“At the current rate of consumption and at the current

level of thinking, the healthcare organizations of today

will be unable to meet demand in the future.

“Our health systems will be unsustainable.” … PricewaterhouseCoopers, HealthCast 2020: Creating a Sustainable Future,

Wellness Paradigm Shift

Reactive Proactive

“Wellness extends the definition of health to encompass a process of integration characterized by awareness, education, and growth.”

… John W. Travis and Regina Sara Ryan, The Wellness Workbook, 3rd edition, Celestial Arts, 2004.

Solving Problems

(Conventional Medically-

Oriented Approaches)

Improving Quality of Life

(Integrated Wellness-

Oriented Approaches)

3 Confidential Med Gen and Life Science Group

Our Values:

DSMI is committed in providing the highest quality patient care

with integrity.

Our dedication to excellence, compassion, devotion to

innovation in the art and science of healing and wellness.

Our Mission:

1. Leadership and excellence in delivering quality healthcare

services

2. Expanding the horizons of medical knowledge through biomedical

research

3. Educating and training physicians and other healthcare professionals

4

Cardiovascular Medicine

Regenerative Medicine

Research & Publications

Genetic Testing / CRO

Education

DSMI Integrated Medicine Concept

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Cardiovascular Medicine

Age Management

Sexual Dysfunction

Preventive Medicine

Nutraceutical Rehabilitation Monitoring

Chronic Heart Disease

Cardiovascular Medicine

Chronic Heart Disease

Monitoring

Age Management

Rehabilitation

Sexual Dysfunction

Chronic Diseases

State of the Art Medical Care

World Class Academic US Institutions

UCLA, UCSD

Cedars Sinai Medical Center

Loma Linda University

CHF

CAD

PAD

CVA

ED

Female SD

Pulm HTN

COPD

Diabetes

Alzheimer’s

Hospital Home

Remote DMSI

Hospital

Rehab Center

Home

Chronic Pain

Regenerative

Medicine

Stem Cell Therapy

Angiogenesis

Cardiac Diseases:

Congestive Heart Failure/

Cardiomyopathy

Coronary Artery Disease

Vascular Disorders:

Gen. atherosclerosis

CAD

PAD

ED

Cerebralsclerosis

Lung Diseases:

Pulm HTN

COPD/Emphysema

Age Management/Anti-Aging:

Degenerative diseases

Skin, Bone, Joints

Diabetes Mellitus

Senile Dementia

Alzheimer’s

Parkinson’s

Pain Management

Dr. Ye

Dr. Bal

Dr. Schwarz

Beverly Hills, CA

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Research & Publications

Data Collection Medical Press

Releases Scientific

Presentations

Peer Reviewed Journals

Publications

National International Meetings

AHA, ACC, ESC, AMA

Scientific Analysis

Bio-Informatics CRO

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Genetic Testing

Clinical Reporting/ Analysis

Cardiovascular Health, Pain Management, Psychiatric Medicine/Oncology

Mental Health/ Toxicology Pharmacogenomics

Next Generation Sequencing ( Clinically Relevant Targets)

Oncology, Infectious Diseases

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Internship

DSMI Operations Team

The combination of Business, Research, Medical and Genetic expertise facilitate

Evidenced-Based Medicine

Clinically relevant training programs and accessible client support

American Board Certified medical doctors

PhD scientists expertise in Molecular Medicine

Professional Medical Executives • Serve as an extension to Practicing Physicians

DSMI

Operations

Team

Business

Medical Research

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Ernst R. Schwarz, MD,Ph.D. FACC,FESC,FSCAI

Clinical and Academic Cardiologist

University of Vienna, Austria,

Philips-University Marburg/Lahn Germany,

Cardiology fellowship: RWTH University of Technology, Aachen, Germany

Professor of Medicine

RWTH University in Aachen, Germany

Cedars Sinai Medical Center , Los Angeles

David Geffen School of Medicine at UCLA

Scholar of the German Heart Foundation

Max-Planck Institute for Experimental and Physiologic Cardiology Bad Nauheim, Germany

University of Southern California in Los Angeles.

Chief of the Department of Cardiology

Harvard-associated Fakeeh Hospital in Jeddah, Saudi Arabia.

