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Supplementary material
Table of ContentsAppendix 1 - ICD9 Mapping.....................................................................................................2
Appendix 2 – Italian stop words used in the ICD9-CM TM analysis.........................................15
Appendix 3 – English stop words used in the Remapped Procedures TM analysis...................16
Appendix 4 – TM on CCS remapped procedures.....................................................................17
Appendix 5 – Complete list of the extracted careflows and remapping into clusters..............19
Appendix 6– Grid search evaluation of CFM parameters........................................................23
Appendix 7–CFM only based histories (Admission and SPU events).......................................25
Appendix 1 - ICD9 MappingMapped Procedures Count of ICD9
CODESCount of
Observations
Lumpectomy 10 4102Plastic Reconstruction On The Breast 26 3413Injection Infusion Of Chemotherapeutic Substances 2 2436Operations on the hemic and lymphatic system 8 1995Cardiovascular System Procedures 7 1257Mastectomy 12 1134Microscopic examination 11 1104Operations on axillary lymph nodes 3 1043Injection Of Therapeutic Substance And Transfusion 22 839Other 20 672Biopsy 5 585Diagnostic Radiology 16 476Diagnostic Ultrasound - Metastases 1 364Rehabilitation 18 345General Surgery 54 289CAT MRI - Metastases 9 282Radioisotope Scan And Function Study - Metastases 5 224Plastic Surgery 13 165Diagnostic Ultrasound 5 156Operations On Respiratory System 11 123Therapeutic Radiology - Metastases 4 109Operations on the nervous system 14 103Operations On The Cardiovascular system 11 95Operation On Musculoskeletal System 10 59Endoscopic Procedure On Digestive System 11 55Diagnostic Radiology - Metastases 12 50Biopsy - Metastases 14 47Procedures Related To The Psyche 5 41Nervous System Procedures 6 34Hyperthermia for Cancer Treatment 2 19Operation On The Female Genital Organs 8 17Ophthalmologic And Otologic Procedures 4 15Operation On The Urinary System 6 9
Endoscopic Procedure On Digestive System - Metastases
2 5
Respiratory intubation and mechanical ventilation 1 2
PROCEDURE REMAPPING ICD9 - CODESBiopsy 06.11
40.1185.1185.1286.11
Biopsy - Metastases 33.2433.2633.2741.3145.2550.1150.1250.9152.1154.2354.2455.2377.4077.49
Cardiovascular System Procedures 88.7288.7789.4389.4489.5089.5289.54
CAT MRI - Metastases 87.0387.0487.4187.4288.0188.0288.3888.9188.93
Diagnostic Radiology 85.9188.9887.1187.1787.3787.4487.4987.6187.6287.6587.6987.7488.0388.1988.3489.53
Diagnostic Radiology - Metastases 87.2187.2287.2387.2487.2987.4388.2188.2688.2788.2888.2988.33
Diagnostic Ultrasound 88.7188.7388.7488.7588.79
Diagnostic Ultrasound - Metastases 88.76Endoscopic Procedure On Digestive System 44.13
45.1645.2345.4245.4351.8551.8854.2157.3257.3357.49
Endoscopic Procedure On Digestive System - Metastases 33.2233.23
General Surgery 00.6200.6404.3705.4406.8908.6440.4142.9243.4143.4943.9944.3944.9945.7345.7545.7645.9346.2146.5147.0147.1948.6348.7449.0149.1149.2949.3949.4950.2250.2951.1051.2251.2351.9853.0353.0453.1453.1753.2153.4153.4953.5153.5953.6154.5954.9154.9355.0370.52
Hypertermia For Cancer Treatement 93.3499.85
Injection Infusion Of Chemotherapeutic Substances 99.2599.28
Injection Of Therapeutic Substance And Transfusion 09.6639.9541.0141.0450.9483.9899.0099.0199.0399.0499.0599.1499.1599.1799.1899.1999.2199.2399.2499.2699.2999.52
Lumpectomy 85.2085.2185.2285.2385.2485.2585.8192.1692.1892.28
Mastectomy 39.9885.3385.3485.3585.3685.4185.4285.4385.4485.4585.4685.48
Microscopic examination 90.5390.5990.7991.0691.3191.3291.3391.4291.6691.8991.99
