andras j. pellionisz ph.d. in computer engineering, ph.d. in biology, ph.d. in physics bio
DESCRIPTION
GENOME ANALYTICS SOFTWARE-ENABLING FRACTAL APPROACH TO A GLOBAL, GENOME-BASED ECONOMY, WITH PERSONALIZED HEALTH-CARE SYSTEMS Featuring the DNA / RNA System as a Fractal Genomic Cerebellum. Andras J. Pellionisz Ph.D. in Computer Engineering, Ph.D. in Biology, Ph.D. in Physics bio - PowerPoint PPT PresentationTRANSCRIPT
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
GENOME ANALYTICSGENOME ANALYTICS
SOFTWARE-ENABLING FRACTAL APPROACH TO A GLOBAL, GENOME-BASED ECONOMY, TO A GLOBAL, GENOME-BASED ECONOMY,
WITH PERSONALIZED HEALTH-CARE SYSTEMSWITH PERSONALIZED HEALTH-CARE SYSTEMS
Featuring the DNA / RNA System as a Fractal Genomic CerebellumFeaturing the DNA / RNA System as a Fractal Genomic Cerebellum
Andras J. PellioniszAndras J. PellioniszPh.D. in Computer Engineering, Ph.D. in Biology, Ph.D. in PhysicsPh.D. in Computer Engineering, Ph.D. in Biology, Ph.D. in Physics
biobio
President of HolGenTech, Inc.President of HolGenTech, Inc.Silicon Valley, CaliforniaSilicon Valley, California
companycompany
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
Genomics is Informatics, 2002System Theory ? Fractal System !
FractoGene, 2002Unification of Neuroscience and Genomics, 2012
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
HoloGenome: a Fractal System – Pellio
nisz FractoGene, 2002
HoloGenome: a Fractal System – Pellio
nisz FractoGene, 2002
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
FractoGene; seed-concept ofrecursion in Pellionisz 1989, USPTO priority Date Aug. 1st, 2002), 2005, 2008, Cold Spring Harbor, 2009, Springer Verlag 2012
Public Domain Fractal Renderingof Heart Coronaries, Lung
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
All Genomes are Fractal? The Indian DNA Certainly is…All Genomes are Fractal? The Indian DNA Certainly is…
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
Dr. Eric Schadt, CSO, Pacific BioSciences: “Of most interest to me are Andras Pellionisz’ ideas around the fractal nature of genomes and how disruptions in such structure may drive phenotypic variation…The detection of these structures and subsequent determination of their association with disease are computationally intense problems. If something like this were shown to be true (disruptions in the fractal structures lead to phenotypic change), it would be truly revolutionaryit would be truly revolutionary.
3D Hilbert-curve (“fractals” go back to Euler!) isa) Ultra dense (fold 2m DNA into 6 micron nucleus)b) Knot-free (for unhindered “pervasive transcription”)c) “See through” (for maximal functional closeness of
linearly remote fragmented genomic regions)
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
High order chromatin architecture shapes the landscape of chromosomal alterations in cancerGeoff Fudenberg, Gad Getz, Matthew Meyerson & Leonid A Mirny
Nature Biotechnology 29,1109–1113 (2011) doi:10.1038/nbt.2049Abstract. The accumulation of data on structural variation in cancer genomes provides an opportunity to better understand the mechanisms of genomic alterations and the forces of selection that act upon these alterations in cancer. Here we test evidence supporting the influence of two major forces, spatial chromosome structure and purifying (or negative) selection, on the landscape of somatic copy-number alterations (SCNAs) in cancer. Using a maximum likelihood approach, we compare SCNA maps and three-dimensional genome architecture as determined by genome-wide chromosome conformation capture (HiC) and described by the proposed fractal-globule model. This analysis suggests that the distribution of chromosomal alterations in cancer is spatially related to three-dimensional genomic architecture and that purifying selection, as well as positive selection, influences SCNAs during somatic evolution of cancer cells.
Link
Independent Experimental Proof of Concept: Independent Experimental Proof of Concept: Fractal Defect Causes CancerFractal Defect Causes Cancer
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
Geoff Fudenberg, Gad Getz, Matthew Meyerson & Leonid A MirnyNature Biotechnology 29,1109–1113 (2011)
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.
Fractal Defect (of a Copy Number AlterationHere) Clogs Transparency;Disrupts “FunctionalProximity”; the Resultis Misregulation (Cancer)
Intact Fractality:The Ultra-DenseGenome is FunctionallyTransparent; Readable in Parallel
February 15, 2012Andras J. Pellionisz
International Conference on Systemics; Cybernetics and Informatics (ICSCI-2012) Hyderabad, India, by Pentagram Res. Ctr.