appendix ii detailed operator exposure calculations ... ii . detailed operator exposure calculations...

Appendix II

Detailed operator exposure calculations including

“screenshots” of the BROWSE software PPP Application & Mixing/Loading LIQUIDS

Appendix I (a): Boom spraying (field crops) Appendix I (b): Orchard sprayers – broadcast air assisted

Appendix I (c): Hand-held applications - outdoor Appendix I (d): Hand-held applications - indoor

1

Appendix I (a) Boom spraying

BROWSE Example Scenarios A_Sc1 & mixing/loading liquids

German model - 20 ha/day

Estimation of operator exposure: German model

Estimation of operator exposure (acc. to the German model)

Active substance (a.s.) Product Intended use(s)

Field Crops, Tractor Mounted (FCTM)

Type of preparation

Application rate (AR) 0.5 kg a.s./ha Treated area per day (A) 20 ha/d Systemic AOEL 0.02 mg/kg bw/d Dermal absorption (DA) 2 % for mixing/loading (m/l)

10 % for application (appl.) Inhalation absorption (IA) 100 % Body weight (BW) 60 kg

Personal protective equipment: BVL code Reduction factor to lower:ST1102 0.08 IM

ST2102 0.02 IM

Particle filtering half mask (appl.) 1) 0.08 IA

0.8 DA(C)

0.02 IA

0.8 DA(C)

SS110 0.01 DM(H)

SS120 0.01 DA(H)

SS2202 0.05 DA(B)

SS420 0.5 DA(C)

SS520 0.05 DA(C)

Estimated inhalation exposure: Factor11

Estimated dermal exposure: Factor1111

TestBROWSE 500 SCearly growth stage cereals

ST2202

ST1203

Protective gloves (appl.) 2)

Protective garment + sturdy footwear (appl.) 2)

Broad-brimmed headgear (appl.) 2)

Hood and visor (appl.) 2)

Personal protective equipment (PPE)no PPE

1) DIN EN 149 (2001), 2) BVL (2006) Guidelines for requirements concerning personal protective equipment in plant protection

Particle filtering half mask (m/l) 1)

Half mask with combined filter (m/l) 1)

Half mask with combined filter (appl.) 1)

Protective gloves (m/l) 2)

no PPE

no PPE

no PPE

Personal protective equipment (PPE)no PPEno PPE

IMIA

DM(H)

DA(H)

DA(C)

DA(B)


Liquid

2

Input parameters considered for the estimation of operator exposure: Formulation type: Liquid Application

technique: Field Crops, Tractor Mounted (FCTM) Application rate (AR): 0.5 kg

Area treated per day (A): 20 ha Dermal hands m/l (DM(H)):

2.4 mg/person/kg a.s.

Dermal absorption (DA): 2 % (concentr.) Dermal hands appl.

(DA(H)): 0.38 mg/person/kg

a.s.

10 % (dilution) Dermal body appl. (DA(B)):


Inhalation absorption (IA): 100 % Dermal head appl. (DA(C)):


Body weight (BW): 60 kg/person Inhalation m/l (IM): 0.0006 mg/person/kg a.s.

AOEL 0.02 mg/kg bw/d Inhalation appl. (IA): 0.001 mg/person/kg a.s.

Operator exposure towards Test

Without PPE With PPE Operators: Systemic dermal exposure after application in early growth stage cereals Dermal exposure during mixing/loading Hands Hands SDEOM(H) = (DM(H) x AR x A x DA) / BW SDEOM(H) = (DM(H) x AR x A x PPE 1) x DA) / BW (2.4 x 0.5 x 20 x 2%) / 60 (2.4 x 0.5 x 20 x 1 x 2%) / 60

External dermal exposure 24 mg/person External dermal exposure 24 mg/person

External dermal exposure 0.4 mg/kg bw/d External dermal exposure 0.4 mg/kg bw/d

Systemic dermal exposure 0.008000 mg/kg bw/d Systemic dermal exposure 0.008000 mg/kg bw/d

Dermal exposure during application Hands Hands SDEOA(H) = (DA(H) x AR x A x DA) / BW SDEOA(H) = (DA(H) x AR x A x PPE 1) x DA) / BW (0.38 x 0.5 x 20 x 10%) / 60 (0.38 x 0.5 x 20 x 1 x 10%) / 60

