the role of the role of --monographs in monographs in ... · capsici fructus ph. eur. cardui mariae...

The role of The role of --monographs in monographs in university research and teachinguniversity research and teachinguniversity research and teachinguniversity research and teaching

Liselotte KrennLiselotte Krenn

„20 Years of ESCOP“„20 Years of ESCOP“

Cologne, 18. 06. 2009Cologne, 18. 06. 2009

History of History of --MonographMonographss

�� 19891989ESCOP Scientific Committee ESCOP Scientific Committee starts work on the monographsstarts work on the monographsstarts work on the monographsstarts work on the monographs

�� 19921992first publication of monographs first publication of monographs and submission to the CPMPand submission to the CPMP

�� 1996/1997/19991996/1997/1999publication of 60 monographspublication of 60 monographs

History of History of --MonographMonographss

History of History of --MonographMonographss

�� 20032003Second editionSecond editioncompletely revised and expanded completely revised and expanded completely revised and expanded completely revised and expanded

�� 20092009SupplementSupplement withwith28 new monographs28 new monographs+ 7 revised monographs+ 7 revised monographs

Elaboration of Elaboration of --MonographsMonographs

Draft of expert or Draft of expert or project leaderproject leader

Check by Sci. Comm. Check by Sci. Comm. Check by Sci. Comm. Check by Sci. Comm. members members

Discussion in Discussion in the Meetingthe Meeting

RevisionRevisionApproval in Approval in Sci. Comm.Sci. Comm.

Board of Board of SupervisorsSupervisors

Final editingFinal editing

As adopted by HMPC 2006

25

Citations of Citations of --MonographMonographss

0

5

10

15

20

1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008

based on a search in Scopusbased on a search in Scopus

Citations of Citations of --MonographMonographss

IRELAND

Advantages of Advantages of --Monographs in Scientific UseMonographs in Scientific Use

�� balanced evaluation of literature due balanced evaluation of literature due to the composition of the Sci. Comm.to the composition of the Sci. Comm.

�� comprehensive compilations of relevant comprehensive compilations of relevant �� comprehensive compilations of relevant comprehensive compilations of relevant pharmacological, toxicological and clinical pharmacological, toxicological and clinical studiesstudies

�� complete list of referencescomplete list of referencesup to 200 per monographup to 200 per monograph

�� Publication of revisions !Publication of revisions !

ClinicalClinical sstudietudiessssinceince 19901990

160Drug monitoringstudies

Open studies

bbased ased onon ESCOPESCOP--MonographMonographss aand Medlinend Medline

0

20

40

60

80

100

120

140

Ginkgo Hypericum Cimicifuga Garlic Harpagophytum

Open studies

ComparativestudiesPlacebo-controlledstudies

Pharm. studies inhumans

Scientific Use of Scientific Use of --MonographMonographss

�� for calculations of dosages in animal studies for calculations of dosages in animal studies

Scientific Use of Scientific Use of --MonographMonographss

�� for calculations of dosages in clinical studies for calculations of dosages in clinical studies

�� as a basis for reviewsas a basis for reviews

Scientific Use of Scientific Use of --MonographMonographss

�� to substanciate indicationsto substanciate indications

Scientific Use of Scientific Use of --MonographMonographss

�� in the developement of courses in in the developement of courses in phytotherapyphytotherapy

as a basis for examinations on as a basis for examinations on

Use of Use of --MonographMonographs s in Teachingin Teaching

�� as a basis for examinations on as a basis for examinations on respective plantsrespective plants

�� as a basis in as a basis in discussdiscussions ofions of the the feasibility of different feasibility of different assaysassays, their , their advantages and limitationsadvantages and limitations

New monographs New monographs in the Supplementin the Supplement

�� Agrimoniae herba Ph.Eur.Agrimoniae herba Ph.Eur.

�� Aloe barbadensis Ph.Eur.Aloe barbadensis Ph.Eur.

�� Angelicae radix Ph.Eur.Angelicae radix Ph.Eur.

�� Ballotae nigrae herba Ph. Eur.Ballotae nigrae herba Ph. Eur.

�� GrindeliaeGrindeliae herbaherba

�� Lavandulae flos Ph.Eur.Lavandulae flos Ph.Eur.

�� Malvae sylvestris flos Ph.Eur.Malvae sylvestris flos Ph.Eur.

�� Melaleucae aetheroleum Ph.Eur.Melaleucae aetheroleum Ph.Eur.

�� BoswelliaBoswellia serrataserrata (Olibanum)(Olibanum)

�� Capsici fructus Ph. Eur.Capsici fructus Ph. Eur.

�� Cardui mariae fructusCardui mariae fructus

�� Centellae asiaticae herba Ph.Eur.Centellae asiaticae herba Ph.Eur.

�� Crataegi fructus Ph. Eur.Crataegi fructus Ph. Eur.

�� Cucurbitae semenCucurbitae semen

�� Curcumae xanth. rhizoma Ph.Eur.Curcumae xanth. rhizoma Ph.Eur.

�� EchinaceaeEchinaceae angustangust.. radixradix PhPh..EurEur..

