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NORMENT – Annual Report 2014 | 12

Annual Report 2014

NORMENT Annual report 2014 |

Norwegian Centre for Mental

Disorders Research (NORMENT)

3 Leader’s comments

4 Vision Statement

5 Scientific aims

6 Achievements 2014

7 Scientific currency

8 Happenings 2014

10 NORMENT Annual Retreat

11 Core Researchers

12 Translational Psychiatry

13 Clinical Psychosis Research

14 Psychiatric Molecular Genetics

15 Brain Imaging

16 Neurocognition

17 Structural MRI

18 Convergent functional genomics

19 Animal models

20 International Cooperation

21 New employees 2014

22 NORMENT Staff

23 Activities 2014

Visits Abroad

Visits from Abroad

Further International Cooperation

24 Presentations 2014

26 Disputations 2014

27 NORMENT in Media

28 Publications 2014

34 Funding

Norwegian Centre for Mental Disorders Research

(NORMENT) is a Norwegian Centre of

Excellence established by the Research Council

of Norway in July 2013.

NORMENT is integrated with the K. G. Jebsen

Centre for Psychosis Research, funded by the

K.G. Jebsen Foundation. This provides a unique

opportunity to perform comprehensive and long-

term research, reaching across the country.

The Centre has a clear clinical profile, involving

investigations of patients with state-of-the art

clinical assessments and research technology,

and translating findings to experimental studies

for the identification of underlying mechanisms.

We have ambitious scientific goals, focusing on

understanding the underlying mechanisms of

severe mental disorders. This is a field with large

unmet needs and lack of knowledge, which

makes the work of our Centre of Excellence very

important. We have focused on four main areas

of activities to answer the following research

questions:

Why do antipsychotic medications have

severe side effects?

How can brain imaging help link genes to

clinical characteristics?

Where is the ‘hidden heritability’ of

severe mental disorders?

How can we predict outcome in patients

experiencing their first signs of disease?

2


We have also provided evidence how animal

models can be used for translational studies

of antipsychotic side effects, and shown how

schizophrenia risk genes relate to immune

system induce abnormal behaviour and

altered brain function when transferred to

mouse models.

These aspects are now followed up in new

clinical studies focusing on prediction of long-

term course and outcome. Emerging data

indicates that early treatment response is a

key predictor. There are always several

challenges involved in developing a new

Centre of Excellence, and the current most

pressing issue is the lack of adequate office

and lab space, which we hope will be

finalized in 2015.

Despite this limitation, the coordination of the

research activity between the different

partners seems to work very well, and we

have been successful in recruiting new and

talented researchers to the Centre.

This makes me very optimistic for the next

year and I look forward to new discoveries in

2015.

Ole A. Andreassen, Director NORMENT

Leader’s comments

The first phase of the NORMENT has been used to

establish the Centre identity, both in terms of

scientific focus and coordinated organisation and

communication. We have made significant

progress in these aspects in 2014, and the first full

year of activity turned out to be a productive and

rewarding year for the NORMENT Centre.

We have continued to develop a synergistic team

of research groups and work units, and established

structures for project coordination, expertise

sharing and strong method platforms. The scientific

achievements have been excellent. We have

participated in discovery of new gene variants

associated with psychiatric disorders, and

especially the Nature paper in July identifying 108

gene variants for schizophrenia was a

breakthrough in the field.

We have also found indications that socioeconomic

stressors in adolescence may increase the risk for

psychotic disorders and that environmental risk

factors reduce the age at onset of bipolar disorder

and are likely to be involved in the development of

the disorder, with indications of gene x

environmental interactions. Using state-of-the-art

brain imaging tools, we have determined how

environmental factors (obstetric complications)

affect brain development, and may play a causative

role in psychiatric disorders.

Furthermore, the Centre has developed new

statistical methodology to boost the power of

genetic studies, thereby strongly increasing the

output from genetics data in many fields of human

disease research.

3


Vision statement

NORMENT’s primary objective is to reveal underlying pathophysiological mechanisms in schizophrenia and bipolar disorder and to develop tools for stratification and outcome prediction, using a vertical synergy approach, with the following sub goals:

1) Define new targets to optimize the ratio of beneficial vs. adverse effects of antipsychotics. 2) Identify genetic variants or expression variation to reveal ‘missing heritability’. 3) Determine new brain imaging phenotypes linking genes and core clinical phenotypes. 4) Use genetic and environmental factors to predict disease progress and outcome.

We will take advantage of the homogeneity of the Norwegian population (genetic background, health care system, registries) as the basis for collecting large samples of affected and unaffected people. These individuals will be characterized with the same clinical, cognitive, biochemical and imaging protocols to identify new mechanisms which will be studied functionally in animal and cell culture models.

Scientific aims

1. Define New Targets for Antipsychotic Medication

Antipsychotic medications are the cornerstone in the treatment of schizophrenia, and have in recent years

also been used for bipolar disorder. The medications are not equally effective for all patients, and have a

limited effect on the core symptoms for approximately 20 % of those treated.

Adverse effects are problematic and in some cases serious, such as cardiovascular risk factors (weight gain,

abnormal fat levels in the blood, diabetes etc.). Research at NORMENT has a particular focus on the

immune and lipid (fat) metabolism systems.

We use animal and other experimental models to enhance our knowledge about the mechanisms of action

of antipsychotic medication. We aim to optimize antipsychotic treatment by increasing the desired effect of

medication and reducing adverse effects.

4


4. Predict Course and Outcome –Including Mortality

Some patients with severe mental disorders recover completely while others develop chronic illness. Currently,

we can mainly make general assumptions about the most likely prognosis for someone who develops a severe

mental illness and are not able to predict the personal outcome for individual patients. One of the main goals for

NORMENT is to investigate how we can improve our understanding of course and outcome. Ultimately, the goal

is to make personalized predictions for patients coming to their first treatment. We are doing this by examining

how genetic- and environmental risk factors influence the course of the disorder, by combining clinical- and

cognitive assessments with brain imaging.

During 2014, the main focus has been on investigating how specific environmental risk factors influence clinical-

, cognitive- and morphological characteristics either individually, or in interaction with other environmental and

genetic risk factors. At present, we are studying the effects of early traumatic events, cannabis use and

migration- with additional studies of how the effects of trauma interact with the effects of cannabis use and of

migration. We have also studied how trauma interacts with genetic factors – in this case variant in the BDNF

gene – on cognition and on structural changes in hippocampal subfields.

This line of research is done in close collaboration with several of NORMENT’s groups and with international

colleagues in Paris, France and Milan, Italy. To study the effects on course and outcome we also need well-

described patient cohorts followed from their first treatment. Within the NORMENT Centre we have established

a large first-treatment schizophrenia spectrum cohort and are working to establish a first-treatment bipolar

spectrum cohort in collaboration with Norwegian colleagues in the NORSMI network. We are now ready to

launch a long-term (5 and 10 year follow ups) of the schizophrenia cohort. We have already started out a five-

year follow up of patients at Innlandet Hospital in collaboration with the regional research network. The first part

of the long-term follow-up will have a particular focus on functioning, cognition and negative symptoms.

3. Brain Imaging: Identify Brain MRI

Phenotypes Linking Genes to Core

Clinical Phenotypes

Advanced neuroimaging techniques including

structural and functional MRI have revolutionized the

understanding of the structural and functional makeup

of the human brain.

NORMENT researchers have contributed to the

identification of structural brain abnormalities in

schizophrenia, including volumetric alterations in front

temporal cortical areas and subcortical structures.

Partly overlapping and partly diverging patterns have

been found in bipolar disorder.

Structural and functional brain phenotypes are highly

heritable, and current research at NORMENT aims to

identify the genetic underpinnings of individual

differences in the structural and functional

organization of the human brain, and to disentangle

the genetic and phenotypic associations with severe

neuropsychiatric disorders.

2. Identify Genetic Factors for Psychiatric

Disorders – Common and Rare Variants

Family and twin studies have shown that

schizophrenia and bipolar disorder have high

heritability. Researchers at NORMENT have

contributed to major international GWA (“genome-

wide association studies”). We have found evidence

for new vulnerability genes for these disorders.

Preliminary results show that inherited changes in

many genes (i.e. gene variants) are involved, but

each variant contributes to a relatively modest degree.

The identified gene variants explain only a small

portion of susceptibility to psychotic disorders.

Heritability is therefore still far from fully explained.

In our research, we use combined approaches that

include new genotyping methods to identify rare

genetic variants. We also use new statistical methods

for mapping multiple gene variants, each of which has

a small effect on its own.

5


Achievements

Implemented new statistical tools for gene

based association analyses and allelic

heterogeneity

Developed a team in translational psychiatry,

focusing on immune and cardiovascular

comorbidity

Finished the protocol for a long-term follow-up

study of first episode patients

New neurocognitive and functional outcome

protocol for 5-, 10-, and future NORMENT

follow up studies developed

Developed a new smartphone app for sampling

of symptom-data in real-time, collaboration

between Bergen and Oslo

Several translational studies listed in Research

aims/deliverables published and/or submitted

Improved the new statistical tools for improved

gene discovery in a range of polygenic complex

disorders

First study on the relationship between

temporal and frontal lobe glutamate

concentrations and PANSS hallucination scores

published

Investigate for consistency of MR measures

across scanners

Longitudinal neuroimaging – 1-year follow-up

finished

Participated in genetic and imaging

genetics consortia for large scale

association discovery

Genotyped a large sample of cases and

controls, nearly 25 000 participants

Developed new MRI multimodal imaging

analysis protocol

Started upgrade of Centre MRI scanners in

both Bergen and Oslo and synchronized

protocols

Established principles for ‘biophysical

psychiatry’ approach

Received NIH funding for a big data grant

(big data to knowledge, BD2K) involving

the ENIGMA study

Completed data collection for cognitive

remediation study and social cognition

PhD project

New biomarkers: NMDA receptor

antibodies, viral serology

6


Scientific currency

60 %

32 %

8 % Impact Factor Distribution - NORMENT

Publications 2014

< 5

5 - 15

> 15

14 %

36 %

50 %

Publications with one or more NORMENT - authores

1

2 - 4

> 5

Papers

NORMENT scientist authored or co-authored 102

papers in international peer-reviewed journals in 2014.

