analytical solution for management of biotech & pharma innovation data collection, data...
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Analytical Solution for Management of Biotech &
Pharma InnovationData collection, data warehousing, analytical design, data analysis and communication of results
Joint Research Project
Dr Daniel Pardo CNRS.France
Dr Eric Jolivet University Toulouse 1.France
Dr Andrei Mogoutov AGUIDEL.
Objectives
Development of a complete directory of Biotech Companies and Labs in France, data collection & update tools, communication services and analytical & reporting tools
Related Products & Services Data collection and management of online directory « Biotech » actors in France
using online questionnaire, existing databases, institutional contacts, company websites and press releases
Consulting services Positioning of companies, projects, products, patents, publications, research fields Startup support Early warning Partnership network building Advice on local promotion Advice on foundation and management of « clusters » Evaluation of projects Market and technological studies Benchmarking, competitiveness Consultancy for valorization actors Communication strategy development Academic research
Software solutions: On-line applications, off-line applications, customized solutions, integration of customers data, analytical tools
Data analysis: Custom methods for the analysis of complex & heterogeneous datasets, text and data mining, relational analysis, GIS, scientometrics
Data Base of Biotech Actors in France ACTORS: Detailed information for public and private
institutions name typology location contacts HR main financial figures technologies products application areas clinical trials customers partners and collaborations company structure and history
LITERATURE: Publications in biomedical journals PATENTS: biotech patents filed in patent offices
Design of Analytical Solution (on/offline)
Back Office-data tables- textual analysis- tools for data update and control
Front Office
Middle Office- a layer of analytical queries - pre-defined queries for multilevel - aggregation, synthesis, indicators
- graphical/analytical interfaces (GIS, Relational Mappings, Statistical Charts)- statistical tables, indicators and textual synthesis- integrated querying tools
DATA UPDATE FEED-BACK
Back Office
Patents
Actors
Literature
Links
ProductsProjects
J ohnson & J ohnson
Glaxo SmithKline plc
Aventis
Wyeth
Merck & Co. Inc.
Roche
Bristol-Myers Squibb Co.
Schering-Plough Corp.
Pfizer
Novartis
Pharmacia
Eli Lilly and Co.
Bayer AG
AstraZeneca
Abbott
NETWORK ORIENTED DATABASE
TechnologiesClusters
A case study:
INSERM . FRANCE
Industrial Partnership Analysis
Valorization & Technology Transfer Department(1980-2003)
Partnership of INSERM Valorization & Technology Transfer Department (1980-2003)
0
20
40
60
80
100
120
140
1980 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003
Nb Of Partners
Nb Of New Partners
Nb Of Contacts
Number of Contracts, Partners and New Partners per year
Main Partners of INSERM Valorization & Technology Transfer Department (1980-2003)
0 20 40 60 80 100 120
BIODE RMA
T ROP HOS
AGUE T T ANT
BIOMAT LANT E
CAP T E LS
E XONHIT
INNOT HE RA
Labor atoi r es GE NE VRIE R
LABORAT OIRE S LE O
Mi l leGen
Monoclonal Antibodies T her apeutics (MAT )
NUCLE IS
ORP HACHE M
VIVALIS
AP CE LLS SA
BIOCOM
LABORAT OIRE L. LAFON
LAE NNE C T E K
P RE IN AND P ART NE RS [LASE RSONICS]
T CLAND
T RANSP HY T O
BIOVE CT OR T HE RAP E UT ICS
DIACLONE
IP SOGE N SAS
LABORAT OIRE S GOE MAR
CORAM
ME T ROVISION
SOLY ME S
SY NT E M
CE RE P
RACIA-ALVAR
ST ALLE RGE NE S
BE SINS INT E RNAT IONAL
GE NSE T S.A.
Labor atoi r e P asteur - CE RBA S.E .L.A.F.A.
LAP HAL
SAT E LE C
INNAT E P HARMA
OVI
BIOCY T E X
LABORAT OIRE S LACT E OL
LABORAT OIRE FRANCAIS DU FRACT IONNE ME NT E T DE S BIOT E CHNOLOGIE S-LFB
IMMUNO-DE SIGNE D MOLE CULE S
T E CHNOME D
T RANSGE NE
BIOP RE DIC Inter national
HY BRIGE NICS S.A
BIOP ROJ E T
IMMUNOT E CH/ BE CKMAN-COULT E R
Areas of Partnership of INSERM Valorization & Technology Transfer Department (1980-2003)
0
50
100
150
200
250
1980-85 1986-90 1991-95 1996-00 2001-03
Biotechnologie/Médicament
Technologie biomédicale
Médicament/Vaccins
Bioréactif/Recherch/Diagnostic
Santé publique
Recherche clinique
Agroalimentaire
INSERM Technology Transfer Contracts
Firms StartUps ME Other/ Research Institutes
1980-2000 22 26 201 38
2001-2003 18 66 73 52
Relational Mapping Of Data Base Heterogeneous network analysis with
Réseau-Lu © (www.aguidel.com) ReseauLu Project:
Data Mining & Text Mining for social sciences ReseauLu software finds patterns and relationships in
data by using statistical and network analysis techniques.
