5TH ANNUALMSK SYMPOSIUM ON

LYMPHOMA 2020

Memorial Sloan Kettering Cancer CenterZuckerman Research Center

May 2-3, 2020 // New York City

State-of-the-Art in Biology, Therapy, and Patient Care

This symposium will feature updated information on lymphoma biology, diagnosis, immunology, and genetics, and ongoing efforts to translate the scientific discoveries into novel treatment strategies for a variety of lymphomas. Faculty will review the current standard of care and present their own perspectives on how they treat various types of lymphomas. Participants will have the opportunity to discuss diagnostic and management cases, and how to incorporate biologic and genetic biomarkers into clinical practice and clinical trials.

The target audience for this symposium includes medical and radiation oncologists, hematopathologists, scientists, and medical trainees involved in the diagnosis, treatment, and biomedical research of lymphoma.

Special Luncheon Events (space is limited)

Participants are invited to attend the special luncheon events, one hosted by the Adult BMT Service and the other hosted by the Myeloma Service. RSVP for the luncheons during course registration (space is limited and we do encourage early registration).

Adult BMT Luncheon (Saturday, 12:00-1:00 pm)The Road to Cure in Relapsed and Refractory DLBCL: via CAR19 or Other Modes of Transplantation?

Myeloma Luncheon (Sunday, 12:00-1:00 pm) Multiple Myeloma in 2020: Monoclonal Antibodies, CAR T cells, Genomic Profiling, and MRD Tracking

Complimentary Networking Reception

Participants are invited to a complimentary networking reception on Saturday evening from 5:30-6:30 pm, which will provide an opportunity to meet and interact with the course faculty and get to know other symposium attendees. RSVP for the reception during registration.

OVERVIEW

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Anas Younes, MD

MSK Symposium Chair

MSK Organizing Committee

Ahmet Dogan, MD, PhD

Joachim Yahalom, MD, FACR

Hans-Guido Wendel, MD

Andrew D. Zelenetz, MD, PhD

Live Simulcast Option Available

Unable to attend this course in person? We are pleased to offer a live simulcast option for this symposium. CME credit is offered for the live simulcast and pre-registration is required. We do hope you will attend in person but understand that can sometimes be a challenge, so we are happy to offer the live simulcast as an option.

Please note that the live simulcast is only available to non-MSK attendees. MSK employees are welcome to register to attend this course in person.

Andrew M. Intlekofer, MD, PhD

Ariela Noy, MD

Christian Buske, MDCCC Ulm/University Hospital Ulm Ulm, Germany

Bjoern Chapuy, MD, PhDUniversity of GöttingenGöttingen, Germany

Riccardo Dalla-Favera, MDColumbia University New York, NY

Martin Dreyling, MD, PhDUniversity of MunichMunich, Germany

John Gribben, MD, DSc, FRCP, FRCPath, FMedSciQueen Mary’s School of MedicineUniversity of LondonLondon, United Kingdom

Michael Hallek, MDClinic I of Internal MedicineUniversity Hospital Cologne Cologne, Germany

Tim Illidge, BSc, PhD, FRCPE, FRCR, FRCPathUniversity of Manchester Manchester, United Kingdom

Ari M. Melnick, MDWeill Cornell Medical College New York, NY

Invited Faculty

Markus Müschen, MD, PhDCity of Hope National Medical CenterDuarte, CA

Michael Reth, PhDUniversity of Freiburg Freiburg, Germany

Jean-Ehrland Ricci, PhDINSERM Nice, France

Davide Rossi, MD, PhDInstitute of Southern Switzerland IOSIBellinzona, Switzerland

Gilles Salles, MD, PhDUniversity of LyonLyon, France

Bouthaina Shbib Dabaja, MDMD Anderson Cancer CenterHouston, TX

Karin Tarte, PhDRennes University HospitalRennes, France

Chi Van Dang, MD, PhDUniversity of PennsylvaniaPhiladelphia, PA

Catherine Wu, MDDana-Farber Cancer InstituteBoston, MA

Christian Grommes, MD Steven Horwitz, MDBrandon Imber, MD Anthony Mato, MD, MSCEDavid J. Straus, MDDana Tsui, PhD

MSK Faculty

7:30 am Registration and Breakfast

8:00 am Welcome and Opening Remarks Anas Younes, MD

PathologyMODERATOR: Ahmet Dogan, MD, PhD

8:05 am Pathology Classification Ahmet Dogan, MD, PhD

8:40 am Introduction and Clinical Application of ctDNA Dana Tsui, PhD

9:10 am Discussion

Diffuse Large B Cell LymphomaMODERATOR: Anas Younes, MD

9:30 am Molecular Pathogenesis Riccardo Dalla-Favera, MD

10:00 am Molecular Classification Bjoern Chapuy, MD, PhD

10:30 am The Tale of Ramos and the Function of CD20 Michael Reth, PhD

11:00 am Evolving Frontline and Salvage Therapy of DLBCL Anas Younes, MD

11:30 am Discussion

12:00 pm Lunch Break

Optional Adult BMT Luncheon* The Road to Cure in Relapsed and Refractory DLBCL: via CAR19 or Other Modes of Transplantation?

*Luncheon RSVP required (space is limited; early registration encourage).

