università degli studi di lecce facoltà di ingegneria ......2018/10/18  · alessandro sannino...

Alessandro Sannino

University of Salento, Lecce (Italy)

Gelesis Inc., Boston (MA)

alessandro.sannino@unisalento.it

Dry and swollen hydrogel

Free Swelling

One example: starting concept

I generation

DVS

Patents

WO 98 58686 (1998)

WO 98 58688 (1998)

First Failure

Egypt Desert

Komatsuna plants grown in a SAP-powered soil

–Source: Green Earth Project

Third Concept: Dialysis

Third Failure

Fourth Concept: Diets

Gastric Bendages

The concept

The Team

Co-founder PureTechVentures & multiplestart-ups

Former President ofPfizer Global R&D

John LaMattina, PhD Yishai Zohar

Christian Demitri, PhD

Chairman CEOWorld leading scientist onpolymer science

World leading scientist onBiomaterials

Inventor

Inventor

Luigi Nicolais

Luigi Ambrosio

Experienced bio-materialsengineer at Univ. ofSalento

Project scientist

20+ years exp. devel-oping devices/drugs

Eyal Ron, PhD

CTO

32 years exp. in clin.studies (metabolic focus)

Hassan Heshmati, MD

CMO

Academic polymerscientist

Alesandro Sannino

Inventor

Industrial Advisory Board

Scientific Advisory Board

Re-designing IP

BROAD IP(7 Families of Pending and Issued Patent Applications)

Materials

Composition of matter and formulations

Manufacturing / Synthesis

Uses

Weight management

Glycemiccontrol

Foods

SAEF® (Super

Absorbent Edible Fiber)

Scale up

GMP

Future Perspectives: IPO

Finance the scale up

to Commercialization(expected in 2020)

http://www.nasdaq.com/article/the-latest-weight-loss-capsule-gelesis-

files-for-a-60-million-ipo-cm461413

Bottom line…

There is much more money than good ideas

Fundraising, Investments,

Divestments: European picture 2016

FUNDRAISING

In 2016, total fundraising reached €74.5bn, the highest level for Europe since 2008 and

a 37% increase on 2015. Almost 400 funds raised new capital, a 9% decrease compared

to 2015, indicating a trend to larger funds

INVESTMENTS

The total equity amount invested in European companies remained stable at €53.7bn,

marking the second highest level since 2008. About a third of this amount was invested

cross-border. The 83% of companies receiving these investments were SMSs

DIVESTMENTS

Over 3,500 European companies were exited in 2016, representing former equity

investments (divestments at cost) of €38.9bn. About 14% lower than 2015, but in line with

the annual average since 2012.

Source: Invest Europe / EDC

Investments by stage: 2016

Investments by sector: 2012-2016

Source: Invest Europe / EDC

US vs EU imbalance

Europe

0.028

US

0.150

VC Investment in proportion

to GDP

Source: Invest Europe / EDC and EVCA Eurostat

The Massachusetts Area

✓ 25,000 enterprises in 2006;

✓ 900 new start ups per year since 2006;

✓ Total of more than 3,000,000 employees;

✓ 2 trillion dollars revenues/year

Together, they would represent the 11th Economic Power of the World

VC Geographical investment flows

Source: Invest Europe / EDC

Drivers in Translational Path:

3 Balances

Falling in Love Love Actually

Drivers in Translational Path:

3 Balances

Falling in Love Love Actually

Risk Specialization

Drivers in Translational Path:

3 Balances

Falling in Love Love Actually

Risk Specialization

Failure Success

Thank You!