an acknowledgment

1
252 - with a pressure effectually blocking the exit of urine from the cortical uriniferous tubules. Clifford White has shown that in puerperal anuria (or oliguria) the renal tubules in the cortex are dilated ; I have confirmed this in an experience of -my own (not yet published). Dr. Begg states that in his cases of anuric diabetic coma the symptoms were those of obstructive suppression of urine. In these cases " certain changes " have been found " which suggest the kidney is an all-important factor." He promises us a further contribution on this part of the subject, which will be awaited with restless interest. Meanwhile, may I make two suggestions ? The one is that Dr. Begg, in his cases of diabetic coma, should regard vomiting as an important patho- logical force, prone to determine renal aberrations. ’The other is clinical: that patients with this disease and impending complication should be placed on their side ; that all means be adopted to limit or prevent vomiting ; and that in the worst cases decapsulation of the kidney should be done. If the patient is to die, it makes no difference whether this event occurs in the theatre or ward ; in eclampsia, patients almost in extremis have been saved by decapsulation ; in diabetic coma, if the blood-sugar has been made to become normal by insulin, the objection to operation surely subsides. Decapsula- tion acts by relieving the cortical pressure (in which the capsule of the organ plays an important part) ; it allows blood to flow again through the cortical vessels, which distension of the uriniferous tubules prevented ; and since blood can now flow through the cortex, there is less to go through the medulla ; thus the block is removed, the vicious circle broken. I am, Sir, yours faithfully, Rugby, July llth. R. H. PABAMORE, F.R.C.S. Eng. R. H. PARAMORE, F.R.C.S. Eng. To the Editor of THE LANCET. SIR,-Dr. A. Clarke Begg classifies diabetic coma into two groups : one the usual type with acidosis and normal blood-urea ; the other, the anuric type with slight or no acidosis, very high blood-urea, very high blood-sugar, and urine volume decreased even to anuria. This classification does not seem to me adequate. Last year Dr. E. F. Skinner and ’I reported in your columns 1 a case of diabetic coma with anuria, under the care of Prof. A. J. Hall, which cannot be placed in either of Dr. Begg’s groups. The blood analysis in this case on admission yielded the following results (per 100 c.cm.) : Blood-sugar, ,0-957 g. ; blood non-protein nitrogen, 110 mg. ; plasma bicarbonate, 15-7 mg. ; ketone bodies, 59.13 mg. ; blood chlorides, 0-465 g. The low plasma bicarbonate and the degree of ketonæmia indicated a severe grade of acidosis not found in Dr. Begg’s cases. Otherwise the findings are similar to those he observed in the cases of coma associated with anuria. It seems, therefore, necessary to con- sider at least two types of " anuric diabetic coma" according to the degree of concomitant acidosis. I am, Sir, yours faithfully, Sheffield, July 19th, 1925. C. GRAY IMRIE. C. GRAY IMRIE. TUMORS AND CANCERS: A COMPLAINT. To the Editor of THE LANCET. SiR,-In your issue of May 23rd is a review of a work by Mr. Hastings Gilford on " Tumors and Cancers." This review struck me, as it has struck others, as an unjust and misleading statement of the nature and scope of the book. It conveys the impres- sion that it is written by one who is himself a cancer researcher, in the narrowest sense of the word, and has taken advantage of the opportunity to make an onslaught on a book distinguished by its breadth and catholicity of view and which therefore puts his own particular work into its proper perspective. Some of his-remarks were written obviously with the intention. .of creating prejudice. Thus one of the undoubted, 1 THE LANCET, 1924, i., 14. if unavoidable, faults of the book is its bulk, but this bulk is largely due to the evident determination of the writer to support every statement with an ample backing of evidence. It is therefore an obvious and flagrant misstatement to say that the author’s conceptions " are so often supported by simple assertions, by bad reasoning." Indeed a more logical or rational exposition of a difficult subject it would be hard to name. Such a statement could only have been made by one who had confined his reading to the " conclusions " and to mere glimpses at the main structure of the book. As for the other comments, some, such as that about alcohol, which is a truism, could have no other purpose than to bias the reader against the book. Then there is a grave and palpable omission. The reviewer is so occupied in his search for weak spots or for sentences which can by disloca- tion be made to appear gauche or ridiculous that he fails to do justice to the merits of the book. He dwells on those theoretical aspects and frills which he finds so disagreeable and says next to nothing of the real structure. In short, he displays his own personal feeling, but does not review the book. Now, Sir, I should not have drawn attention to this subject now were it not for the circumstances that such a book as the book in question is so much needed at this juncture in order to form a background for recent achievements in laboratory research. It is therefore exceedingly unfortunate that an important volume containing such a recent and balanced outlook and review of cancer work in all its aspects should have been treated so scurvily by your reviewer. Finally I may add that in writing as I now do I am expressing not only my own opinion but those of others who are equally impressed with the injustice that has been done and with the desire that the information contained in " Tumors and Cancers " should not be suppressed but should be broadcasted to all who wish to take a sane and just view of the present situation.-I am, Sir, yours faithfully, Basingstoke, July 26th, 1925. NOLAN DALY. NOLAN DALY. THE REMUNERATION OF R.A.M.C. OFFICERS. To the Editor of THE LANCET. SIR,—The action of the British Medical Association with regard to the Royal Army Medical Corps recalls their similar action a few years ago with regard to the Royal Naval Medical Service. It is further an admitted fact that there is great difficulty in obtaining medical men for all three combatant services. It is to be hoped that the present dispute will lead to an exhaustive investigation of the lack of attraction to these great services. In my opinion a supply of good men will be obtained only if the opportunities to do first-class medical and stirgical work and to keep themselves abreast with advances in their professional work are afforded. Such opportunities under existing circumstances are quite inadequate. Some time ago I submitted a comprehensive scheme to a committee, which included the Directors-Oeneral of the three medical services. It was damned with faint praise; but I do not despair that some such scheme may yet receive the official benediction. I am, Sir, yours faithfully, J. HERBERT PARSONS. Queen Anne-street, Cavendish-square, W., July 23rd, 1925. I am, Sir, yours faithfully, J. HERBERT PARSONS. AN ACKNOWLEDGMENT. To the Editor of THE LANCET. SIR,—In connexion with the second edition of the " Encyclopaedia, Medica," Vol. XIII., article Diabetes, we have to regret that on p. 641 an acknowledgment was not made of the nomogram there represented to Dr. W. M. Feldman and Mr. A. J. V. Umanski, the authors of the article in THE LANCET, Feb. llth, 1922, p. 273, where the nomogram originally appeared. We are, Sir, yours faithfully, Edinburgh, July 23rd. W. GREEN AND SON. LTD. W. GREEN AND SON. LTD.

