CNS PharmacologyAnti-epileptic drugs

1.The mechanism of action of antiepileptic drugs is :a) Enhancement of GABA-ergic (inhibitory) transmissionb) inhibition of excitatory (usually glutamate-ergic) transmissionc) Modification of ionic conductanced) All of the above .

2.which of the following has an impotent effect on the T-type calcium channels in thalamic neurons?a) Carbamazepineb) Lamotriginec) Ethosuximided) Phenytoin .

3.The drug which does not produce a voltage-dependent inactivation of sodium channels is :a) Lamotrigineb) Carbamazepinec) Phenytoind) Vigabatrine .

4.The antiepileptic drug, which produce inhibition of the central effects of excitatory amino acids is :a) Ethosuximideb) Lamotriginec) Diazepamd) Tiagabine .

5.The drug which is not used for partial and generalized tonic-clonic seizures is :a) Carbamazepineb) Valproatec) Phenytoind) Vigabatrine .

6.The drug which is used for absence seizures is :a) Sodium valproateb) Phenobarbitalc) Carbamazepined) Phenytoin .

7.The drug which is used for myoclonic seizures is:a) Primidoneb) Carbamazepinec) Clonazepamd) Phenytoin .

8.The most effective drug in status epilepticus in adults is :a) Carbamazepineb) Ethosuximide

1

CNS PharmacologyAnti-epileptic drugs

c) Diazepamd) Zonisamide .

9.Regarding phenytoin:a) It effects on Ca2+ currents, reducing the low-threshold (T-type) currentb) It blocks Na+ channels c) It inhibits GABA-transaminase, which catalyzes the breakdown of GABAd) None of the above .

10. Phenytoin is used in the treatment of:a) Petit mal epilepsyb) Grand mal epilepsyc) Myoclonic seizuresd) None of the above .

11. Dose-related adverse effect caused by phenytoin is:a) Physical and psychological dependenceb) Gingival hyperplasia c) Exacerbated grand mal epilepsyd) Steven-Johnson syndrome .

12. Granulocytopenia , GI irritation and facial hirsutism are possible adverse effects of:a) Phenobarbitalb) Ethosuximidec) Phenytoin d) Carbamazepine .

13. which of the following does not induce hepatic microsomal enzymes ?a) Carbamazepine b) Phenytoinc) Phenobarbitald) Sodium valproate .

14. The drug of choice for partial seizures is:a) Carbamazepineb) Diazepamc) Ethosuximided) Phenytoin .

15. The mechanism of action of Carbamazepine appears to be similar to that of:a) Benzodiazepinesb) Sodium valproatec) Phenytoind) Ethosuximide .

16. Which of the following is also effective in treating trigeminal neuralgia?a) Carbamazepine

2

CNS PharmacologyAnti-epileptic drugs

b) Phenytoinc) Vigabatrined) Lamotrigine .

17. The most common adverse effects of Carbamazepine are:a) Diplopia, ataxia, and nauseab) Gingival hyperplasia, hirsutismc) Sedation, physical and psychological dependenced) All of the above .

18. Phenobarbital causes :a) Physical and phychological dependenceb) Exacerbated petit mal epilepsyc) Sedationd) All of the above .

19. Lamotrigine can be used alone in the treatment of all the following except :a) Partial seizuresb) Absencec) Myoclonic seizuresd) Generalized tonic - clonic seizures .

20. The mechanism of action of vigabatrine is : a) Direct action on the GABA receptor-chloride channel complexb) Inhibition of GABA aminotransferasec) NMDA receptor blockade via the glycine binding sited) Inhibition of GABA neuronal reuptake from synapses .

21. The mechanism of topiramate’s action is:a) Reduction of excitatory glutamate-ergic neurotransmissionb) Inhibition of voltage sensitive Na+ channelsc) Potentiation of GABA-ergic neuronal transmissiond) All of the above .

22. The drug of choice in the treatment of petit mal (absence seizures) is:a) Phenytoinb) Ethosuximidec) Phenobarbitald) Carbamazepine .

23. adverse effects of ethosuximide are all the following except :a) Gastric upset such as anorexia, pain, nausea and vomitingb) Exacerbated grand mal epilepsyc) Fatigue , Dizziness and headache d) Aggressive behavior .

24. Sodium valproate is very effective against all the following except :a) Absence seizures

3

CNS PharmacologyAnti-epileptic drugs

b) Myoclonic seizuresc) Generalized tonic-clonic seizuresd) Partial seizures .

25. The drug of choice in the treatment of myoclonic seizures is:a) Sodium valproateb) Phenobarbitalc) Phenytoind) Ethosuximide .

26. Which of the following antiepileptic drugs may produce teratogenicity?a) Phenytoinb) Valproatec) Topiramated) All of the above .

27. The most dangerous effect of antiepileptic drugs after large overdoses is:a) Respiratory depressionb) Gastrointestinal irritationc) Alopeciad) Sedation

4

Answers :1.d2.c3.d4.b5.d6.a7.c8.c9.b10.b11.b12.c13.d

14.a15.c16.a17.a18.d19.d20.b21.d22.b23.d24.d25.a26.d27.a