Nervous System Procedures 03.3189.1389.1489.1589.1789.19
Operation on Musculoskeletal System 77.6080.5981.9181.9283.3283.9188.3193.0893.1697.87
Operation On The Female Genital Organs 65.3165.4965.5365.6265.6368.2969.1989.26
Operation On The Urinary System 05.5405.9855.5156.3156.8196.49
Operations on axillary lymph nodes 40.2240.2340.51
Operations On Respiratory System 34.0934.9134.9389.3789.3889.6693.1893.9093.9193.9693.99
Operations On The Cardiovascularsystem 03.7038.5938.9138.9338.9538.9939.2739.5039.9086.0799.61
Operations on the hemic and lymphatic system 04.0304.0940.1940.2440.2940.5240.5340.59
Operations on the nervous system 00.3600.4203.5303.9003.9103.9203.9303.9403.9604.8004.8104.9905.3105.39
Ophthalmologic and Otologic Procedures 21.8640.2195.0295.03
Other 08.2308.6108.6308.8608.8708.9757.9489.0189.0289.0389.0589.0689.0789.0889.0989.6189.6593.0799.7999.84
Plastic Reconstruction On The Breast 85.8208.5683.4385.3185.3285.5085.5185.5385.5485.8585.8785.8985.9385.9485.9585.9686.0286.6386.6986.7086.7286.7586.8486.9388.9488.97
Plastic Surgery 86.6078.4986.0186.0486.0986.1986.2286.2386.2886.5986.8993.5796.59
Procedures Related To The Psyche 94.0994.1294.3794.3894.42
Radioisotope Scan And Function Study - Metastases 92.0192.0992.1492.1592.19
Rehabilitation 93.0193.0393.0993.1193.1293.1393.1493.1793.1993.2293.2793.3693.3893.3993.7493.8293.8394.63
Respiratory intubation and mechanical ventilation 96.70Therapeutic Radiology - Metastases 92.24
92.2592.2692.29
Appendix 2 – Italian stop words used in the ICD9-CM TM analysisList of stop words available in the R package topicmodels
[1] "ad" "al" "allo" "ai" "agli" "all" [7] "agl" "alla" "alle" "con" "col" "coi" [13] "da" "dal" "dallo" "dai" "dagli" "dall" [19] "dagl" "dalla" "dalle" "di" "del" "dello" [25] "dei" "degli" "dell" "degl" "della" "delle" [31] "in" "nel" "nello" "nei" "negli" "nell" [37] "negl" "nella" "nelle" "su" "sul" "sullo" [43] "sui" "sugli" "sull" "sugl" "sulla" "sulle" [49] "per" "tra" "contro" "io" "tu" "lui" [55] "lei" "noi" "voi" "loro" "mio" "mia" [61] "miei" "mie" "tuo" "tua" "tuoi" "tue" [67] "suo" "sua" "suoi" "sue" "nostro" "nostra" [73] "nostri" "nostre" "vostro" "vostra" "vostri" "vostre" [79] "mi" "ti" "ci" "vi" "lo" "la" [85] "li" "le" "gli" "ne" "il" "un" [91] "uno" "una" "ma" "ed" "se" "perché" [97] "anche" "come" "dov" "dove" "che" "chi" [103] "cui" "non" "più" "quale" "quanto" "quanti" [109] "quanta" "quante" "quello" "quelli" "quella" "quelle" [115] "questo" "questi" "questa" "queste" "si" "tutto" [121] "tutti" "a" "c" "e" "i" "l" [127] "o" "ho" "hai" "ha" "abbiamo" "avete" [133] "hanno" "abbia" "abbiate" "abbiano" "avrò" "avrai" [139] "avrà" "avremo" "avrete" "avranno" "avrei" "avresti" [145] "avrebbe" "avremmo" "avreste" "avrebbero" "avevo" "avevi" [151] "aveva" "avevamo" "avevate" "avevano" "ebbi" "avesti" [157] "ebbe" "avemmo" "aveste" "ebbero" "avessi" "avesse" [163] "avessimo" "avessero" "avendo" "avuto" "avuta" "avuti" [169] "avute" "sono" "sei" "è" "siamo" "siete" [175] "sia" "siate" "siano" "sarò" "sarai" "sarà" [181] "saremo" "sarete" "saranno" "sarei" "saresti" "sarebbe" [187] "saremmo" "sareste" "sarebbero" "ero" "eri" "era" [193] "eravamo" "eravate" "erano" "fui" "fosti" "fu" [199] "fummo" "foste" "furono" "fossi" "fosse" "fossimo" [205] "fossero" "essendo" "faccio" "fai" "facciamo" "fanno" [211] "faccia" "facciate" "facciano" "farò" "farai" "farà" [217] "faremo" "farete" "faranno" "farei" "faresti" "farebbe" [223] "faremmo" "fareste" "farebbero" "facevo" "facevi" "faceva" [229] "facevamo" "facevate" "facevano" "feci" "facesti" "fece" [235] "facemmo" "faceste" "fecero" "facessi" "facesse" "facessimo" [241] "facessero" "facendo" "sto" "stai" "sta" "stiamo" [247] "stanno" "stia" "stiate" "stiano" "starò" "starai" [253] "starà" "staremo" "starete" "staranno" "starei" "staresti" [259] "starebbe" "staremmo" "stareste" "starebbero" "stavo" "stavi" [265] "stava" "stavamo" "stavate" "stavano" "stetti" "stesti" [271] "stette" "stemmo" "steste" "stettero" "stessi" "stesse" [277] "stessimo" "stessero" "stando"