In addition to algorithms, the software has features to simplify the graphical representation of the data structures.
The software simplifies the integration of analytical algorithms and visualization tools with database technology.
Main Areas of Partnership of INSERM Valorization & Technology Transfer Department (1980-2003) Per Period
Biotechnologie/Médicament
2001-03
1996-00
Technologie biomédicale
1991-95
Médicament/Vaccins
Bioréactif/Recherch/Diagnostic
1986-90
1980-85
Santé publique
Recherche clinique
Agroalimentaire
INSERM Bio-technological Network: Areas of Partnership of INSERM vs. Companies
IMMUNOTECH/BECKMAN-COULTER
Immunologie
Neurologie/NeurobiologieBIOPROJ ET
Cancérologie
HYBRIGENICS S.A
Biologie cellulaire
BIOPREDIC International
TECHNOMED
TRANSGENE
Chirurgie
IMMUNO-DESIGNED MOLECULES
Nutrition
Endocrinologie/maladies métaboliques
OVI
Virologie/SIDA/MST
BESINS INTERNATIONAL
Néphrologie - Urologie
LAPHAL
SATELEC
INNATE PHARMA
Biologie moléculaire
Hématologie
BIOCYTEX
Cardiologie
GENSET S.A.
LABORATOIRES LACTEOL
Transplantation (greffe)
Toxicologie
Gastro-entérologie
Hépatologie
Génétique médicale/Maladies génétiques et congén.
Epidémiologie
Dermatologie
Pathologie vasculaire
Orthopédie
Ostéoporose
Autres maladies infectieuses et/ou transmissibles
Biomathématiques et biostatistiques
Reproduction, fertilité
Laboratoire Pasteur - CERBA S.E.L.A.F.A.
Physiologie/Physiopathologie
Biochimie
Inflammation
Microbiologie
INSERM labs vs. Companies
IMMUNOTECH/BECKMAN-COULTERHU U 573
BIOPROJ ET
BIOPREDIC International
INSERM U 556TECHNOMEDLABORATOIRES LACTEOL
TRANSGENE
BIOCYTEX
INSERM IFR 75
INSERM U 258
IMMUNO-DESIGNED MOLECULES
INSERM U 448
INSERM U 510
CF U 277
HYBRIGENICS S.A
HU U 454
INSERM U 119
INSERM U 280
INSERM U 522
INSERM U 255
CNRS U 136
HU U 596
INNATE PHARMA
ORPHACHEM
Laboratoire Pasteur - CERBA S.E.L.A.F.A.
BESINS INTERNATIONAL
SYNTEM
RACIA-ALVAR
HU U 437
STALLERGENES
INSERM IFR 57
INSERM U 268
SOLYMES
CNRS U 463
INSERM U 519
INSERM U 370
TCLAND
PR U 136
INSERM ERM 322
SATELEC
INSERM U 476 U U 455
AP U 457
U U 461
CNRS U 528
INSERM U 590
U ERM 203
BIOCOM
BIOMATLANTE
U U 463
INSERM E 9903
U U 136
INSERM E 3
GENSET S.A.
HU U 399
HU U 428
HU U 430 INSERM E 350
Monoclonal Antibodies Therapeutics (MAT)
LAPHALAGUETTANT
INSERM U 412
LABORATOIRES GOEMAR
INSERM U 484
INSERM U 564
LABORATOIRE L. LAFON
INSERM U 571
HU E 9906
GENOPOIETIC
INSERM E 116
DYNABIO
CNRS U 533
INSERM U 589
CNRS U 400
INSERM U 588
CEREP
Centre International de Toxicologie
NUCLEIS
LABORATOIRES LEO
LAENNEC TEK
MEDecine-BIOlogie-MEDiterranée
MilleGen
CNRS U 520
INSERM U 514
INSERM U 431
INSERM U 450
INSERM U 271
Optis France
INSERM U 488
INSERM U 540
INSERM U 536
HU U 533
INSERM U 478
HU U 541
IPSOGEN SAS
AP CELLS SA
PR U 393
Bioalliance Pharma
HU U 503
BIODERMA
INSERM U 460
CNRS U 582
DIACLONE
INSERM U 525
ARKOPHARMA
VIVALIS
ZZ U 258
INSERM IFR 116
HU CIC 6
INNOTHERA
INSERM U 463
PROSKELIABIOVECTOR THERAPEUTICS
EXONHIT
INSERM U 136
CliniGenetics
“French BioIndustry” – Data Base First data set - 450 companies Preliminary data Exploratory analysis First Draft
Working “Paper” – 15/06/04
French biotech collaboration network
INSERM
CNRS
Aventis
PROTEUS S.A.
