supercritical fluids micronization techniques
Post on 12-Sep-2021
19 Views
Preview:
TRANSCRIPT
Supercritical Fluids Supercritical Fluids Supercritical Fluids Supercritical Fluids micronization techniquesmicronization techniquesmicronization techniquesmicronization techniques
University of SalernoUniversity of SalernoDepartment of Chemical Engineering
University of University of TurkuTurkuDepartment of Biochemistry and Food Chemistry
Renata Adami Renata Adami Renata Adami Renata Adami PhD studentDept. Biochemistry and Food ChemistryUniversity of Turku FINLANDrenada@utu.fiDept. Chemical and Food EngineeringUniversity of Salerno ITALYradami@unisa.it
FINNISH CHEMICAL SOCIETY Compressed fluid technologies divisionCompressed fluid technologies divisionCompressed fluid technologies divisionCompressed fluid technologies divisionSeminar, Helsinki 23 November 2006
15.12.2006 Renata Adami
OutlineOutlineOutlineOutline
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesoSCF as a solventSCF as a solventSCF as a solventSCF as a solventoSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteoSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventoSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
Production of Production of Production of Production of micromicromicromicroand nanoparticlesand nanoparticlesand nanoparticlesand nanoparticles
products for aerosol1 µm < d < 5 µm
suspensions for injectiond < 500 nm
microparticlesmicroparticlesmicroparticlesmicroparticles
nanoparticlesnanoparticlesnanoparticlesnanoparticles
d < 200 nm directly to the organs
improvement of solubility characteristicsimprovement of solubility characteristicsimprovement of solubility characteristicsimprovement of solubility characteristics
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
Spray-dryinglarge PSD
high Temperature
Jet-millinglarge PSD
compounds denaturation
Liquid Antisolvent Crystallization
large PSD
residual solvents
Traditional ProcessesTraditional ProcessesTraditional ProcessesTraditional ProcessesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
gasgasgasgas----likelikelikelike
High High High High diffusivitydiffusivitydiffusivitydiffusivity
LowLowLowLow viscosityviscosityviscosityviscosity
liquidliquidliquidliquid----likelikelikelike
High densityHigh densityHigh densityHigh density
SupercriticalSupercriticalSupercriticalSupercritical FluidsFluidsFluidsFluids
Best control of PS PSDBest control of PS PSDBest control of PS PSDBest control of PS PSD
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
RRapidapidapidapid EExpansionxpansionxpansionxpansion of of of of SSupercriticalupercriticalupercriticalupercritical SSolutionolutionolutionolution
PParticles fromarticles fromarticles fromarticles from GGasasasas----SSaturated aturated aturated aturated SSolutionsolutionsolutionsolutions
RESSRESS
PGSSPGSS
SCF SCF SCF SCF asasasas a a a a solventsolventsolventsolvent
SCF SCF SCF SCF asasasas a solutea solutea solutea solute
®®
Supercritical Supercritical Supercritical Supercritical FluidsFluidsFluidsFluids basedbasedbasedbasedMicronization Micronization Micronization Micronization ProcessesProcessesProcessesProcesses
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
DDepressurizationepressurizationepressurizationepressurization of anof anof anof an EExpanded xpanded xpanded xpanded
LLiquidiquidiquidiquid OOrganicrganicrganicrganic SSolutionolutionolutionolution
DELOSDELOS
SSupercritical upercritical upercritical upercritical AAssisted ssisted ssisted ssisted AAtomizationtomizationtomizationtomizationSAASAA
CCarbon dioxidearbon dioxidearbon dioxidearbon dioxide AAssisted ssisted ssisted ssisted
NNebulization withebulization withebulization withebulization with aaaa BBubble ubble ubble ubble DDryerryerryerryerCANCAN--BDBD
SCF SCF SCF SCF asasasas a a a a cocococo----solventsolventsolventsolvent
®®
®®
®®