List of stop words added for the analysis presented in this paper
[1] "altra" "altre" "altro" "altri" "altrove" [6] "routine" "nas" "semplice" "strutture" "classificate" [11] "classificato" "microscopici" "sistema" "sostanza" "sostanze" [16] "determinazione" "diagnostica" "dinamico" "assiale" "computerizzata"[21] "farmaci" "apparato" "arteriosa" "arterioso" "venosa" [26] "venoso" "misto" "mista" "monitoraggio" "sistemica" [31] "periferico" "ossa" "cellule" "gruppo" "mammella" [36] "definito" "limitato" "invasive" "misure" "procedure" [41] "body" "total" "complessive" "definite" "generale" [46] "attivi" "passivi" "stato" "passo" "coltura"
[51] "approfondito" "esame" "accesso" "dispositivo" "limitate" [56] "continua" "positiva" "contemporaneo" "mediante" "occupazionale" [61] "matrice" "plica" "ungueale" "unghia" "dilatazione" [66] "esofago" "iniezione" "infusione"
Appendix 3 – English stop words used in the Remapped Procedures TM analysisList of stop words available in the R package topicmodels
[1] "i" "me" "my" "myself" "we" "our" [7] "ours" "ourselves" "you" "your" "yours" "yourself" [13] "yourselves" "he" "him" "his" "himself" "she" [19] "her" "hers" "herself" "it" "its" "itself" [25] "they" "them" "their" "theirs" "themselves" "what" [31] "which" "who" "whom" "this" "that" "these" [37] "those" "am" "is" "are" "was" "were" [43] "be" "been" "being" "have" "has" "had" [49] "having" "do" "does" "did" "doing" "would" [55] "should" "could" "ought" "i'm" "you're" "he's" [61] "she's" "it's" "we're" "they're" "i've" "you've" [67] "we've" "they've" "i'd" "you'd" "he'd" "she'd" [73] "we'd" "they'd" "i'll" "you'll" "he'll" "she'll" [79] "we'll" "they'll" "isn't" "aren't" "wasn't" "weren't" [85] "hasn't" "haven't" "hadn't" "doesn't" "don't" "didn't" [91] "won't" "wouldn't" "shan't" "shouldn't" "can't" "cannot" [97] "couldn't" "mustn't" "let's" "that's" "who's" "what's" [103] "here's" "there's" "when's" "where's" "why's" "how's" [109] "a" "an" "the" "and" "but" "if" [115] "or" "because" "as" "until" "while" "of" [121] "at" "by" "for" "with" "about" "against" [127] "between" "into" "through" "during" "before" "after" [133] "above" "below" "to" "from" "up" "down" [139] "in" "out" "on" "off" "over" "under" [145] "again" "further" "then" "once" "here" "there" [151] "when" "where" "why" "how" "all" "any" [157] "both" "each" "few" "more" "most" "other" [163] "some" "such" "no" "nor" "not" "only" [169] "own" "same" "so" "than" "too" "very"
List of stop words added for the analysis presented in this paper
[1] "system" "substance" "substances" "procedure" "procedures" [6] "operation" "operations" "general" "related" "microscopic"[11] "study" "function" "scan"
Appendix 4 – TM on CCS remapped proceduresUsing the same procedure described in the Methods section and applied to the ICD9-CM case, to choose the number of topics of the model we performed a grid search on K ranging from 2 to 13, and evaluated consistency, redundancy, importance, and perplexity. Consistency does not change with k, and it is always greater than 0.75. Redundancy is 0 up until K=6, never reaching values higher than 0.25. Importance slowly decreases between K=3 and K=7, with a steeper decrease from K=7. Perplexity shows a fast increase for K>7. In general, given the low number of words in the dictionary, models with higher number of topics over-describe the documents’ space.
