ARNOLD STANLEY VINCENT BURGEN

PUBLICATIONS

1. Physiological effects of alkyl polyphosphates. Burgen, A.S V., Keele,, C A., Chennells, M., del Castillo, J., Floyd, W.F., Slome, D., Wright, S. Nature, Lond. 1947, 160, 760

2. Urinary excretion of phosphatases in man. Burgen, A.S.V., Lancet, 1947, i,

329. 3. The action of alloxan and related compounds on alkaline phosphatase

Burgen, A.S.V. and Lorch, J.I. Biochem. J. 1947, 41, 223 . 4. The skin lesions of monocytic leukaemia. Fairburn, E.A. and Burgen, A.S

V. Brit. J. Cancer, 1947, 1, 352 5. The action of botulinum toxin on the isolated rat diaphragm.

Burgen, A.S V , Dickens, F., Zatman, L.J. J. Physiol. Lond. 1948, 107, 40.

6. A simplified method for the estimation of chloroform in blood. Burgen, A.S.V. Brit. med. J., 1948, i, 1238.

7. Tetra-ethylpyrophosphate in myasthenia gravis. Burgen, A.S V., Keele, C.A., McAlpinc, D Lancet 1948, i, 519.

8. Quantitative studies of procaine metabolism in the cat. Burgen, A.S.V. and

Keele, C.A. Brit. J. Pharm & Chemotherapy, 1948, 3, 128 9.* The action of botulinum toxin on the neuromuscular junction.

Burgen, A.S.V., Dickens, F., Zatman, L.J. J. Physiol. Lond. 1949, 109, 10 10. The pharmacology of the methyl and benzyl esters of N-crotonic betaine.

Burgen, A.S.V., and Hobbiger, F. Brit. J. Pharmacol. , 1949, 4, 229

11. The mechanism of action of anti-cholinesterase drugs. Burgen, A.S V. Brit. J. Pharm & Chemotherapy. 1949, 4, 219 12. Pharmacological actions of tetraethylpyrophosphate and hexaethyltetraphosphate. Burgen, A.S.V., Keele, C A., & Slome, D. J.Pharm.Exp.Ther., 1949, 96 , 396

13.The assay of anticholinesterase drugs by the chromodacryorrhoca response in rats. Burgen, A S V. Brit. J. Pharmacol., 1949, 4, 185

14.The inhibition of cholinesterases by alkylphosphates and alkylphenolphosphates Burgen, A S V. and Hobbiger, F. Brit. J. Pharmacol. , 1949 , 6 , 593

15. Cholinesterase and succinic dehydrogenase in the central nervous system of the dog. Burgen, A.S.V., and Chipman, L.M. J. Physiol. Lond. 1951, 114, 296

16. The location of cholinesterase in the central nervous system.

Burgen, A S.V., and Chipman, L.M. Quart.J. exp. Physiol., 1952, 37 ,61. 17*. The membrane resting and action potentials of the cat auricle. Burgen,

A.S.V. and Terroux, K.G. J. Physiol. Lond. 1953, 119, 139 18*.On the negative inotropic effect in the cat's auricle. Burgen, A S.V. and

Terroux, K.G. J. Physiol. Lond.. 1953, 120, 449

19. Osmotic work of the salivary secretion. Burgen, A.S.V. Amer.J . Physiol .1954, 179, 623

20. Central and Sensory Transmission. Burgen A.S.V. Pharmacol.

Rev.,1954, 6 , 9 5

21. Methods for studying the reflex activity of the frog's spinal cord. Bunzl A., Burgen A.S.V., Delisle Burns B., Pedley N., andTerroux K.G. Brit. J.Pharmacol. 1954 9 229.

. 22. Water solute and cell exchanges in the dog's pleural fluid.

Burke H.E., Stewart P.B. Burgen A.S.V. Trans.Amer.Clin.Climat.Ass 195 5 67, 46

23.* The secretion of potassium in saliva. Burgen A.S.V.

J.Physiol. 1956, 132, 20

24. The Osmotic work of salivary secretion in the dog. Burgen A.S.V. J.Cell. and Comp.Physiol,1955 45 465

25. A theoretical treatment of glucose reabsorption in the kidney. Burgen A.S.V. Can.J.Biochem.Physiol. 1956 34 466.

26*. The secretion of non-electrolytes in the parotid saliva.

Burgen A.S.V. J.Cell and Comp.Piiysiol. 1956 48, 113.

27. The specificity of brain choline acetylase. Burgen A.S.V. Burke G., Desbarats-Schonbaum M-L. Brit.J.Pharmacol. 1956 11 308.

. 28*.Two inhibitory fibres forming synapses with a single nerve cell in

the lobster. Burgen A.S.V., Kuffler S.W. Nature, Lend. 1957 180 1491. 29.The effect of nervous system extracts on inhibition and excitation in

single nerve cells. Eliot C.R., Kaji A., Seeman P., Ubell E., Kuffler S.W. and Burgen A.S.V. Biol. Bull., Woods Hole, 1957, 113, 344

30.The physiological ultrastructure of cell membranes. Burgen A.S.V.

