antibiotics fix

7/26/2019 Antibiotics Fix

1/22

Antibiotics

Drug Adult Dose Pediatric (Age > 1

mo) Dose

Dose in

Renal

Failure a(CrCl ures2

=ero&enem N/A 1 g IV q $

!

g IV q $

!

N/A %"#%

mg/kg

IV q $ !

%.5 g IV q

# !

Dori&enem N/A %.5 g IV q

$ !

%.5 g IV q

$ !

N/A N/A %.5 g IV

q # !

For meningitis #% mg/kg

IV q $ !

#% mg/kg

IV q $ !

N/A % mg/kg

IV q # !

Fluoro@uinolones d

Ci&ro.loacin %.5"%.75 g

q 1 !

%."%.# g

IV q $"1

!

%.# g IV q

$ !

1%"15

mg/kg

IV q 1

! in

select

circumst

1%"15

mg/kg

IV q 1

! in

select

circumst

%.5"%.75

g *o q #

!

or

%."%.# g

IV q # !


13/22

ances2 ances2

6tended,release .or

uncom&licated cystitis

%.5 g q #

! for &

days

N/A N/A N/A N/A N/A

!emi.loacin &% mg q# !

N/A N/A N/A N/A 13% mg*o q # !

Le%o.loacin %.5"%.75

g q # !

%.5"%.75

IV g q #

!

%.75 g IV

q # !

N/A N/A %.5"%.5

g *o or

IV q #$ !

=oi.loacin %.# g q #

!

%.# g IV q

# !

%.# g IV q

# !

N/A N/A %.# g q #

! *o or

IV

or.loacin b %.# g q 1

!

N/A N/A N/A N/A %.# g *o q

# !:.loacin %."%.# g q

1 !

%.# g IV q

1 !

%."%.# g

IV q 1 !

N/A N/A %.1"%. g

*o or IV q

# !

=acrolides

Ait#romycin %.5 g on

day 10 t!en

%.5 g q #

! for #

days

%.5 g IV q

# !

%.5 g IV q

# !

N/A %.5 g *o

on day 10

t!en %.5

g *o q #

! for #

days or%.5 g IV q

# !

For nongonococcal

cer%icitis and uret#ritis

1 g for 1

dose

N/A N/A N/A N/A N/A

For tra%elers diarr#ea 1 g for

1dose

N/A N/A 5"1%

mg/kg

for 1

N/A N/A


14/22

dose

For tonsillitis or

aryngitis

N/A N/A N/A 1

mg/kg

for 5

days

N/A N/A

For otitis media or

community,ac@uired

&neumonia

N/A N/A N/A 1%

mg/kg

on day

10 t!en 5

mg/kg

once/da

y on

days "

5

N/A N/A

Clarit#romycin %.5"%.5 g

q 1 !

?tended@

release6 1

g q # !

N/A N/A 7.5

mg/kg q

1 !

N/A %.5"%.5

g *o q #

!

6ryt#romycin base b %.5"%.5 g

q 3 !

N/A N/A 1%"13.3

mg/kg q

$ !

or

7.5"1.5

mg/kg q

3 !

N/A %.5 g *o

q 3 !

Fidaomicin %. g q 1

!

N/A N/A N/A N/A %. g *o q

1 !

Lactobionate N/A %.5"1 g IV

q 3 !

1 g IV q 3

!

N/A &.75"5.%

mg/kg

IV q 3 !

%.5 g IV q

3 !


15/22

!luce&tate N/A %.5"1 g IV

q 3 !

1 g IV q 3

!

N/A &.75"5.%

mg/kg

IV q 3 !

%.5 g IV q

3 !

For ! &reo&erati%e

bo"el &re&aration

1 g for &

doses

N/A N/A %

mg/kgfor &

doses

N/A N/A

elit#romycin $%% mg q

# !

N/A N/A N/A N/A $%% mg

*o q # !

'ul.onamides and trimet#o&rim

'ul.isoaole 1.% g q 3 ! 5 mg/kg

IV q 3 !

not

a)ailale

in S2

N/A &%"&7.5

mg/kg q

3 !

or

%"5

mg/kg q

# !

N/A 1 g *o q

1"# !

'ul.amet#iole %.5"1 g q

3"$ !

N/A N/A 7.5"

11.5

mg/kg q

3 !

N/A N/A

'ul.amet#oaole 1 g q $"1

!

N/A N/A 5"&%

mg/kg q

1 !

N/A 1 g *o q

# !

rimet#o&rim %.1 g q 1

!

or

%. g q #

!

N/A N/A mg/kg

q 1 !

for 1%

days for

BI

N/A %.1 g *o q

# !

rimet#o&rim/sul.amet#o

aolee

%.13/%.$ g

q 1 !