External dermal exposure 3.8 mg/person External dermal exposure 3.8 mg/person



Body Body SDEOA(B) = (DA(B) x AR x A x DA) / BW SDEOA(B) = (DA(B) x AR x A x PPE 2) x DA) / BW (1.6 x 0.5 x 20 x 10%) / 60 (1.6 x 0.5 x 20 x 1 x 10%) / 60




Head Head SDEOA(C) = (DA(C) x AR x A x DA) / BW SDEOA(C) = (DA(C) x AR x A x PPE 3) x DA) / BW

(0.06 x 0.5 x 20 x 10%) / 60 (0.06 x 0.5 x 20 x 1 x 10%) / 60


External dermal exposure 0.01 mg/kg bw/d External dermal 0.01 mg/kg bw/d

3

exposure


Total systemic dermal exposure: SDEO = SDEOM(H) + SDEOA(H) + SDEOA(B) + SDEOA(C)


Total external dermal exposure 44.4 mg/person Total external dermal exposure 44.4 mg/person

Total external dermal exposure 0.74 mg/kg bw/d Total external dermal exposure 0.74 mg/kg bw/d

Total systemic dermal exposure 0.042 mg/kg bw/d Total systemic

dermal exposure 0.042 mg/kg bw/d

Operators: Systemic inhalation exposure after application in early growth stage cereals Inhalation exposure during mixing/loading

SIEOM = (IM x AR x A x IA) / BW SIEOM = (IM x AR x A x PPE 4) x IA) / BW

(0.0006 x 0.5 x 20 x 100%) / 60 (0.0006 x 0.5 x 20 x 1 x 100%) / 60

External inhalation exposure 0.006 mg/person External inhalation exposure 0.006 mg/person

External inhalation exposure 0.0001 mg/kg bw/d External inhalation exposure 0.0001 mg/kg bw/d

Systemic inhalation exposure 0.000100 mg/kg bw/d Systemic inhalation exposure 0.000100 mg/kg bw/d

Inhalation exposure during application SIEOA = (IA x AR x A x IA) / BW SIEOA = (IA x AR x A x PPE 4) x IA) / BW (0.001 x 0.5 x 20 x 100%) / 60 (0.001 x 0.5 x 20 x 1 x 100%) / 60




Total systemic inhalation exposure: SIEO = SIEOM + SIEOA Total systemic inhalation exposure: SIEO = SIEOM + SIEOA

Total external inhalation exposure 0.016000 mg/person Total external

inhalation exposure 0.016000 mg/person

Total external inhalation exposure 0.000267 mg/kg bw/d Total external

inhalation exposure 0.000267 mg/kg bw/d

Total systemic inhalation exposure 0.000267 mg/kg bw/d Total systemic


Total systemic exposure: SEO = SDEO + SIEO Total systemic exposure: SEO = SDEO + SIEO

Total systemic exposure 2.53600 mg/person Total systemic exposure 2.53600 mg/person

Total systemic exposure 0.042267 mg/kg bw/d Total systemic exposure 0.042267 mg/kg bw/d

% of AOEL 211.3 % % of AOEL 211.3 % 1) reduction factor for gloves is 0.01 (professional applications) and 0.5 (home/allotment garden applications), resp. 2) reduction factor for protective garment is 0.05 (prof. appl.) and 0.5 (workwear, home/allotment garden appl.), resp. 3) reduction factor for broad brimmed headgear and hood and visor is 0.5 and 0.05, respectively (professional appl.) 4) reduction factor for RPE is 0.08 (particle filter) and 0.02 (combined vapour and particle filter), resp. (prof. appl.)

4

20 ha/day

Estimation of operator exposure (acc. to the German model)



Type of preparation




ST2102 0.02 IM


0.8 DA(C)

0.02 IA

0.8 DA(C)

SS110 0.01 DM(H)

SS120 0.01 DA(H)

SS2202 0.05 DA(B)

SS420 0.5 DA(C)

SS520 0.05 DA(C)



TestBROWSE 500 SCearly growth stage cereals

ST2202

ST1203











no PPE

no PPE

no PPE


IMIA

DM(H)

DA(H)

DA(C)

DA(B)


Liquid

5



technique: Field Crops, Tractor Mounted (FCTM) Application rate (AR): 0.5 kg





a.s.