Supercritical Fluids basedSupercritical Fluids basedSupercritical Fluids basedSupercritical Fluids basedMicronization ProcessesMicronization ProcessesMicronization ProcessesMicronization Processes
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
SSupercritical upercritical upercritical upercritical AAntintintinti----SSolventolventolventolventSASSAS
SCF SCF SCF SCF asasasas anananan antiantiantianti----solventsolventsolventsolvent
GGas as as as AAntintintinti----SSolventolventolventolventGASGAS
AAerosol erosol erosol erosol SSolventolventolventolvent EExtractionxtractionxtractionxtraction SSystemystemystemystemASESASES
SSolutionolutionolutionolution----EEnhanced nhanced nhanced nhanced DDispersion by ispersion by ispersion by ispersion by SSupercritical fluidsupercritical fluidsupercritical fluidsupercritical fluidsSEDSSEDS
PPrecipitation with recipitation with recipitation with recipitation with CCompressed ompressed ompressed ompressed AAntintintinti----solventssolventssolventssolventsPCAPCA
SupercriticalSupercriticalSupercriticalSupercritical FluidsFluidsFluidsFluids basedbasedbasedbasedMicronization Micronization Micronization Micronization ProcessesProcessesProcessesProcesses
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
solubility of the compound in the SCF
morphology of the product depends on material structure and operative parameters
no use of organic solvents
limits for applications: many attractive substrates not enough soluble into the SCF
characteristicscharacteristicscharacteristicscharacteristics
RESSRESSRESSRESSSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
CO2CO2
pump
Active substance
Expansion vessel
EXTRACTION UNIT
PRECIPITATION UNIT
pump
Active substance
Expansion vessel
EXTRACTION UNIT
PRECIPITATION UNIT
pump
Active substance
Expansion vessel
EXTRACTION UNIT
PRECIPITATION UNIT
RESSRESSRESSRESSSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
inorganic and organic compounds
pharmaceuticals
polymers, biopolymers
very fine particles (d=0.5-20 µm) withnarrow diameter distributions
microcapsules or microspheres of composite materials
productsproductsproductsproducts
CarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepineCarbamazepine
[P. M. Gosselin et al., 2003]
GriseofulvinGriseofulvinGriseofulvinGriseofulvinGriseofulvinGriseofulvinGriseofulvinGriseofulvin (SC(SC(SC(SC(SC(SC(SC(SC--------CHFCHFCHFCHFCHFCHFCHFCHF33333333)))))))) ββββββββ--------SitosterolSitosterolSitosterolSitosterolSitosterolSitosterolSitosterolSitosterol
[M. Türk et al., 2002]
RESSRESSRESSRESSSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
solubility of SC-CO2in melted or liquid-suspended
substances
CO2as atomization vector and viscosity reducer
particles produced from a great variety of substances
limits: drug thermal stability up to melting conditions
difficulties in monitoring the PS
characteristicscharacteristicscharacteristicscharacteristics
PGSSPGSSPGSSPGSS®®SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
Saturation
Expansion
Product
CO2
Saturation
Expansion
Product (polymer)
CO2
PGSSPGSSPGSSPGSS®®SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
inorganic and organic compounds
pharmaceuticals
microspheres 1->100 µmmicrocomposite particles
productsproductsproductsproducts
BaTiOBaTiOBaTiOBaTiOBaTiOBaTiOBaTiOBaTiO33333333
[Z. Novak et al. 2001]
TheophyllineTheophyllineTheophyllineTheophyllineTheophyllineTheophyllineTheophyllineTheophylline/HPO (/HPO (/HPO (/HPO (/HPO (/HPO (/HPO (/HPO (HydrogenatedHydrogenatedHydrogenatedHydrogenatedHydrogenatedHydrogenatedHydrogenatedHydrogenated PalmPalmPalmPalmPalmPalmPalmPalm Oil)Oil)Oil)Oil)Oil)Oil)Oil)Oil)
[M. Rodrigues et al. 2004]
PGSSPGSSPGSSPGSS®®SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
limited solubility between SC-CO2and liquid solvent
efficient coating between the two phases
use of N2for maintenance of temperature during the
process
low temperature
atmospheric pressure
solvent: organic solvents, WATER
characteristicscharacteristicscharacteristicscharacteristics
