MCO1) Adverse effects of aminaglycosides include the following except

a) Nephrotoxicity and ototoxicityb) Neuromuscular blockade .c) Pseudomembranouscol i t is .d) hypersensitivity reactions .

2) Concerning vancomycin , the following are correct except ;a) lt inhibits synthesis of bacterial cellwallb) lt is used intravenously as seconds chojce drug in pseucomembranous colitisc) lt is effective as first choice drug against ORSA ( MRSA)d) Histamine release is one of its adverse effects

3) Antimicrobials contraindicated in infants and childr€n includea) Tetracyclineb) Clindamycinc) Clinafloxacind) Chloramphenjcol

4) The following antitubercular drug can cause gouty arthritis :

the following except

a) Ethambutolb) Pyrazinamidec) Streptomycind) tNH

5) The antimicrobial thatcould be safely given orally in lats pregnancy with gramnegative infections is :

a) Tetracyclineb) Ceftriaxonec) Cefaclord) Cotrimoxasole

6) Th€ elimination half l ife of which of the following drugs remains unchanged when itis administered to patients suffering from impaired renal function i

a) CefoDerazone.b) Azithromycin.c) Doxycycline.d) All of the above .

7) The elimination half l ife of which of the following drugs remains unchanged when isadministered to patients suffering from impaired renal function :

a) Tetracyclineb) Erythromycin.c) Doxycyclined) All of the above

8) A cephalosporin with increased activity against anaerobic bacteria is ;a) Cephalexinb) Cefuroximec) Cefoxitind) Cefazolin

9) A characteristic adverse effect associated with the use of ampicill in is :a) phototoxicityb) l\4aculopapularrashc) Acute haemolytic anemiad) Agranulocytosis

10) Adverse effects of Rifampicin include all ofthe following except:a) Flu like effects.b) Red discolouration of secretionsc) Increased plasma level of concomitanfly used drugsd) lt is required to increase dose of concomitanflv used druos.

12) The following drugs may interfere with plasma level of othlr drugs except:a) Ciprofloxacin.b) Chloramphenicol.c) Rifamoicin.d) Amoici l l in.

13) The following antibiotics inhibit bacterial ce wall synthesis except:a) Cephalosporinsb) penicill insc) Erythromycind) Vancomycin

14) All the following antimicrobials are correcfly matched to their uses oxcept:a) Rifampicin - prophylaxis of meningitisb) metronidazole - anaerobic infectionsc) Amoxicill in - typhoid feverd) Cephalexin - treatment of meningitis

15) All the following antitubercular drugs can affect other drug's l6vel exc€pt :a) Rifamoicinb) INHc) Streptomycind) l\y'oxifloxacin

16) All the following antitubercular drugs are not hepatotoxic except:a) Ethambutolb) Pyrazinamidec) Ceftriaxoned) Capreomycin

'17) All the following are adverse effects of vancomycin except:a) Pseudomembranous colitisb) Ototoxicityc) Nephrotoxictyd) Red-man syndrome

'18) All the following are contraindicated in renal dysfunction excepta) Doxycyclineb) Tetracyclinec) Gentamycind) Amohotericin B

19) All the following are true about cotrimoxazole except:a) lt is the treatment of choice for pneumonia due to pneumocystis cariniib) lt is an alternative to chloramphenicol for enteric feverc) lt is replaced by trimethoprim alone for urinary tract infections due to E.colid) lt is a combination of trimethoprim and clavulanic acid

20) All the following are used against penicill inase producing Staphylococci except:a) Cloxacill in.b) Clindamycin.c) Co-trimoxazole.d) Amoxicill in.

21) All the following_concerning antitubercular drugs are correct except:a) lsoniazide, Rifampicjn and cycloserine are first_line druosb) Hepatrc damage can occur with isoniazjde and Rifampiiinc) Ethambutol induces optic neuritisd) Pyrazinamide rnduces hyperuricemia

22) The following increase the risk of nephrotoxicityof gentamycin except :a) Age over 70 years .b) Prolonged course of therapy .c) Concurrent vancomycin therapyd) Concurrent therapy with penicill jn

23) All the following statements correcflychemotherapeutic agent except :

identify the mechanism

a) Aminoglycosides - irreversibly bind to 3OS ribosomeb) Tetracycline - reversibly binds to SOS ribosomec) Chloramphenicol - irreversibly binds to 50S ribosomed) Macrolides - reversibly bind to S0S ribosome.