Of the papers published in 2014, 25 papers appeared

in journals with an impact factor above 5. Six of these

appeared in journals with an impact factor above 15,

(one with impact factor above 35). In general the

quality and visibility of publications from the Centre is

high.

NORMENT scientists have extensive collaborations

with national and international research groups. More

than 50 % of the papers published in 2014 with one or

more NORMENT authors are the result of

collaborations with national institutions. Impact factor

based on collaborations are illustrated in the figures

below. NORMENT publications in 2014 are presented

on page 28 of this report. National and international

collaborators are listed on page 20 and 22.

Dissemination of research result

NORMENT members gave 48 talks as

invited speakers at international scientific

meetings in 2014. In addition 105 oral

presentations and 56 posters were

presented by NORMENT scientists.

NORMENT staff gave also 65 lectures,

aimed at a targeted audience and the

general public.

These include postgraduate lectures,

research seminars, training course at

universities and hospitals. Talks, posters

and dissemination activities aimed at

targeted audience and the public, as well as

media coverage, are listed in the back of

this report.

Prizes and awards:

Professor Kenneth Hugdahl was awarded the

2014 “Møbius” prize, from the Research Council

of Norway.

http://www.forskningsradet.no/no/Nyheter/Forsk

ningsrdet_deler_ut_tre_priser_i_dag/125400158

1512?lang=no

Professor Kenneth Hugdahl received honorary

Meltzer Award for 2013, from University of

Bergen.

http://www.uib.no/aktuelt/63020/meltzers-

%C3%A6respris-til-kenneth-hugdahl

Post doc Monica Aas received 2014 NARSAD

Young Investigator Grant for her studies on the

effects of trauma in schizophrenia and bipolar

disorders.

Post doc Martin Steen Tesli received Travel

Award, at World Congress of Psychiatric

Genetics, Copenhagen October 2014.

Prof. Ole A. Andreassen became new member

of National Academy of Science and Letters

7

http://www.forskningsradet.no/no/Nyheter/Forskningsrdet_deler_ut_tre_priser_i_dag/1254001581512?lang=no



http://www.uib.no/aktuelt/63020/meltzers-%C3%A6respris-til-kenneth-hugdahl

http://www.uib.no/aktuelt/63020/meltzers-%C3%A6respris-til-kenneth-hugdahl


1

Happenings 2014

Illustration: Trine Vik Lagerberg, Carmen Simonsen and

Akiah Ottesen Berg (postdocs in the Clinical group) on their

bikes at the Lucca seminar.

Illustration: Petter Andreas Ringen and Levi Kvitland with

their posters at the Conference of the International Society

of Bipolar Disorders in Seoul, March 2014.

Lucca seminar:

In August, the clinical group’s postdocs participated in the annual writing seminar in Lucca, Tuscany, together

with the clinical research groups in Stavanger and Bergen. The seminar was the second inter-regional

seminar at this location, and further strengthened our ongoing inter-regional collaborations.

Illustration: Early Saturday morning in

Lucca. Carmen Simonsen and Monica

Aas at work with their colleagues from

Bergen and Stavanger.

Illustration: Christine Demmo with her

poster at the Conference of the

International Society of Bipolar Disorders

in Seoul, March 2014.

8


2

Kenneth Hugdahl received The

Award for Outstanding

Research (Møbius Prize) from

the Research Council of

Norway.

Monica Aas received 2014

NARSAD Young Investigator

Grant for her studies on the

effects of trauma in

schizophrenia and bipolar

disorders.

The 22nd World Congress of Psychiatric Genetics in Copenhagen.

The 22nd World Congress of Psychiatric Genetics (WCPG) took place during 12-16 October 2014,

organized by a Scandinavian committee that included five of the NORMENT Core Researchers (Ole A.

Andreassen, Ingrid Melle, Vidar M. Steen, Srdjan Djurovic and Stephanie Le Hellard).

Srdjan Djurovic was hired as

professor II, at Clinical

Institute 2, University of

Bergen.

NORMENT researchers were responsible for a symposium on "the interplay between genetics and early

trauma in severe mental disorders" as well as a satellite symposium entitled "Leveraging Population

Registries and Biobanks for Neuropsychiatric Research: Experiences from the Nordic Countries and

Opportunities for the HORIZON 2020 Initiative of the European Union". In addition, NORMENT

contributed significantly to the scientific program through lectures and poster presentations".

9


1

12

6

6

1

PhD Students

Post docs

Senior Scientists

Core Researchers

Scientific Advisory Board

Speakers at Annual Retreat

3

NORMENT Annual Retreat 2014 4

NORMENT Annual Retreat took place in Oslo, September 15-

16. The program consisted of plenary lectures with updates,

new findings and ongoing projects, synergy workshops with

project planning, as well as poster sessions.

In addition, there were presentations by our Scientific Advisory

Board, who also contributed with comments and feedback. A

total of 85 people participated, in an enthusiastic and

interactive atmosphere, and we had a successful annual

NORMENT dinner.

The conference took place at Quality Hotel Expo at Fornebu,

close to the fjord with easy transportation from city center and

airport.

Visiting Scientific

Advisory Board (SAB)

Michael Green

Terry Jernigan

Marcella Rietschel

10


Core Researchers

NORMENT has organized the research into

interdisciplinary research groups with complementary

expertise. Each research group is led by a senior

researcher. NORMENT has eight Core Researchers.


Translational Psychiatry

Achievements in 2014:

Actively involved in a large international

consortium which led to the discovery of 108

risk genes for schizophrenia, and participated

in several discoveries of common gene

variants for psychiatric disorders.

Developed new statistical tools for improved

gene discovery in a range of polygenic

complex disorders.

Showed how polygenic factors are associated

with diagnostic groups and brain phenotypes.

Developed a team in translational psychiatry,

focusing on immune and cardiovascular

comorbidity.

Group leader:

Ole A. Andreassen,

Professor UiO, OUS

Group members:

Andrew Brown

Ingrid Dieset

Thomas Bjella

Aree Witoelar

Verena Zuber

Saurabh Srinivasan

Eva Zsuzsanna Hoseth

Yunpeng Wang

Sigrun Hope

Eivind Bakken

Francesco Bettella

Tuomo Mikael Marttunen

Ragni Mørch

Wen Li

Martin Tesli

Nils Eiel Steen

Terje Nærland

Lars Tjelta Westlye

Daniel Quintana

Karolina Kauppi

Tobias Kaufmann

Nhat Trung Doan

Christine Lycke Brandt

Kristina Skåtun

Ingeborg Bolstad

Ambitions for 2015:

Finish the long range phasing of the

Norwegian population, and apply this

approach to severe mental illness.

Further improve the novel biotstatistical

tools, and apply them to core phenotypes

in psychiatry, focusing on brain imaging

and cross-disorder phenotypes.

Integrate our “biophysical psychiatry”

approach with clinical EEG measures.

Facilitate the investigations of immune

and cardiovascular comorbidity, and

multimodal imaging.

12


Clinical Psychosis Research

.

Group leader:

Ingrid Melle,

Professor UiO, OUS.

Group members:

Trine Vik Lagerberg

Jannicke Fjæra Andresen

Idun Huflåtten

Camilla Bakkalia Büchmann

Carmen Simonsen

Erlend Gardsjord

Monica Aas

Mari Nerhus

Ann Færden

Petter Andreas Ringen

Akiah Ottesen Berg

Levi Røstad Kvitland

Marit Haram

Nasrettin Sömnez

Tiril Østefjells


The main focus for the research group is the

Centre’s Aim # 4 – the study of how genetic and

environmental factors influence course and

outcome in psychotic disorder.

The main focus in 2014 has been on the effect

of environmental risk factors and gene x

environment interactions on cross sectional

outcome, with a focus on early trauma,

migration and cannabis. This work is done in

close collaboration with other CR groups (in

particular molecular genetics, structural imaging

and Neurocognition) with several publications.

We have also finished the protocol for a long-

term follow-up study of first episode patients.

Ambitions for 2015:

In December 2014 we received additional

external funding to launch the long-term

follow-up.

The ambition for 2015 is to start out the

first wave of follow-ups.

In addition, we will continue the work on

short-term effects of environmental risk

factors, including studies on interactions

with polygenetic risk scores in

collaboration with other CR groups in the

Centre.

13


Psychiatric Molecular Genetics


Several translational studies listed in

Research aims/deliverables published

and/or submitted

Inclusion of samples for stem cells project

and building up stem cells infrastructure

3 new postdocs recruited

New national /international collaborations

established

Ambitions for 2015:

Produce and further characterize

induced pluripotent stem cells and

induced neurons

Continue with disease modelling using

stem cell and cell cultures

Continuation of translational projects,

including deeper molecular

characterization and molecular

phenotyping

Continuation of work at international

collaboration (eg. CNV ENIGMA, PGC

BD, …)

Group leader:

Srdjan Djurovic,

Professor OUS, UiB.

Group members:

Lavinia Athanasiu

Ida Elken Sønderby

Lars Hansson

Elin Inderhaug

Matthieu Vandenberghe

Agata Impellizzeri

Christian Melbø-Jørgensen

Kristine Kjeldal

Malik Mumtaz Hussain Taqi

14


Brain Imaging, Cognition


First study on the relationship between

temporal and frontal lobe glutamate

concentrations and PANSS hallucination

scores published.

We have started the analysis of fMRI and

DTI data from the first wave of BP2

patients, with a focus on correlations with

auditory hallucinations.

We have developed a new smartphone

app for sampling of symptom-data in real-

time, collaboration with Oslo CRs.

Ambitions for 2015:

Finish data analysis of the first wave BP2 patients,

especially mapping the temporal characteristics of

auditory hallucinations.

Run a first test of iPod app for sampling of data on

frequency and duration of auditory hallucinations,

collaborations with Oslo and Finland.