&"5 mg

B4P/kg

5 mg

B4P/kg

&"3 mg

B4P/kg

&"3 mg

B4P/kg

Not

recomme


16/22

IV q 3"$ ! IV q 3 ! q 1 ! IV q 1

!

nded if

ot!er

alternati)

es are

a)ailale2For Pneumocystis

Biro%ecii&neumonia e

%.&/1.3 g

q $ ! for

1 days

5 mg

B4P/kg

IV q $ !

for 1

days

5 mg

B4P/kg

IV q 3"$ !

5"3.3

mg

B4P/kg

q $ !

or

&.75"5

mg

B4P/kg

q 3 !

5"3.3

mg

B4P/kg

IV q $ !

or

&.75"5

mg

B4P/kg

IV q 3 !

If

essential0

5 mg

B4P/kg

IV q # !

or

1.5 mg

B4P/kg

IV q 3 !

etracyclines

Doycycline %.1 g q 1

!

%.1 g IV q

1 !

%.1 mg IV

q 1 !

Age : $

yr6 "#

mg/kg q

# !

or

1"

mg/kg q

1 !

Age : $

yr6 "#

mg/kg

IV q #

!

or

1"

mg/kg

IV q 1!

%.1 g IV

or *o q 1

!

=inocycline %.1 g q 1

!

%.1 g IV q

1 !

%.1 g IV q

1 !

N/A N/A %.1 g IV

or *o q 1

!

etracycline b %.5"%.5 g

q 3 !

N/A N/A Age : $

yr6

3.5"

N/A 'oycycl

ineused

instead


17/22

1.5

mg/kg q

3 !

igecycline N/A 1%% mg0

t!en 5%mg 5 mg

for se)ere

!e*atic

dysfunctio

n2 IV q 1

!r

Same as

adultdose f

N/A N/A Same as

adult dose

:t#ers

Clindamycin %.15"%.#5

g q 3 !

%.3 g IV q

3 ! to %.8

IV g q $ !

%.8 g IV q

$ !

.3"3.3

mg/kg q

$ !

or

"5

mg/kg q

3 !

3.3"1&.

mg/kg

IV q $ !

or

5"1%

mg/kg

IV q 3 !

%.15"%.#5

g *o q 3 !

or

%.3"%.8 g

IV q 3"$

!

C#loramenicol %.5"1 g q

3 !

%.5"1.% g

IV q 3 !

1 g IV q 3

!

N/A 1.5"

1$.75

mg/kg

IV q 3 !

%.5"1.%

g IV q 3 !

For meningitis N/A 1.5mg/kg q 3

!

maimum

6 # g/day2

1.5mg/kg IV

q 3 !

maimum

6 # g/day2

N/A 1$.75"5

mg/kg

IV q 3 !

1.5mg/kg IV

q 3 !

maimu

m6 #

g/day2

Colistin (&olymyin 6) N/A .5"5

mg/kg/day

.5"5

mg/kg/day

N/A N/A 1.5 mg/kg

q &3 !


18/22

IV in "#

doses

IV in "#

doses f

Dalba%ancin N/A 1%%% mg

as a single

dose0folloed

y a 5%%@

mg dose 1

k later

1%%% mg

as a single

dose0folloed

y 5%%@mg

dose 1 k

later

N/A N/A 1%%% mg

as a

singledose0

folloed

y a 5%%@

mg dose 1

k later

Da&tomycin N/A #"3 mg/kg

IV q # !

$"1%

mg/kg IV

q # ! f

N/A N/A #"3

mg/kg IV

q #$ !

Fos.omycin A single

dose of & g

in &"# o>

of ater

N/A in S N/A N/A N/A A single

dose of &

g in &"#

o> of

ater

Lineolid %.3 g q 1

!

%.3 g IV q

1 !

%.3 g IV q

1 !

1%

mg/kg q

$ !

1%

mg/kg

IV q $ !

%.3 g IV

or *o q 1

!

=etronidaole

For anaerobic in.ection 7.5 mg/kg

q 3 ! notto eceed

# g/day2

7.5 mg/kg

IV q 3 !not to

eceed #

g/day2

7.5 mg/kg

IV q 3 !not to

eceed #

g/day2

7.5

mg/kg q3 !

7.5

mg/kgIV q 3 !

&.75

mg/kg IVor *o q 3

! not to

eceed

g/day2

For tric#omoniasis g for 1

dose

or

N/A N/A N/A N/A N/A


19/22

%.5 g q 1

! for 7

days

For Clostridium di..icile$

induced diarr#ea(&seudomembranous

colitis)

%.5 g q 3"$

! for 1%"1# days

5%% mg IV

q 3"$ !

5%% mg IV

q 3 !

7.5

mg/kg q$ !

7.5

mg/kgIV q 3 !

5% mg

*o or IV q$ !