24) Amikacin has the following advantage over gentamycin.a) Better oral absorption.b) Less nephrotoxicc) Less susceptible to bacterial inactivation.d) Less allergenic.

25) Aminoglycosides have the following characters except:a) They are inetfective against anaerobic organismsb) They act by inhibiting protein synthesis.c) They can be absorbed well after oral intake .d) They are ineffective in treatment of menincitis.

26) Aminogtycosides inhibit bacterial protein sy;thesis by :a) Binding to 30S rlbosome leading to inhibiton of bindinq to tRNAb I Binding to 30S nooso.ne reading to mrsreading of mRNA codec) Binding to 50S r bosome preventing transJocation of peptide charnd) Binding to 50S ribosome leadrng to inhrbition of transpeptidatiorl

27) A narrow spectrum oral drug, effective against +ve gm anerobic bacteria is;a) Vancomvcinb) Aztreonamc) Tobramycind) Cl indamvcin

28) Antibiotic - associated pseudomembranous colitis is mostl ikely to be caused by:a) Vancomycinb)AZithromycin.c) Clindamycjn.d) l\i letronidazole.

29) Antimicrobials effective in anaerobic infections include alla) Chloramphenicol

the following except:

b) Gentamycinc) Clindamycind) L4etronidazole

30) A patient with hypersensitivity to penicill in V acquired an infection withstreptococcus pneumonia, which of the following antimicrobiats w6uld be thebest choice for that patient:a) Amoxvcill in / clavulanate.

of actiOn of the

b) Cefaclor.c) Erythromycin.d) Ampicill in.

3'l) A bacteriostatic antibiotic that becomes bactericidal at highfoncentration is :a) Tetracycline.b) Erythromycin.c) Vancomycin.d) AmDicill in.

32) Arrange the following beta lactam antibiotics according to their spectrum of action ( themost narrow soectrum first ) :

a) lmipenem b) Aztreonam c) Amoxycill ina) a,o,cb) a, c,bc) b.a.cd) b,c,ae) c,a,D

33) Arthralgia may be an adv€rsg effect of:a) capreomycinb) pyrazinamidec) rifampicind) ethambutal

34) Augmentin is a combination ofa) broad spectrum penicill in and antistaph penicill inb) broad spectrum penicill in and B-lactamase inhibitorc) antipseudomonal penicill in and antistaph penicill ind) none of the above

35) A 6l year old woman who is allergic to penicill in and cefoxetin has a staphylococcalsepticemia with organisms resistani to tetracycline and erythromycin . The mostappropriate for treatment of this patient is:a) Carbenic i l l inb) Cefaclorc) Amoxicill ind) Vancomycin

36) Clindamycin has the following except:a) associated with diarrheab) active against anaerobesc) active against some gram-positive organismsd) active against most gfam-negative organisms

37) Concerning aminoglycosides, the following are true except:a) They are mainly effective in anaerobic gram negative bacteriab) They cause concentration - dependent not time -dependent bacterial kil l ingc) Their doses should be adjusted according to creatinine clearanced) They have synergistic antimicrobial effects with B-lactams

38) Concerning aminoglycosides, the following are true except:a) They are mainly effective in aerobic gram negative bacteria.b) They cause time - dependent not concentration - dependent bacterial kil l ing.c) Their doses should be adjusted according to creatinine clearance.d) They have synergistic antimicrobial effects with B-lactams.

39) Concerning fluroquinolones, the following are true except;a) They are mainly used in anaerobic gram negative bacteria

b) Cloxacill inc) Piperacill ind) Nafcill in

50) lsoniazide is a primary antituberular agent that:a) Requires pyridoxine supplementation .b) May discolor tears. Saliva, feces and urinec) lvlay be otoboxicd) ls given only intramuscularly

51) Macrolides inhibit bacterial protein synthesis by :a) Binding to 30S ribosome leading to inhibition of binding to IRNA.b) Binding to 30S ribosome leading to misreading of mRNA code.c) Binding to 50S ribosome preventing translocation of peptide chain.d) Binding to 50S ribosome leading to inhibition of transpeptidation.

52) One of the following about ceftriaxone is correct :a) lt is bactericidal .b) It acts by inhibiting protein synthesis.c) lt is effective orally and parentrally.d) Hepatic toxicity is a main side effect.