Head of the heart failure and transplant section

Chief of the cardiology clinics

University of Texas Medical Branch (UTMB) Galveston, Texas.

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Diplomat of the American Board of Internal Medicine,

Triple board certified Internal Medicine, Cardiology, Advanced Heart Failure &

Transplant Cardiology

Specialist in Interventional Cardiology, Age Management and Sexual Dysfunction

Basic Research

Translational Application, Cardio-protection

Clinical Research

Heart Failure, Sexual Dysfunction and the Ageing Heart.

Dr. Schwarz has authored more than 150 articles in

scientific Journals and is Contributing writer and editor

of several books linking erectile dysfunction and

coronary artery disease

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Dr. Schwarz Director of Multidisciplinary Heart Failure Research

Cedars Sinai Medical Center

Nathan S. Bryan, Ph.D. Professor of Molecular Medicine

The University of Texas Health Science Center at Houston

Dr. Bryan has spent the past 15 years in nitric oxide and Cardiovascular

Research. Earned Bachelor of Science in Biochemistry from the University of

Texas at Austin and his doctoral degree from Louisiana State University School of

Medicine, recipient of Dean’s Award for Excellence in Research. Pursued post-

doctoral training as a Kirschstein Fellow at Boston University School of Medicine

and later joined the Institute of Molecular Medicine, University of Texas Health

Science Center in Houston, now part of the Texas Therapeutics Institute (TTI).

Dr. Bryan is credited with several seminal discoveries in the Nitric Oxide field.

Discoveries and findings have unveiled novel therapeutic treatment and

prevention of human disease associated with NO insufficiency. Dr. Bryan has

published a number of Highly Cited papers and authored/edited 4 books. He has

three issued US patents and 6 pending worldwide. Dr. Bryan is also the co-

founder and Chief Science Officer of Neogenis Labs, a University of Texas portfolio

company started to commercialize nitric oxide based technologies and diagnostics.

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16

Dr. Guido Sauter is the head of the Department of Pathology in Hamburg,

Eppendorf, known for his role in the development of the WHO

classification of Urogenital Tumors. In his time at the University of Basel,

Institute of Pathology he pioneered the development of tumor microarrays

and managed a world reference laboratory for the international Breast

Cancer research group.

Professor Sauter has received numerous international awards and sits on

the Editorial Board of several leading scientific journals, served on SWISS

Health Reimbursement Committee, Roche, Astra Zeneca, Novartis.

Professor Guido Sauter MD, Ph.D.

Hamburg, Germany

Dr. Bal Raj MD. FRCSC Beverly Hills Orthopedic Institute, California

Orthopedic Surgeon,

• American, Canadian and Dubai Board Certified

• Subspecialty – Hip and Knee replacement /Sport Surgeries

Hospital Privileges

• Linden Surgery Center, Beverly Hills, CA

• Miracle Mile Medical Center, Beverly Hills, CA

• Olympia Hospital, Beverly Hills, CA

• Hollywood Community Hospital, Culver City, CA

• Mission Community Hospital, Panorama City, CA

Memorial University PGME, St.John’s, Canada

• Department of Orthopedic Surgery

http://www.drhipandknee.com/dr-raj-articles/

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Dr. Ross Hauser MD

Physiatrist Loyola University

Physical Medicine & Rehabilitation

University of Illinois College of Medicine

• American Board of Physical Medicine and Rehabilitation

Licenses: FL State Medical, IL State Medical, PA State Medical and WI State Medical

Caring Medical Rehabilitation Services, S.C. (CMRS) for Prolotherapy. Specialize in treating chronic pain and sports injuries, utilizing the comprehensive Hackett-Hemwall Prolotherapy technique.

The Hauser Diet® Natural Medicine Program to maximize wellness and healing, and for those desiring to achieve optimal weight and energy.

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Dr. Patrick Dillon, Ph.D.

Clinical Genomics, Diagnostics, Life Sciences &

Biotechnology

Experience in Design Control and Product Development following FDA QSR and compliance with ISO 13485.

Served as Chief Scientific Officer of several companies providing business, R&D and commercial development strategies. Built and led an R&D organization of over 100 scientists for Invitrogen ( now Life Technologies) engaged in the development of a broad range of life sciences products including gene isolation tools, gene cloning and protein expression/analysis systems including proprietary reagents, cell lines, and vectors, as well as other technologies for use in drug discovery and research/development applications. Identifying all human genes and identifying gene targets to develop therapies and understanding to improve the human condition.