Without PPE With PPE Operators: Systemic dermal exposure after application in early growth stage cereals Dermal exposure during mixing/loading Hands Hands SDEOM(H) = (DM(H) x AR x A x DA) / BW SDEOM(H) = (DM(H) x AR x A x PPE 1) x DA) / BW (2,4 x 0,5 x 50 x 2%) / 60 (2,4 x 0,5 x 50 x 1 x 2%) / 60


External dermal exposure 1 mg/kg bw/d External dermal exposure 1 mg/kg bw/d


Dermal exposure during application Hands Hands SDEOA(H) = (DA(H) x AR x A x DA) / BW SDEOA(H) = (DA(H) x AR x A x PPE 1) x DA) / BW (0,38 x 0,5 x 50 x 10%) / 60 (0,38 x 0,5 x 50 x 1 x 10%) / 60




Body Body SDEOA(B) = (DA(B) x AR x A x DA) / BW SDEOA(B) = (DA(B) x AR x A x PPE 2) x DA) / BW (1,6 x 0,5 x 50 x 10%) / 60 (1,6 x 0,5 x 50 x 1 x 10%) / 60




Head Head SDEOA(C) = (DA(C) x AR x A x DA) / BW SDEOA(C) = (DA(C) x AR x A x PPE 3) x DA) / BW (0,06 x 0,5 x 50 x 10%) / 60 (0,06 x 0,5 x 50 x 1 x 10%) / 60



6

exposure




Total external dermal exposure 111 mg/person Total external dermal exposure 111 mg/person




Operators: Systemic inhalation exposure after application in early growth stage cereals Inhalation exposure during mixing/loading SIEOM = (IM x AR x A x IA) / BW SIEOM = (IM x AR x A x PPE 4) x IA) / BW (0,0006 x 0,5 x 50 x 100%) / 60 (0,0006 x 0,5 x 50 x 1 x 100%) / 60




Inhalation exposure during application SIEOA = (IA x AR x A x IA) / BW SIEOA = (IA x AR x A x PPE 4) x IA) / BW (0,001 x 0,5 x 50 x 100%) / 60 (0,001 x 0,5 x 50 x 1 x 100%) / 60















7

THE UK PREDICTIVE OPERATOR EXPOSURE MODEL (POEM)

Application methodProduct BROWSE 500 SC Active substanceFormulation type a.s. concentration 500 mg/mlDermal absorption from product 2 % Dermal absorption from spray 10 %ContainerPPE during mix/loading PPE during applicationDose 1 l/ha Work rate/day 50 haApplication volume 200 l/ha Duration of spraying 6 h

Container size 5 litresHand contamination/operation 0.01 mlApplication dose 1 litres product/haWork rate 50 ha/dayNumber of operations 10 /dayHand contamination 0.1 ml/dayProtective clothing NoneTransmission to skin 100 %Dermal exposure to formulation 0.1 ml/day

DERMAL EXPOSURE DURING SPRAY APPLICATIONApplication technique Tractor-mounted/trailed boom sprayer: hydraulic nozzlesApplication volume 200 spray/haVolume of surface contamination 10 ml/hDistribution Hands Trunk Legs

65% 10% 25%Clothing None Permeable PermeablePenetration 100% 5% 15%Dermal exposure 6.5 0.05 0.375 ml/hDuration of exposure 6 hTotal dermal exposure to spray 41.55 ml/day

ABSORBED DERMAL DOSEMix/load Application

Dermal exposure 0.1 ml/day 41.55 ml/dayConcen. of a.s. product or spray 500 mg/ml 2.5 mg/mlDermal exposure to a.s. 50 mg/day 103.875 mg/dayPercent absorbed 2 % 10 %Absorbed dose 1 mg/day 10.3875 mg/day

INHALATION EXPOSURE DURING SPRAYINGInhalation exposure 0.01 ml/hDuration of exposure 6 hConcentration of a.s. in spray 2.5 mg/mlInhalation exposure to a.s. 0.15 mg/dayPercent absorbed 100 %Absorbed dose 0.15 mg/day

PREDICTED EXPOSURETotal absorbed dose 11.5375 mg/dayOperator body weight 60 kgOperator exposure 0.192291667 mg/kg bw/day

Test

EXPOSURE DURING MIXING AND LOADING

Tractor-mounted/trailed boom sprayer: hydraulic nozzles

None None

water-based

5 litres 45 or 63 mm closure

8

EFSA Calculator (March 2014 version) Operator exposure for BROWSE 500 SC outdoor spray applicationsApplication rate of active substance 0.5 kg a.s./ha i_AppRate