53) Ototoxicity can follow the administration of the following except :a) Ethacrynic acid.b) Gentamycin.c) Frusemide.d) Cefuroxime.

54) Pick out tho betalactamase inhibitor for co.administration with penicill ins:a) Ethacrynic acidb) Sulbactam.c) l\,4onobactam.d) Moxalactam.

55) Pneumococcal meningitis in a'14 year old patient is treated with :a) Erythromycin.b) Rifamoicin.c) Cettriaxone.d) Ciprofloxacin.

56) Pseudomembranous colitis may be treated with ;a) Cl indamycinb) Vancomycinc) Metronidazoled) bandc

57) Regarding isonizide ( INH) , the following are true €xcept:a) lt inhibits the synthesis of mycolic acid in mycobacterial cell wab) lt produces hepatic toxicity in rapid acetylators.c) lt causes stimulation of hepatic microsomal enzymes.d) lts neurotoxicity can be prevented by pyridoxine.

58) The antibiotic of choice in hepatic coma is:a) Cephalexin.b) ChloramDhenicol.c) Neomycin.d) Penicill in G.

59) The antimicrobial drug that is safely given in renal impairment isa) Gentamvcin.

b) Vancomycin.c) Doxycyclined) Tetracycline.

60)The aminoglycoside most likely to remaingentamicin-resistance is :a) Streptomycin.b) Amikacin.c) Neomycin.d) Kanamycin.

a useful therapeutic agent in the event of

61) One of ths following drugs is effective against anaerobic bacteria:a) Ceftriaxoneb) Flucloxaill inc) Benzathine oenicill ine) l\4etronidazole

62) The best ag€nt of the following drugs effective against meningocdcci is:a) Ceftriaxoneb) Flucloxacill inc) Doxycyclined) Benzathinepenicill in

63) The best agent of the following drugs effective against mycoplasma is:a) Ceftriaxoneb) Doxycyclinec) Benzathine penicill ind) Metronidazole

64) The best agent of the following drugs effective against Staph aureus isia) l\y'etronjdazoleb) Flucloxacill inc) Doxycyclined) Benzathine penicill in

65) The.b^est agent of following drugs effective prophylactic in Strept. hemolyficus is:a) Ceftriaxone.b) Flucloxacill in.c) Doxycycline.d) Benzathine penicill in.

66) The drug of choice for methicill in- resistant Staphylococcus aureus is:a) Oxacill in.b) Gentamycin.c) Vancomycin.d) PiDeraci l l in.e) None of the above.

67) The drug ot choice in a patient with allergy to penicill in is :a) lmioenemb) Cefradinc) Aztreonam.d) Erythromycin.

68) The following drug is effective in treatment of anaerobic infection :a) Streptomycin.b) Gentamyctn.c) Clindamycin.d) Ciprofloxacin.

69) The following drugs are better avoided with orala) Co-trimoxazole.b) Erythromycin.c) AmDicill in.

except:

d) Chloramphenicol.70) The following drugs are contraindicated in infants and children except:

a) Tetracyclines.b) Co-trimoxazole.c) Cefradin.d) Ciorofloxacin.

71) All of the following drugs can be used in anasrobic infection except:a) Tindiazole.b) Clindamycin.c) Gentamycin.d) Cefoxitin.

72) All of the following are true regarding Rifampicin except:a) Inhibits DNA dependent RNA polymerase enzyme.b) Induces fluid discoloratior,.c) Increase plasma level of theophylline.d) Etfective in treatment ofTB.

73) All of the following are true regarding quinolones except:a) lnhibit DNA gyrase enzyme.b) Clinafloxacin is 4'n generation and used in anerobic jnfection.c) Ciproflaxacin is more effective than levofloxacin in pneuomonia.d) Norfloxacin is used in UTI only as it does not achieve systemic level.

74) Which of the following used in prophylaxsis of meningitis:a) Ciprofloxacin.b) Gentamycln.c) RifamDicin.d) lsoniazide.

75) Typhoid fever in 12 years old patient has favism is treated byia) Co trimoxazole.b) Ciorofloxacin.c) Amoxacjll in.d) Chloramohenicol.

76.Which of the following is considered the 1"! in patient allergic to penicill ina lmtpenem.b. Cefazolin.c. Erythromycin.d. Aztreonam.

77.Chose the best drug for a patient with history of allergyto penicill inandsuffering from severe infection by -ve bacill i.

a. Ampicill in and sulbactam.b. Aztreonam.

