this type of genetic disorder requires both parents to “donate” a defective gene

This type of genetic disorder requires both parents to “donate” a defective gene

Autosomal recessive (2 little letters: aa, bb, ff) found on 1 of the first 22 chromosomes

What is it called when an offspring is heterozygous for a recessive genetic disorder?

A carrier (Dd, Hh, Aa)

There are no carriers for these fatal diseases. If you have one copy of this gene then you HAVE the disease

Autosomal Dominant

Give an example of 1 autosomal dominant disease

1- Huntington’s Chorea - like Parkinson’s

where physical and mental abilities deteriorate2 - Marfan’s syndrome – Lincoln was thought to have this (very tall – usually die of heart problems)

the most common genetic disorder among black people. Red blood cells are abnormally shaped

Sickle cell anemia

This genetic disorder is seen in all races of people and animals where pigment (color) is missing

Albinism

X-linked genetic disorders are carried on the X chromosome

Sex linked genetic disorder

With sex linked genetic disorders, why is it that boys are mostly affected?

Girls have XX so if 1 X is damaged, the other chromosome dominatesBUT

boys have XY so if the X is damaged, the Y cannot compensate

Who is the carrier for sex linked disorders?

Women are carriers of the disease – They DO NOT have it, but with each pregnancy they have a 50-50 chance of passing it on to their sons – those sons are NOT carriers

Give 1 example of a sex linked disorder

hemophilia (The Royal Disease of Europe), color blindness, Duchenne’s Muscular Dystrophy and Adrenoleukodystrophy (ALD)

the most commonly inherited genetic disorder among Caucasian people. It produces a great deal of phlegm build up.

Cystic fibrosis

The universal blood donor

Type O

Aside from taking blood, where else can your blood type be found?

Bodily fluids such as saliva, semen and vaginal secretions

What are the 4 different blood types?

A = IA IA or IAiB = IBIB or IBi

AB = IAIB

O = ii

The universal blood recipient

Type AB

These genetic disorders are most common among people of Eastern European origin – both parents must be carriers

Jewish genetic disorders such as:Tay-Sachs, Niemann-Pick, Canavan’s Disorder, Bloom’s Disease,

Familial Dysautonomia and Fanconi Anemia

A diagram that shows the occurrence or appearance of a particular gene or organism from 1 generation to the next

Pedigree chart

Name common pedigree symbols

Interpret the following pedigree chart:

1 – autosomal dominant disease because the chart shows no carriers

2- in generation II, three out of the 5 siblings have the disease3 – out of the generation II sibling that got married (2) who have the disease, they passed the disease to 50% of their

offspring

Interpret this chart:

Sex linked trait (for color blindness) because most of the females are carriers and most of the males get the disorder

Cross an male with type AB blood with a female who is heterozygous type A

Female: IAiMale: IAIB

Result:2 type A offspring: IAIA, Iai

1 type AB: IAIB

1 type B: IBi