Can.J.Biochem.Physiol. 1957 35,569.

31*. The effects of some amino acids on the perfused lobster heart. Enger P.E.S., Burgen A.S.V. Biol.Bull 1957 113 345.

32*The secretion of iodide in saliva. Burgen A.S.V,. Seeman P.

Can.J.Biochem.Physiol. 1957 35 481. 33. The place of the basic medical sciences in clinical education.

Burgen A.S.V. Canad.med.Ass.J. 1958 78 467. 34. Symposium on neurosecretion. Burgen A.S.V.

Can.J.Biochem.Physiol. 1959 37, 307.

35*.A method for measuring the turnover of fluid in the pleural and other serous cavities. Burgen A.S.V., Stewart P.B. J.Lab.Clin.Med. 1958 52 118

36.*The turnover of fluid in the dog's pleural cavity. Stewart P.B.,

Burgen A.S.V. J.Lab.Clin.Med. 1958 52 212 37. The secretion of lithium in saliva. Burgen A.S.V.

Can.J.Biochem.Physiol. 1958 36, 409.

38* The role of the salivary duct system in the formation of the saliva. Burgen A.S.V. Seeman P. Can.J.Biochem.Physiol. 1958, 36, 119.

39* The sites of transfer of sodium, potassium, and iodide in the

parotid duct system of the dog. Burgen A.S.V., Godwin Terroux K., Gonder E., Can.J.Biochem.Physiol. 1959 37, 359.

40. *Transfusion reactions due to plasma incompatibility in dogs

Bliss J.Q,, Johns D.G., Burgen A.S.V. Circulat. Res. 1959, VII 79-85 41. *Plasma volume expansion and reactions after infusion of autologous and

non-autologous plasma in man. Hutchison J.L., Freedman S.O., Richards B.A. and Burgen A.S.V. J. Lab. Clin. Med. 1960, 56, 734

42. Oxygen consumption and blood flow in the submaxilliary gland of the dog. Godwin Terroux K., Sekelj P., Burgen A.S.V. Canad. J. Biochem. Physiol. 1959, 37, 5

43. Cutaneous and systematic reactions to human plasma.Bliss,J.Q.,Hutchison,J.L. and

Burgen A.S.V.. J. Allergy 1960, 31, 134 43.

44. The salivary glands - some contemporary problems. Burgen A.S.V. Canadian Dental Assoc Journal,1960, 26, 258 45.Gastrointestinal absorption and excretion of Mg 28 in man. Graham L.A., Caesar J.J., and Burgen A.S.V. Metabolism, 1960, 9, 646. 46. Physiology of the salivary gland. Burgen A.S.V., Emmelin N.G. 1961, London, Edward Arnold

47. The disposal of tritiated folic acid injected intravenously in man. Johns D.G., Sperti S., Burgen A.S.V. Canad. Med. Assoc. Journal, 1961, 84, 77

48*.The metabolism of tritiated folic acid in man. Johns D.G., Sperti, S. and Burgen A.S.V.

, J. Clin. Invest. 1961, 40, 1684. 49.Application of analogue computer to measurement of intestinal absorption rates with tracers. Silverman M. and Burgen A.S.V. J. Appl. Physiol. 1961, 16, 911 50.Influx sites in the duct system of the dog parotid gland. Burgen A.S.V., Terroux K.G., J.Physiol. 1962 161, 399.

51.Comparison of effectiveness of autologous and nonautologous plasma in oligemic shock in dogs. Elias G.L., Gurd F.N., Hampson L.G., Burgen A.S.V. Circulat.Res. 1962 XI, 857-871.

52. Retinotectal connexions after retinal regeneration. Burgen A.S.V.

Grafstein B. Nature, Lond. 1962 196 898.

53. Absorption of folic acid from the small intestine of rat. Burgen A.S.V., Goldberg N.J., Brit.J.Pharmacol. 1962 19; p. 313

54. The Structure and function of cell membranes. Burgen A.S.V. Can.J.Biochem .Physiol.

1962, 40, 1253

55. The effect of changes in the rate of flow of saliva on the concentration of iodide in parotid saliva. Burgen A.S.V. Terroux, K.G. J.Physiol. 1962 163, 239.

56*. Changes in the permeability of the salivary gland caused by sympathetic stimulation and by catecholamines. Martin K., Burgen A.S.V. J. Gen.Physiol. 1962 46, 225

57.Formation of iodinated protein in saliva. Weiss M., Weiss G., Terroux K.G. Burgen

A.S.V. Nature.Lond. 1962 194 186.

58. The role of plasma colloid osmotic pressure in the regulation of extracellular fluid. Burgen A.S.V. Francombe W.H. Excerpta Medica. Int.Cong. 1962 series 48.