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Professor Ercument Ovali Acıbadem Labcell, Istanbul, Turkey

Cellular Therapy Products, Chondrocytes Manufacturing and Stem Cell Banking

Affiliated to Acıbadem Sağlık Hizmetleri ve Tic A.Ş.-

Established in 2003 approval and accredited of Ministry of Health, Turkey

meeting the demands for the banking of autologous cord blood.

Contributed to studies on cardiac stem cell therapies in patients through

processing autologous bone marrow cells.

Providing services for cell processing, freezing, banking and thawing for

autologous peripheral stem cell therapies

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Vijay Mahant, M.S, Ph.D.

21

Scientist and an entrepreneur with 28 years of

experience in immuno- and molecular diagnostics.

Executive positions and founder/co-founder of diagnostic companies with diverse

experiences in R&D, involved in fund raising, Initial Public Offerings (IPOs), 25

issued patents and 15 patents pending, co-authors of chapters in scientific/medical

books, published articles, developed and manufactured over 35 products with

hundreds of million dollars of revenues, managed intellectual property, including in

and out licensing, experience in Regulations (FDA and foreign) and Technical

Support.

Executive Management

William (Bill) Davidson Co-Founder and Vice Chairman

Founder and Chairman of MESA Inc..

Formerly a tenured Professor of Management at the University of Southern

California, Global practice leader for the telecom and media.

Bill has been involved in more than 50 ventures and served on more than a dozen

boards of director, Recently, as the non-executive chairman of Aquahydrate and

helped guide the successful transition to professional management.

Basir K. Sohail Co-Founder and CEO

Brings more than 25 years of global experience in molecular, personalized

medicine, companion diagnostics, reference and research laboratory operations

management, track record of success with FDA 510K approval, CE-Mark In-Vitro Diagnostics

(IVD) and international expansion introducing novel technologies.

Consults on genetic analysis solutions for Life Technologies worldwide. Served as Vice President

Commercial Operations for Thermo-Fisher Scientific. Director Worldwide Marketing at Abbott

Laboratories, drove significant sales and profit growth through pharmacogenomic oncology initiatives

(i.e. PathVysion® HER-2 diagnostic for Herceptin® therapy) business development, licensing, and

strategic planning.

As the U.S. Marketing Director for Stago (France) spearheaded major change initiatives

to resolve corporate image and brand. International Marketing Manager for Sigma Aldrich Corporation

and Bayer AG as Technical Sales and Marketing for the US. MSc. in Biochemistry and an MBA.

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Frank Luketich Co-Founder and Chief Operating Officer

Frank brings over 30 years leadership experience of the Healthcare and Medical Device industry in business development and commercialization of new products. Exemplary track record of success in all aspects of the cardiology and cardiac surgery fields developing and establishing successful sales channels, Served on various positions with leading companies such as Spacelabs, Edward's Lifesciences, Abiomed, Zoll Medical, CardiacAssist, and Syncardia systems.

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Brings more than 30 years of global management experience in molecular

biology related companies. He has a track record of success in

establishment of start-up companies to break even in less than 2 years.

Mr. Fehmer has serve as director of commercialization of new technologies at Protedyne Corp. in

Europe. Managing director for a1-Biotech (an Anachem Group Company) and business development

for several other biotech related companies. Developed molecular business in Russia and

established sales channels for Illumina Inc, next generation sequencing a turnover of $20 million in

first year of business. He has vast experience in cord blood and stem cell banking (José Carrera

Foundation, Cord Blood Donation Center Munich “Knochenmarkspende Deutschland e.V”.).

Mr. Fehmer currently serves as a Director for Europe and Middle East for

TSE Systems GmbH with constant growth and a very positive business outlook.

Mr. Jürgen Fehmer Executive Sourcing and planning

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Andrew Pearce Asia Pacific Operations

With more than 25 years of medical, scientific & industrial process control

instrumentation in New Zealand. Worked in sales, product and marketing

management, cofounding & directorship. International Medical Device

distribution, expanding the market penetration & growing the business in

Asia Pacific, Russia & Eastern Europe and the Middle East. Concurrent

development of unique sophisticated Cyberthosis technology from

Switzerland for neuro rehabilitation and other unique rehabilitation

instrumentation.