SAASAASAASAA®SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
SAASAASAASAA®
2040
2040
20
2040
E. E. E. E. ReverchonReverchonReverchonReverchon SwissSwissSwissSwiss PatentPatentPatentPatent 1209/01, 20011209/01, 20011209/01, 20011209/01, 2001
11111111
33333333
22222222
44444444
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
productsproductsproductsproducts� micromicromicromicro andandandand submicro crystalline particlessubmicro crystalline particlessubmicro crystalline particlessubmicro crystalline particles
� micromicromicromicro and nanoand nanoand nanoand nano particlesparticlesparticlesparticles (100(100(100(100 nmnmnmnm ---- >5 >5 >5 >5 µµµµm)m)m)m)� inorganic compoundsinorganic compoundsinorganic compoundsinorganic compounds
� pharmaceuticalspharmaceuticalspharmaceuticalspharmaceuticalsNaClNaClNaClNaClNaClNaClNaClNaCl fromfromfromfromfromfromfromfrom HHHHHHHH22222222OOOOOOOO
TetracyclineTetracyclineTetracyclineTetracyclineTetracyclineTetracyclineTetracyclineTetracyclinefromfromfromfromfromfromfromfrom HHHHHHHH
22222222OOOOOOOO
RifampicinRifampicinRifampicinRifampicinRifampicinRifampicinRifampicinRifampicin fromfromfromfromfromfromfromfrom HHHHHHHH22222222OOOOOOOO
AluminumAluminumAluminumAluminumAluminumAluminumAluminumAluminum SulfateSulfateSulfateSulfateSulfateSulfateSulfateSulfatefromfromfromfromfromfromfromfrom HHHHHHHH
22222222OOOOOOOO
[E. Reverchon et al., 2003][E. Reverchon et al., 2003]
SAASAASAASAA®SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
Batch OperationBatch OperationBatch OperationBatch OperationBatch OperationBatch OperationBatch OperationBatch Operation
SemicontinuousSemicontinuousSemicontinuousSemicontinuousSemicontinuousSemicontinuousSemicontinuousSemicontinuous OperationOperationOperationOperationOperationOperationOperationOperation
SAS processesSAS processesSAS processesSAS processes
Discontinuous for the solid phaseDiscontinuous for the solid phaseDiscontinuous for the solid phaseDiscontinuous for the solid phase
Continuous for the fluid phaseContinuous for the fluid phaseContinuous for the fluid phaseContinuous for the fluid phaseGas batch SASGas batch SASGas batch SASGas batch SAS
Liquid batch SASLiquid batch SASLiquid batch SASLiquid batch SAS
SASSASSASSAS
the solute insoluble in the antisolvent
the liquid solvent completely miscible in the supercritical antisolvent at the process conditions
characteristicscharacteristicscharacteristicscharacteristics
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
CO 2
pump
Solution of active substance
particles
Expanded solution
CO 2
pump
Solution of active substance
particles
Expanded solution
Gas Gas Gas Gas Gas Gas Gas Gas batchbatchbatchbatchbatchbatchbatchbatch SASSASSASSASSASSASSASSAS
LiquidLiquidLiquidLiquidLiquidLiquidLiquidLiquid batchbatchbatchbatchbatchbatchbatchbatch SASSASSASSASSASSASSASSAS
precipitation precipitation precipitation precipitation occurs in the occurs in the occurs in the occurs in the liquid rich phaseliquid rich phaseliquid rich phaseliquid rich phase
precipitation occurs precipitation occurs precipitation occurs precipitation occurs in supercritical fluid in supercritical fluid in supercritical fluid in supercritical fluid rich phaserich phaserich phaserich phase
Batch SASBatch SASBatch SASBatch SAS
GASGASGASGASSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
liquid solution and supercritical anti-solvent are continuously delivered to the precipitation vessel P
CO 2
pump
nozzle
High pressure vessel
pump
P vent
Low pressure tank
P P
CO 2
nozzle
P P
SemiSemiSemiSemi----continuouscontinuouscontinuouscontinuous SASSASSASSAS
SAS SAS SAS SAS –––– ASES ASES ASES ASES –––– SEDS SEDS SEDS SEDS ---- PCAPCAPCAPCA
ASESASESASESASESASESASESASESASES
SAS SAS SAS SAS SAS SAS SAS SAS –––––––– SEDS SEDS SEDS SEDS SEDS SEDS SEDS SEDS --------PCAPCAPCAPCAPCAPCAPCAPCA
delivering in codelivering in codelivering in codelivering in co----current modecurrent modecurrent modecurrent mode