59. Infusion of non-autologous plasma: effects of chlorpheniramine and prednisolone and adrenaline. Hutchison J L., Burgen A.S.V. Brit.Med.J. 1963 ii 904.

60. Osmotic activity of gastric secretion. Burgen A.S.V. 1963 Pathophysiology of

peptic ulcer. McGill University Press, Montreal. 61. Intestinal absorption of tritium-labelled folic acid in idiopathic steatorrhea.

Kinnear D.G., Johns D.G., Maclntosh P.C., Burgen A.S.V. and Cameron D.G. Can. Med.Ass.J. 1963 89, 975

62.Some processes concerned with the secretion of sodium, bromide and

chloride in saliva. Burgen A.S.V., Terroux K.G. J.Physiol., 1963 169, 663. 63. Pattern of optic nerve connections following retinal regeneration. Grafstein.B.,

Burgen A.S.V., Progress in Brain Research 1964, 6, 126.

64. The comparative activity of arecoline and arecoline N-Metho salt. Burgen A.S.V. J.Pharm. 1964, 16, 638.

65. The predictive value of animal toxicity tests. Burgen A.S.V.

Eval.New Drugs in Man. proc 2nd International Pharmacological Meeting. 1963.

66*.The inhibition of noradrenaline uptake by sympathomimetic amines in

the rat isolated heart. Burgen A.S.V. L.L. Iversen. Brit. J. Pharmacol., 1965 25 ., 1. 67. The role of ionic interaction at the muscarinic receptor. Burgen A.S.V. Brit.J. Pharmacol. 1965, 25 ,

68. The secretion of non-electrolytes by the salivary glands. Burgen A.S.V. Res.on Pathogenesis of Cystic Fibrosis , 1966. Wickersham Prtnting Co. 69.The uptake of isoprenaline and noradrenaline by the perfused rat heart.

Callingham B.A., Burgen A.S.V. Molec.Pharmacol. 1966, 2 , 37. 70. The pharmacological basis of drug interactions in the nervous system.

Burgen A.S.V. Excerpts Medica Intl.Congress Series 129. 1966. 71. L'Action des medicaments muscariniques sur le flux de rubidium dans

lea tissus musculaires lisses. Burgen A.S.V. J.Physiol.Paris 1966.58 481. 72. The drug-receptor complex. Burgen A.S.V. J.Pharm.Pharmac. 1966,

18, 137-149. 73. Membrane potentials and the secretory activity of the acinar cells.

Burgen A.S.V. in Secretory Mechanisms of Salivary Glands 1967. Academic Press, New York.

74. Secretory processes in the salivary glands. Burgen A.S.V. in Handbook of

Physiology Chapter 35. 1967.

75. Investigation of a hapten-antibody complex by nuclear magnetic resonance. Burgen A.S.V., Jardetzky O., Metcalfe J.C., Wade-Jardetzky, N. Proc. Nat.Acad.Sciences, 1967, 58, 447.

76. The effects of Drugs on membrane transport. Burgen.A.S.V. Proc. roy.Soc.Med. 1967 60 .329.

77. The proton relaxation of benzyl alcohol in erythrocyte membranes. Metcalf J.C., Seeman P.,Burgen,A.S.V. Molec.Pharmacol., 1968, 4. 87.

78*. The action of acetylcholine and other drugs on the efflux of potassium and rubidium from smooth muscle of the guinea-pig intestine.Burgen A.S.V. Spero,L. Brit.J.Pharmacol.,1968, 34 ,99.

79. Anaesthetics and cell membranes. Burgen A.S.V. Arch.Pharmak.

Exp. Path., 1968, 2, 259.

80. On the mechanism of binding of choline derivatives to an anticholine antibody. Metcalfe J.C., Burgen A.S.V. Jardetzky O. Molecular .Association in Biology. 1968, Academic Press, New York.

81. Calcium excitable cells. Burgan A.S.V., Proc.roy.Soc.Med., 1968,

61 67. 82. The state of quaternary ammonium ions in solution. Burgen

A.S.V., Nogrady T., Brit.J.Pharmacol. 1969, 35 ,375.

83. Spin-lattice relaxation of methyl protons in some compounds of biological interest. Nogrady T., Burgen A.S.V. J.Amer.Chem.Soc.,1969, 91, 3890.

84.The structural features determining the affinity of haptens for an antibody binding acetylcholine. Marlow H.F., Metcalfe J.C. and Burgen A.S.V. Molec.Pharmacol., 1969, 5, 166.

85. The specifity of drug receptors. An immunochemical model for cholinergic receptors. Marlow H.F., Metcalfe J.C., Burgen A.S.V. Molec.Pharmacol., 1969, 5 , 156.

86. The application of nuclear magnetic resonance to pharmacological problems. Burgen A.S.V., Metcalfe J.C. J.Pharm.Pharmacol., 1970, 22, 153.