First attempt to analyze already acquired GABA

neurotransmitter concentrations from the same

brain areas as glutamate, and run against the

fluctuations of auditory hallucinations in the course

of a day. Finish analysis of BAVQ data from 420 patients,

collected in Norway, Australia, and UK.

Group leader:

Kenneth Hugdahl, Professor

UiB

Group members:

Josef Bless

Maiken Brix

Alex Craven

Gerard Dwyer

Lars Ersland

Liv Falkenberg

Renate Grüner

Marco Hirnstein

Erik Johnsen

Bjørg Kocbach

Kristiina Kompus

Galyna Kovalchuk

Rune Kroken

Else-Marie Løberg

Susanne Passow

Igne Sinkevicute

Karsten Specht

15


Neurocognition


Completed data collection for cognitive

remediation study and social cognition PhD

project.

Completed cognitive and functional outcome

protocol for long-term follow-up study of first

episode patients

PhD completed: Longitudinal neurocognitive

trajectories in first-episode psychosis:

Relationships between illness severity and

cognitive course

Two PhDs recruited to project on genetics of

attention and effort in healthy controls

The group has contributed to approximately 20

papers that were published in 2014

Ambitions for 2015:

Writing up of cognitive remediation study,

social cognitive post-doc project and

longitudinal first treatment bipolar study

Contribute to first wave of data collection

for long-term follow-up study

Continue development of new

computerized scoring software for social

and emotional processing in psychosis

Startup of data collection project on

genetics of attention and effort in healthy

controls

Group leader:

Kjetil Sundet, Professor

UiO

Group members:

Torill Ueland

Anja Vaskinn

Thomas Espeseth

Vilja Bidtnes

Kristoffer Grimstad

Tale Moldestad

Beathe Haatveit

Christine Demmo

Jens Marius Halvorsen

June Lystad

Tone Hellvin

16


Structural MRI


Continued search for biological and environmental

correlates/effects to brain neuroanatomical changes.

Reported hippocampal subfields reductions in severe

psychoses and how perinatal asphyxia is related with

limbic structures in bipolar disorder.

New biomarkers: NMDA receptor antibodies, viral

serology.

Longitudinal neuroimaging – 1-year follow-up

finished.

Participated in genetic and imaging genetics

consortia for large scale association discovery.

Investigate for consistency of MR measures across

scanners.

Scandinavian multisite translational study on

adolescent psychosis now comprises three sites

(UiO and Karolinska Institutet and recent up-start in

Bergen)

Ambitions for 2015:

Detail the characterization of brain

phenotypes and clinical symptoms, use of

stimulants and pharmacological agents.

Implement use of app for sampling symptom-

data in real time together with Hugdahl

Bergen group.

Characterize clinical sample for early trauma,

infection exposure and NMDA autoimmunity

and search for association with genetic risk

scores and brain phenotypes.

Expand adolescent early-onset psychosis to

more Scandinavian sites.

Group leader:

Ingrid Agartz,

Professor UiO

Group members:

Kristine Engen

Tiril Pedersen Gurholt

Cecilie Bhandari

Hartberg

Unn Kristin H. Haukvik

Elisabeth Lange

Vera Lonning

Lynn Mørch-Johnsen

Stener Nerland

Ragnar Nesvåg

Kjetil Nordbø

Jørgensen

Thorny Olafsdottir

Runar Smelror

Erik Jönsson

17


Convergent functional genomics


Implemented new statistical tools for

gene-based association analysis and

allelic heterogeneity.

Identified genes and groups of genes

implicated in cognition and brain

imaging traits, both in NORMENT-

grounded studies and through

participation in international consortia.

Ambitions for 2015:

Further develop gene-based studies for allelic heterogeneity between psychiatric disorders and relevant traits.

Finely map and characterize in silico the implication of a few genomic loci associated with schizophrenia.

Develop epigenetic studies for the characterization of human-specific methylated regions in complex traits and gene by environment influence in psychiatric traits.

Characterize the differential methylation induced by cannabis exposure.

Group leader:

Stéphanie le Hellard,

Professor UiB

Group members:

Niladri Banerjee

Carla Fernandes

Sudheer Giddaluru

Tatiana Polushina

Anne Kristin Stavrum

Ghazal Zakeri

18


Animal Models


Identified genes and groups of genes

implicated in cognition and brain imaging

traits, both in NORMENT-grounded studies

and through participation in international

consortia.

Implemented methods for analysis of human

whole exome and whole genome sequencing

data, and identified novel disease genes.

Established long-acting formulation of

antipsychotic drugs as a new approach for

modelling metabolic adverse effects.

Group leader:

Vidar M. Steen, Professor

UiB

Group members:

Hans-Richard Brattbakk

Jorunn S Bringsli

Inger H Duus

Kari M Ersland

Carla Fernandes

Rita Holdhus

Marianne Navdal

Silje Skrede

Christine Stansberg

Tomasz Stokowy

Ambitions for 2015:

Further explore the genetics and functional

genomics of schizophrenia-associated

genes involved in lipid metabolism,

immunity and synaptic signaling

Establish and improve experimental animal

models for studying brain myelination and

long-term effects of antipsychotic drugs

Further develop strategies and methods for

human gene annotation

19


International Cooperation

The research requires close cooperation with leading research

environments, both national and international. The

researchers are participating in a series of international

networks, and have several bilateral research programs with

international institutions, both in the European Union and in

USA.

In addition to this, the Centre works actively to recruit

excellent researchers internationally.

The Centre facilitates the exchange of staff between the

participants and international collaborators. In 2014 we had 3

post docs abroad, and 4 international guest researchers were

associated with the Centre.

International Guest Researchers Anders M. Dale and Wes Thompson, UCSD, USA; Sven

Cichon, Basel, Swizerland; Frank Larøi, Liege, Belgium.

Scientific Advisory Committee

NORMENT has established an Advisory Committee of

external scientific researchers. Their tasks are as follows:

Terry Jernigan, Professor at University of California. San Diego.

Michael Foster Green, Professor at University of California. Los Angeles.

Contribute to NORMENT’s research activity by evaluating and advising on the activities within each of the research groups of the Centre and by acting as scientific advisors to the Centre Director.

Contribute by giving an annual lecture at postgraduate level.

Take an active part in NORMENT’s annual Meetings.

Participate in preparing an annual written evaluation with SWOT analysis.

Provide advice to the NORMENT leadership in strategic decisions

Marcella Rietschel, Professor at University of Mannheim.

20


New employees 2014

Anne-Kristin Stavrum. Ph.D in Bio-informatics, UiB

Matthieu Vandenberghe, Ph.D.Postdoctoral fellow

Aree Witeolar, Ph.D.Postdoctoral fellow

Niladri Banerjee, Master in Sciences, UiB

Ingrid Dieset, Ph.D. Associate Professor

Sudheer Giddaluru. Ph.D in Biomedicine, UiB

Erik Johnsen. Leader of the Norment -associated Bergen Psychosis

Project

Ida Elken Sønderby, Ph.D. Postdoctoral fellow

Erik Gunnar Jönsson, Professor

Agata Impellizzeri. Ph.D. Postdoctoral fellow

Tuomo Mikael Marttunen Seyran Kahlili. Consultant

Frank Larøi. Psychologist and Professor, UiB

Jeanette Haatveit, Admin. Consultant

Jannicke Fjæra Anderssen, Cand psychol. Ph.D Student

Malik Mumtaz Hussain Taqi Scientist

Runar Smelror, Scientific assistant

Linn Christin Norbom, Scientific assistant

Wen Li, Scientist Nhat Trung Doan, Ph.D in Medical

Imaging. Postdoctoral fellow

Daniel Quintana, Ph.D in Psychology. Postdoctoral fellow

Tone Hellvin, Ph.D in Psychology

Dag Alnæs, Ph.D Student Sofie R. Aminoff., Ph.D.

Postdoctoral fellow

Tor Johannes Helleland, IT assistant

Nina Chung Mathiesen Sunniva Grimstad Marlene Kristiansen Johre

21


NORMENT Staff Senior scientists, Professors and Associate Professors Erik Gunnar Jönsson, Professor Erik Johnsen, Professor II Ingrid Dieset, Associate Professor Jan Ivar Røssberg, Professor II Lars Ersland, Scientist, MR-physicist Lars Tjelta Westlye, Associate Professor Renate Grüner, Associate professor, MR physicist Rene Westerhausen, Senior Scientist Thomas Espeseth, Associate Professor Unn Haukvik, Associate Professor

Research Fellows Beathe Haatveit, MSc Camilla Büchmann, Cand.psychol. Carla Fernandes, MSc Christine Demmo, Cand.psychol. Christine Lycke Brandt, MSc Dag Alnæs, Cand.psychol. Elisabeth Lange, Cand.med. Erlend S. Dørum, Cand. med. Erlend Gardsjord, Cand.med. Eva Hoseth, Cand.med. Geneviève Richard, MA.psychol. Helene Barder, Cand.psychol. Ingeborg Bolstad, MSc Jannicke Fjæra Anderssen, Cand.psychol. Kjetil Nordbø Jørgensen, Cand.psychol. Kristina Skåtun, MSc Levi Kvitland, Cand.psychol. Liv Falkenberg, MSc Luiz Goulart, Cand.med. Lynn Mørk Johnsen, Cand.med. Maiken Brix, Cand.med. Mari Nerhus, Cand.med. Marit Haram, Cand.med. Morten Mattingsdal, MSc Nathalia Zak, Cand.med. Niladri Banerjee, MSc Saurabh Srinivasan, MSc Siren Tønnessen, Cand.psychol. Thorny Olafsdottir, Cand.med. Tiril Østefjells, Cand.psychol. Vera Lonning, Cand.med.