Assumed area treated (AOEM model) 50 ha/dayAmount of active substance applied 25 kg a.s./day i_AmoutAS

Dermal absorption of the product 2.00% i_AbsorpProduct

Dermal absorption of in-use dilution 10.00% i_AbsorInuse

Formulation type Soluble concentrates, emulsifiable concentrate, etc.Indoor or Outdoor application OutdoorApplication method Downward sprayingApplication equipment Vehicle-mountedSeason not relevant

OutdoorSoluble concentrates, emulsifiable concentrate, etc.Downward sprayingVehicle-mounted

75th centile 95th centile

Hands 57881 218196 AOEM

Body 34276 183491 AOEM

Head 1297 7114 AOEM

Protected hands (gloves) 280 4952 AOEM

Protected body (workwear or protective garment and sturdy footwear)

412 3656 AOEM

Protected head (hood and face shield)

21 403 AOEM

Inhalation 10 31 AOEM

Protective Equipment Protection factor Inhalation Protection factorGlovesClothing As aboveHead and respiratory PPE 1 1

Water soluble bag 1 Applies only to wettable powders or granules


Hands 3708 24212 AOEM

Body 2073 10688 AOEM

Head 98 296 AOEM



57 139 AOEM



Closed cabvehicle mounted

upward spraying only

1. TotalWith RPE/PPE

Longer term

2.4718578

0.0411976

205.99%

Acute

11.7450706

0.1957512

% of AAOEL 978.76%

Comment

Select for inclusion

Mix

ing a

nd lo

adin

g

Exposure values µg exposure/day mixed and loaded

Reference Comment


None - T-Shirts and Shorts

No

None

No

No

Without RPE/PPE

Total systemic exposure from mixing, loading and application (mg a.s./day)

2.4718578

Appl

icatio

n

Exposure values µg exposure/day applied

Reference

NoNone - T-Shirts and Shorts

None

Total systemic exposure from mixing, loading and application per kg body weight (mg/kg bw/day)

0.1957512

978.76%


0.0411976

% of AOEL 205.99%


11.7450706

9

2. Longer term exposure

2.1 Mixing and loadingFormula

Without RPE/PPEHands D15*i_AbsorpProduct

Body D16*i_AbsorpProduct

Head D17*i_AbsorpProduct

Inhalation D21*i_AbsorpInhalation

Sum With RPE/PPE (as selected above)Hands D18*i_AbsorpProduct

Body D19*i_AbsorpProduct or D15*i_AbsorpProduct*F24

Head D20*i_AbsorpProduct or D17*i_AbsorpProduct*F25

Inhalation D21*i_AbsorpInhalation*G25

Sum Water soluble C70*F26

2.2 ApplicationFormula

Without RPE/PPEHands D30*i_AbsorpInuse

Body D31*i_AbsorpInuse

Head D32*i_AbsorpInuse


Sum With RPE/PPE (as selected above)Hands D33*i_AbsorpInuse

Body D34*i_AbsorpInuse or D31*i_AbsorpInuse*F38

Head D32*i_AbsorpProduct*F39


Sum

3. Acute exposure3.1 Mixing and loading

Formula

Without RPE/PPEHands E15*i_AbsorpProduct

Body E16*i_AbsorpProduct

Head E17*i_AbsorpProduct

Inhalation E21*i_AbsorpInhalation

Sum With RPE/PPE (as selected above)Hands E18*i_AbsorpProduct

Body E19*i_AbsorpProduct or E16*i_AbsorpProduct*F24

Head E20*i_AbsorpProduct or E17*i_AbsorpProduct*F25

Inhalation E21*i_AbsorpInhalation*G25



Without RPE/PPEHands E30*i_AbsorpInuse

Body E31*i_AbsorpInuse

Head E32*i_AbsorpInuse




Head E32*i_AbsorpProduct*F39


Sum

9.6477701 0.1607962

9.7991912 0.16331995.1946576 0.0865776

Systemic exposure [µg a.s. /day] Systemic exposure [µg a.s./kg bw/day]