87. The use of nuclear magnetic resonance (NMR) in pharmacology.

Burgen A.S.V., Metcalfe J.C. 4th.Cong.Pharmacol. 1969.

88. Receptor mechanism . Burgen A.S.V.

Ann.Rev.Pharmacol.,1970, 10, 7. 89. Sulphonamide complexes of human carbonic anhydrases ultraviolet difference spectroscopy. King R.W., Burgen A.S.V., Biochim. Biophys.Acta. 1970, 207, 278.

90. The nature of complex formation. Burgen A.S.V. Ciba

Foundation Symposium on Molecular Properties of drugs 1970, 263.

91. The effects of calcium and magnesium on the response of intestinal smooth muscle to drugs. Burgen,A.S.V., Spero L. Brit.J.Pharmacol.,1970, 40 , 492.

92*. Influence of pH on the kinetics of complex formation between aromatic sulfonamides and human carbonic anhydrase. Taylor P.W.,King R.W., Burgen A.S.V. Biochemistry, 1970, 9 ,3894.

93. Kinetics of complex formation between human carbonic anhydrases and aromatic sulfonamides. Taylor P.W., King R.W., Burgen A.S.V. Biochemistry 1970, 9 , 2638.

94. The binding of benzyl alcohol to erythrocyte membranes. Burgen A.S.V., Colley C.M., Metcalfe J.C., Metcalfe S.M. and Turner C.B.,Brit.J.Pharmacol. 1970, 39, 217.

95. Investigation of ligand binding with cobalt (II) human carbonic anhydrase by 1 H and 19F magnetic resonance spectroscopy. Taylor P.W., Feeney J., Burgen A.S.V., Biochemistry 1971, 10 ,3866.

96. Conformatorial studies of oxytocin and lysine vasopressin in aqueous

solution using high resolution NMR. Feeney J., Roberts, G.C.K., Rockey J.H., Burgen A.S.V., Nature New Biology 1971, 232 , 108

. 97. Inhalation Anaesthesia: Mode of action. Burgen A.S.V.. General Anaesthesia (third edition) Ed.T.Cecil Gray and J.F. Nunn Volume I ( Basic Sciences) Butterworths. 1971. 98. Labelling of cholinergic receptors in subcellular fractions from rat

cerebral cortex. Hiley C.R., Young J.M. Burgen A.S.V. Biochem.J. 1972 , 127 ,.86.

99. Shifting targets for our magic bullets. In: The Challenge of life: biomedical progress

and human values. Burgen, A.S.V., in Roche Anniversary Synposium, Basel 1971. Edited by Kunz R.M. and Fehr H. Basel, Birkhauser Verlag. 1972 p.374.

. 100. The action of botulinum toxin on neuromuscular transmission. Burgen A.S.V. In: International Encyclopedia of Pharmacology and Therapeutics, Section 14 Vol. 1. Edited by Cheymol. J., Oxford Pergamon Press, 1972.

101. J.F. Gaddum's Pharmacology, seventh edition, London, Oxford University

Press, 1972. by Burgen A.S.V.and Mitchell J.F. 102. Conformational study of some component peptides of pentagastrin. Feeney, J.,

Roberts, G.G.K., Brown J.P., Burgen A.S.V., Gregory H., J.Chem. Soc. Perkin Trans. 1972, II, 601.

. 103. Homologues of benzilylcholine mustard. Young J.M. Hiley C.R.and

Burgen A.S.V. J.Pharm.Pharmac. 1972, 24, 950. 104. Cyanide binding to carbonic anhydrase. A 13 C-nuclear-magnetic resonance

study. Feeney J., Burgen A.S.V., Grell E., Eur.J.Biochem. 1973, 34, 107.

105. The binding of 3 H-propylbenzilylcholine mustard by longitudinal muscle strips from guinea-pig small intestine. Burgen A.S.V., Hiley C,R., and Young J.M., Br.J.Pharmacol., 1974, 50 ,145.

. 106. The distribution of muscarinic receptor sites in the nervous system

of the dog. Hiley C.R., Burgen A.S.V. Journal of Neurochemistry, 19 74 , 22 , 159.

107. The properties of muscarinic receptors in mammalian cerebral cortex.

Burgen A.S.V., Ililey C.R., Young J.M. Br.J.Pharmac. 1974. 51 2 79. 108. Unequivocal assignments of NH proton magnetic resonance bands in oxytocin

using 2 H and 15 N substituted molecules. Bradbury A.F., Burgen A.S.V . Feeney J., Roberts C.C.K., Smyth D.G. FEBS Letters 1974, 42, 179.

109. Structure-activity relationships in the sulphonamide-carbonic

anhydrase systems. Burgen A.S.V., King R.W. Brit.J.Pharm. 1974, 51, 126P.