delivering in counterdelivering in counterdelivering in counterdelivering in counter----current modecurrent modecurrent modecurrent mode
11111111
33333333
22222222
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
• DMSODMSODMSODMSO
• NMPNMPNMPNMP
• MeOHMeOHMeOHMeOH
• EtOHEtOHEtOHEtOH
• AcetoneAcetoneAcetoneAcetone
• DichloromethaneDichloromethaneDichloromethaneDichloromethane
• EthylEthylEthylEthyl AcetateAcetateAcetateAcetate
UsualUsualUsualUsual SolventsSolventsSolventsSolvents
SASSASSASSAS
• MethyleneMethyleneMethyleneMethylene chloridechloridechloridechloride
• TolueneTolueneTolueneToluene
• CyclohexanoneCyclohexanoneCyclohexanoneCyclohexanone
• ButylButylButylButyl BromideBromideBromideBromide
• MEKMEKMEKMEK
• HexaneHexaneHexaneHexane
• THFTHFTHFTHF
• DMFDMFDMFDMF
OtherOtherOtherOther SolventsSolventsSolventsSolvents
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
ExplosivesExplosivesExplosivesExplosives improvementimprovementimprovementimprovement of of of of combustioncombustioncombustioncombustion processprocessprocessprocess
PolymersPolymersPolymersPolymers, , , , biopolymersbiopolymersbiopolymersbiopolymers chromatographychromatographychromatographychromatography, , , , adsorbentsadsorbentsadsorbentsadsorbents, , , , catalystcatalystcatalystcatalystsupportssupportssupportssupports, , , , drugdrugdrugdrug delivery systemdelivery systemdelivery systemdelivery system
PharmaceuticalPharmaceuticalPharmaceuticalPharmaceutical principlesprinciplesprinciplesprinciples improvementimprovementimprovementimprovement of of of of therapeutictherapeutictherapeutictherapeuticaction of action of action of action of drugsdrugsdrugsdrugs
ColoringColoringColoringColoring mattermattermattermatter, , , , superconductorssuperconductorssuperconductorssuperconductors, , , , catalystscatalystscatalystscatalysts
improvementimprovementimprovementimprovement of of of of coloringcoloringcoloringcoloring power, power, power, power, surfacesurfacesurfacesurface areasareasareasareas, , , , superconductingsuperconductingsuperconductingsuperconducting
propertiespropertiespropertiesproperties
ApplicationsApplicationsApplicationsApplications
SASSASSASSASSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
AcYAcY from DMSOfrom DMSO
[E. Reverchon et al., 1998, 2002]
GdAcGdAcGdAcGdAcGdAcGdAcGdAcGdAc from DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSO
Superconductor Superconductor Superconductor Superconductor precursorsprecursorsprecursorsprecursors
SASSASSASSASSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
DextranDextranDextranDextranDextranDextranDextranDextranfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSO
PLLA from PLLA from PLLA from PLLA from PLLA from PLLA from PLLA from PLLA from Methylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene Cloride
[E. Reverchon et al., 2000]
LLLLLLLL--------PLA PLA PLA PLA PLA PLA PLA PLA from from from from from from from from Methylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene ClorideMethylene Cloride
[L.S. Tu at al., 2002]
BiopolymersBiopolymersBiopolymersBiopolymers
SASSASSASSASSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
Tetracycline from NMPTetracycline from NMPTetracycline from NMPTetracycline from NMPTetracycline from NMPTetracycline from NMPTetracycline from NMPTetracycline from NMP
Amoxicillin from NMP Amoxicillin from NMP Amoxicillin from NMP Amoxicillin from NMP Amoxicillin from NMP Amoxicillin from NMP Amoxicillin from NMP Amoxicillin from NMP
RifampicinRifampicinRifampicinRifampicinRifampicinRifampicinRifampicinRifampicin from DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSOfrom DMSO
PharmaceuticalsPharmaceuticalsPharmaceuticalsPharmaceuticalsSASSASSASSAS
[E. Reverchon et al., 1999, 2002]
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
Ascorbic Acid Ascorbic Acid Ascorbic Acid Ascorbic Acid Ascorbic Acid Ascorbic Acid Ascorbic Acid Ascorbic Acid from EtOHfrom EtOHfrom EtOHfrom EtOHfrom EtOHfrom EtOHfrom EtOHfrom EtOH
