1. Anastrozole TabletsAnastrozole tablets (Anazole) is used for the treatment ofbreast cancer in hormone receptor positive post-menopausalwomen. It is also used for adjuvanttreatment of early breast cancer in hormone receptorpositive postmenopausal women who have received 2 to 3years of adjuvant Tamoxifen as well as reduction in theincidence of contralateral breast cancers in postmenopausal women receiving Anastrozole tablets asadjuvant treatment for early breast cancer. The Swiss Pharmacy, Geneva Switzerland

2. Anastrozole TabletsChemical Structure The Swiss Pharmacy, Geneva Switzerland 3. Anastrozole TabletsActive IngredientThe active pharmaceutical ingredientcontained in Anazole tablets isAnastrozole.Each 1 mg tablet of Anazole contains1mg Anastrozole. The Swiss Pharmacy, Geneva Switzerland 4. Anastrozole TabletsRecommended Dosage Adults:One tablet (1 mg) of Anastrozole tablets (Anazole)has to be taken orally once a day. Anastrozole canbe taken with or without food. The Swiss Pharmacy, Geneva Switzerland 5. Anastrozole TabletsContraindicationsGeneric Anastrozole Tablets(Anazole) is contraindicated inpatients with the following conditions:Known hypersensitivity to Anastrozole or anyinactive ingredient of this medication.Anastrozole tablets (Anazole) should not be used inpregnant or lactating women. The Swiss Pharmacy, Geneva Switzerland 6. Anastrozole TabletsSide Effects of Anastrozole Tablets (Anazole)The most common possible side effects ofAnastrozole Tablets occurring in 1% or more ofthe patients are Hot flushes, Gastrointestinalupsets including nausea and diarrhoea,Headache, Rash, Loss of hair, Vaginal dryness,Asthenia, joint pain or stiffness, Carpal TunnelSyndrome, Increases in alkaline phosphatase,alanine aminotransferase and aspartateaminotransferase. The Swiss Pharmacy, Geneva Switzerland 7. Anastrozole TabletsWarnings And PrecautionsAnastrozole is not recommended for use in children or inpre-menopausal women as safety and efficacy have notbeen established in these groups of patients.In women with pre-existing ischemic heart disease, anincreased incidence of ischemic cardiovascular eventsoccurred with Anastrozole use compared to Tamoxifenuse. Consider risks and benefits.Increases in total cholesterol may occur in patientsadministered Anastrozole. Consider cholesterol monitoring. The Swiss Pharmacy, Geneva Switzerland 8. Anastrozole TabletsWarnings And PrecautionsAs Anastrozole lowers circulating oestrogen levels itmay cause a decrease in bone mineral density with apossible consequent increased risk of fracture.Studies have showed that patients receivingAnastrozole tablets (Anazole) had a mean decreasein both lumbar spine and total hip bone mineraldensity (BMD) compared to baseline. Consider bonemineral density monitoring.Anastrozole tablets (Anazole) has not beeninvestigated in patients with severe hepatic or severerenal impairment. The potential risk/benefit to suchpatients should be carefully considered beforeadministration of Anastrozole tablets. The Swiss Pharmacy, Geneva Switzerland 9. Anastrozole TabletsAnastrozole OverdoseClinical trials have been conducted with a range ofdoses of Anastrozole tablets, up to 60 mg in a singledose given to healthy male volunteers and up to 10mg daily given to post-menopausal women withadvanced breast cancer; these dosages were welltolerated. A single dose of Anastrozole tablets thatresults in life-threatening symptoms has not beenestablished.Acute toxicity was seen in animals at a dosegreater than 45 mg/kg (equivalent to 2.7 g). The Swiss Pharmacy, Geneva Switzerland 10. Anastrozole TabletsOverdose TreatmentThere is no specific antidote to overdosage andtreatment must be symptomatic. In themanagement of an overdose, consider thatmultiple agents may have been taken.Vomiting may be induced if the patient is alert.Dialysis may be helpful because Anastrozole isnot highly protein bound. General supportivecare, including frequent monitoring of vital signsand close observation of the patient, isindicated. The Swiss Pharmacy, Geneva Switzerland 11. Anastrozole TabletsAnazole Tablets 1 mg fromAlpha Pharma Ltd., IndiaFor more information click here The Swiss Pharmacy, Geneva Switzerland