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Page 1: AN ACKNOWLEDGMENT

252

- with a pressure effectually blocking the exit of urinefrom the cortical uriniferous tubules.

Clifford White has shown that in puerperal anuria(or oliguria) the renal tubules in the cortex are

dilated ; I have confirmed this in an experience of-my own (not yet published). Dr. Begg states thatin his cases of anuric diabetic coma the symptomswere those of obstructive suppression of urine. Inthese cases " certain changes " have been found" which suggest the kidney is an all-important factor."He promises us a further contribution on this partof the subject, which will be awaited with restlessinterest. Meanwhile, may I make two suggestions ?The one is that Dr. Begg, in his cases of diabeticcoma, should regard vomiting as an important patho-logical force, prone to determine renal aberrations.’The other is clinical: that patients with this diseaseand impending complication should be placed ontheir side ; that all means be adopted to limit or

prevent vomiting ; and that in the worst cases

decapsulation of the kidney should be done. If thepatient is to die, it makes no difference whether thisevent occurs in the theatre or ward ; in eclampsia,patients almost in extremis have been saved bydecapsulation ; in diabetic coma, if the blood-sugarhas been made to become normal by insulin, theobjection to operation surely subsides. Decapsula-tion acts by relieving the cortical pressure (in whichthe capsule of the organ plays an important part) ; itallows blood to flow again through the corticalvessels, which distension of the uriniferous tubulesprevented ; and since blood can now flow throughthe cortex, there is less to go through the medulla ;thus the block is removed, the vicious circle broken.

I am, Sir, yours faithfully,Rugby, July llth. R. H. PABAMORE, F.R.C.S. Eng.R. H. PARAMORE, F.R.C.S. Eng.

To the Editor of THE LANCET.

SIR,-Dr. A. Clarke Begg classifies diabetic comainto two groups : one the usual type with acidosisand normal blood-urea ; the other, the anuric typewith slight or no acidosis, very high blood-urea, veryhigh blood-sugar, and urine volume decreased even toanuria. This classification does not seem to meadequate. Last year Dr. E. F. Skinner and ’Ireported in your columns 1 a case of diabetic comawith anuria, under the care of Prof. A. J. Hall, whichcannot be placed in either of Dr. Begg’s groups.The blood analysis in this case on admission yieldedthe following results (per 100 c.cm.) : Blood-sugar,,0-957 g. ; blood non-protein nitrogen, 110 mg. ;plasma bicarbonate, 15-7 mg. ; ketone bodies,59.13 mg. ; blood chlorides, 0-465 g. The lowplasma bicarbonate and the degree of ketonæmiaindicated a severe grade of acidosis not found inDr. Begg’s cases. Otherwise the findings are similarto those he observed in the cases of coma associatedwith anuria. It seems, therefore, necessary to con-sider at least two types of " anuric diabetic coma"according to the degree of concomitant acidosis.