Post docs Akiah Ottesen Berg, PhD in Psychology Andrew Brown, PhD in Biostatistics Anja Vaskinn, PhD in Psychology Anne Kristine Stavrum, PhD in Informatics Carmen Simonsen, PhD in Psychology Cecilie Bhandari Hartberg, PhD in Medicine Daniel Quintana, PhD in Psychology Francesco Bettella, PhD in Biostatistics Ida Sønderby, PhD in Molecular Genetics

Kari M. Ersland, PhD in Biomedicine Karolina Kauppi, PhD in Medicine Kristina Kompus, PhD in Psychology Lavinia Athanasiu, PhD in Molecular Genetics Martin Tesli, PhD in Medicine Monica Aas, PhD in Psychology Nhat Trung Doan, PhD in Medical Imaging Silje Skrede, PhD in Biomedicine Sudheer Giddaluru, PhD in Biostatistics Tatiana Polushina, PhD in Applied mathematics Tobias Kaufmann, PhD in Psychology Tomasz Stokowy, PhD in Bioinformatics Tone Hellvin, PhD in Psychology Torbjørn Elvsåshagen, PhD in Medicine Trine Vik Lagerberg, PhD in Psychology Verena Zuber, PhD in Biostatistics Yunpeng Wang, PhD in Biostatistics

Research Students Claire L. Poppy, MA psychology Hanne Smevik, MA psychology Natalia Tesli, MA cognitive science Nina C. Mathiesen, MA psychology Synøve Kamøy, research student in medicine Inger Duus, research student in medicine

Other Research Personell Galyna Kovalchuk, MA, Research Assistant Ghazal Zakeri, Research assistant Idun Bernadotte Huflåtten, Cand Psychol Kristoffer Grimstad, Cand.psychol. Martina J. Lund, MA psychology Tale Moldestad, Cand Pscyhol. Vilja Bidtnes, Cand.psychol. Christian Melbø-Jørgensen, Msc Malik Mumtaz Hussain Taqi, PhD

Technical and Administrative Positions Alex Craven, Research technician Bilal Safdar, Economist Cecilie Evjen, Lab Assistant Christine Stansberg, Senior Engineer Eivind Bakken, Head Nurse Elin Inderhaug, Bioengineer Gerard Dwyer, Research Technician Hans-Richard Brattbakk, Chief Engineer Jeanette Haatveit, Admin. Consultant Jorunn Bringsli, Chief Engineer Kate Eli Frøland, Senior Excecutive Officer Kristine Kjeldal, MSc Lars Johan Hansson, MSc Lena Stabell, Psychiatric Nurse Line Gundersen, Nurse Marianne Navdal, Lab Engineer Ragnhild Bettina Storli, Admin. Consultant Rita Holdhus, Chief Engineer Runar Kristiansen, Database Assistant Tanzeela Parveen, Medical Secretary Thomas Bjella, Database Consultant Vegard K. Lillevoll, IT Engineer Øyvind Rustan, Scientific Assistant

22


Activities 2014

Visits Abroad

Post doc Andrew Brown holds a 50 % position at

the Sanger Institute (a genomics and genetics

research institute), UK.

Post doc Yunpeng Wang is a visiting post doc

Multimodal Imaging Laboratory (MMIL), UCSD,

USA: Prof Anders M. Dale

PhD Student Dag Alnæs, Post doc Tobias

Kaufmann and Associate Professor Lars T. Westlye

visited the FMRIB Centre, University of Oxford, in

November.

Post doc Silje Skrede, March 20 – April 30:

research stay in the lab of prof. Miguel López,

CIMUS, University of Santiago de Compostela,

Spain.

Post doc Martin Steen Tesli visited Institute of

Psychiatry, King's College London, in June

Post doc Verena Zuber visited UCSD, San Diego in

January and Karolinska, Stockholm in September.

Visits from Abroad

SCID, PANSS and DSM-V workshop – Joseph

Ventura, UCLA. He visited us in March 2nd-7th.

European Bipolar Research Network (ENBREC) –

from Paris, France visited us May 19th.

NORMENT Scientific Advisory Committee: Terry

Jernigan (San Diego, USA), Michael Green (Los

Angeles, USA) and Marcella Rietschel (Mannheim,

Germany) visited in September for NORMENT’s

annual gathering.

Professor Anders M. Dale, Multi-Modal Imaging

Laboratory at University of California, San Diego

visited us from September 2-19 2014.

Associate Professor Alex Hoischen (Radboud

University Medical Center, the Netherlands) visited

us for two weeks in March and August 2014.

International Cooperation

University of Oxford, UK: Prof Steve Smith, Dr

Eugene P Duff, Dr Evangelos Roussos, Dr Gwen

Douaud

Multimodal Imaging Laboratory, UCSD, USA: Prof

Anders M. Dale, Prof Wes Thompson

Max Planck UCL Centre for Computational

Psychiatry and Ageing Research, Berlin, GE: Dr

Douglas G. Garrett

deCODE, Iceland: Dr Hreinn Stefansson, Dr

Omar Gustafsson

Laboratory of Neuro ImagingKeck School of

Medicine, University of Southern California, USA:

Dr Derrek Hibar, Prof Paul M Thompson

University of Copenhagen, DK: Associate

professor Randi Starrfelt, Professor Thomas

Werge

Brain Innovation BV, Maastricht, NL: Dr Ralph

Brecheisenl.

International Consortium on Hallucinations

Research (ICHR), coordinated from University of

Western Australia.

Karolinska Institutet, Sweden: Stockholm Child

and Adolescent Psychosis Study. Christina

Hultman, Epidemiology Genetics.

University of Oxford, UK. Angela Vincent

immunity, Guy Goodwin bipolar disorder.

Psychiatric Genomics Consortium (PGC). Pat

Sullivan UNC, USA, John Kelsoe UCSD, USA,

Mick O’Donovan Cardiff, UK.

Bipolar Disorder Network. Paris, France. Bruno

Etain, Chantal Henry. Newcastle, UK, Jan Scott.

Dresden, Germany, Michael Bauer.

Institute of Psychiatry. London, UK. Robin Murray,

E. Vassos, M. DeForti, Psychosis research

23


Selected presentations 2014

International presentations:

“Trauma, Mental Health, and Undocumented Migration.“ Post doc Akiah O. Berg. European Society for Trauma and Dissociation (ESTD) Conference, March, Copenhagen “Neurocognitive decrements are present in

intellectually superior schizophrenia.”

Post Doc Anja Vaskinn

Schizophrenia International Research Society,

Cognition Satellite meeting. Florence, Italy.

“MR in psychiatry” Professor Ingrid Agartz,

World Congress of the World Association of

Dynamic Psychiatry, St Petersburg, Lecture, MR

in psychiatry, St Petersburg, Russia.

“The relation between antipsychotic medication

history and ten-year outcome in first episode

psychosis”. Professor Ingrid Melle, 9th Early

Intervention in Psychosis Conference, Tokyo,

Japan.

“Perception of sounds that do not exist” Professor

Kenneth Hugdahl, Keynote speaker Nordic

Network Conference on Sounds, Music, and the

Brain, Helsinki, June.

“GWAS identifies common variants associated

with pharmacokinetics of psychotropic drugs”

Post doc, Lavinia Athanasiu, SCNP,

Copenhagen.

“Childhood Trauma as Risk Factor in Psychotic

Disorders- in Search of Mechanisms” Post doc

Monica Aas. The 4th Biennial Schizophrenia

International Research Society Conference,

Florence, Italy.

“Hypothalamus-pituitary-adrenal axis function in

psychosis and high risk for psychosis.” Post doc

Monica Aas, 44th ISPNE Conference, Sex and

Gender Across the Lifespan. Montreal, Canada.

“Additive association between childhood trauma

and bdnf val66met on volume of hippocampal

subfields- exploring the role of BDNF RNA. Post

doc Monica Aas, 22nd World Congress of Psychiatric Genetic, Copenhagen, Denmark. “Can new psychiatric genetics findings facilitate drug target identification?” Professor Ole A. Andreassen, SCNP Copenhagen, Denmark “Beyond Bonferroni: Large Scale Inference for Complex Disorders” Professor Ole A. Andreassen, Lecture WCPG October 13. “The Interplay between Genetics and Early Trauma in Severe Mental Disorders”. Professor Stephanie Le Hellard, Discussant, selected symposium. XXIInd World Congress of Psychiatric genetics, Copenhagen, Oct. 12-16. “Processing speed and its components – associations with age and indices of brain white matter microstructure.” Senior scientist Thomas Espeseth, the `Expert Workshop on Processing Speed and Cognitive Ageing’. The Royal Society of Edinburgh, April 30th.

“Indications of a dose - response relationship

between cannabis use and age at onset in

bipolar disorder.” Post doc Trine Vik Lagerberg,

16th Annual Conference of the International

Society for Bipolar Disorders, South Korea, Seoul.

National dissemination:

"Fysisk helse og mortalitet ved FEP tilstander,

hva vet vi og hva kan vi gjøre: Aktivitet -

motivasjon – helse". Post doc Andreas Ringen,

10. nasjonale TIPS-konferanse, Stavanger.

"Hvordan går det med personer med

psykoselidelser over tid - Hvor mange blir friske?"

Post doc Carmen Simonsen, i regi av

Fagforbundet, Gaustad sykehus - December.

“Heart rate variability in psychiatric Illness.” Post

doc Daniel S. Quintana.. Modum Bad Hospital,

Oslo, Norway.

«Hvorfor tidlig behandling? Kliniske implikasjoner

av en moderne psykoseforståelse» Professor

Ingrid Melle, Bergen tidlig psykose symposium,

Bergen.

24


"Neurocognition and occupational functioning in

schizophrenia spectrum disorders" PhD Student

June Lystad, Norsk Forum for Nevropsykiatri,

Oslo

"Kognitiv trening og arbeid". PhD Student June

Lystad, Verdensdagen for psykisk helse, Oslo

University College, Oslo.

“White matter meeting: everything you need and

want to know about white matter” Post doc Kari

Ersland, 06-07.02.Trondheim, Norway

“New technology in hallucinations research – app

methods” Professor Kenneth Hugdahl, Seminar

Speaker Nansen Neuroscience Network Meeting,

Oslo

"Nevropsykologi og kognitive funksjoner.

Implikasjoner for behandling og oppfølging ved

psykiske lidelser". Professor Kjetil S. Sundet,

Emnekurs i nevropsykiatri, LiPS (Leger i

Psykiatrisk Spesialisering), Bergen.

"Kartlegging av kognitiv funksjonssvikt".