1157.6203495 19.2936725

25.9417939 0.4323632

1157.6203495 19.2936725

685.5102706 11.4251712

25.9417939 0.4323632

685.5102706 11.4251712

9.6477701 0.16079621878.7201841 31.3120031

370.8099673 6.1801661


1878.7201841 31.31200311878.7201841 31.3120031

9.8856277

370.8099673 6.1801661

207.3338439 3.45556419.7991912 0.16331995.1946576 0.0865776

593.1376600

4363.9117894 72.73186323669.8134329 61.1635572142.2790305 2.3713172

207.3338439 3.4555641

593.1376600 9.8856277


4363.9117894 72.7318632

3669.8134329 61.1635572

8207.0074712 136.7834579

31.0032184 0.5167203136.78345798207.0074712


142.2790305 2.3713172

0.516720331.0032184

8207.0074712 136.7834579

0.308854258.9677191

18.53124973538.0631440

2421.1810668 40.35301781068.8000000 17.8133333

29.5508274 0.4925138

29.5508274 0.492513818.5312497 0.3088542

3538.0631440 58.9677191

2421.1810668 40.3530178

1068.8000000 17.8133333

10

BROWSE Model

Boom spraying; version 4.92

BROWSE Example Scenario A_Sc1 & ML_Sc1a

11

20 ha/day median

15

Appendix I (b) Orchard sprayers – broadcast air assisted

BROWSE Example Scenarios A_Sc3 & mixing/loading liquids

German model - 8 ha/day Estimation of operator exposure (acc. to the German model)


High Crops, Tractor Mounted (HCTM)

Type of preparation




ST2102 0.02 IM


0.8 DA(C)

0.02 IA

0.8 DA(C)

SS110 0.01 DM(H)

SS120 0.01 DA(H)

SS2202 0.05 DA(B)

SS420 0.5 DA(C)

SS520 0.05 DA(C)



TestBROWSE 500 SCPome Fruit

ST2202

ST1203











no PPEno PPE

no PPE


IMIA

DM(H)

DA(H)

DA(C)

DA(B)


Liquid


16


technique: High Crops, Tractor Mounted (HCTM) Application rate (AR): 0.5 kg





a.s.








Without PPE With PPE Operators: Systemic dermal exposure after application in Pome Fruit Dermal exposure during mixing/loading Hands Hands SDEOM(H) = (DM(H) x AR x A x DA) / BW SDEOM(H) = (DM(H) x AR x A x PPE 1) x DA) / BW (2,4 x 0,5 x 8 x 2%) / 60 (2,4 x 0,5 x 8 x 1 x 2%) / 60




Dermal exposure during application Hands Hands SDEOA(H) = (DA(H) x AR x A x DA) / BW SDEOA(H) = (DA(H) x AR x A x PPE 1) x DA) / BW (0,7 x 0,5 x 8 x 10%) / 60 (0,7 x 0,5 x 8 x 1 x 10%) / 60




Body Body SDEOA(B) = (DA(B) x AR x A x DA) / BW SDEOA(B) = (DA(B) x AR x A x PPE 2) x DA) / BW (9,6 x 0,5 x 8 x 10%) / 60 (9,6 x 0,5 x 8 x 1 x 10%) / 60




Head Head SDEOA(C) = (DA(C) x AR x A x DA) / BW SDEOA(C) = (DA(C) x AR x A x PPE 3) x DA) / BW (1,2 x 0,5 x 8 x 10%) / 60 (1,2 x 0,5 x 8 x 1 x 10%) / 60



Systemic dermal exposure 0.008000 mg/kg bw/d Systemic dermal 0.008000 mg/kg bw/d

17

exposure Total systemic dermal exposure: SDEO = SDEOM(H) + SDEOA(H) + SDEOA(B) + SDEOA(C)






Operators: Systemic inhalation exposure after application in Pome Fruit Inhalation exposure during mixing/loading SIEOM = (IM x AR x A x IA) / BW SIEOM = (IM x AR x A x PPE 4) x IA) / BW (0,0006 x 0,5 x 8 x 100%) / 60 (0,0006 x 0,5 x 8 x 1 x 100%) / 60




Inhalation exposure during application SIEOA = (IA x AR x A x IA) / BW SIEOA = (IA x AR x A x PPE 4) x IA) / BW (0,018 x 0,5 x 8 x 100%) / 60 (0,018 x 0,5 x 8 x 1 x 100%) / 60















18

German model - 10 ha/day Estimation of operator exposure (acc. to the German model)



Type of preparation




ST2102 0.02 IM


0.8 DA(C)

0.02 IA

0.8 DA(C)

SS110 0.01 DM(H)

SS120 0.01 DA(H)

SS2202 0.05 DA(B)

SS420 0.5 DA(C)

SS520 0.05 DA(C)



TestBROWSE 500 SCPome Fruit

ST2202

ST1203











no PPEno PPE

no PPE


IMIA

DM(H)

DA(H)

DA(C)

DA(B)


Liquid

19



technique: High Crops, Tractor Mounted (HCTM) Application rate (AR): 0.5 kg





a.s.