�� FumariaeFumariae officinalisofficinalis herbaherba

�� GraminisGraminis rhizomarhizoma PhPh..EurEur..

�� Millefolii herba Ph.Eur.Millefolii herba Ph.Eur.

�� Paullinia cupana (Guaraná)Paullinia cupana (Guaraná)

�� Pruni africanae cortex Ph. Eur. Pruni africanae cortex Ph. Eur.

�� Ratanhiae radix Ph.Eur.Ratanhiae radix Ph.Eur.

�� Rosae pseudoRosae pseudo--fructus Ph.Eur.fructus Ph.Eur.

�� Symphyti radix for topical useSymphyti radix for topical use

�� Vaccinium macrocarpon (Cranberry)Vaccinium macrocarpon (Cranberry)

�� ViolaeViolae herbaherba cumcum floreflore PhPh.. EurEur..

�� Vitis viniferae foliumVitis viniferae folium

Samples of new monographs Samples of new monographs in the Supplementin the Supplement

Revisions Revisions in the Supplementin the Supplement

�� Cynarae foliumCynarae folium

�� Echinacea pallidae radix Ph. Eur.Echinacea pallidae radix Ph. Eur.

�� Echinacea purp. radix Ph. Eur.Echinacea purp. radix Ph. Eur.�� Echinacea purp. radix Ph. Eur.Echinacea purp. radix Ph. Eur.

�� EchinaceaEchinacea purppurp.. herbaherba

�� EleutherococciEleutherococci radixradix PhPh.. EurEur..

�� HarpagophytiHarpagophyti radixradix PhPh.. EurEur..

�� ValerianaeValerianae radixradix PhPh.. EurEur..

�� ZingiberisZingiberis rhizomarhizoma PhPh.. EurEur..

ESCOP Supplement 2009ESCOP Supplement 2009

IN PRESSIN PRESSandandandand

AVAILABLE AVAILABLE SOONSOON

www.escop.comwww.escop.com

New monographs New monographs under preparationunder preparation

Many Thanks to the Many Thanks to the Supervising EditorsSupervising Editors

�� Prof. Robert AntonProf. Robert Anton�� Dr. Desmond Corrigan Dr. Desmond Corrigan �� Prof. Pierre DelaveauProf. Pierre Delaveau

�� Prof. Dr. Dr. Dieter LoewProf. Dr. Dr. Dieter Loew

�� Prof. Evelyne Ollivier Prof. Evelyne Ollivier

Prof. Dr. R. SallerProf. Dr. R. Saller�� Prof. Pierre DelaveauProf. Pierre Delaveau�� Prof. Dr. Gerhard Franz Prof. Dr. Gerhard Franz �� Prof. Dr. Catherine Prof. Dr. Catherine HarvalaHarvala

�� Prof. Dr. Fritz H. KemperProf. Dr. Fritz H. Kemper�� Prof. Dr. med. Prof. Dr. med. Karin KraftKarin Kraft�� ProfProf.. WolfgangWolfgang KubelkaKubelka

�� Prof. Dr. R. SallerProf. Dr. R. Saller

�� Prof. Dr. Heinz Schilcher Prof. Dr. Heinz Schilcher

�� Prof. Dr. Thomas Simmet Prof. Dr. Thomas Simmet

�� Prof. Dr. Otto SticherProf. Dr. Otto Sticher

�� Prof. Franco F. VincieriProf. Franco F. Vincieri

�� Prof. Dr. Arnold VlietinckProf. Dr. Arnold Vlietinck

Many Thanks to the Many Thanks to the Members of the Sci. Comm.Members of the Sci. Comm.

�� AnnaAnna RitaRita BiliaBilia II�� PeterPeter RR.. BradleyBradley GBGB�� JanJan GG.. BruhnBruhn SS�� JozefJozef GG.. CorthoutCorthout BB

�� FrédériqueFrédérique LafforgueLafforgue FF�� NorbertNorbert LinnenbrinkLinnenbrink CHCH�� MariaMaria CarmenCarmen RecioRecio EE

�� JozefJozef GG.. CorthoutCorthout BB�� IngunnIngunn EgebergEgeberg NN�� MarijkeMarijke FraterFrater--SchröderSchröder CHCH�� NicolaNicola FuzzatiFuzzati II�� LeneLene GudiksenGudiksen DKDK�� DidierDidier GuédonGuédon FF�� StephenStephen HicksHicks GBGB�� IngridIngrid HookHook IRLIRL�� Stephan F.A.J. Stephan F.A.J. HorstenHorsten NLNL

�� MariaMaria CarmenCarmen RecioRecio EE�� GeorgGeorg SeidelSeidel DD�� EkremEkrem SezikSezik TRTR�� BarbaraBarbara SteinhoffSteinhoff DD�� SonjaSonja SturmSturm AA�� FF.. MM.. vanvan denden DungenDungen NLNL�� EckhartEckhartWildiWildi CHCH�� MartinMartinWilloughbyWilloughby GBGB�� JensJens KK..WoldWold NN

Thank you for your attention!Thank you for your attention!