Professor Kjetil Søren Sundet. Workshop 1:

Nevropsykologi. Den 10. nasjonale TIPS-

konferansen, Schizofrenidagene, Stavanger.

"Cannabis use in early bipolar disorder" Phd

Student Levi Røstad Kvitland Norsk forum for

nevropsykiatri, Oslo.

"Affektive lidelser - diagnose, symptom og

underliggende mekanismer". Professor Ole A.

Andreassen. Nasjonal konferanse akuttpsykiatri

Oslo 14. februar

"Forkortet livslengde ved psykoser. Årsaker og

intervensjoner". Professor Ole A. Andreassen.

Tidlig Psykose Symposium 2014, Bergen 2. juni

“Modelling blue-blocking treatment in rats.” Post

doc Silje Skrede, Psykiatriveka 2014, Bergen.

"Metabolske bivirkninger av antipsykotiske

medikamenter" Post doc Silje Skrede, Norsk

forening for rus- og avhengighetsmedisin (Nfram),

Bergen.

"Kognitiv trening for å øke funksjonsevnen ved

førstegangspsykose." Senior scientist Torill

Ueland, Tidlig intervensjon ved psykoser den 10.

nasjonale TIPS-konferansen, Schzofrenidagene

Stavanger.

"Polygenetics of attention and effort: Uncovering

brain circuit pathologies in schizophrenia". Senior

scientist Thomas Espeseth, seminar on

cognition in psychosis disorders, Engø, August

22nd, 2014.

“Miljømessige risikofaktorer ved psykoselidelser” Post doc Trine Vik Lagerberg, ved Medisinsk Fakultets 200 års jubileumsseminar for unge forskere, Litteraturhuset. "Psykosens anatomi - matcher hjernekartet til terrenget?" Post doc Unn Kristin Haukvik, Forskningsdagene 2014, Litteraturhuset, Oslo "Sykdom og arv. Fra sjeldne genfeil til folkesykdommer". Professor Vidar M Steen, lecture at Dnlf-course on "Genetikk i klinisk praksis", Gardermoen, February "Metabolic effects of antipsychotic drugs: Some bad guys and some good guys?" Professor Vidar M Steen, Plenary lecture at Psykiatriveka 2014, Bergen, March.

25


Disputations 2014

Aina Holmèn, Cand. psychol. (January 23, 2014)

“Neurocognition in early-onset schizophrenia with a particular focus on executive function” Supervisors: Bjørn Rishovd Rund Ingrid Melle

Torbjørn Elvsåshagen, Cand. med. (May 19, 2014) “A study of cortical structure and plasticity in bipolar II disorder.” Supervisors: Ulrik Fredrik Malt Ole A Andreassen

Liv Eggset Falkenberg, MSc. (December 5, 2014) «Neuronal underpinnings of healthy and dysfunctional cognitive control». Supervisors: Kenneth Hugdahl Rene Westerhausen

Helene Barder, Cand.psychol. (June 23, 2014) “Longitudinal neurocognitive trajectories in first-episode psychosis: Relationships between illness severity and cognitive course.” Supervisors: Kjetil Sundet, Bjørn Rishovd Rund and Svein Friis

Erlend Mork, Cand. Psychol. (September 4,2014) “Self-harm in patients with schizophrenia; risk factors and clinical characteristics.” Supervisor: Lars Mehlum

Morten Mattingsdal, Cand. Scient. (September 2, 2014) ”Functional profiling of single-nucleotide polymorphisms associated with bipolar disorder.” Supervisor: Ole A. Andreassen Srdjan Djurovic Eivind Hovig

Unni Brattlien, Cand. Med. (May 28, 2014) "The relevance of premorbid and prodromal phases in psychotic disorders” Supervisors: Merete Øie Ingrid Melle

26


NORMENT in the Media

Professor Kenneth Hugdahl at the University of

Bergen gets Research Council award for

excellence, Møbius Award, for his pioneering

research on the brain.

http://www.forskningsradet.no/no/Nyheter/Forsk

ningsrdet_deler_ut_tre_priser_i_dag/12540015

81512?lang=no

http://www.nrk.no/hordaland/far-pris-for-

forsking-pa-indre-stemmer-1.12021725

Seven Norment researchers participated in the

project "ENIGMA”, through "The ENIGMA -

Schizophrenia Working Group ".

http://enigma.ini.usc.edu/ongoing/enigma-

schizophrenia-working-group/

Norwegian researchers have contributed to

discover over a hundred new genetic variants

that increase the risk of schizophrenia, of which

83 have not been previously described.

http://tidsskriftet.no/article/3238155

http://forskning.no/sykdommer/2014/07/over-

100-schizofreni-gener-funnet

Researchers have evaluated a mobile app for

self-training of auditory attention. The app is

designed to test the participants' ability to focus

their attention and to concentrate on one

specific sound via headphones. The results

show that training not only improved the

participants' achievements, it also had an

impact on how the brain handled the task.

http://journalofinternetinterventions.com/brain-

fitness-go-mobile-cognitive-training-effects-

neural-plasticity/

Ole A. Andreassen is one of 15 new members

of the National Academy of Science and Letters,

Mathematics - and Natural academics class,

the group of medical sciences.

http://www.dnva.no/c40213/artikkel/vis.html?tid

=40214

Andres M. Dale is a visiting researcher at

Norment and among the most successful

Norwegians abroad in category «academia ".

http://www.aftenposten.no/spesial/Hvem-

mener-du-fortjener-a-bli-karet-til-Norges-mest-

fremgangsrike-7531554.html#.U0m1CPmSySr

Commentator Hilde Haugsgjerd writes in

Aftenposten March 2: "The journal Nature has

editorialized designated the present decade to

psychiatry decades. Internationally happens

advances in research on the brain, about genes

and the relationship between heredity and

environment for mental illness. Last year

opened Norwegian Centre for research on

mental disorders a collaboration between the

Universities of Bergen and Oslo and Oslo

University Hospital."

http://www.aftenposten.no/meninger/kommenta

rer/Et-lite-lys-i-tunnelen-

7486808.html#.UyBO03bKzIX

Ole A. Andreassen being interviewed in

connection with his lecturing under NevroNor’s

annual conference organized by the Research

Council.

http://www.forskningsradet.no/no/Nyheter/Pa_v

ei_inn_i_psykiatriens_tiar/1253991607534?WT.

mc_id=nyhetsbrev-ForskningsradetNorsk

“Be careful with cannabis!” Cannabis probably

plays a role in triggering the onset of psychotic

disorders. Caution with regard to cannabis use

should thus be exercised. Read the debate

article to Trine Vik Lagerberg, PhD and

specialist in clinical psychology, and Levi

Røstad Kvitland, fellow and psychologist,

Aftenposten Knowledge.

http://www.aftenposten.no/viten/Var-forsiktig-

med-cannabis-7619359.html

Post doc Akiah O. Berg has written a blog post,

association for intercultural psychology.

http://www.psykologforeningen.no/Fag-og-

profesjon/Blogger/FIP-blogg/Det-ubehagelige-

blikket-innover

27

http://www.nrk.no/hordaland/far-pris-for-forsking-pa-indre-stemmer-1.12021725

http://www.nrk.no/hordaland/far-pris-for-forsking-pa-indre-stemmer-1.12021725

http://enigma.ini.usc.edu/ongoing/enigma-schizophrenia-working-group/

http://enigma.ini.usc.edu/ongoing/enigma-schizophrenia-working-group/

http://tidsskriftet.no/article/3238155

http://forskning.no/sykdommer/2014/07/over-100-schizofreni-gener-funnet

http://forskning.no/sykdommer/2014/07/over-100-schizofreni-gener-funnet

http://journalofinternetinterventions.com/brain-fitness-go-mobile-cognitive-training-effects-neural-plasticity/



http://www.dnva.no/c40213/artikkel/vis.html?tid=40214

http://www.dnva.no/c40213/artikkel/vis.html?tid=40214

http://www.aftenposten.no/spesial/Hvem-mener-du-fortjener-a-bli-karet-til-Norges-mest-fremgangsrike-7531554.html#.U0m1CPmSySr



http://www.aftenposten.no/meninger/kommentarer/Et-lite-lys-i-tunnelen-7486808.html#.UyBO03bKzIX



http://www.forskningsradet.no/no/Nyheter/Pa_vei_inn_i_psykiatriens_tiar/1253991607534?WT.mc_id=nyhetsbrev-ForskningsradetNorsk



http://www.aftenposten.no/viten/Var-forsiktig-med-cannabis-7619359.html

http://www.aftenposten.no/viten/Var-forsiktig-med-cannabis-7619359.html

http://www.psykologforeningen.no/Fag-og-profesjon/Blogger/FIP-blogg/Det-ubehagelige-blikket-innover




Publications 2014 1. Aas M, Aminoff SR, Vik Lagerberg T, Etain B, Agartz

I, Andreassen OA, Melle I. Affective lability in

patients with bipolar disorders is associated with high

levels of childhood trauma. Psychiatry Res. 2014

Aug

2. Aas M, Dazzan P, Mondelli V, Melle I, Murray RM,

Pariante CM. A systematic review of cognitive

function in first-episode psychosis, including a

discussion on childhood trauma, stress, and

inflammation. Front Psychiatry. 2014 Jan

3. Aas M, Etain B, Bellivier F, Henry C, Lagerberg T,

Ringen A, Agartz I, Gard S, Kahn JP, Leboyer M,

Andreassen OA, Melle I. Additive effects of

childhood abuse and cannabis abuse on clinical

expressions of bipolar disorders. Psychol Med. 2014

Jun;44

4. Aas M, Haukvik UK, Djurovic S, Tesli M, Athanasiu

L, Bjella T, Hansson L, Cattaneo A, Agartz I,

Andreassen OA, Melle I. Interplay between

childhood trauma and BDNF val66met variants on

blood BDNF mRNA levels and on hippocampus

subfieldsvolumes in schizophrenia spectrum and

bipolar disorders. J Psychiatr Res. 2014Dec

5. Aas M, Pedersen G, Henry C, Bjella T, Bellivier F,

Leboyer M, Kahn JP, Cohen RF, Gard S, Aminoff

SR, Lagerberg TV, Andreassen OA, Melle I, Etain

B.Psychometric properties of the Affective Lability

Scale (54 and 18-item version) in patients with

bipolar disorder, first-degree relatives, and healthy

controls. J Affect Disord. 2014 Oct

6. Andreassen OA, Harbo HF, Wang Y, Thompson WK,

Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke

S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P;

The Psychiatric Genomics Consortium (PGC) Bipolar

Disorder and Schizophrenia Work Groups; The

International Multiple Sclerosis Genetics Consortium

(IMSGC), McEvoy LK, Desikan RS, Lie BA, Djurovic

S, Dale AM; The Psychiatric Genomics Consortium

PGC Bipolar Disorder and Schizophrenia Work

Groups; The International Multiple Sclerosis

7. Andreassen OA, McEvoy LK, Thompson WK, Wang

Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E,

Gautvik K, Aukrust P, Karlsen TH, Djurovic S,

Desikan RS, Dale AM; International Consortium for

Blood Pressure Genome-Wide Association Studies,

Genetic Factors for Osteoporosis Consortium.