[F. E. Wubbolts et al., 1999]
ParaParaParaParaParaParaParaPara--------Hydroxybenzoic Acid Hydroxybenzoic Acid Hydroxybenzoic Acid Hydroxybenzoic Acid Hydroxybenzoic Acid Hydroxybenzoic Acid Hydroxybenzoic Acid Hydroxybenzoic Acid from Methylene Chloridefrom Methylene Chloridefrom Methylene Chloridefrom Methylene Chloridefrom Methylene Chloridefrom Methylene Chloridefrom Methylene Chloridefrom Methylene Chloride
Lysozyme from Lysozyme from Lysozyme from Lysozyme from Lysozyme from Lysozyme from Lysozyme from Lysozyme from DMSODMSODMSODMSODMSODMSODMSODMSO
[P. York et al., 2000]
FoodFoodFoodFood additivesadditivesadditivesadditives
SASSASSASSAS
[L.S. Tu at al., 2002]
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
SAS SAS SAS SAS apparatusapparatusapparatusapparatus
SAS laboratory apparatusSAS laboratory apparatusSAS laboratory apparatusSAS laboratory apparatusUniversity of Salerno (Italy)University of Salerno (Italy)University of Salerno (Italy)University of Salerno (Italy)
SAS semiSAS semiSAS semiSAS semi----industrial apparatus industrial apparatus industrial apparatus industrial apparatus MTT MTT MTT MTT AgrifoodAgrifoodAgrifoodAgrifood Research FinlandResearch FinlandResearch FinlandResearch Finland
Liquid solution
CO 2 pump max 10 kg/h
pump
vent
CO 2
Inj e c tor of 20 0 micron
precipitator L/D ratio of 5 I.V. 0.5 dm 3
P
low pressure tank
11111111
33333333
22222222
1111111133333333
22222222
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
SAS SAS SAS SAS laboratorylaboratorylaboratorylaboratory----scalescalescalescale plantplantplantplant
University of Salerno (Italy)University of Salerno (Italy)University of Salerno (Italy)University of Salerno (Italy)
SCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
MTT MTT MTT MTT AgrifoodAgrifoodAgrifoodAgrifood Research Finland, Research Finland, Research Finland, Research Finland, JokioinenJokioinenJokioinenJokioinen (Finland)(Finland)(Finland)(Finland)
SAS pilotSAS pilotSAS pilotSAS pilot----scale scale scale scale plantplantplantplantSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniquesSCF and micronization techniques
SCF as a solventSCF as a solventSCF as a solventSCF as a solventSCF as a soluteSCF as a soluteSCF as a soluteSCF as a soluteSCF as a coSCF as a coSCF as a coSCF as a co----solventsolventsolventsolventSCF as an antiSCF as an antiSCF as an antiSCF as an anti----solventsolventsolventsolvent
SAS micronization apparatusSAS micronization apparatusSAS micronization apparatusSAS micronization apparatus
15.12.2006 Renata Adami
for your attentionfor your attentionfor your attentionfor your attention
15.12.2006 Renata Adami
ReferencesReferencesReferencesReferencesP. M. Gosselin, R. Thibert, M. Preda and J. N. McMullen, Polymorphic properties of Polymorphic properties of Polymorphic properties of Polymorphic properties of micronizedmicronizedmicronizedmicronized carbamazepinecarbamazepinecarbamazepinecarbamazepine produced by RESS produced by RESS produced by RESS produced by RESS International Journal of Pharmaceutics (2003) 252 (1-2), 225-233J. Jung and M. Perrut, Particle design using supercritical fluids: Literature and pateParticle design using supercritical fluids: Literature and pateParticle design using supercritical fluids: Literature and pateParticle design using supercritical fluids: Literature and patent survey, nt survey, nt survey, nt survey, J Supercrit. Fluids, (2001) 20 (3), 179-219S. Moshashaee, M. Bisrat, R.T. Forbes, H. Nyqvist, P. York, Supercritical fluid processing of proteins. I: Supercritical fluid processing of proteins. I: Supercritical fluid processing of proteins. I: Supercritical fluid processing of proteins. I: LysozymeLysozymeLysozymeLysozyme precipitation from organic precipitation from organic precipitation from organic precipitation from organic solution.solution.solution.solution. Eur. J. Pharm. Sci. (2000), 11(3), 239-245.