110. NMR studies of the binding of substrate analogues to L.Casei Dihydrofolate reductase. Burgen A.S.V., Dann J., Feeney J.,Roberts G.C.K., Yuferov V.P., Brit. J. Pharmacol., 1974, 51,126p.

111. Two populations of acetylcholine receptors in guinea-pig ileum. Burgen A.S.V., Hiley C.R. Brit.J.Pharm.1974, 51, 127P

112*. Nuclear magnetic resonance studies of the binding of substrate analogues and coenzyme to dihydrofolate reductase from lactobacillus casei. Roberts G.C.K., Feeney J. Burgen A.S.V., Yuferov V. Dann J.G. and Bjur R. Biochem., 1974, 13, 5351.

113*. The binding of flexible ligands to macromolecules. Burgen A.S.V., Roberts G.C.K. and Feeney J. Nature 1975 253 753.

114* A nuclear magnetic resonance study of the interaction between vancomycin and acetyl-D-alanyl-D alanine in aqueous solution. Brown J.P., Feeney J. and Burgen A.S.V. Mol. Pharmacol., 1975, 11, 119 115. Research: The possibilities of medical innovation. Burgen A.S.V..Proc. Roy. Soc. Med.1975, 67, 1273-1274

116. Conformational studies on hormonal peptides using nuclear

magnetic resonance spectroscopy. Feeney J., Roberts G.C.K., and Burgen A.S.V. in Molecular and Quantum Pharmacology pp. 301-312. Ed. E. Bergmann and B.Pullman. D. Reidel Publishing Company, Dordrecht-Holland.

117. A structure-activity study by nuclear,magnetic resonance of peptide interactions with vancomycin. Brown J.P. Terenius L., Feeney J. and Burgen A.S.V. Molecular Pharmacology 1975, 11, 126

118*. 31 P nuclear magnetic resonance studies of NADPH and NADP+ binding to L.casei dihydrofolate reductase. Feeney, J., Birdsall, B., Roberts C.C.K., and Burgen A.S.V. Nature 1975, 257 , 564.

119. The use of an alkylating antagonist in investigating the properties of muscarinic receptors. Hiley C. R., Burgen A.S.V. in

Cholinergic Mechanisms Ed. P.C. Waser, Raven Press. New York 1975.

120. Interactions of agonists and antagonists with the muscarinic

receptor. Hulme E.G., Burgen A.S.V., Birdsall N.J.M., L'Inserm 1975. 50. 49.

121. Binding of agonists and antagonists to muscarinic receptors.

Birdsall N.J.M., Burgen A.S.V. Hiley C.R., and Hulme E.C., J.Supramolecular structure 1976, 4, 367.

122. A nuclear magnetic resonance study of nicotinamide adenine dinucleotide phosphate binding to lactobacillus casei dihydrofolate reductase. Way, James L. Birdsall B., Feeney J., Roberts C.C.K., and Burgen A.S.V. Biochemistry 1975 , 14, 3470.

123. *Kinetic aspects of structure-activity relations; the binding of

sulphonamides by carbonic anhydrase. King R.W., and Burgen A.S.V. Proc.R.Soc. London B., 1976, 193, 107.

124. Animals in medical progress. Burgen A.S.V. ,Conquest, 1976,

167, 2.

125. Preparation of selectively deuterated aromatic amino acids for use in IH NMR studies of proteins. Griffiths D.V. Feeney J., Roberts G.C.K. Burgen A.S.V. Biochimica et Biophysica Acta, 1976, 446, 479.

126. 'Les recepteurs muscariniques. Burgen A.S.V.,Actualités Pharmacologiques,1977, 29, 143.

127. Axotomy causes loss of-muscarinic receptors and loss of synaptic contacts in the hypoglossal nucleus. Rotter A. Birdsall N.J.M., Burgen A.S.V. Field P.M., and Raisman G. ,Nature, 1977. 266. 734

128*. IH Nuclear Magnetic Resonance Studies of Lactobacillus casei dihydrofolate reductase; effects of substrate and inhibitor binding on the histidine residues. Birdsall B. Griffiths D.V. Roberts G.C.K.,Feeney.J. Burgen A.S.V. Proc. R. Soc. Lond. B., 1977, 196, 251.

129. 1H Nuclear magnetic resonance studies of the tyrosine residues of selectively deuterated Lactobacillus casei dihydrofolate reductase. Feeney J., Roberts G.C.K., Birdsall B. Griffiths D.V., King R.W., Scudder P. and Burgen A.S.V. Proc. R. Soc. Lond. B., 1977, 196, 267.

130. Occupancy of muscarinic acetylcholine receptors stimulates a guanylate cyclase in neuroblastoma cells. Strange P.G. Birdsall N.J.M.,Burgen A.S.V. Biochem. Soc. Trans., 1977, 5, 189

131*. The binding of antagonists to brain muscarinic receptors.