.c. lmrpenem,d. Cefazolin.

78.The penicill in G with the longesl duration of action is:a. Procaine penicill in.b. Benzathine penicill in.c. Penicill in V.

a nticoag r,r/a nts

d. Benzyl penicill in.79.The main reason for limited use of Chloramphenicol

a. Nephrotoxicity.b. Aplastic anemia.c. Hepatic toxicity.d. Ototoxicity.

80.Which of the following is not a semisyntheticpenic i l l in:a. Procaine penicill in.b. Ampici l t in.c. Cloxacill in.d. Carbenicill in.

8l.Which of the following drug may inducea. Erythromycin.b. Streptomycin.c. Vancomycin.d. Clarithromycin.

is the highiincidence of:

flushing and redness after raDid lvl:

commonly with:S2.Antibiotic associated pseudomembranous colitis occursa. Amoxacill in.b. Metronidazole.c. Cl indamycin.d. Vancomycin.

83.Which of the following drug is most suitable for anaerobic dentat infection:a. Gentarnycin.b. Erythromycinc. Cl indamycind. Aztreonam.

84.All of the following drugs effective in anaerobic infections exceDt:a. Cefoxitineb. Chloramphenicolc. GentamVctn.d l\4etronidazole.

85. Which_of the following drug can cross BBB and effective in meningitis.a. Gentamycln.b. Cefoperazone.c. Ceftrioxone.d. Doxyclc l jne.

86.Which of the following is side effect of quinolones.a. Otoioxicity.b. Pseudomembranous coiitis.c. Arthropathy.d. Teeth discoloration.

87. All following adverse effects are matched with corresponding drug except:a. Cefoperazone / Disulfiram like action.b. Vancomycin/ Red man syndrome.c. Outdated tetracyclines / fanconi syndrome.d. Sulfonamides / Grey baby syndrome.

88. All following indications are matched with the corresponding drug excepr:a. Prophylactic in rheumatic fever / Benzathine Denicill in.b. Cefoxitin: l\,4ixed anerobic infections.c. Vancomycin / Typhoid fever.

d. Metronidazole / Psedomembranous colitis.89.All following adverse effects are matched with corresponding drug except:

a. Rifampicin / Flu like syndrome.b. INH / nephrotxicity.c. Ethamutol / Optic neuritis.d. Pyrazinamide / gouty arthritis.

90. Macrolides: all of the following are true excepta. Bactericidal in large doses.b. Eyrhromycin is one of them and jnduces cholestatic jaundice.c. Spectinomycin is one of them and used in resistant;onorrhea.d. Inhibit translocatton reaction of bacterial ribosome.

91. Which of the following is not effective in typhoid fever:a. Penic i l l in V.b. Amoxacill in.c. Ampicill in.d. Co trimoxazole.

92. Which of the following is not effective in BTt:a. Doxycline.b. Ceftrioxone.c. Rifampicin.d. centamycin.

93. Which of the following is not effective in pseudomonas infections:a. Cefoperazone.b. lmipenem.c. Penicill in G.d. Gentamycin.

94.Which ofthe following is not used in gonorrhea:a. Penic i l l in cb. Spectinomycin.c. Norfloxacrn.d. Vancomycin.

95. Which of the following is used safely in pregnancy:Gentamycin.Erythromycin.Doxycycline.l\4oxifloxacin.following pairs are true except:

Clinafloxacin / inhjbits DNA gyrazeINH / Inhibits mycolic acid synthesis.Cefrazolin / inhibits transpeptidase enzyme.Rifampjcin / inhibits RNA d dent DNA

a.b.c.d.

96. All of thea.b.cd. lc l InnrDrts KNA 0e0en ovtmera:e

2=b 6=d 9=b '10=c12=d 14=d 16=b 18=a 19=d 20=d 22=d23=b 24=c 26=b 27=d 28=c 29=b 30=c 31=b 32=d

35=d 36=d 38=b 39=a 40=d 41=b 42=c 43=b 44=C45=D 46=C 48=C 50=A 54=B56=D 59=C 60=B 61=D 62=A 63=B 64=B 65=D 66=C67=D 68=C 69=C 7O=Q 76=c78=b 79=b 80=a 82=c 83=c 84=c B6=c 87=d 88=c89=b 90=c 91=a 92=d 93=c 94=d 95=b 96=d