Identifying common genetic variants in blood

pressure due to polygenic pleiotropy with associated

phenotypes. Hypertension. 2014 Apr

8. Andreassen OA, Thompson WK, Dale AM. Boosting

the power of schizophrenia genetics by leveraging

new statistical tools. Schizophr Bull. 2014 Jan

9. Andreassen OA, Zuber V, Thompson WK, Schork

AJ, Bettella F; PRACTICAL Consortium; CRUK

GWAS, Djurovic S, Desikan RS, Mills IG, Dale AM.

Shared common variants in prostate cancer and

blood lipids. Int J Epidemiol. 2014 Aug;43(4):1205-

14.

10. Andreou D, Söderman E, Axelsson T, Sedvall GC,

Terenius L, Agartz I, Jönsson EG. Polymorphisms in

genes implicated in dopamine, serotonin and

noradrenalin metabolism suggest association with

cerebrospinal fluid monoamine metabolite

concentrations in psychosis. Behav Brain Funct.

2014 Jul

11. Badcock JC, Hugdahl K. A synthesis of evidence on

inhibitory control and auditory hallucinations based

on the Research Domain Criteria (RDoC) framework.

Front Hum Neurosci. 2014 Mar 26

12. Bauer M, Glenn T, Alda M, Andreassen OA,

Angelopoulos E, Ardau R, Baethge C, Bauer R,

Bellivier F, Belmaker RH, Berk M, Bjella TD, Bossini

L, Bersudsky Y,Cheung EY, Conell J, Del Zompo M,

Dodd S, Etain B, Fagiolini A, Frye MA, Fountoulakis

KN, Garneau-Fournier J, González-Pinto A, Harima

H, Hassel S, Relationship between sunlight and the

age of onset of bipolar disorder: an international

multisite study. J Affect Disord. 2014 Oct;167

13. Berg AO, Andreassen OA, Aminoff SR, Romm KL,

Hauff E, Melle I. The impact of immigration and

visible minority status on psychosis symptom profile.

Soc Psychiatry Psychiatr Epidemiol. 2014

Nov;49(11):1747-57.

14. Boraska V, Franklin CS, Floyd JA, Thornton LM,

Huckins LM, Southam L, Rayner NW, Tachmazidou

I, Klump KL, Treasure J, Lewis CM, Schmidt U,

Wellcome Trust Case Control Consortium 3, Estivill

X, Hinney A, Sullivan PF, Collier DA, Zeggini E, Bulik

CM. A genome wide association study of anorexia

nervosa. Mol Psychiatry. 2014 Oct;19

15. Brandt CL, Eichele T, Melle I, Sundet K, Server A,

Agartz I, Hugdahl K, Jensen J, Andreassen OA.

Working memory networks and activation patterns in

schizophrenia and bipolar disorder: comparison with

healthy controls. Br J Psychiatry. 2014

16. Bratlien U, Øie M, Haug E, Møller P,

Andreassen OA, Lien L, Melle I. Environmental

28


factors during adolescence associated with later

development of psychotic disorders - a nested case-

control study. Psychiatry Res. 2014 Mar

17. Brown AA, Buil A, Viñuela A, Lappalainen T, Zheng

HF, Richard JB, Small KS, Spector TD, Dermitzakis

ET, Durbin R. Genetic interactions affecting human

gene expression identified by variance association

mapping. Elife. 2014 Apr 25;3:e01381

18. Buil A, Brown AA, Lappalainen T, Viñuela A, Davies

MN, Zheng HF, Richards JB, Glass D, Small KS,

Durbin R, Spector TD, Dermitzakis ET. Gene-gene

and gene-environment interactions detected by

transcriptome sequence analysis in twins. Nat

Genet.

19. Bull H, Ueland T, Lystad JU, Evensen S, Friis S,

Martinsen EW, Falkum E.Validation of the Work

Behavior Inventory. Nord J Psychiatry. 2014 Nov

13:1-7

20. Bøen E, Westlye LT, Elvsåshagen T, Hummelen B,

Hol PK, Boye B, Andersson S, Karterud S, Malt UF.

Regional cortical thinning may be a biological marker

for borderline personality disorder. Acta Psychiatr

Scand. 2014 Sep;130(3):193-204. doi:

10.1111/acps.12234. PMID: 24571788.

21. Bøen E, Westlye LT, Elvsåshagen T, Hummelen B,

Hol PK, Boye B, Andersson S, Karterud S, Malt UF.

Smaller stress-sensitive hippocampal subfields in

women with borderline personality disorder without

posttraumatic stress disorder. J Psychiatry Neurosci.

2014 Mar;3

22. Cappelen AW, Eichele T, Hugdahl K, Specht K,

Sørensen EØ, Tungodden B. Equity theory and fair

inequality: a neuroeconomic study. Proc Natl Acad

Sci U S A. 2014 Oct 28;111(43):15368-72.

23. Christoforou A, Espeseth T, Davies G, Fernandes

CP, Giddaluru S, Mattheisen M, Tenesa A, Harris

SE, Liewald DC, Payton A, Ollier W, Horan M,

Pendleton N, Haggarty P, Djurovic S, Herms S,

Hoffman P, Cichon S, Starr JM, Lundervold A,

Reinvang I, Steen VM, Deary IJ, Le Hellard S.

GWAS-based pathway analysis differentiates

between fluid and crystallized intelligence. Genes

Brain Behav.2014 Sep;13(7)

24. Clark KA, Helland T, Specht K, Narr KL, Manis FR,

Toga AW, Hugdahl K.Neuroanatomical precursors of

dyslexia identified from pre-reading through to age

11. Brain. 2014 Dec;137

25. Dahl J, Ormstad H, Aass HC, Malt UF, Bendz LT,

Sandvik L, Brundin L, Andreassen OA. The plasma

levels of various cytokines are increased during

ongoing depression and are reduced to normal

levels after recovery. Psychoneuroendocrinology.

2014 Jul

26. Desikan RS, Thompson WK, Holland D, Hess CP,

Brewer JB, Zetterberg H, Blennow K, Andreassen

OA, McEvoy LK, Hyman BT, Dale AM; Alzheimer’s

Disease Neuroimaging Initiative Group. The role of

clusterin in amyloid-β-associated neurodegeneration.

JAMA Neurol. 2014 Feb

27. Douaud G, Groves AR, Tamnes CK, Westlye LT,

Duff EP, Engvig A, Walhovd KB, James A, Gass A,

Monsch AU, Matthews PM, Fjell AM, Smith SM,

Johansen-Berg H. A common brain network links

development, aging, and vulnerability to disease.

Proc Natl Acad Sci U S A. Epub 2014 Nov 24.

28. Elvsåshagen T, Moberget T, Bøen E, Hol PK, Malt

UF, Andersson S, Westlye LT. The surface area of

early visual cortex predicts the amplitude of the

visual evoked potential. Brain Struct Funct. 2014.

29. Engvig A, Fjell AM, Westlye LT, Skaane NV, Dale

AM, Holland D, Due-Tønnessen P, Sundseth O,

Walhovd KB. Effects of cognitive training on gray

matter volumes in memory clinic patients with

subjective memory impairment. J Alzheimers Dis.

2014

30. Espeseth T, Vangkilde SA, Petersen A, Dyrholm M,

Westlye LT. TVA-based assessment of attentional

capacities-associations with age and indices of

brainwhite matter microstructure. Front Psychol.

2014

31. Falkenberg LE, Westerhausen R, Craven AR,

Johnsen E, Kroken RA, L Berg EM, Specht K,

Hugdahl K. Impact of glutamate levels on neuronal

response and cognitive abilities in schizophrenia.

Neuroimage Clin. 2014 Apr 2

32. Fernandes CP, Westlye LT, Giddaluru S,

Christoforou A, Kauppi K, Adolfsson R, Nilsson LG,

Nyberg L, Lundervold AJ, Reinvang I, Steen VM, Le

Hellard S, Espeseth T. Lack of association of the

rs1344706 ZNF804A variant with cognitive functions

and DTI indices of white matter microstructure in two

independent healthy populations. Psychiatry Res.

2014 Apr 30

33. Finseth PI, Morken G, Malt UF, Andreassen OA,

Vaaler AE. Risk factors of cycle acceleration in

acutely admitted patients with bipolar disorder. Acta

Psychiatr Scand. 2014 Nov;130(5):388-96.

29


34. Finseth PI, Sønderby IE, Djurovic S, Agartz I, Malt

UF, Melle I, Morken G, Andreassen OA, Vaaler AE,

Tesli M. Association analysis between suicidal

behaviour and candidate genes of bipolar disorder

and schizophrenia. J Affect Disord. 2014 Jul

35. Fjell AM, Westlye LT, Grydeland H, Amlien I,

Espeseth T, Reinvang I, Raz N, Dale AM, Walhovd

KB; Alzheimer Disease Neuroimaging Initiative.