Hulme E.C. ,Birdsall N.J.M. ,Burgen A.S.V. and Mehta P. Molecular pharmacology, 1978, 14, 737.

132*. The binding of agonists to brain muscarinic receptors.

Birdsall N.J.M., Burgen A.S.V., and Hulme E.C. Molecular Pharmacology, 1978, 14, 723.

133. Processes underlying the interaction of chemicals with biological systems. Burgen A.S.V.in Biological Activity and Chemical Structure Edited by J.A. Keveroing Buisman, Amsterdam, Elsevier Scientific, 1977. 83.

134. Proximity of two tryptophan residues in dihydrofolate reductase determined by 19F NMR. Kimber B.J. Feeney J. Roberts G.C.K., Birdsall B. Griffiths D.V., and Burgen A.S.V. Nature, 1978, 271, 184

135. Nuclear magnetic resonance studies of ligand binding to dihydrofolate reductase. Burgen A.S.V. Feeney J. Roberts G.C.K. Brit. J. Pharmacol., 1977, 59, 521p.

136. 31P and 1H NMR studies of coenzyme binding to dihydrofolate reductase. Birdsall S. Burgen A.S.V., Feeney J.and Roberts G.C.K. Brit. J. Pharmacol, 1977, 59, 520P

137. Co-operativity in ligand binding to dihydrofolate reductase. Birdsall B., Burgen A.S.V., Feeney J., Rodrigues de Miranda J.F., and Roberts G.C.K. Brit. J. Pharmacol., 1977, 59, 521P.

138. Cooperativity in ligand binding to dihydrofolate reductase. Birdsall B., Burgen A.S.V., Rodrigues de Miranda J.F. and Roberts G.C.K.Biochemistry, 1978, 17, 2102

139. 31P NMR studies of the binding of adenosine-2’ phosphate to

Lactobacillus casei dihydrofolate reductase. Birdsall B., Roberts G.C.K., Feeney J., and Burgen A.S.V. FEBS Lett., 1977, 80, 313.

140. Interactions of peptides derived from the C-Fragment of ß-Iipotropin with brain opiate receptors, Birdsall N.J.M., Bradbury A.F., Burgen A.S.V. .Hulme E.C., Smyth D.G. and Snell C.R. Brit. J. Pharmacol., 1976, 58, 460p.

141. Correlations between the binding properties and pharmacological responses of muscarinic receptors. Birdsall N.J.M., Burgen A.S.V.andHulme E.C. Cholinergic Mechanisms and Psychopharmacology.Edited by D.J. Jenden, New York, Pienum Press, 1978, 25.

142. Muscarinic receptors: ionic Perturbation of the binding properties. Birdsall N.J.M., Burgen A.S.V. ,Hulme, E.C. andWells J.W. Brit. J. Pharmacol. 1977, 59, 503P

143. Large scale purification and characterization of dihydrofolate reductase from a methotrexate-resistant strain of Lactobacillus casei.Dann J.G., Ostler G, Bjur R.A., King R.W., Scudder P.,Turner P.C., Roberts G.C.K., and Burgen A.S.V. Biochem. J., 1976, 157, 559.

144. Dihydrofolate reductase , II: Interactions with the coenzyme , NADPH. Feeney J.,Birdsall B., Roberts G.C.K. and Burgen A.S.V.in NMR in biology. Edited by R.A. Dwek, London, Academic Press, 1977, 111.

145. 19F Nuclear magnetic resonance studies of ligand binding to 3-fluorotyrosine- and 6-fluorotryptophan containing dihydrofolate reductase from Lactobacillus casei. Kimber B.J., Griffiths O.V.,Birdsall B., King R.W., Scudder P Feeney J. Roberts G.C.K. and Burgen A.S.V. Biochemistry, 1977, 16, 3492

146. Dihydrofolate reductase: the use of fluorine-labelled and selectively deuterated enzyme to study substrate and inhibitor binding. Roberts G.C.K., Feeney J. ,Birdsall B. Kimber S., Griffiths D.V., King R.W., and Burgen A.S.V. in NMR in Biology. Edited by R.A. Dwek.London, Academic Press, 1977, 95.

147. Gaddum's Pharmacology. Eighth Edition. Burgen, A.S.V. and Mitchell, J.F. Oxford University Press. 1978,

148. A study of the muscarinic receptor by gel electrophoresis.

Birdsall, N.J.M., Bur-gen A.S.V., Hulme E.C., Brit. J. Pharmacol., 1979, 66 ,337.

149. Dimensions in health research. Search for the Medicines of

Tomorrow. Burgen A.S.V. in Alfred Pletscher's 60th birthday symposium, Basle. Edited by H. Weissback and R.M. Kunz. New York, Academic Press, 1978, 3.

150. Multiple classes of muscarinic receptor binding sites in the brain. Birdsall N.J.M., Burgen A.S.V. ,Hulme E.C. In: Advances in pharmacology and therapeutics. 1: Receptors. Edited by J. Jacob, Oxford, Pergamon Press, 1978, 75.

