“The Global In Vitro Fertilization Market”

Dr. Peter Svalander

Presentation outline

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The Total Fertility Rate is declining below the replacement rate (2.1) to sustain population levels

2015

These new demographics may threaten living standards …

• Falling productivity and increasing dependency will reduce potential GDP growth from 2.1% to 1.3% a year

• Age-related spending as a proportion of GDP in will increase:• Pensions: 7.4% (2000) to 10.8% (2050)• Health care: 6.0% (2000) to 9.3% (2050)

• As a consequence of ageing, share of EU in global output is expected to decrease:

• EU from 18% (2000) to 10% (2050)• US from 23% (2000) to 26% (2050)

Grant J, et al

Rand Corporation Report, ESHRE 2006

ARTAssisted Reproductive Technology

IVFIn Vitro Fertilization

IVFEmbryoFreezing

PGD ICSI IVMEmbryoImaging

IVA

History of IVF

U.K. Australia U.K. Belgium Denmark Japan

IVF: In Vitro Fertilization

PGD: Pre-implantation Genetic Diagnostics

ICSI: Intracytoplasmic Sperm Injection

IVM: In Vitro Maturation

IVA: In Vitro Activation

Australia

1978 1984 1990 1991 1994 2009 2013

For IVF, Embryo Freezing, PGD, ICSI, IVA: Dates above indicate first baby born

Last major innovation in IVF

In Vitro Fertilization (IVF)

IVF

Intra Cytoplasmic Sperm Injection (ICSI)

Heffner LJ

NEJM, 2004; 351:1927-1929

Fertility declines and birth defects increase with age

Maternal Age at Delivery (yr)

Risk of Down’s

Syndrome

Risk of Any Chromosomal Abnormality

20 1/667 1/526

25 1/1200 1/476

30 1/952 1/385

35 1/378 1/192

40 1/106 1/66

45 1/30 1/21

* Modified by Hook et al, JAMA 1983; 249:2034-8

Risk of Down Syndrome and Chromosomal Abnormalities at

Live Birth, According to Maternal Age*

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Fertile women who plan on becoming mothers in their 30s and 40s should freeze their eggs

Infertility will affect 1 in 3 women havingchildren in their late 30s.

Egg freezing when young will allow women to choose number of babies to have and when.

Women are much more likely to achieve their desired family size.

Source: Martin Varsavsky, personal communication

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30% of couples who undergo IVF never get to have a baby with their own eggs

n=2678

n=1360

n=836

n=1290

Source: Malizia, B.A. et al. 2009. Cumulative Live-Birth Rates after In Vitro Fertilization. N Engl J Med, 360:236-43.

Source: https://www.youtube.com/watch?v=isRaHszrPc4

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