Z. Novak, Z. Knez, I. Ban, M. Drofenik, Synthesis of barium Synthesis of barium Synthesis of barium Synthesis of barium titanatetitanatetitanatetitanate using supercritical CO2 drying of gels.using supercritical CO2 drying of gels.using supercritical CO2 drying of gels.using supercritical CO2 drying of gels. J Supercrit. Fluids (2001), 19(2), 209-215.
E. Reverchon, G. Della Porta, A. Di Trolio, S. Pace, Supercritical Antisolvent Precipitation of Nanoparticles of SupSupercritical Antisolvent Precipitation of Nanoparticles of SupSupercritical Antisolvent Precipitation of Nanoparticles of SupSupercritical Antisolvent Precipitation of Nanoparticles of Superconductor Precursors,erconductor Precursors,erconductor Precursors,erconductor Precursors,Ind. Eng. Chem. Res. (1998), 37(3), 952-958.
E. Reverchon, G. Della Porta, Production of antibiotic microProduction of antibiotic microProduction of antibiotic microProduction of antibiotic micro---- and and and and nanonanonanonano----particles by supercritical antisolvent precipitation,particles by supercritical antisolvent precipitation,particles by supercritical antisolvent precipitation,particles by supercritical antisolvent precipitation, Powder Tech. (1999), 106(1-2), 23-29.
E. Reverchon, Supercritical antisolvent precipitation of microSupercritical antisolvent precipitation of microSupercritical antisolvent precipitation of microSupercritical antisolvent precipitation of micro---- and and and and nanonanonanonano----particles,particles,particles,particles, J. Supercrit. Fluids (1999), 15(1), 1-21.
E. Reverchon, G. Della Porta, M.G. Falivene, Process parameters and morphology in amoxicillin micro and Process parameters and morphology in amoxicillin micro and Process parameters and morphology in amoxicillin micro and Process parameters and morphology in amoxicillin micro and submicrosubmicrosubmicrosubmicro particles generation by particles generation by particles generation by particles generation by supercritical antisolvent precipitation,supercritical antisolvent precipitation,supercritical antisolvent precipitation,supercritical antisolvent precipitation, J. Supercrit. Fluids (2000), 17(3), 239-248.
E. Reverchon, G. Della Porta, I. De Rosa, P. Subra, D. Letourneur, Supercritical antisolvent micronization of some biopolymers,Supercritical antisolvent micronization of some biopolymers,Supercritical antisolvent micronization of some biopolymers,Supercritical antisolvent micronization of some biopolymers, J. Supercrit. Fluids (2000), 18(3), 239-245.
E. Reverchon, SupercriticalSupercriticalSupercriticalSupercritical----Assisted Atomization To Produce MicroAssisted Atomization To Produce MicroAssisted Atomization To Produce MicroAssisted Atomization To Produce Micro---- and/or Nanoparticles of Controlled Size and Distribution,and/or Nanoparticles of Controlled Size and Distribution,and/or Nanoparticles of Controlled Size and Distribution,and/or Nanoparticles of Controlled Size and Distribution, Ind. Eng. Chem. Res. (2002), 41(10), 2405-2411.
E. Reverchon, I. De Marco, G. Della Porta, RifampicinRifampicinRifampicinRifampicin microparticles production by supercritical antisolvent precipimicroparticles production by supercritical antisolvent precipimicroparticles production by supercritical antisolvent precipimicroparticles production by supercritical antisolvent precipitation.tation.tation.tation. Int. J. Pharm. (2002), 243(1-2), 83-91.