a) b)
c) d)
Remapped procedures
TOPIC WORDS # Words TOPIC LABEL
1 axillarylymphnodes
3 Lymph nodes operations
2 plasticbreastreconstruction
3 Plastic
3 therapeuticmetastasestransfusiondiagnosticcardiovascular
10 Other exams and therapies
radiologyultrasoundotherrehabilitationexamination
4 injectionchemotherapeuticinfusion
3 Chemotherapy
5 lumpectomyhemiclymphatic
3 Lumpectomy
6 mastectomybiopsy
2 Mastectomy / Biopsy
Appendix 5 – Complete list of the extracted careflows and remapping into clusters
Cluster Event 1 Event 2 Event 3 Event 41 Lumpectomy;
prosthesisOUT OUT OUT
1 Mastectomy; prosthesis
OUT OUT OUT
1 Mastectomy; prosthesis
Plastic; prosthesis
OUT OUT
1 Mastectomy; prosthesis
Skin graft / Lymph nodes operations; skin
OUT OUT
1 Plastic; prosthesis
OUT OUT OUT
1 Plastic; prosthesis
Plastic; prosthesis
OUT OUT
1 Plastic; prosthesis
Skin graft / Lymph nodes operations; skin
OUT OUT
1 Plastic; prosthesis
Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
OUT
1 Skin graft / Lymph nodes operations; skin
OUT OUT OUT
1 Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
OUT OUT
1 Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
Plastic; prosthesis
OUT
1 Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
OUT
1 Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
Plastic; prosthesis
1 Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
1 Skin graft / Lymph nodes operations; prosthesis
OUT OUT OUT
2 Lumpectomy; removal
Chemotherapy; tumor
Chemotherapy; tumor
Chemotherapy; tumor
2 Lumpectomy; Chemotherapy; Chemotherapy; OUT
removal tumor tumor2 Lumpectomy;
removalChemotherapy; tumor
Day Hospital; SPU visit
OUT
2 Lumpectomy; removal
Chemotherapy; tumor
Other exams and therapies; tumor
OUT
2 Lumpectomy; removal
Chemotherapy; tumor
OUT OUT
2 Lumpectomy; removal
Day Hospital; SPU visit
Day Hospital; SPU visit
Day Hospital; SPU visit
2 Lumpectomy; removal
Day Hospital; SPU visit
Day Hospital; SPU visit
OUT
2 Lumpectomy; removal
Day Hospital; SPU visit
OUT OUT
2 Lumpectomy; removal
Lumpectomy; removal
Day Hospital; SPU visit
OUT
2 Lumpectomy; removal
Lumpectomy; removal
OUT OUT
2 Lumpectomy; removal
Other exams and therapies; tumor
Chemotherapy; tumor
OUT
2 Lumpectomy; removal
Other exams and therapies; tumor
OUT OUT
2 Lumpectomy; quadrantectomy
Day Hospital; SPU visit
Day Hospital; SPU visit
OUT
2 Lumpectomy; quadrantectomy
Day Hospital; SPU visit
OUT OUT
2 Mastectomy; removal
Chemotherapy; tumor
Chemotherapy; tumor
OUT
2 Mastectomy; removal
Chemotherapy; tumor
OUT OUT
2 Mastectomy; removal
Day Hospital; SPU visit
Day Hospital; SPU visit
OUT
2 Mastectomy; removal
Day Hospital; SPU visit
OUT OUT
2 Mastectomy; unilateral
Chemotherapy; tumor
Chemotherapy; tumor
OUT
2 Mastectomy; unilateral
Chemiotherapy; tumor
OUT OUT
2 Mastectomy; unilateral
Day Hospital; SPU visit
OUT OUT
2 Mastectomy; prosthesis
Chemiotherapy; tumor
OUT OUT
2 Mastectomy; prosthesis
