama+F
S33R4 56P6
Regression Statistics
3ultiple R 0"99999
R Suare 0"9999$#
djusted R 0"9999$!
Standard : 0"009$#
5bser
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0"192!% 0"001 0"#912 2# '0"%%#29
! 0"9%2 0 '0"%%1$2# # '0"!9!29
# 0"0#9!9% 0 '0"290! !# '0"221!!
'0"220%$ 0 '0"%12 ## 0"0#$29
% '0"#002# 0"00 1"#$#!1$ # 0"!%2
$ '0"%$012$ 0"00! 0"9#%$9 %# 0"20#%
9 '1"9$%% '0"00% '1"91#!# $# 0"9001110 '1"$992% 0"00 0"% 9# 1"1%$##
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5rde 1 ln 'k"t8ln 0
5rde 0 'kt80
9;k el
jam
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Setela* pemberian dosis #00 mg secara i
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erikut
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Sampel l plasma seorang pasien diambik seteka* oral dosis 10 mg dari larutan benIodi
t (jam) C(ng"ml) Ln Ce/p !"e(e/p'0"0$$"t) ?ari data di sampingJ
0"2# 2"$# 1"0!%19 a" tentukan tetapan k
0"# #"! 1"9199 b" tetapkan ka denga
0"%1 %"%# 2"0!%9 c" tentukan persamaa
1 9"$# 2"2$%!%1 d" tentukan 6 ma/2 1"2 2"%$#011 e" berapa =d apabila
! 22"1# "09%$%
2"01 "1#929 ?iasumsikan $0@ oa
10 19"09 2"9!91#
1! 1"9 2"1$$9
20 %"9% 2"0%#$!
S33R4 56P6
Regression Statistics
3ultiple R 0.08377
R Suare 0"00%01$
djusted R '0"1!$%
Standard : 0"##102
5bser
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2"#19#2 0"1% 1"19#$2 1"11111 2"%$#011
% 2"#!!$01 0"!0! 0"%$!#1 %2"22222 2"9!91#
$ 2"#%00!1 0"01$!% 0"119991 $" "09%$%
9 2"0%901 '0"#221% '1"02#! 9!"!!!!! "1#929
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iaIepin
ec eliminasi
metode residusi
n .ang menggambarkan konenstrasi obat dalam plasma dari benIodiaIepin baru
$0@
t terabsorpsA tentukan -aA t1;2 eliminasiA tma/A =d
$$er 9!%&"
"09#0#
0"0%92
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Non-Compartmental Analysis of Plasma Data after Intravenous
Time Unit h Method Linear Trapezoidal
Conc Unit μg/ml Analyst X200CA_P!
"ose #2$ "ate 20%&'('2%
"ose Unit mg Time %$)00)0$
Time Conc ln(C) AUC AUMC R0*2$ $%*++ +*,+#2-$+-&& &*(%&2$ %*&0(0&2$
0*$ -(*0$ (*+0(-(0$(0- 22*0##-$ -*#+&2$
0*-$ #2*,% (*(%--$$% (%*-0#-$ 20*2+-%#-$
% #$*%% (*((+,(($+-$ &2*-%%2$ +#*&(#-$ '0*,,,,0((0$,
%*$2 #%*-& (*(0+-##%2&$ %0&*0,-($ ,+*0##,02 '0*,,,,,+0$(#
2 -$*$% (*+2(2&$0,-# %(+*#(22$ %$,*%$,-$ '0*,,,,,(&2%
+ &2*0# (*%2#(2+#-$, 2%2*&+-2$ +2-*-#,-$ '0*,,,,,+&($
( $2*+2 +*,$-+-#-0-% 2&,*#+-2$ $2$*$(,-$ '0*,,,,,,,((+
& +&*0# +*$#$-+#&,$2 +$#*2+-2$ ,$%*+0,-$ '0*,,,,,,,+2&
# 2(*## +*2%(0&(2&-, (%,*%,-2$ %+&&*#2,-$ '0*,,,,,,,%%2
%2 %%*#+ 2*(-0&+#&-# (,2*&%-2$ 20(#*#2,-$ '0*,,,,,,#&(2
%# +*## %*+$$#+$%$+& $+,*-(-2$ 2(*22,-$2( %*2- 0*2+,0%&,00$ $$$*%,-2$ 2,#$*%#,-$
PK Solver 2.0
0 5 10 15 20 25
0
10
20
30
40
50
60
70
80
90
Time (h)
Concenr!ion ("#$ml)
100
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0 5 10 15 20 25
