arginine cardio
TRANSCRIPT
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 1
Arginine Cardio: Evidence-based reduction of blood pressure (1)
L-Arginine is the precursor of Nitric Oxide
L-Citrulline potentiates the bioavailability of L-arginine
Arginine Cardio is the L-Arginine supplement that has the highest L-citrullineContent
Nitric Oxide causes vasodilation and thereby reduces blood pressure.
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 2
Arginine Cardio: Evidence-based reduction of blood pressure (2)
L-Arginine is not being marketed by pharmaceutical industrywith a multi million dollar budget for promotion.
Clinical trials with L-arginine to lower blood pressure have been performedby independent academic research institutions, with small research budgets.
Therefore, patient numbers in clinical trials with L-arginine are comparatively small.
However, there is a recent meta-analysis summarizing clinical trials with L-arginine.
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 3
Dong et al.; American Heart Journal 2011
11 randomized, double-blind, placebo-controlled trials involving 387 participants with oral L-arginine intervention ranging from 4 to 24 g/d
[…] Compared with placebo, L-arginine intervention significantly lowered systolic blood pressure by 5.39 mm Hg (95% CI −8.54 to −2.25, P = .001) anddiastolic BP by 2.66 mm Hg (95% CI −3.77 to −1.54, P = .001).
Arginine Cardio: Evidence-based reduction of blood pressure (3)
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 4
Dong et al.; American Heart Journal 2011L-Arginine better Placebo better
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 5
Dong et al.; American Heart Journal 2011L-Arginine better Placebo better
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 6
Dong et al.; American Heart Journal 2011
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 7
Arginine Cardio: Evidence-based reversal of atherosclerosis (1)
Nitric Oxide has been known to protect from atherosclerosis ever sincethe Nobel Prize for Medicine was awarded for this finding in 1998.
L-Arginine is the precursor of Nitric Oxide. Animal experiments have unequivocally proven in different models and in various laboratories around the world that L-arginine can reverse atheroslcerosis.
Whilst no big, multinational studies could be performed with L-arginine due tolack of funding from public sources, multiple studies have shown reversal ofendothelial dysfunction, the early clinical sign of atherosclerosis, by L-arginine.
We have a collection of case reports that show reversal of atherosclerotic plaquein humans during a few months of L-arginine intake.
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 8
Böger et al., Atherosclerosis 1995; 117: 273 – 284
Study A: Prevention of Plaque Build-Up
Design:
0 8 weeks
Control
Cholesterol
Cholesterol + L-Arginine
Results:
Cholesterol
Cholesterol; treated with L-arginineCONTROL CHOLESTEROL
051015202530354045505560
Car
otid
intim
al p
laqu
e ar
ea
[%
of t
otal
intim
a]
*
CHOL.+ L-ARGININE
#
(0)
A. carotis
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 9
Böger et al., Circulation 1997; 96: 1282-1290
Study B: Stopping the Progression of Plaque Build-Up
Design:
0 10 weeks
Control
Cholesterol
Results:
164
Cholesterol + L-Arginine
Cholesterol
Cholesterol + Lovastatin
Control
0 weeks164
Intim
al p
laqu
e ar
ea(c
arot
id a
rter
y) [%
]
0
50
40
30
20
10
-92%
„Dietary L-arginine completely suppressed the aggravation of intimal plaque formation during the second part of the study Lovastatin treatment significantly reduced the progression of plaque formation but did not completely block it.“
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 10
Candipan et al., Arterioscler. Thromb. Vasc. Biol. 1996; 16: 44-50
Study C: Reversal of Pre-Existing Plaque
Design:
0 18 weeks
Cholesterol
Results:
2310
Cholesterol
Cholesterol + L-Arginine
0 weeks2310
Intim
al p
laqu
e ar
ea(c
arot
id a
rter
y) [%
]
0
75
60
45
30
15
„This is the first demonstration that restoration of NO activity can induce regression of preexisting intimal lesions and provides evidence that L-arginine therapy may be of potential clinical benefit “
Cholesterol
1814
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 11
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 12
© Arginine Benefits LLC, 2013Author: Dr. Rainer Böger Page 13