IDM SA
IMSTAR
GENOWAY
GENFIT
INRASanofi-Synthélabo
IPSOGEN
NUCLEIS SA
CEA
AVIDIS
Institut Curie
Merck & Co.
Pierre FABRE
Cambridge University
Degussa
Exonhit
FLAMEL TECHNOLOGIES
Curie Institute
THERAPTOSIS
Obetherapy Biotechnology
Servier
RD-BIOTECH
Cellectis
Pasteur Institute
Optis
Oncodesign
Accelrys
Aventis Pasteur
MolecularEnginesLaboratories
Abbott
BioMérieux
IRD
MedarexBIOSTATEM
UCB Pharma
TRANSGENE
DIATOS SA
Cytheris SA
Urogen
BTPharmaHYBRIGENICS S.A
VIVALIS
NICOX
Neovacs SA
Nautilusbiotech
Millegen
MetabolixExplorer
TcLand
It-Omics
Drugabusesciences
PROSKELIA PHARMACEUTICALS
INNOPSYS
Syntem
INTEGRAGEN
GeneOdysse
Eurorad
MatbioPharma
Midi Pyrénées Region: Heterogeneous NetworksCompanies & Technologies of Midi Pyrénées Region “Very preliminary analysis” Source: MidiBiotech survey Next steps:
Systematic collection of exhaustive data Scientific analysis of data
biologie moléculaire
biochimie
Drug delivery
immunologie
pharmacologie toxicologie
bioinformatiqueCAYLA SARL
ENDOCUBE
enzymologie
GTP Technology
INNADEV PHARM
MILLEGEN
SCANELIS
PHYSIOGENEX
ACTIGENICS
nanobiotechnologieKOBO PRODUCT
NANOBIOTIX
AVOGADRO
ARGENE BIOSOFT
ABTECH (Paris)
expérimentation animale
Institut Européen de Biologie Cellulaire I.E.B.L.A.R.A. Laboratoire - Europe Sols
BT Pharma
BIOSENTEC
physiopathologie
biologie cellulaire
ABTECH (Toulouse)
INNOPSYS
génomique
génétique animale
thérapie génique
recherche clinique
fermentation
Additional Analysis: Scientometrix of publications database Case study : Research Community on Mental
Retardation and Genetics Source – PubMed data base
Pimentel MM
Fryns J P
Chelly J
Munnich A
Moraine C
Vekemans M
van Bokhoven HYntema HG
Ropers HH
Cormier-Daire VGosset PPrieur M
Hamel BC
Le Merrer M
Colleaux L
Lyonnet S
Raynaud M
Turleau C
Amiel J
Niikawa N
Matsumoto NOhashi H
Romana S
Frints SG
des Portes V
Fukushima Y
Oudakker AR
Ozilou C
De Blois MC
Rio MRaoul O
Kleefstra T
Kurosawa K
Moizard MP
Faivre L
de Vries BB
Yoshiura KOkamoto NKondoh T
Gomot M
Kalscheuer V
Kalscheuer VM
Gécz J
Harada N
Lacombe D
Marynen PFroyen GPartington M
Turner G
Hamel B
Oostra BA
Kishino T
Borghgraef M
Briault S
Kurotaki N
Neri G
Philip N
Renieri A
Guerrini R
Meloni I
Hagerman RJ
Devriendt K
Schwartz CE
Hagerman PJ
Ogata T
Kerr B
Tassone F
Bienvenu T
Verloes A
Larizza L
Mandel J L
Mégarbané A
Scheffer IE
Strømme P
Gottardi GFinelli P
Bardoni B
David A
Lev D
Gecz J
Willemsen R
Toutain A
Grigsby J
J acquemont SStevenson RE
Goto Y
Brunner HG
Giardino D
Schinzel A
Dobyns WB
Carrozzo R
Shaffer LG
Schenck A
Das S
Zollino M
Lubs HA
Waschek J A
Bongarzone ER
Weiler IJ
Campagnoni AT
Stankiewicz P
Schonmann V
Kooy RF
Romano C
Syrrou M
Sherman SL
Clayton-Smith J
Chiurazzi P
Starke H
Warren ST
Kubota T
Kashork CD
Silengo M
Lelievre V
Bakker CE
Lerman-Sagie TRagusa A
Itoh M
Hu Z
Reyniers E
Greenough WT
Riegel M
Liehr T
Bartsch O
Bocian E
Morava E
Weeber EJ
Flint J
Walsh CA
Sweatt JD
Mazurczak T
Nakao M
Gal A
Komaki H
Biesecker LG
Hennekam RC
Lubec G
Jakobs C
Nelson DL
Schanen C
Rauch A
Kutsche KBassell GJ