Day Hospital; SPU visit
OUT OUT
2 Skin graft / Lymph nodes operations; removal
Chemiotherapy; tumor
Chemiotherapy; tumor
OUT
2 Skin graft / Lymph nodes
Chemiotherapy; tumor
OUT OUT
operations; removal
2 Skin graft / Lymph nodes operations; removal
Day Hospital; SPU visit
Day Hospital; SPU visit
OUT
2 Skin graft / Lymph nodes operations; removal
Day Hospital; SPU visit
OUT OUT
3 Mastectomy; removal
Chemotherapy; tumor
Chemotherapy; tumor
Plastic; prosthesis
3 Mastectomy; removal
Chemiotherapy; tumor
Plastic; prosthesis
OUT
3 Mastectomy; removal
Day Hospital; SPU visit
Day Hospital; SPU visit
Plastic; prosthesis
3 Mastectomy; removal
Day Hospital; SPU visit
Plastic; prosthesis
Day Hospital; SPU visit
3 Mastectomy; removal
Day Hospital; SPU visit
Plastic; prosthesis
OUT
3 Mastectomy; removal
Plastic; prosthesis
Day Hospital; SPU visit
OUT
3 Mastectomy; unilateral
Chemotherapy; tumor
Plastic; prosthesis
OUT
4 Lumpectomy; removal
Lumpectomy; quadrantectomy
OUT OUT
4 Lumpectomy; removal
Mastectomy; removal
OUT OUT
4 Lumpectomy; removal
Mastectomy; unilateral
OUT OUT
4 Lumpectomy; quadrantectomy
Lumpectomy; removal
OUT OUT
4 Lumpectomy; quadrantectomy
Lumpectomy; quadrantectomy
OUT OUT
5 Lumpectomy; removal
Plastic; prosthesis
OUT OUT
5 Lumpectomy; removal
Skin graft / Lymph nodes operations; removal
OUT OUT
5 Lumpectomy; removal
Skin graft / Lymph nodes operations; skin
OUT OUT
5 Lumpectomy; removal
Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
OUT
5 Mastectomy; removal
Plastic; prosthesis
OUT OUT
5 Mastectomy; removal
Plastic; prosthesis
Plastic; reconstruction
OUT
5 Mastectomy; removal
Plastic; prosthesis
Skin graft / Lymph nodes
OUT
operations; skin5 Mastectomy;
removalPlastic; prosthesis
Skin graft / Lymph nodes operations; skin
Skin graft / Lymph nodes operations; skin
5 Mastectomy; unilateral
Plastic; prosthesis
OUT OUT
5 Mastectomy; unilateral
Plastic; prosthesis
Plastic; reconstruction
OUT
5 Mastectomy; unilateral
Plastic; prosthesis
Skin graft / Lymph nodes operations; skin
OUT
6 Day Hospital; SPU visit
Lumpectomy; removal
OUT OUT
6 Day Hospital; SPU visit
Mastectomy; removal
Day Hospital; SPU visit
OUT
6 Day Hospital; SPU visit
Mastectomy; removal
OUT OUT
6 Day Hospital; SPU visit
OUT OUT OUT
6 Day Hospital; SPU visit
Skin graft / Lymph nodes operations; removal
OUT OUT
7 Lumpectomy; removal
Other exams and therapies; exercises
OUT OUT
7 Mastectomy; removal
Other exams and therapies; exercises
OUT OUT
8 Chemiotherapy; biopsy
OUT OUT OUT
8 Lumpectomy; removal
OUT OUT OUT
8 Lumpectomy; quadrantectomy
OUT OUT OUT
8 Mastectomy; removal
OUT OUT OUT
8 Mastectomy; unilateral
OUT OUT OUT
8 Skin graft / Lymph nodes operations; removal
OUT OUT OUT
9 Lumpectomy; removal
Other exams and therapies; ultrasound
OUT OUT
9 Lumpectomy; removal
Other exams and therapies; exams
OUT OUT