Dr. Schwarz Wellness Packages

New Suite of Proprietary DSMI Wellness Products

• Proprietary blend of Natural / Culturally-based Healing Ingredients;

• Proven Therapeutic Value

• Clinical and Evidence-Based Medicine performance studies

DSMI Wellness Product Categories (initial)

Preventive Cardio

Erectile Dysfunction (NO-based)

Chronic Fatigue preventive medicine for Women

• Educate Consumers on therapeutic value of treatments

Erectile Dysfunction (Oxford

American Urology Library)

Ernst R. Schwarz (Editor)

Effect of Nutrient Supplements on Cardiovascular Health*

Cardiovascular Treatments Programs

Literature on cardiovascular disease development reveal oxidative stress, inflammation and autoimmune dysfunction as few primary contributors

3 promising nutrient supplements include:

Resveratrol – Polyphenol found mainly in grape skin

– Seen in several human epidemiological studies to have:

Ability to reduce risk of morbidity/mortality from cardiovascular complications

Widely-known antioxidant and antiapoptoic effects

Role in mechanisms involved in improved cardiac function,. i.e., attenuate heart contraction associated with heart failure

Reverse dyslipidemia

Curcumin – Phytoceutical and polyphenol, main active ingredient in turmeric

– Seen in animal models and human subjects to have:

Anti-atherosclerotic, anti-inflammatory and anti-oxidant properties

Cardioprotective abilities

Lower low-density lipoprotein-cholesterol

Raise high-density lipoprotein-cholesterol

Reduce lipid peroxidation

Nitric Oxide – Endogenous molecule, naturally occurring

– Plays important role in:

Regulating myocardial contractility

Maintaining endothelial structure

Maintaining blood pressure

– Studies have shown:

Inhibited nitric oxide production can lead to pathogenesis of many common cardiovascular diseases such as essential hypertension and atherosclerosis 29

Source: Dr. Ernst Schwarz presentation, California Medical Institute, Beverly Hills, CA, USA

The discovery of NO and its function is one of the most

important in the history of cardiovascular medicine.'‘

Dr. Valentin Fuster

1998 President of American Heart Association

The New York Times October 13, 1998

Nitric Oxide in Regenerative and

Preventative Medicine

Nitric Oxide is the requisite signal for stem cell differentiation

into target cell types

The bioavailability of NO in patients may predict stem cell

therapy success or failure

NO

Cardiovascular System

Respiratory Tract

Immunology

Cell Proliferation

Central Nervous System

Peripheral

Nervous System

Gastrointestinal/

Urogenital Tract

Vasorelaxation

Blood Cell Regulation

Myocardial Contractility

Microvascular Permeability

Bronchodilatation

Asthma, ARDS

NANC nerve-mediated

Relaxation

Learning and Memory

Pain Sensitization

Epilepsy

Neurodegeneration

Central BP Control

Apoptosis

Angiogenesis

Tumor Cell Growth

Unspecific Immunity

Inhibition of Viral Replication

Transplant Rejection

Penile Erection

Pre-term Labour

Regeneration

Mobilization of resident stem cells

Targeted differentiation

Our Recent Publications

Vitamin D:

Studies show an alarming association between vitamin D deficiency and heart failure, but mixed results from prospective vitamin D supplementation trials necessitate further trials to test efficacy of vitamin D therapy in heart failure.

Andropause:

Increasing data reveals the impact of low levels of androgen in older age (andropause) on the progression of cardiovascular disease, leading to a controversial discussion that hormone replacement therapy used for male menopause may preserve the integrity of cardiovascular health in older age.

Testosterone:

Since heart failure is influenced by neurohormonal regulation adjustments, studies show male patients with heart failure are severely testosterone deficient; clinical trials confirm that they symptomatically improve when treated with testosterone

supplementation.

Growth Hormone:

Because growth hormone is necessary for cardiac growth and function, experimental studies and clinical trials illustrate how this hormone has potential as an adjunctive therapy in treating heart failure since it has protective effects in the

cardiovascular system.