Hanauer A
Korenberg JR
Kunze J
Hayek G
Estivill X
Oshimura M
De Vellis J
Graham JM
Andria G
Mental retardation & Genetics co-authorship network 2001-2004
Highly Clustered Network with mediation through individuals
Autism & Genetics semantic network 1964-2003
Syndromic approach
autismgene
syndrome
child
chromosome
patient
family
serotonin
mutation
association
region
analysis
childhood
polymorphism
mental
parent
linkageschizophrenia
receptor
marker
psychiatric
rett
genetics
disequilibrium
phenotype locus
mecp
human
retardation
transporter
deletion
language
susceptibility
behavior
multipleincidence
impairment
relative
duplication
promoter
deficit
spectrum
specific adult
aspect
attention
boy
candidate
diagnosis
hyperactivity
expression
complex
abnormality
history
evaluation
characteristic
transmission
platelet
subunit
psychosis
screening
personality
sclerosis
sibling
onset maletwo
variant
young
translocation
autosomal
relationship
connection
cytogenetic
sex
ratio
strategy
symptom
dup
touretteasperger
treatment
anomaly
angelman
adolescent
beta
phenotypes
medical
minor
investigation
inv
intellectual
monozygotic
neurobiology
novel
hoxa
hla
disability
perspective
psychiatry
fmr
finding
female
population
possible
etiology
epilepsy
probands
problem
mapping
heterogeneity
Alcimed
AVIDIS
GeneIt
Galenix Development
SkinEthic
Bionisis SA
PROTEIN'-EXPERT
Picometrics
BiométhodesSA
Pfizer
BIOSTATEM
Glaxosmithkline
PolymerExpert
Innovaction
Idealp-Pharma
Aventis
Servier
Roche
APTERYXMabGene
Sanofi-Synthelabo
CNRS
BMS
INSERM
Entomed
AureusPharma
BIOPROJ ET
Galderna
Adiatec SA
IPSOGEN
L'Oréal
Eli Lilly
Trophos
Innate Pharma
Sanofi
J &J
UCB
BioMérieux Exelixis
Confidential
Curagen Corporation
Evologic
European Bioinformatics Institute (EBI)E.I. DuPont de Nemours
European Big pharma & biotech companies
Galderma
Ellipse Pharmaceuticals
ETHYPHARM
french and european leaders of food industry
Diatos
BIO-RAD
Amgen
Aptanomics
Astra Zenecca
AVENTIS PASTEURAVENTIS PASTEUR MSD
Aventis PharmaBarr Labs
BASF........
Baxter
Biosite
BESINS INTERNATIONAL
Chelatec
Bionexis
Bioprotein
BIOVAIL
Boehringer Ingelheim
BTPharma
CEA-Life Science Division
CERMER
Charabot
CHAUVIN
Bayer
Sangstat
Hopitaux universitaires de Genève
Neurotech
Novartis
Nycomed Imaging S.A
Ondeo
Ophthalmic distributors
Ophthalmic industries
Organon P&G
Pasteur Institute
phamraceutical groups in France and Europe
MYCOSPHERE S.a.r.l.
RhoBio
Milkhaus
Sorebio (Ares Serono)
Sumitomo
TEVA
Thomson Derwent.
Trèves
Urogene
USA Customers
USDA
VETOQUINOL
VigiCell
Wyeth
RD-BIOTECHIpsen
Genencor International
Genethon
Genoscope
Genzyme
Groupe Fournier
Henkel
3M
IMTSSA
YAMANOUCHI
Infobiogen
Inpharzam
NEUROLAB
Integragen
GEMACBIO (Gemac SA)
IRBM spA-Merck Italy
Isover saint-Gobain
IVAX
Laboratoires Ceraver.
Lancaster/Coty
LVMH
major pharmaceutical and agrochemical companies
Merck
MERCK Generics
MERCK SANTE
MêTiS Biotechnologies
Inserm.Protein'eXpert
French biotech market structure – subset of Network of Clients
Squares – subset of companies, circles – clients