Appendix 6 – Grid search evaluation of CFM parameters CFM algorithm parameters were selected following the grid-search approach presented in Section 2.3. In particular, we performed a grid search by varying min_support in the range 2-50 and max_length in the range 3-10. The Figure below shows a heatmap with the corresponding values for the number of careflows, the average number of patients per careflow, the average number of missed events, and the true match rate for each value of the pair of parameters min_support and max_length.Red values should be avoided, choosing minimum support and maximum history length accordingly. As can be seen from red boxes on heatmap, some indicators need to be maximized (true match rate and mean number of patients per careflow), and other to be minimized (number of mined careflows, mean number of missed events). The last heatmap reports a normalized score that combines all four parameters. All the single indicators have been normalized on a scale from 0 to 1, where 0 corresponds to the old red box values and 1 to the lighter values. The normalized values are combined together using the mean. As seen in the last heatmap, the best score is reached in the interval between 5 and 10 events for minimum_support and a maximum_history_length larger than 5 events. Choosing 10 as minimum support allows deriving less than one hundred histories.
Appendix 7–CFM only based histories (Admission and SPU events) History Regrouping
History HistEvents Recode
Hist_1_SubHist_9 _SPUBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUT H0
Hist_1_SubHist_3 _SPUBreastSurgery_OUT_OUT_OUT_OUT_OUT_OUT H0
Hist_1_SubHist_4 _SPUOncology_OUT_OUT_OUT_OUT_OUT_OUT H0
Hist_1_SubHist_2 _AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUT_OUT H1
Hist_1_SubHist_17 _AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT H2
Hist_1_SubHist_14 _AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT H2
Hist_1_SubHist_10 _AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT H2
Hist_1_SubHist_5 _AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUT H2
Hist_1_SubHist_11 _AdmissionBreastSurgery_AdmissionBreastSurgery_SPUOncology_OUT_OUT_OUT_OUT H2
Hist_1_SubHist_6 _AdmissionBreastSurgery_AdmissionOncology_OUT_OUT_OUT_OUT_OUT H3
Hist_1_SubHist_7 _AdmissionBreastSurgery_SPUBreastSurgery_OUT_OUT_OUT_OUT_OUT H4
Hist_1_SubHist_8 _AdmissionBreastSurgery_SPUOncology_OUT_OUT_OUT_OUT_OUT H5
Hist_1_SubHist_13 _AdmissionBreastSurgery_SPUOncology_SPUOncology_OUT_OUT_OUT_OUT H5
Hist_1_SubHist_16 _AdmissionBreastSurgery_SPUOncology_SPUOncology_SPUOncology_OUT_OUT_OUT H5
Hist_1_SubHist_18 _AdmissionBreastSurgery_SPUOncology_SPUOncology_SPUOncology_SPUOncology_OUT_OUT H5
Hist_1_SubHist_12 _AdmissionBreastSurgery_SPUOncology_AdmissionBreastSurgery_OUT_OUT_OUT_OUT H6
Hist_1_SubHist_15 _AdmissionBreastSurgery_SPUOncology_SPUOncology_AdmissionBreastSurgery_OUT_OUT_OUT H6
Phenotypes – Table 1
Hisotry H0 H1 H2 H3 H4 H5 H6
Number of patients 160 1513 706 51 65 604 247