Accelerating cortical thinning: unique to dementia or

universal in aging? Cereb Cortex. 2014 Apr;24

36. Genetics Consortium IMSGC. Genetic pleiotropy

between multiple sclerosis and schizophrenia but not

bipolar disorder: differential involvement of immune-

related gene loci. Mol Psychiatry. 2014 Jan 28

37. Gjevik E, Sandstad B, Andreassen OA, Myhre AM,

Sponheim E. Exploring the agreement between

questionnaire information and DSM-IV diagnoses of

comorbid psychopathology in children with autism

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38. Griffiths ST, Aukland SM, Markestad T, Eide GE,

Elgen I, Craven AR, Hugdahl K. Association between

brain activation (fMRI), cognition and school

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39. Greenwood PM, Espeseth T, Lin MK, Reinvang I,

Parasuraman R. Longitudinal change in working

memory as a function of APOE genotype in midlife

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40. Gupta CN, Calhoun VD, Rachakonda S, Chen J,

Patel V, Liu J, Segall J, Franke B, Zwiers MP, Arias-

Vasquez A, Buitelaar J, Fisher SE, Fernandez G,

van Erp TG, Potkin S, Ford J, Mathalon D, McEwen

S, Lee HJ, Mueller BA, Greve DN, Andreassen O,

Agartz I, Gollub RL, Sponheim SR, Ehrlich S, Wang

L, Pearlson G, Glahn DC,Sprooten E, Mayer AR,

Stephen J, Jung RE, Canive J, Bustillo J, Turner JA.

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41. Gusev A, Lee SH, Trynka G, Finucane H,

Vilhjálmsson BJ, Xu H, Zang C, Ripke S, Bulik-

Sullivan B, Stahl E; Schizophrenia Working Group of

the Psychiatric Genomics Consortium; SWE-SCZ

Consortium, Kähler AK, Hultman CM, Purcell SM,

McCarroll SA, Daly M, Pasaniuc B, Sullivan PF,

Neale BM, Wray NR, Raychaudhuri S, Price AL;

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Genomics Consortium;SWE-SCZ Consortium.

Partitioning heritability of regulatory and cell-type-

specific variants across 11 common diseases. Am J

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42. Haram M, Tesli M, Dieset I, Steen NE, Røssberg JI,

Djurovic S, Andreassen OA, Melle I. An attempt to

identify single nucleotide polymorphisms contributing

to possible relationships between personality traits

and oxytocin-related genes. Neuropsychobiology.

2014

43. Haug E, Øie M, Andreassen OA, Bratlien U, Raballo

A, Nelson B, Møller P, Melle I. Anomalous self-

experiences contribute independently to social

dysfunction in the early phases of schizophrenia and

psychotic bipolar disorder. Compr Psychiatry. 2014

Apr

44. Haukvik UK, McNeil T, Lange EH, Melle I, Dale AM,

Andreassen OA, Agartz I. Pre- and perinatal hypoxia

associated with hippocampus/amygdala volume in

bipolar disorder. Psychol Med. 2014 Apr

45. Haukvik UK, Rimol LM, Roddey JC, Hartberg CB,

Lange EH, Vaskinn A, Melle I, Andreassen OA, Dale

A, Agartz I. Normal birth weight variation is related to

cortical morphology across the psychosis spectrum.

Schizophr Bull. 2014 Mar

46. Haukvik UK, Westlye LT, Mørch-Johnsen L,

Jørgensen KN, Lange EH, Dale AM,Melle I,

Andreassen OA, Agartz I. In Vivo Hippocampal

Subfield Volumes in Schizophrenia and Bipolar

Disorder. Biol Psychiatry. 2014 Jul 3.

47. Helle S, Gjestad R, Johnsen E, Kroken RA,

Jørgensen HA, Løberg EM. Cognitive changes in

patients with acute phase psychosis--effects of illicit

drug use. Psychiatry Res. 2014 Dec 30

48. Henriksen TE, Skrede S, Fasmer OB, Hamre B,

Grønli J, Lund A. Blocking blue light during mania -

markedly increased regularity of sleep and rapid

improvement of symptoms: a case report. Bipolar

Disord. 2014

49. Hill WD, Davies G, van de Lagemaat LN,

Christoforou A, Marioni RE, Fernandes CP, Liewald

DC, Croning MD, Payton A, Craig LC, Whalley LJ,

Horan M, Ollier W, Hansell NK, Wright MJ, Martin

NG, Montgomery GW, Steen VM, Le Hellard S,

Espeseth T, Lundervold AJ, Reinvang I, Starr JM,

Pendleton N, Grant SG, Bates TC, Deary IJ. Human

cognitive ability is influenced by genetic variation in

components of postsynaptic signalling complexes

assembled by NMDA receptors and MAGUK

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50. Hirnstein M, Hugdahl K, Hausmann M. How brain

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51. Hirnstein M, Hugdahl K. Excess of non-right-

handedness in schizophrenia: meta-analysis of

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52. Huckins LM, Boraska V, Franklin CS, Floyd JA,

Southam L; GCAN; WTCCC3,Sullivan PF, Bulik CM,

Collier DA, Tyler-Smith C, Zeggini E, Tachmazidou I;

GCAN;WTCCC3. Using ancestry-informative

markers to identify fine structure across 15

populations of European origin. Eur J Hum Genet.

2014 Oct;22

53. Johns LC, Kompus K, Connell M, Humpston C,

Lincoln TM, Longden E, Preti A, Alderson-Day B,

Badcock JC, Cella M, Fernyhough C, McCarthy-

Jones S, Peters E, Raballo A, Scott J, Siddi S,

Sommer IE, Larøi F. Auditory verbal hallucinations in

persons with and without a need for care. Schizophr

Bull. 2014 Jul

54. Kauppi K, Westlye LT, Tesli M, Bettella F, Brandt CL,

Mattingsdal M, Ueland T, Espeseth T, Agartz I, Melle

I, Djurovic S, Andreassen OA. Polygenic Risk for

Schizophrenia Associated With Working Memory-

related Prefrontal Brain Activation in Patients With

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2014 Nov 11

55. Kessler U, Schoeyen HK, Andreassen OA, Eide GE,

Malt UF, Oedegaard KJ, Morken G, Sundet K,

Vaaler AE. The effect of electroconvulsive therapy

on neurocognitive function in treatment-resistant

bipolar disorder depression. J Clin Psychiatry.2014

Nov;75(11):e1306-13.

56. Kroken RA, Løberg EM, Drønen T, Grüner R,

Hugdahl K, Kompus K, Skrede S, Johnsen E. A

critical review of pro-cognitive drug targets in

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57. Kroken RA, Kjelby E, Wentzel-Larsen T, Mellesdal

LS, Jørgensen HA, Johnsen E. Time to

discontinuation of antipsychotic drugs in a

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strategies. Ther Adv Psychopharmacol. 2014 Dec;4

58. Kvitland LR, Melle I, Aminoff SR, Lagerberg TV,

Andreassen OA, Ringen PA. Cannabis use in first-

treatment bipolar I disorder: relations to clinical

characteristics. Early Interv Psychiatry. 2014 Apr 17.

59. Lagerberg TV, Kvitland LR, Aminoff SR, Aas M,

Ringen PA, Andreassen OA, Melle I. Indications of a

dose-response relationship between cannabis use

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2014 Jan 30

60. Lange EH, Nesvåg R, Ringen PA, Hartberg CB,

Haukvik UK, Andreassen OA, Melle I, Agartz I. One

year follow-up of alcohol and illicit substance use in

first-episode psychosis: does gender matter? Compr

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61. Langeveld J, Bjørkly S, Auestad B, Barder H,

Evensen J, Ten Velden Hegelstad W, Joa I,

Johannessen JO, Larsen TK, Melle I, Opjordsmoen

S, Røssberg JI, Rund BR, Simonsen E, Vaglum P,

McGlashan T, Friis S. Treatment and violent

behavior in persons with first episode psychosis

during a 10-year prospective follow-up study.

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62. Le Hellard S, Steen VM. Genetic architecture of

cognitive traits. Scand J Psychol. 2014 Jun

63. Lencz T, Knowles E, Davies G, Guha S, Liewald DC,

Starr JM, Djurovic S, Melle I, Sundet K, Christoforou

A, Reinvang I, Mukherjee S, DeRosse P, Lundervold

A, Steen VM, John M, Espeseth T, Räikkönen K,

Widen E, Palotie A, Eriksson JG, et al. Molecular

genetic evidence for overlap between general

cognitive ability and risk for schizophrenia: a report

from the Cognitive Genomics consorTium

(COGENT). Mol Psychiatry. 2014 Feb;19

64. Lystad JU, Falkum E, Mohn C, Haaland VØ, Bull H,

Evensen S, Rund BR, Ueland T.The MATRICS

Consensus Cognitive Battery (MCCB): performance

and functionalcorrelates. Psychiatry Res. 2014 Dec

30;220(3)

65. Løberg EM, Helle S, Nygård M, Berle JØ, Kroken

RA, Johnsen E. The Cannabis Pathway to Non-

Affective Psychosis may Reflect Less

Neurobiological Vulnerability. Front Psychiatry. 2014

Nov

66. Morken F, Helland T, Hugdahl K, Specht K. Children

with dyslexia show cortical hyperactivation in

response to increasing literacy processing demands.

Front Psychol. 2014 Dec 22

67. Nesvåg R, Schaer M, Haukvik UK, Westlye LT,

Rimol LM, Lange EH, Hartberg CB, Ottet MC, Melle

I, Andreassen OA, Jönsson EG, Agartz I, Eliez S.

Reduced brain cortical folding in schizophrenia

revealed in two independent samples. Schizophr

Res. 2014 Feb;15

68. Nicodemus KK, Hargreaves A, Morris D, Anney R,

Gill M, Corvin A, Donohoe G; Schizophrenia

Psychiatric Genome-wide Association Study

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(GWAS) Consortium; Wellcome Trust Case Control

Consortium 2. Variability in working memory

performance explained by epistasis vs polygenic

scores in the ZNF804A pathway. JAMA Psychiatry.