I am, Sir, yours faithfully,Sheffield, July 19th, 1925. C. GRAY IMRIE.C. GRAY IMRIE.

TUMORS AND CANCERS: A COMPLAINT.To the Editor of THE LANCET.

SiR,-In your issue of May 23rd is a review of awork by Mr. Hastings Gilford on " Tumors andCancers." This review struck me, as it has struckothers, as an unjust and misleading statement of thenature and scope of the book. It conveys the impres-sion that it is written by one who is himself a cancerresearcher, in the narrowest sense of the word, andhas taken advantage of the opportunity to make anonslaught on a book distinguished by its breadth andcatholicity of view and which therefore puts his ownparticular work into its proper perspective. Some ofhis-remarks were written obviously with the intention..of creating prejudice. Thus one of the undoubted,

1 THE LANCET, 1924, i., 14.

if unavoidable, faults of the book is its bulk, but thisbulk is largely due to the evident determination of thewriter to support every statement with an amplebacking of evidence. It is therefore an obvious andflagrant misstatement to say that the author’sconceptions " are so often supported by simpleassertions, by bad reasoning." Indeed a more logicalor rational exposition of a difficult subject it would behard to name. Such a statement could only have beenmade by one who had confined his reading to the" conclusions " and to mere glimpses at the mainstructure of the book. As for the other comments,some, such as that about alcohol, which is a truism,could have no other purpose than to bias the readeragainst the book. Then there is a grave and palpableomission. The reviewer is so occupied in his searchfor weak spots or for sentences which can by disloca-tion be made to appear gauche or ridiculous that hefails to do justice to the merits of the book. He dwellson those theoretical aspects and frills which he findsso disagreeable and says next to nothing of the realstructure. In short, he displays his own personalfeeling, but does not review the book.Now, Sir, I should not have drawn attention to

this subject now were it not for the circumstancesthat such a book as the book in question is so muchneeded at this juncture in order to form a backgroundfor recent achievements in laboratory research. It istherefore exceedingly unfortunate that an importantvolume containing such a recent and balanced outlookand review of cancer work in all its aspects shouldhave been treated so scurvily by your reviewer.

Finally I may add that in writing as I now do Iam expressing not only my own opinion but those ofothers who are equally impressed with the injusticethat has been done and with the desire that theinformation contained in " Tumors and Cancers "

should not be suppressed but should be broadcastedto all who wish to take a sane and just view of thepresent situation.-I am, Sir, yours faithfully,

Basingstoke, July 26th, 1925. NOLAN DALY.NOLAN DALY.

THE REMUNERATION OF R.A.M.C. OFFICERS.

To the Editor of THE LANCET.

SIR,—The action of the British Medical Associationwith regard to the Royal Army Medical Corps recallstheir similar action a few years ago with regard to theRoyal Naval Medical Service. It is further an

admitted fact that there is great difficulty in obtainingmedical men for all three combatant services. It is tobe hoped that the present dispute will lead to anexhaustive investigation of the lack of attraction tothese great services. In my opinion a supply of goodmen will be obtained only if the opportunities to dofirst-class medical and stirgical work and to keepthemselves abreast with advances in their professionalwork are afforded. Such opportunities under existingcircumstances are quite inadequate. Some time agoI submitted a comprehensive scheme to a committee,which included the Directors-Oeneral of the threemedical services. It was damned with faint praise;but I do not despair that some such scheme may yetreceive the official benediction.

I am, Sir, yours faithfully,J. HERBERT PARSONS.

Queen Anne-street, Cavendish-square, W.,July 23rd, 1925.

I am, Sir, yours faithfully,J. HERBERT PARSONS.

AN ACKNOWLEDGMENT.To the Editor of THE LANCET.

SIR,—In connexion with the second edition of the" Encyclopaedia, Medica," Vol. XIII., article Diabetes,we have to regret that on p. 641 an acknowledgmentwas not made of the nomogram there represented toDr. W. M. Feldman and Mr. A. J. V. Umanski, theauthors of the article in THE LANCET, Feb. llth,1922, p. 273, where the nomogram originally appeared.

We are, Sir, yours faithfully,Edinburgh, July 23rd. W. GREEN AND SON. LTD.W. GREEN AND SON. LTD.