E. Reverchon, I. De Marco, G. Della Porta, Tailoring of Tailoring of Tailoring of Tailoring of nanonanonanonano---- and microand microand microand micro----particles of some superconductor precursors by supercritical particles of some superconductor precursors by supercritical particles of some superconductor precursors by supercritical particles of some superconductor precursors by supercritical antisolvent precipitation,antisolvent precipitation,antisolvent precipitation,antisolvent precipitation, J. Supercrit. Fluids (2002), 23(1), 81-87.
E. Reverchon, G. Della Porta, Micronization of antibiotics by supercritical assisted atomizatiMicronization of antibiotics by supercritical assisted atomizatiMicronization of antibiotics by supercritical assisted atomizatiMicronization of antibiotics by supercritical assisted atomization,on,on,on, J. Supercrit. Fluids (2003), 26(3), 243-252.
E. Reverchon, Process for the production of micro and/or Process for the production of micro and/or Process for the production of micro and/or Process for the production of micro and/or nanonanonanonano particles,particles,particles,particles, PCT Int. Appl. (2003), 20 pp. WO 2003004142
E. Reverchon, A. Spada, Crystalline Microparticles of Controlled Size Produced by SupercCrystalline Microparticles of Controlled Size Produced by SupercCrystalline Microparticles of Controlled Size Produced by SupercCrystalline Microparticles of Controlled Size Produced by Supercriticalriticalriticalritical----Assisted Atomization,Assisted Atomization,Assisted Atomization,Assisted Atomization, Ind. Eng. Chem. Res. (2004), 43(6), 1460-1465.
M. Rodrigues, N. Peirico, H. Matos, E. Gomes de Azevedo, M.R. Lobato, A.J. Almeida, MicrocompositesMicrocompositesMicrocompositesMicrocomposites theophyllinetheophyllinetheophyllinetheophylline/hydrogenated palm oil /hydrogenated palm oil /hydrogenated palm oil /hydrogenated palm oil from a PGSS process for controlled drug delivery systems,from a PGSS process for controlled drug delivery systems,from a PGSS process for controlled drug delivery systems,from a PGSS process for controlled drug delivery systems, J Supercrit. Fluids (2004), 29(1-2), 175-184.L.S. Tu, F. Dehghani, N.R. Foster, Micronization and microencapsulation of pharmaceuticals using a Micronization and microencapsulation of pharmaceuticals using a Micronization and microencapsulation of pharmaceuticals using a Micronization and microencapsulation of pharmaceuticals using a carbon dioxide antisolvent.carbon dioxide antisolvent.carbon dioxide antisolvent.carbon dioxide antisolvent. Powder Tech (2002), 126(2), 134-149.
M. Turk, P. Hils, B. Helfgen, K. Schaber, H.J. Martin, M.A. Wahl, Micronization of pharmaceutical substances by the Rapid ExpansioMicronization of pharmaceutical substances by the Rapid ExpansioMicronization of pharmaceutical substances by the Rapid ExpansioMicronization of pharmaceutical substances by the Rapid Expansion of n of n of n of Supercritical Solutions (RESS): a promising method to improve biSupercritical Solutions (RESS): a promising method to improve biSupercritical Solutions (RESS): a promising method to improve biSupercritical Solutions (RESS): a promising method to improve bioavailability of poorly soluble pharmaceutical agents,oavailability of poorly soluble pharmaceutical agents,oavailability of poorly soluble pharmaceutical agents,oavailability of poorly soluble pharmaceutical agents, J Supercrit. Fluids(2002), 22(1), 75-84.
F.E. Wubbolts,O.S.L. Bruinsma, G.M. van Rosmalen, DryDryDryDry----spraying of ascorbic acid or acetaminophen solutions with supercspraying of ascorbic acid or acetaminophen solutions with supercspraying of ascorbic acid or acetaminophen solutions with supercspraying of ascorbic acid or acetaminophen solutions with supercritical carbon ritical carbon ritical carbon ritical carbon dioxide.dioxide.dioxide.dioxide. J Crystal Growth (1999), 198/199 (1), 767-772.
top related