For amebiasis %.5"%.75 g

q $ ! for

1% days

folloed

y*aromo

mycin*o

%.5 g q $ !

for 7 days

%.75 g IV

q $ ! for

1% days

folloed

y*aromo

mycin*o

%.5 g q $ !

for 7 days

%.75 g IV

q $ ! for

1% days

folloed

y*aromo

mycin*o

%.5 g q $ !

for 7 days

11.3"

13.3

mg/kg q

$ ! for

7"1%

days

11.3"

13.3

mg/kg

IV q $ !

for 7"1%

days

N/A

For giardiasis %.5 g q 3"

$ ! for 5"7

days

N/A N/A 5 mg/kg

q 3"$ !

for 5

days

N/A N/A

itro.urantoin macrocrys

tals

5%"1%%

mg q 3 !

N/A N/A 1.5"

1.75

mg/kg q

3 !

N/A Not

recomme

nded

itro.urantoinmono#ydrate/macrocrystals

1%% mg q1 !

N/A N/A N/A N/A N/A

:rita%ancin N/A 1%% mg

as a single

dose

1%% mg

as a single

dose

N/A N/A 1%% mg

as a

single

dose

uinu&ristin/dal.o&ristin N/A 7.5 mg/kg

IV q $"1

7.5 mg/kg

IV q $ !

N/A 7.5

mg/kg

7.5 mg/kg

IV q $"1


20/22

! IV q 1

! for

com*lic

ated

skin orskin

structure

infectio

n

or

7.5

mg/kg q

$ ! for

serious

infectio

ns

!

Ri.am&in b

For * %.3 g q #

!

%.3 g IV q

# !

N/A 5"1%

mg/kg q

1 !

or

1%"%

mg/kg q

# !

1%"%

mg/kg

IV q #

!

%.&"%.3 g

IV or *o q

# !

For meningococcal

e&osure

%.3 g q 1

! for #

doses

N/A N/A Age = 1

mo6 1%

mg/kg q

1 ! for

days

Age - 1

mo6 5

N/A %.3 g *o q

1 ! for #

doses


21/22

mg/kg q

1 ! for

days

For aemoilus

in.luenaee&osure

% mg/kg

q # ! for# days not

to eceed

3%% mg q

# !2

N/A N/A %

mg/kg q# ! for

# days

Age - 1

mo6 1%

mg/kg q

# ! for

# days

N/A % mg/kg

q # ! for# days

not to

eceed

3%% mg q

# !2

For staylococcal

in.ections (used "it# a

&enicillin5 cealos&orin5

or%ancomycin)

%.& g q $ !

or

%.3"%.8 g q

# !

%.& g IV q

$ !

or

%.3"%.8 g

IV q # !

%.& g IV q

$ !

or

%.3"%.8 g

IV q # !

%.& g IV

or *o q $

!

or

%.3"%.8 g

IV or *o q

# !

Ri.a&entine

For &ulmonary * (as

&art o. a 2, or 3, drug

regimen)

Initial

*!ase

mo26 %.3 g

tice/kContinuati

on *!ase

# mo26 %.3

g once/k

N/A N/A N/A N/A N/A

For latent * (in

combination

"it#isoniaid)

%.8 g

once/k &

mo2

N/A N/A N/A N/A N/A


22/22

ediolid %% mg q

# !

%% mg IV

q # !

%% mg IV

q # !

N/A N/A %% mg

*o or IV q

# !

ela%ancin N/A 1% mg/kg

IV q # !

1% mg/kg

IV q # !

N/A N/A N/A

Eancomycin 15 mg q

3 ! only

effecti)e

for C.

difficile"

induced

diarr!ea

15 mg/kg

IV q 1 !

often 1 g

q 12

15 mg/kg

IV q 1 !

N/A 1&

mg/kg

IV q $ !

or

1%

mg/kg

IV q 3 !

%.5"1.% g

IV q k

For meningitis N/A 1 g IV q $

!

or

1.5 g IV q

1 !g

1 g IV q $

!

or

1.5 g IV q

1 !

N/A 15

mg/kg

IV q 3 !

15 mg/kg

IV q k

a nitial loading dose s#ould be e@ui%alent to t#e usual dose .or &atients "it# normal renal

.unction5 .ollo"ed by a dose adBusted .or renal .ailure Dosing adBustments o. aminoglycosides

s#ould be assisted by measuring &ea (dra"n 1 # a.ter t#e start o. a 20,min E in.usion) and

troug# (dra"n 20 min be.ore net dose) serum le%els

b Rate or etent o. absor&tion is decreased "#en t#e drug is taen "it# .ood

c Dosage s#ould not eceed t#at .or adults

d #ese drugs are generally a%oided in c#ildrene Dose is based on =P

. #e standard o. care .or dosing o. t#is antibiotic .or serious in.ections is com&le and ra&idly

e%ol%ing (see discussion o. indi%idual drug .or a more in.ormation)

g n addition5 intrat#ecal or intra%entricular %ancomycin 10$0 mg/day may be necessary5 and

dose may need to be adBusted to ac#ie%e troug# C'F le%els o. 10$0 g/mL

/A 8 not a&&licableG =P 8 trimet#o&rim

antibiotics fix

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