Our Recent Sexual Dysfunction Articles:

A study was conducted to evaluate the impact of sexual dysfunction on the quality of life, physical and mental health, and depressive symptoms after heart transplantation with results revealing that recipients with sexual dysfunction had worse general health but not depressive symptoms. This indicates a more physically-related cause.

As an early correlate for the presence of ischemic heart disease, sexual dysfunction can be treated with 3 phosphodiesterase-5 (PDE-5) inhibitors which also have effects on cardiovascular health, eliciting in vivo and in vitro studies to examine the beneficial effects of these inhibitors in myocardial infarction and endothelial dysfunction.

Common amongst heart failure patients, erectile dysfunction has a negative impact on the quality of life which prompted a case report of a patient with heart failure who underwent cardiac resynchronization therapy and, subsequently, improved sexual function in the patient was achieved.

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Clinical Genetic Testing

Pharmacogenomics and Bio-Informatics

Pain Management

New Born Screening

Infectious Diseases

Women’s Health

Oncology

Confidential 33

Genetic Testing

Improve patient healthcare and well-being through the delivery of genomic information which will allow for a personalized approach to an individual’s healthcare decisions and lifestyle choices.

“One of the most important components of personalized

medicine is pharmacogenomics, the study of genetic variations

that influence individual response to drugs.”

•American Medical Association, Pharmacogenomics: Increasing the safety and effectiveness of drug therapy, 2012

Many Patients Fail to Respond

to Prescription Drugs

PGx Testing Benefits Patients by Optimizing Therapy

Personalized Medicine & Genetic Testing Going Beyond Services of Conventional Medical Providers

Personalized Health Services are the key to future Medical and Wellness Management

DSMI offers Sophisticated Medical Diagnostics and Systems for patient assessment, plan development and progress monitoring

Specializing in Molecular Diagnostic Testing

• Pharmacogenetics

– Cardiovascular

– Pain Management

– Psychiatric Medicine

– Oncology

• Wellness Genomics

• Consumer Genomics

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Summary

DSMI offers new concepts in medical wellness within US Medical Practice Guidelines

State of the art medical therapy for End Stage Heart Disease

Training and consulting of local Physicians according to the US Guidelines

Leading edge Stem Cell Therapy

Scientific usage of treatment data and publications for PR

• DSMI Proactive Wellness Packages

– Proprietary blend of Natural / Culturally-based Healing Ingredients;

– Proven Therapeutic Value formulated exclusively by Dr. Schwarz and his scientific team

• Personalized Medicine

– Individualized, Physician-Directed, Proactive Wellness Plan

– Advanced Medical Treatments, Products and Protocols

Preeminent Team

• Extensive experience in Cardiology, Pain Management, Molecular Medicine, Oncology and Genetics

• Proven business acumen for success

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Heal The Human Suffering

With Cutting Edge Science

Thank You

38

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Founder and Chairman

Clinical and Academic Cardiologist

Expertise:

Heart Failure

Sexual Dysfunction and Aging Heart

Cardiovascular Research

Molecular Medicine

Therapeutic Treatment and Prevention associated with NO

insufficiency

Molecular Pathologist Developed WHO classification of Urogenital Tumors, Pioneer of TMA , Breast Cancer research, Serve on Swiss

medical Reimbursement for oncology treatment

Ernst Schwarz Nathan Bryan Guido Sauter

Orthopedic Surgeon

Specialty- Hip and Knee replacement/ sports surgeries and Pain

Management

Medical Rehabilitation Prolotherapy treating

chronic pain and Sports injuries

Wellness Program

Cardiac Stem Cell Therapies, cGMP

manufacturing Chondrocytes and Tissue Engineering, Stem Cell

Banking

Raj Bal Ross Houser E. Ovali

Clinical Genomics, Pharmacogenomics

and Clinical Research

Cardio, Oncology, Pain Management

Scientific Regulatory, Technical Support,

Nutraceutical and IP Co Founder and CEO

Patrick Dillon Vijay Mahant B. K Sohail

Co Founder and

Vice Chairman

Co Founder and

COO

Sourcing and Planning

Europe and Russia

Jürgen Fehmer Frank Luketich Bill Davidson

Asia Pacific Operations

Andrew Pearce