1
10
Time (h)
Concenr!ion ("#$ml)
0 5 10 15 20 251
10
100
Time (h)
Concenr!ion ("#$ml)
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Constant Infusion Input
R%!&' !r!meer Uni !l*eLam.da_z %/h 0*%#$,00+$$+
t%/2 h +*-2#$,$2(+(
Tma h %
0*,,,-#(,2+- Cma μg/ml #$*%%
0*,,,,#(%2$+ T_in1sion h %*$
0*,,,,#-((,% Clast_o.s/Cma 0*0%(,2%#&$#
0*,,,,#(-(# AUC 0't μg/mlh $$$*%,-2$
0*,,,,,,#&0# AUC 0'in_o.s μg/mlh $&2*02##&$%2
0*,,,,,,#20+ AUC 0't/0'in_o.s 0*,#-#((-22$
0*,,,,,,-++& AUMC 0'in_o.s μg/mlh32 +%#$*#,-+&($0,,
0*,,,,,,($&& MT 0'in_o.s h (*,%#$&$+$-(
4z_o.s 5mg6/5μg/ml6 -*#,&%((#(&%Cl_o.s 5mg6/5μg/ml6/h %*(&-#,&%+2$
4ss_o.s 5mg6/5μg/ml6 -*2%,,(+0&$&
30
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30
30
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6ime C ln C k"t eK'k"t
0 0
0"2# #1" "9$2%# "!12# '0"0!!92 0"9#!#%2
0"# %!"0# !"0!%!1 1#"%2# '0"0929$! 0"91120$
0"%# $2"91 !"!1%%# 19"2 '0"19!% 0"$9$1!
1 $#"11 !"!!9!# 21"002#1"#2 $1"% !"!0%$$ !"$2 SlopeJ (ka)
2 %#"#1 !"2!2# %"%!!$ intercept
2"0$ !"12$!2! $"%9#
! #2"2 "9#%%9 #%"2
"0$ "#$#%9 $$"! Pers 2J 10
$ 2!"$$ "21!0! 0"9
12 11"$ 2"!%09 %"!2
1$ "$$ 1"##$# !%"1
2! 1"2% 0"2901% 1#"!#
S33R4 56P6 r 0"99
slope ke '0"1$
Regression Statistics intercept !"1
3ultiple R 0.99818
R Suare 0"99
djusted R 0"99#999 slope titi '0"1$#9$
Standard : 0"0$$% intercept !"%02#9
5bser
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,"eK'k"t CN'C ln (CN'C)
?ari data dapatkan kontsanta laj
10#"22# #"$9#! "9$%0!! apaka* mungkin ba*a kaOk u
100"!!#2 2"9#1% "2%1$1 dari dataA metode mana untuk
9#"$$21# 12"9%21# 2"#2$0# ?ari data diatasA kalkulasikan t
apaka* anda akan mempertimb'2"$!$!%$ ln ka 1"02919!1%2
!"9$#$2 109"%91!
"$/eK'2"$#"t
Persamaan farmakokinetik o
Pers 1 ' pers 2
b
a 6 3a/ ln ka'ln ke;ka'ke
C
kel b ln kel '1"%1!%9$
a0 pers 1 Cp0110"2/eK'0"1$"t
,
Signicance F
1"#%:'01
Loer 9!" #$$er 9!"oer 9!%& $$er 9!%&
!"#!0 !"9#9#1 !"#!0 !"9#9#1
'0"1$$!9 '0"1%29% '0"1$$!9 '0"1%29%
;ka'k
;2
110"2 >((0"1 ))× 8 '109"$ Q>((2"$ )) 5
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u absorpsi -a dan laju konstantadd
tuk obat dalam larutan+bagaiamana menentukan k mana .ang merupakan k el
enentukan konsantanta absorpsi" Hagner'7elsonA Loo'Rieglman
a/A
ngkan armakkinetik ini untuk mengikuti model 1 kompartemen+mengapa+
at terseut adala!"
6ma/ 1C "%
Cma/ $#"11
1"02'1"%;2"$'0"1$
'0"2#9#!2
intercept;slope8109";2"$
'2#"2$%0
9"1%$#%
1$"%1% C ,;b8;a
0
0
10
20
0
!0
#0
0
%0
$0
90
0
0
0"#
1
1"#
2
2"#
"#
!
!"#
#
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# 10 1# 20 2# 0
Pro#l $ ter!ada% &
ProTl C ter*adap 6
Linear (ProTl C ter*adap 6)
# 10 1# 20 2# 0
Column C
Linear (Column C)
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P*armacokinetic 1 compartment
= 〖〗>(0 )
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