2014 Jul

69. Norheim KB, Le Hellard S, Nordmark G, Harboe E,

Gøransson L, Brun JG, Wahren-Herlenius M,

Jonsson R, Omdal R. A possible genetic association

with chronic fatigue in primary Sjögren's syndrome: a

candidate gene study. Rheumatol Int. 2014 Feb

70. Nordvik JE, Walle KM, Nyberg CK, Fjell AM,

Walhovd KB, Westlye LT, Tornas S. Bridging the

gap between clinical neuroscience and cognitive

rehabilitation: the role of cognitive training, models

of neuroplasticity and advanced neuroimaging in

future brain injury rehabilitation. NeuroRehabilitation.

2014

71. Nurnberger JI Jr, Koller DL, Jung J, Edenberg HJ,

Foroud T, Guella I, Vawter MP, Kelsoe JR;

Psychiatric Genomics Consortium Bipolar Group.

Identification of pathways for bipolar disorder: a

meta-analysis. JAMA Psychiatry. 2014 Jun

72. Ocklenburg S, Schlaffke L, Hugdahl K,

Westerhausen R. From structure to function in the

lateralized brain: how structural properties of the

arcuate and uncinate fasciculus are associated with

dichotic listening performance. Neurosci Lett. 2014

Sep 19;580:32-6.

73. Ousdal OT, Andreassen OA, Server A, Jensen J.

Increased amygdala and visual cortex activity and

functional connectivity towards stimulus novelty is

associated with state anxiety. PLoS One. 2014 Apr

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74. Ousdal OT, Specht K, Server A, Andreassen OA,

Dolan RJ, Jensen J. The human amygdala encodes

value and space during decision making.

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75. Passow S, Westerhausen R, Hugdahl K,

Wartenburger I, Heekeren HR, Lindenberger U, Li

SC. Electrophysiological correlates of adult age

differences in attentional control of auditory

processing. Cereb Cortex. 2014 Jan

76. Plessen KJ, Hugdahl K, Bansal R, Hao X, Peterson

BS. Sex, age, and cognitive correlates of

asymmetries in thickness of the cortical mantle

across the life span. J Neurosci. 2014

77. Reckless GE, Ousdal OT, Server A, Walter H,

Andreassen OA, Jensen J. The left inferior frontal

gyrus is involved in adjusting response bias during a

perceptual decision-making task. Brain Behav. 2014

May;4

78. Reikvam H, Tamburini J, Skrede S, Holdhus R,

Poulain L, Ersvaer E, Hatfield KJ, Bruserud Ø.

Antileukaemic effect of PI3K-mTOR inhibitors in

acute myeloid leukaemia-gene expression profiles

reveal CDC25B expression as determinate of

pharmacological effect. Br J Haematol. 2014 Jan;16

79. Ringen PA, Engh JA, Birkenaes AB, Dieset I,

Andreassen OA. Increased mortality in

schizophrenia due to cardiovascular disease - a non-

systematic review of epidemiology, possible causes,

and interventions. Front Psychiatry. 2014 Sep

80. Ruderfer DM, Fanous AH, Ripke S, McQuillin A,

Amdur RL; Schizophrenia Working Group of

Psychiatric Genomics Consortium; Bipolar Disorder

Working Group of Psychiatric Genomics Consortium;

Cross-Disorder Working Group of Psychiatric

Genomics Consortium, Gejman PV, O'Donovan MC,

Andreassen OA, Djurovic S, Hultman CM, Kelsoe

JR, Jamain S, Landén M, Leboyer M, Nimgaonkar V,

Nurnberger J, Smoller JW, Craddock N, Corvin A,

Sullivan PF, Holmans P, Sklar P, Kendler KS.

Polygenic dissection of diagnosis and clinical

dimensions of bipolar disorder and schizophrenia.

Mol Psychiatry. 2014 Sep;19(9)

81. Schizophrenia Working Group of the Psychiatric

Genomics Consortium. Biological insights from 108

schizophrenia-associated genetic loci. Nature. 2014

Jul 24;511

82. Sexton CE, Walhovd KB, Storsve AB, Tamnes CK,

Westlye LT, Johansen-Berg H, Fjell AM. Accelerated

changes in white matter microstructure during aging:

a longitudinal diffusion tensor imaging study. J

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83. Skrede S, Martins L, Berge RK, Steen VM, López M,

Fernø J. Olanzapine depot formulation in rat: a step

forward in modelling antipsychotic-induced metabolic

adverse effects. Int J Neuropsychopharmacol. 2014

Jan;17

84. Specht K, Baumgartner F, Stadler J, Hugdahl K,

Pollmann S. Functional asymmetry and effective

connectivity of the auditory system during speech

perception is modulated by the place of articulation

of the consonant- A 7T fMRI study. Front Psychol.

2014

85. Steen NE, Methlie P, Lorentzen S, Dieset I, Aas M,

Nerhus M, Haram M, Agartz I, Melle I, Berg JP,

Andreassen OA. Altered systemic cortisol

metabolism in bipolar disorder and schizophrenia

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spectrum disorders. J Psychiatr Res. 2014 May

86. Steinberg S, de Jong S, Mattheisen M, Costas J,

Demontis D, Jamain S, Pietiläinen OP, Lin K, Papiol

S, Huttenlocher J et al. GROUP, Common variant at

16p11.2 conferring risk of psychosis. Mol Psychiatry.

2014 Jan;19(1)

87. Storsve AB, Fjell AM, Tamnes CK, Westlye LT,

Overbye K, Aasland HW, Walhovd KB. Differential

longitudinal changes in cortical thickness, surface

area and volume across the adult life span: regions

of accelerating and decelerating change. J Neurosci.

2014 Jun 18

88. Strand BH, Langballe EM, Rosness TA, Bergem AL,

Engedal K, Nafstad P, Tell GS, Ormstad H, Tambs

K, Bjertness E; GENIDEM-group. Age, education

and dementia related deaths. The Norwegian

Counties Study and The Cohort of Norway. J Neurol

Sci. 2014 Oct 15

89. Sönmez N, Røssberg JI, Evensen J, Barder HE,

Haahr U, Ten Velden Hegelstad W, Joa I,

Johannessen JO, Langeveld H, Larsen TK, Melle I,

Opjordsmoen S, Rund BR, Simonsen E, Vaglum P,

McGlashan T, Friis S. Depressive symptoms in first-

episode psychosis: a 10-year follow-up study. Early

Interv Psychiatry. 2014 Jun

90. Ten Velden Hegelstad W, Joa I, Barder H, Evensen

J, Haahr U, Johannessen JO, Langeveld J, Melle I,

Opjordsmoen S, et al. Variation in duration of

untreated psychosis in an 18-year perspective. Early

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91. Tesli M, Espeseth T, Bettella F, Mattingsdal M, Aas

M, Melle I, Djurovic S, Andreassen OA. Polygenic

risk score and the psychosis continuum model. Acta

Psychiatr Scand. 2014 Oct

92. Thompson PM, Stein JL, Medland SE, Hibar DP,

Vasquez AA, Renteria ME, Toro R,Jahanshad N,

Schumann G, Franke B, Wright MJ, Martin NG,

Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J,

Alpert K, Andreasen NC, Andreassen OA,

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93. Thoresen C, Endestad T, Sigvartsen NP, Server A,

Bolstad I, Johansson M, Andreassen OA, Jensen J.

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94. Vaskinn A, Ueland T, Melle I, Agartz I, Andreassen

OA, Sundet K. Neurocognitive Decrements are

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95. Walhovd KB, Fjell AM, Espeseth T. Cognitive decline

and brain pathology in aging--need for a

dimensional, lifespan and systems vulnerability view.

Scand J Psychol.

96. Walhovd KB, Storsve AB, Westlye LT, Drevon CA,

Fjell AM. Blood markers of fatty acids and vitamin D,

cardiovascular measures, body mass index, and

physical activity relate to longitudinal cortical thinning

in normal aging. Neurobiol Aging. 2014 May

97. Westerhausen R, Kompus K, Hugdahl K. Mapping

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98. Wirgenes KV, Tesli M, Inderhaug E, Athanasiu L,

Agartz I, Melle I, Hughes T, Andreassen OA,

Djurovic S. ANK3 gene expression in bipolar

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Sep;205(3)

99. Zablocki RW, Schork AJ, Levine RA, Andreassen

OA, Dale AM, Thompson WK. Covariate-modulated

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100. Zai CC, Manchia M, Sønderby IE, Yilmaz Z, De Luca

V, Tiwari AK, Squassina A, Zai GC, Shaikh SA,

Strauss J, King N, Le Foll B, Kaplan AS, Finseth PI,

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Kennedy JL. Investigation of the genetic interaction

between BDNF and DRD3 genes in suicidical

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101. Zeller B, Tamnes CK, Kanellopoulos A, Amlien IK,

Andersson S, Due-Tønnessen P, Fjell AM, Walhovd

KB, Westlye LT, Ruud E. Response to A.A.M. van

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102. Øie M, Skogli EW, Andersen PN, Hovik KT, Hugdahl

K. Differences in cognitive control in children and

adolescents with combined and inattentive subtypes

of ADHD. Child Neuropsychol. 2014

33


Funding

Financing projects with academic affiliation at the center

Other project funding from the Research Council 8 426 International project funding 0 Government project funding and other public financing 18 578 Private project funds and other private financing 5 640

Total funding from external projects

32 644

Financing overall academic activity

70 417

Personnel resources FTEs (summarized from the Centre staff tab)

Professors, researchers etc. 17,0

Doctoral fellows 12,3

Postdoctoral fellows 15,0

Visiting researchers 0,2

Technical / adm. staff 13,1

Actual financing of all academic activity at the center (in thousand NOK)

2014

Funding agreed in the contract and reported in eRapport, but there partly under different funding categories

Own financing 6 807 Proceeds from partner (s) to the host institution 320 Internal funding from partners (in kind) 13 146 Research Council (SFF-grant) 17 500 External project funds included in the contract 0

Total financing of the center as agreed in the contract

37 773

34


35


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annual report 2014 - universitetet i oslo · gene variants for schizophrenia was a breakthrough in...

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