Age 55.7(14.0) 63.1(13.0) 52.7(11.6) 66.1(13.0)
59.2(13.9) 58.6(12.2) 50(10.7)
Type of Surgery
Lumpectomy99(61.88)
1329(87.84) 287(40.65) 34(66.67) 38(58.46) 479(79.3) 62(25.1)
Mastectomy61(38.12)
184(12.16) 419(59.35) 17(33.33) 27(41.54) 125(20.7) 185(74.9)
Histological Type
DCIS In situ cancer 25(15.62)
170(11.24) 116(16.43) 5(9.8) 9(13.85) 6(0.99) 6(2.43)
CDI Invasive ductal cancer120(75)
1090(72.04) 464(65.72) 38(74.51) 39(60) 511(84.6) 195(78.95)
CLI Invasive lobular cancer15(9.38)
253(16.72) 126(17.85) 8(15.69) 17(26.15) 87(14.4) 46(18.62)
Grading
G125(15.62)
272(17.98) 91(12.89) 6(11.76) 6(9.23) 16(2.65) 11(4.45)
G287(54.37)
965(63.78) 432(61.19) 30(58.82) 38(58.46) 268(44.37) 114(46.15)
G348(30)
276(18.24) 183(25.92) 15(29.41) 21(32.31) 320(52.98) 122(49.39)
Neoadjuvant chemotherapy
No85(53.12)
1407(92.99) 642(90.93) 39(76.47) 61(93.85) 525(86.92) 213(86.23)
Yes74(46.25)
88(5.82) 60(8.5) 12(23.53) 2(3.08) 70(11.59) 31(12.55)
Unknown1(0.62)
18(1.19) 4(0.57) 0(0) 2(3.08) 9(1.49) 3(1.21)
Cancer multifocality
NO121(75.62)
1230(81.3) 471(66.71) 38(74.51) 47(72.31) 468(77.48) 153(61.94)
Yes39(24.38)
283(18.7) 235(33.29) 13(25.49) 18(27.69) 136(22.52) 94(38.06)
Staging
Stage 054(33.75)
201(13.28) 128(18.13) 6(11.76) 10(15.38) 28(4.64) 12(4.86)
Stage 163(39.38)
925(61.14) 343(48.58) 21(41.18) 30(46.15) 221(36.59) 67(27.13)
Stage 222(13.75)
333(22.01) 181(25.64) 12(23.53) 20(30.77) 236(39.07) 104(42.11)
Stage 321(13.12)
54(3.57) 54(7.65) 12(23.53) 5(7.69) 119(19.7) 64(25.91)
Biomolecular subtype
Luminal A69(43.12)
1048(69.27) 400(56.66) 28(54.9) 38(58.46) 152(25.17) 88(35.63)
Luminal B52(32.5)
366(24.19) 213(30.17) 17(33.33) 19(29.23) 279(46.19) 98(39.68)
Her2+27(16.88)
17(1.12) 31(4.39) 2(3.92) 0(0) 71(11.75) 27(10.93)
TNBC12(7.5)
82(5.42) 62(8.78) 4(7.84) 8(12.31) 102(16.89) 34(13.77)
Hormone therapy
NO60(37.5)
250(16.52) 143(20.25) 16(31.37) 14(21.54) 213(35.26) 71(28.74)
Yes100(62.5)
1263(83.48) 563(79.75) 35(68.63) 51(78.46) 391(64.74) 176(71.26)
Chemotherapy
NO64(40)
1341(88.63) 480(67.99) 27(52.94) 52(80) 90(14.9) 30(12.15)
Yes96(60)
172(11.37) 226(32.01) 24(47.06) 13(20) 514(85.1) 217(87.85)
Radiotherapy
NO74(46.25)
328(21.68) 412(58.36) 17(33.33) 28(43.08) 103(17.05) 126(51.01)
Yes86(53.75)
1185(78.32) 294(41.64) 34(66.67) 37(56.92) 501(82.95) 121(48.99)
Lipofilling intervention
No142(88.75)
1496(98.88) 425(60.2) 46(90.2) 55(84.62) 579(95.86) 164(66.4)
Yes18(11.25)
17(1.12) 281(39.8) 5(9.8) 10(15.38) 25(4.14) 83(33.6)
Local/loco-regional recurrence (Yes) 18(11.25) 14(0.93) 76(10.76) 2(3.92) 8(12.31) 40(6.62) 37(14.98)
Metastasis - Distant recurrence (Yes)
32(20) 18(1.19) 38(5.38) 8(15.69) 6(9.23) 115(19.04) 43(17.41)
Exitus (Yes) 18(11.25) 15(0.99) 27(3.82) 16(31.37) 5(7.69) 68(11.26) 27(10.93)
Loco-Regional Recurrence – Survival (disease-free) curves – time in months
Distant Metastasis - survival (disease-free) curves
Death – survival curves