Chronic Lymphocytic Leukemia (CLL)MODERATOR: Andrew D. Zelenetz, MD, PhD

1:00 pm Pathogenesis John Gribben, MD, DSc, FRCP, FRCPath, FMedSci

1:30 pm Current Management Michael Hallek, MD

2:00 pm Novel Treatment Approaches Andrew D. Zelenetz, MD, PhD

2:30 pm Real World Experience Anthony Mato, MD, MSCE

3:00 pm Discussion

3:20 pm Break

Follicular Lymphoma MODERATOR: Hans-Guido Wendel, MD

3:40 pm Epigenetics Ari M. Melnick, MD

4:00 pm Role of the Microenvironment Karin Tarte, PhD

4:20 pm Targeting Serine Metabolism in Follicular Lymphoma Hans-Guido Wendel, MD

4:40 pm Therapy of FL Gilles Salles, MD, PhD

5:10 pm Discussion

5:30 pm Adjourn

Networking ReceptionParticipants are invited to a complimentary networking reception from 5:30-6:30 pm in the lobby of Zuckerman Research Center. Hors d’oeuvres and refreshments will be served.

Saturday, May 2, 2020

FACULTY SCHEDULE

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Faculty DisclosureIt is the policy of MSK to make every effort to insure balance, independence, objectivity, and scientific rigor in all continuing medical education activities which it provides as an ACCME accredited provider. In accordance with ACCME guidelines and standards, all faculty participating in an activity provided by MSK are expected to disclose any significant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services which are discussed by the faculty members in an educational presentation. As required by the ACCME, when an unlabeled use of a commercial product or an investigational use not yet approved for any purpose is discussed during an educational activity, MSK requires the speaker to disclose that the product is not labeled for the use under discussion or that the product is still investigational.

7:30 am Breakfast

Focus on Tumor MetabolismMODERATOR: Andrew Intlekofer, MD, PhD

8:00 am Introduction to Tumor Metabolism Andrew Intlekofer, MD, PhD

8:10 am Metabolic Control of T Cell Lymphoma Andrew Intlekofer, MD, PhD

8:30 am Metabolic Gatekeepers in B Cell Malignancies Markus Müschen, MD, PhD

8:50 am Metabolism and Lymphoma: From Basic to Translational Research

Jean-Ehrland Ricci, PhD

9:10 am Mitochondrial Reprogramming and Resistance to BCL2 Inhibition in Lymphoid Malignancies

Catherine Wu, MD

9:30 am TBA Chi Van Dang, MD, PhD

9:50 am Discussion

10:00 am Break

How I Treat (Session I)MODERATOR: David J. Straus, MD

10:20 am MCL Martin Dreyling, MD, PhD

10:50 am Marginal Zone: Molecular Pathogenesis and Treatment Approaches

Davide Rossi, MD, PhD

11:20 am Hodgkin Lymphoma David J. Straus, MD

11:50 am Discussion

12:00 pm Lunch Break

Optional Myeloma Luncheon Multiple Myeloma in 2020: Monoclonal Antibodies, CAR T cells, Genomic Profiling, and MRD Tracking

*Luncheon RSVP required (space is limited; early registration encourage).

Novel Approaches in Radiation TherapyMODERATOR: Joachim Yahalom, MD, FACR

1:00 pm Immunoradiotherapy Tim Illidge, BSc, PhD, FRCPE, FRCR, FRCPath

1:20 pm Radiation Therapy in the Era of CAR T cells Brandon Imber, MD

1:40 pm Proton Therapy in Lymphoma Bouthaina Shbib Dabaja, MD

2:00 pm Discussion

2:20 pm Break

How I Treat (Session II)MODERATOR: Ariela Noy, MD

2:40 pm Waldenstrom Christian Buske, MD

3:00 pm Burkitt Lymphoma and HIV Lymphoma Ariela Noy, MD

3:20 pm T Cell Lymphoma Steven Horwitz, MD

3:40 pm Primary CNS Lymphoma Christian Grommes, MD

4:00 pm Discussion

4:30 pm Closing Remarks Anas Younes, MD

4:45 pm Adjourn

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Sunday, May 3, 2020 REGISTRATION

Registration Fees Early Rate* General

Physicians (MDs, PhDs and DOs) $350 $400

Nurses, PAs and Other Healthcare Professionals $150 $200

Residents and Fellows $100 $150

Industry Professionals** $650 $700

Live Simulcast*** $550 $600

*Early registration rates available through March 7, 2020.**Industry professionals may attend MSK CME activities for their own education. Marketing, sales, and promotion of products and services is strictly prohibited at MSK CME activities.

***Please note that the live simulcast is only available to non-MSK employees. MSK employees are welcome to register to attend this course in person.

Register online:

mskcc.org/lymphomacourseCourse registration includes continental breakfast, lunch, and refreshment breaks. Please contact cme@mskcc.org at least one week prior to the course if you have any special dietary requests or require any specific accommodations.

• MSK CME offers a discounted rate for MSK Alumni, MSK Cancer Alliance and Cancer Care Partners. If you are a member of one of these groups, please contact cme@mskcc.org for more information.

• MSK employee registration is complimentary. However, you must complete course registration in order to attend this course.

Symposium Location Zuckerman Research Center417 East 68th StreetNew York, NY

MSK has negotiated special rates and amenities at select hotels in Manhattan. For more information, visit: mskcc.org/lymphomacourse

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Accreditation

Memorial Sloan Kettering Cancer Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

AMA Credit Designation StatementMSK designates this live activity for a maximum of 16.75 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

mskcc.org/lymphomacourse