Without PPE With PPE Operators: Systemic dermal exposure after application in Pome Fruit Dermal exposure during mixing/loading Hands Hands SDEOM(H) = (DM(H) x AR x A x DA) / BW SDEOM(H) = (DM(H) x AR x A x PPE 1) x DA) / BW (2.4 x 0.5 x 10 x 2%) / 60 (2.4 x 0.5 x 10 x 1 x 2%) / 60




Dermal exposure during application Hands Hands SDEOA(H) = (DA(H) x AR x A x DA) / BW SDEOA(H) = (DA(H) x AR x A x PPE 1) x DA) / BW (0.7 x 0.5 x 10 x 10%) / 60 (0.7 x 0.5 x 10 x 1 x 10%) / 60




Body Body SDEOA(B) = (DA(B) x AR x A x DA) / BW SDEOA(B) = (DA(B) x AR x A x PPE 2) x DA) / BW (9.6 x 0.5 x 10 x 10%) / 60 (9.6 x 0.5 x 10 x 1 x 10%) / 60




Head Head SDEOA(C) = (DA(C) x AR x A x DA) / BW SDEOA(C) = (DA(C) x AR x A x PPE 3) x DA) / BW (1.2 x 0.5 x 10 x 10%) / 60 (1.2 x 0.5 x 10 x 1 x 10%) / 60



20

exposure








Operators: Systemic inhalation exposure after application in Pome Fruit Inhalation exposure during mixing/loading SIEOM = (IM x AR x A x IA) / BW SIEOM = (IM x AR x A x PPE 4) x IA) / BW (0.0006 x 0.5 x 10 x 100%) / 60 (0.0006 x 0.5 x 10 x 1 x 100%) / 60




Inhalation exposure during application SIEOA = (IA x AR x A x IA) / BW SIEOA = (IA x AR x A x PPE 4) x IA) / BW (0.018 x 0.5 x 10 x 100%) / 60 (0.018 x 0.5 x 10 x 1 x 100%) / 60















21

UK POEM - 15 ha/day THE UK PREDICTIVE OPERATOR EXPOSURE MODEL (POEM)



DERMAL EXPOSURE DURING SPRAY APPLICATIONApplication technique Tractor-mounted/trailed broadcast air-assisted sprayer: 500 l/haApplication volume 200 spray/haVolume of surface contamination 400 ml/hDistribution Hands Trunk Legs

10% 65% 25%Clothing None Permeable PermeablePenetration 100% 2% 5%Dermal exposure 10 5.2 5 ml/hDuration of exposure 6 hTotal dermal exposure to spray 121.2 ml/day


Dermal exposure 0.03 ml/day 121.2 ml/dayConcen. of a.s. product or spray 500 mg/ml 2.5 mg/mlDermal exposure to a.s. 15 mg/day 303 mg/dayPercent absorbed 2 % 10 %Absorbed dose 0.3 mg/day 30.3 mg/day



Test


22

UK POEM - 10 ha/day THE UK PREDICTIVE OPERATOR EXPOSURE MODEL (POEM)



DERMAL EXPOSURE DURING SPRAY APPLICATIONApplication technique Tractor-mounted/trailed broadcast air-assisted sprayer: 500 l/haApplication volume 200 spray/haVolume of surface contamination 400 ml/hDistribution Hands Trunk Legs

10% 65% 25%Clothing None Permeable PermeablePenetration 100% 2% 5%Dermal exposure 10 5.2 5 ml/hDuration of exposure 6 hTotal dermal exposure to spray 121.2 ml/day


Dermal exposure 0.02 ml/day 121.2 ml/dayConcen. of a.s. product or spray 500 mg/ml 2.5 mg/mlDermal exposure to a.s. 10 mg/day 303 mg/dayPercent absorbed 2 % 10 %Absorbed dose 0.2 mg/day 30.3 mg/day



Test


23

EFSA Calculator (March 2014 version)

Operator exposure for BROWSE 500 SC outdoor spray applicationsApplication rate of active substance 0.5 kg a.s./ha i_AppRate

