Animal Research Animal Research Administration UpdateAdministration Update

Kathy WadsworthDirector

Office of Animal Research Oversight (OARO)

Tissue Sharing Requirements Reminder/Update

Tissue Sharing: PurposeTissue Sharing: Purpose

A means of increasing the benefits derived from experimental animals while minimizing the number of animals used.

The ARC encourages PIs to share animals/animal tissues whenever possible.

ARC Policy on Tissue Sharing ARC Policy on Tissue Sharing RequirementsRequirements

A Tissue Sharing Form may be used in lieu of formal ARC approval, when tissue is obtained from another source that does not involve an increase in animal numbers or changes to existing approved procedures. 

Tissue Sharing: Tissue Sharing: Typical Typical ScenarioScenario

Investigator “A” harvests tissues following completion of a study using a mouse model.

Investigator “B” requests livers from mice used in investigator “A’s” study for in-vitro research. 

Transfer between UCLA investigators, if: • a) both investigators have approved ARC protocols, • b) the tissue being obtained originates from the

same genus as that listed in the recipient investigator’s protocol, and

• c) the tissue originates from non-USDA covered species.

Transfer from a UCLA investigator to an outside institution, if the tissue originates from non-USDA covered species.

Please note that although completion of a Tissue Sharing Form is not required in these cases, investigators are still expected to meet requirements #1-3 of the form.

A Tissue Sharing Form is A Tissue Sharing Form is notnot necessary when … necessary when …

Tissue Sharing Form: Tissue Sharing Form: ExceptionsExceptions

If modifications to the ARC protocol are required to accommodate the use or transfer of tissues, ARC review and approval of an amendment application is required prior to implementation of such changes.  

Tissue Sharing Form: Tissue Sharing Form: ExceptionsExceptions

If your funding agency requires formal IACUC approval for the use of animal tissues, the ARC requests that a tissue sharing protocol be submitted using the online Research Application Tracking System (RATS).

http://rats.research.ucla.edu 

For more information, see the OARO website: http://www.research.ucla.edu/rats_help/manual/PoliciesAndGuidelines/PoliciesGuidelines_TissueSharing.asp

ARC Policy on Tissue Sharing ARC Policy on Tissue Sharing RequirementsRequirements

Sharing Live AnimalsSharing Live Animals

Surplus Experimental Animal Resource Sharing (SEARS)

Means of sharing live animals between studies.

http://vmp.healthsciences.ucla.edu/research/surplus-animals/

What About MTAs?What About MTAs?

You may need to contact your MTA specialist to determine whether your request to share tissues or animals is covered by your MTA.

http://www.oip.ucla.edu/onlinemta 

uclamta@research.ucla.edu or 310-794-2641

ARC: Who to Contact at OARO?ARC: Who to Contact at OARO?

Director Kathy Wadsworth Assist. Director Compliance &

Education Andy Perkins Assist. Director ARC Jennifer Perkins

(310) 206-6308

arc@oaro.research.ucla.edu

http://www.oaro.research.ucla.edu