151. The use of transferred nuclear overhauser effects in the

study of the conformations of small molecules bound to proteins. Albrand J.P., Birdsall B., Feeney J., Roberts G.C.K. , and Burgen A.S.V. International Journal of Biological Macromolecules. 1979 1 37.

152. Muscarinic receptors: Biochemical and binding studies.

Birdsall N.J.M., Burgen A.S.V., and Hulme E.C. In: Recent advances in receptor chemistry. Edited by F. Gualteri, M. Gianneli and C.Melchiore. Elsevier, Amsterdam, 1979, 71

153. Nuclear magnetic resonance studies of the binding of trimethoprim to dihydrofolate rcductase.Cayley, J. ,Albrand J.P., Feeney J., Roberts, C.C.K. ,Piper E.A. and Burgen A,S.V. Biochemistry ,1970, 18, 3886

154. Muscarinic receptors in the central nervous system of

the rat.I.Technique for autoradiographic localisation of the binding of propylbenzilylcholine mustard and its distribution in the forebrain. Rotter, A. ,Birdsall N.J.M. Burgen A.S.V., Field P.M., Hulme E.C. and Raisman G. Brain Research, 1979. 11 , 141.

155. Muscarinic receptors in the central nervous system of the rat. IV.A comparison og the effects of axotomy and

deafferentation on the binding of(3H)propylbenzilylcholine mustard and associated synaptic changes in the hypoglossal and pontine nuclei. Rotter, A., Birdsall N.J.M., Burgen A.S.V., Field P.M., Smolen A., and Raisman G. Brain Research, 1979. 1, 207.

156. NMR evidence for the structure of the complex between penicillin and the DD-carboxypeptidese of streptomyces R61. Degelaen J., Feeney J., Roberts. G.C.K., Burgen A.S.V., Frere J.M., and Ghuysen,J. FEBS LETTERS, 1979, 98 , 53.

157. A nuclear magnetic resonance study of the degradation of penicillin G in acidic solution. Degelaen J P., Loukas S.L., Feeney J., Roberts G.C.K.,and Burgen A.S.V. Journal of the Chemical Society, Perkin, 1979,II, 86.

158. Molecules of Life. Phillips D.C., Burgen A.S.V. ,Feeney J.,

Roberts G.C.K., Abraham E.P., Waley S.C. In: Highlights of British Science, London, Royal Society, 1978, 193.

159*. Guanine nucleotides modulate muscarinic receptor binding in the heart. Berrie C.P., Birdsall N.J.M. Burgen A.S.V., and Hulme E.C. Biochemical and Biophysical Research Communications. 1979, 87 ,1000.

160. The effects of ions on the binding of agonists and antagonists to muscarinic receptors. Birdsall N.J.M., Burgen A.S.V. ,Hulme E.C., and Wells J.W. Brit. J. Pharmacol. 1979, 67, 371.

161*The character of the muscarinic receptors in different regions of the rat brain.Birdsall N.J.M., Hulme E.C., Burgen A.S.V. Proc.Roy.Soc.B., 1979, 207,

162. Dale & Dudley's discovery of acetylcholine in mammals.

Burgen A.S.V. Trends in Neuroscience 1979,.

163. Drug receptors. Burgen,A.S.V. In: British Medical Bulletin. Smooth muscle 1979, 25, 269.

164. The binding properties of muscarinic receptors in the brain of the frog ( R.temporaria). Birdsall N.J.M., Burgen A.S.V., and Hulme E.C. Brain Research, 1980, 184,385.

165. Ontogeny of muscarinic receptors in rat brain.

Kuhar M.J. Birdsall N.J.M. Burgen A.S.V. and Hulme E.C. Brain Research, 1980, 184, 375.

166. Modulation of the binding properties of muscarinic receptors

and evidence for receptor-effector couplings. Birdsall N.J.M. Berri&, C.P., Burgen A.S.V., and Hulme E.C. Proceedings of the first International Colloquium on Receptors, neurotransmitters and peptide hormones. Edited by

M.J. Kuhar, S. Enna and C. Pepeu. Raven Press, 1979. 167. Effects of p-chloromercuribenzoate on muscarinic receptor

binding in the rat brain. Birdsall N.J.M. Burgen A.S.V., Hulme E.C. and Wong E.H.F. Brit. J. Pharmacol. 1979, .

168. Muscarinic receptors and the nature of their reaction with agonists and antagonists. Burgen A.S.V., Birdsall N.J.M., and Hulme E.C. In: IUPAC Medicinal Chemistry Symposium. Edited by M.A. Simkins, Oxford. Cotswold Press, 19 7 9 .

169. Interpretation of displacement binding data on the muscarinic cholinergic receptor.Wells J.W., Birdsall N.J.M., Burgen A.S.V., Hulme E.C. Proceedings of the Canadian Biochemical Society, 1979.