Assumed area treated (AOEM model) 10 ha/dayAmount of active substance applied 5 kg a.s./day i_AmoutAS

Dermal absorption of the product 2.00% i_AbsorpProduct

Dermal absorption of in-use dilution 10.00% i_AbsorInuse

Formulation type Soluble concentrates, emulsifiable concentrate, etc.Indoor or Outdoor application OutdoorApplication method Upward sprayingApplication equipment Vehicle-mountedSeason not relevant

OutdoorSoluble concentrates, emulsifiable concentrate, etc.Upward sprayingVehicle-mounted



Body 11058 114960 AOEM

Head 259 1423 AOEM



99 731 AOEM

Protected head (hood and face shield)

4 81 AOEM



Water soluble bag 1 Applies only to wettable powders or granules



Body 44058 257081 AOEM

Head 5790 35536 AOEM



575 1123 AOEM



Closed cabvehicle mounted

upward spraying only

1. TotalWith RPE/PPE

Longer term

6.7623804

0.1127063

563.53%

Acute

36.3972003

0.6066200

% of AAOEL 3033.1%

Comment


Mix

ing a

nd lo

adin

g

Exposure values µg exposure/day mixed and loaded

Reference Comment


None - T-Shirts and Shorts

No

None

No

No

Without RPE/PPE


6.7623804

Appl

icatio

n

Exposure values µg exposure/day applied

Reference

NoNone - T-Shirts and Shorts

None


0.6066200

3033.1%


0.1127063

% of AOEL 563.53%


36.3972003

24

2. Longer term exposure

2.1 Mixing and loadingFormula

Without RPE/PPEHands D15*i_AbsorpProduct

Body D16*i_AbsorpProduct

Head D17*i_AbsorpProduct


Sum With RPE/PPE (as selected above)Hands D18*i_AbsorpProduct

Body D19*i_AbsorpProduct or D15*i_AbsorpProduct*F24

Head D20*i_AbsorpProduct or D17*i_AbsorpProduct*F25




Without RPE/PPEHands D30*i_AbsorpInuse

Body D31*i_AbsorpInuse

Head D32*i_AbsorpInuse


Sum With RPE/PPE (as selected above)Hands D33*i_AbsorpInuse

Body D34*i_AbsorpInuse or D31*i_AbsorpInuse*F38

Head D32*i_AbsorpProduct*F39


Sum

3. Acute exposure3.1 Mixing and loading

Formula

Without RPE/PPEHands E15*i_AbsorpProduct

Body E16*i_AbsorpProduct

Head E17*i_AbsorpProduct




Head E20*i_AbsorpProduct or E17*i_AbsorpProduct*F25




Without RPE/PPEHands E30*i_AbsorpInuse

Body E31*i_AbsorpInuse

Head E32*i_AbsorpInuse




Head E32*i_AbsorpProduct*F39


Sum

5.9760397 0.0996007

579.0000000 9.6500000158.4463480 2.6407725


335.3343742 5.5889062

5.1883588 0.0864726

335.3343742 5.5889062

221.1500189 3.6858336

5.1883588 0.0864726

221.1500189 3.6858336

5.9760397 0.0996007567.6487916 9.4608132

1051.4852718 17.5247545


567.6487916 9.4608132567.6487916 9.4608132

103.2455270

1051.4852718 17.5247545

4405.8000000 73.4300000579.0000000 9.6500000158.4463480 2.64077256194.7316199

1246.2806759 20.77134462299.1995952 38.3199933

28.4558061 0.4742634

4405.8000000 73.4300000

6194.7316199 103.2455270


1246.2806759 20.7713446

2299.1995952 38.3199933

3603.7731156 60.0628853

29.8370385 0.497284060.06288533603.7731156


28.4558061 0.4742634

0.497284029.8370385

3603.7731156 60.0628853

6.8893298546.5571197

413.359788432793.4271795

3118.4000000 51.973333325708.0673911 428.46778993553.6000000 59.2266667

3553.6000000 59.2266667413.3597884 6.8893298

32793.4271795 546.5571197

3118.4000000 51.9733333

25708.0673911 428.4677899

25

BROWSE Model

Orchard sprayer; version 4.94

BROWSE Example Scenarios A_Sc3 & ML_Sc1a

26

8ha/day –median

29

appendix ii detailed operator exposure calculations ... ii . detailed operator exposure calculations...

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