zonare rsna powerpoint version 4 by 3

AGENDA✴Company Overview

✴Technology Differentiation

✴Product Solutions

✴Clinical Assessments

Company Overview✴ Founded in 1999

✴ Over 5,000 systems installed

✴ Headquartered in Mountain View, CA– Sales & support: USA, Germany & Canada– Distributed in over 70 countries

✴ Financial– Revenue greater than 20% growth– Profitable Q4 2011

✴ 125 Employees– More than 12% of revenue invested in R&D

Management TeamTim MarcotteCOO

Recent Experience:VNUS Medical Technologies

Glen McLaughlin, Ph.D.Founder & CTO

Recent Experience:Cardiac Pathways

Michael GablerVP Engineering

Recent Experience:Aptix Corporation

Doug TefftVP International

Recent Experience:SonoSite, ATL

P.J. RylandVP Business Development and Corporate Accounts

Recent Experience:Siemens, Acuson

Scott WilliamsSr. Director Global Service

Recent Experience:Siemens, Acuson

Dan TibbetsSr. Director Manufacturing

Recent Experience:Lamb Research, Boston Scientific

ACHIEVEMENTS

2004 2005 2006 2007 2008 2009 2010 2011 2012

z.one

z.one advanced hardware

z.one miniCartz.one ultraCart z.one ultraCart sp

Pediatrics

29 US patents issued

Technology:✴ Fast image acquisition

✴ Continuous transmit / receive focus

✴ Channel and RF data

ZONESonographyTM Technology(ZST) will become the next industry standard method of generating ultrasound images as it is overcominga number of the barriers of digital beamformation.

ZST is two generations ahead of traditional digital beamformation technology.— Frost & Sullivan 2011

Digital Beamformation Zone Sonography

Fast image acquisition provides Acoustic Currency✴Improved temporal accuracy✴Multiple modalities without compromise

Temporal image coherence

Motion Artifact due to slow

shutter speed

No Motion Artifact due to fast

shutter speed

Compounding Compounding + CD-Mode

Continuous Transmit / Receive focus Transmit provides better contrast resolution

(-50 dB) Receive provides better detail resolution

(-20 dB) No need to blend multiple Tx focus zone

images

Independent Nyquist sampling requirements for Transmit and Receive

Applicable for all multi dimensional imaging modalities

Zone Sonography Technology

BeamformerTechnology

PSF

Legend

✴Image Benefits:-Improved detail resolution-Improved contrast resolution-Improved penetration-Better uniformity-Improved Doppler sensitivity

Zone Sonogaphy Technology

Beamformer Technology

PSF

Zone Sonography Technology Beamformer Technology

✴ Sound speed correction

✴ Retrospective imaging capabilities

✴ Enhanced auto optimization capabilities

Channel and RF data enables Patient Specific Imaging

I/Q DataSet

CD to

Power

CWScale

Elastography

B-ModeSettings

CD-ModeSettings

PW-ModeSettings

AutoOptimize

ContrastSettings

Variability of sound speed within patients lead to lower detail and contrast resolution resulting in decreased diagnostic confidence

sound speed correction reduces image variability across patients V= 1540 m/s

V < 1540 m/s

V > 1540 m/s

Patient Specific Imaging

Corrected SS (1480 m/s)Assumed SS (1540 m/s)

Patient Specific Imaging (Phantom)

Corrected SS (1480 m/s) Assumed SS (1540 m/s)

Patient Specific Imaging (Phantom)

Corrected SS (1460 m/s) Assumed SS (1540 m/s)

Clinical Solutions✴ Radiology

– Pediatrics– Bariatrics

✴ Vascular

✴ Interventional Radiology

✴ Emergency Department

Radiology: Pediatrics✴ Premium imaging performance

– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging

✴ Retrospective image processing

✴ Full transducer offering– C10-3, P10-4, C9-4t, & C9-3

✴ One touch image optimization

✴ Battery powered (3-hour)

✴ Wireless ready

✴ Highly mobile

Radiology: Bariatric✴ Premium imaging performance

– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging

✴ Full transducer offering– C4-1 & C6-2

✴ CW-Doppler on C4-1– Improved penetration / sensitivity– No aliasing

✴ One touch image optimization

✴ Battery powered (3-hours)

✴ Highly mobile

Vascular✴ Premium image performance

– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging

✴ Full transducer offering– L8-3, L10-5, L14-5sp, L14-5w,

C9-3, C6-2 & P4-1c

✴ Intuitive user interface

✴ One touch image optimization

✴ Streamlined workflow

✴ Structured reporting

Interventional Radiology✴ Premium image performance

– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging

✴ Full transducer offering– L8-3, L10-5, L14-5sp, L14-5w,

C9-3, C6-2 & P4-1c

✴ One touch image optimization

✴ Intuitive user interface

✴ Full screen display capabilities

✴ Battery powered (3-hours)

✴ Highly mobile

Emergency Department✴ Premium image performance

– Dynamic transmit / receive focus– Acoustic currency– Patient specific imaging

✴ Full transducer offering– L8-3, P4-1c, C4-1 & E9-4

✴ Intuitive user interface

✴ Full screen display capabilities

✴ One touch image optimization

✴ Battery powered (3-hours)

✴ Highly mobile

✴ Accreditation, reporting & billing packages

Clinical Assessment

Superior performance from

neonates to bariatrics

Clinical Assessment: Cincinnati Children’s Hospital

As an international leader in improving child health, Cincinnati Children’ s Hospital Medical Center is one of the largest pediatric radiology facilities in the country, performing more than 200,000 imaging procedures each year. Clinical procedures and treatments pioneered at Cincinnati Children’s are used throughout the world. U.S. News & World Report has ranked Cincinnati Children’ s the third best children’s hospital in the nation in general pediatrics in its 2011-12

ZONARECompetitive Premium System

14 day neonate coronal view

ZONARECompetitive Premium System

Left kidney in 1 month neonate

ZONARECompetitive Premium System

Right kidney transverse, abscess

ZONARECompetitive Premium System

Patent IVC post liver transplant in 9 year old

ZONARECompetitive Premium System

Obese 16 year old liver / kidney

Brian Coley

“In my experience, the highly mobile ZONARE ultrasound system delivers premium pediatric imaging performance in practical applications. Using the C10-3, C9-3, and C6-2 transducers, ZONARE provides consistently uniform imaging at depth on neonates to difficult to image teenagers, with color Doppler performance comparable to our other premium systems” said Dr. Coley.

Radiologist-in-Chief, Cincinnati Children’ s Hospital Medical Center

Clinical Assessment: Winnipeg’s Health Science Center

Winnipeg’s Health Science Centre is the largest health care referral, teaching and research center serving residents of Manitoba, Northwestern Ontario and Nunavut and is one of the largest facilities of its kind in Canada. The ultrasound department conducts approximately 18,000 exams annually and is dedicated to providing quality imaging using the most advanced technology available.

Liver ascites

Morbidly Obese Patient

Morbidly Obese Patient

Edward Lyons

“When imaging the liver in large patients with ZONARE’s C6-2 and C4-1 probes, I feel that the penetration and image quality is equivalent to what I have seen on premium scanners using similar probe technology,” said Dr. Lyons.

Professor and Past Chairman of Radiology, Professor of Obstetrics and Gynecology