170*.Pirenzepine Distinguishes between different subclasses of muscarinic receptors. Hammer R., Berrie C.P., Birdsall N.J.M. Burgen A.S.V. and Hulme E.C. Nature 1980, 283, 90.

171. The origins and future of biological standardisation. Burgen A.S.V.In:Dr J. Spaander Symposium, Bilthoven 1979 , 218.

172. Photo-CIDNP Studies of the Influence of Ligand Binding on the Surface Accessibility of Aromatic Residues in Dihydrofolate Reductase.J. Feeney, G.C.K. Roberts, R. Kaptein, B. Birdsall, A. Gronenborn and A.S.V. Burgen Biochemistry 1980 19, 2466.

173. Proton Nuclear Magnetic Resonance Studies of the Effects of Ligand Binding on Tryptophan Residues of Selectively Deuterated Dihydrofolate Reductase from Lactobacillus casei. J. Feeney, C.C. . Roberts, J W. Thomson, R.W. King, D.V. Griffiths, and A.S.V. Burgen Biochemistry 1980 ,19, 2316.

174. Histidine Residues of l,actabacillus casei Dihydrofolate Reductase:Paramagnetic Relaxation and Deuretium-exchange studies and assignments.

Assignments.P. Wyeth, A. Gronenborn, B.Birdsall, G.C.K. Roberts, J.Feeney, and A.S.V.Burgen. Biochemistry 1980,19,2608.

175.Binding of Coenzyme Analogues to Lactobacillus casei Dihydrofolate Reductase:Binary and Ternary Complexes. B. Birdsall, A.S.V. Burgen, and G.C.K. Roberts Biochemistry 1980, 19 , 3723.

176. Effects of Coenzyme Analogues on the Binding of p--

Aminobenzoyl-L-glutamate and 2,4-Diaminopyrimidine to Lactobacillus casei Dihydrofolate Reductase B.Birdsall, A.S.V, Burgen, and G.C.K. Roberts Biochemistry 1980, 19 , 3732.

177. Phosphorus-31 Nuclear Magnetic Resonance Studies of the

Binding of Oxidized Coenzymes to Lactobacillus casei Dihydrofolate Reductase. E.I. Hyde, B. Birdsall, G.C.K. Roberts, J. Feeney and A.S.V. Burgen. Biochemistry 1980 19 3746.

178*.Competitive Binding Studies with Multiple Sites Effects

Arising from Depletion of the Free Radioligand. J.W. Wells, N.J.M. Birdsall, A.S.V. Burgen, and E.C. Hulme. Biochimica et Biophysics, 1980, 632, 464.

179. The use of Saturation Transfer NMR Experiments to Monitor the Conformational Selection Accompanying Ligand-Protein Interactions. B. Birdsall, J. Feeney, C.C.K. Roberts and A.S.V. Burgen FEBS Letters 1980, 120, 107.

180. Pirenzepine a I,igand with original Binding Properties to Muscarinic Receptors. N.J.M.Birdsall, A.S.V. Burgen, R. Hammer, E.C. Hulme, and J. Stockton R.Scand. J. Gastroent. 1980, 15, Suppl. 66, 1.

181.Negative cooperativity between folinic acid and coenzyme in

their binding to L.casei dihydrofolate reductase. B. Birdsall, A.S.V. Burgen, E.I. Hyde, G.C.K. Roberts and J.Feeney Biochemistry. 1981, 20, 7186.

182. The charge state of trimethoprim binding to L.casei diliydrofolate reductase. G.C.K. Roberts, J. Feeney, A.S.V. Burgen and S. Daluge. FEBS Letters 1981, 131 , 85.

183. 13 C NMR Evidence for three slowly interconverting conformations of the dihydrofolate reductase-NADP --folate complex B. Birdsall, A Gronenborn, G.M. Clore, G.C.K. Roberts, J. Feeney and A.S.V. Burgen. BBRC 1981, 101, 1139.

184. H1 Nuclear magnetic resonance study of the complexes of two diastereoisomers of Folinic Acid with Dihydrofolate Reductase. J.Feeney, B. Birdsall, J.P. Albrand, G.C.K. Roberts, A.S.V. Burgen, P.A. Charlton and D.W. Young. Biochemistry 1981, 20, 1837.

185. Subclasses of muscarinic receptors in: Psychopharmacology

and Biochemistry of Neurotransmitter Receptors. N.J.M. Birdsall, E.C. Hulme, P.. Hammer and J. Stockton and A.S.V.Burgen. ed. H.I.Yamamura,Elsevier, N.Y.1981, 97, 137.

186. Two populations of binding sites for muscarinic antagonists

in the rat heart. E.C. liulme, C.P. Berrie, N.J.ti. Birdsall, and A.S.V. Burgen Eur.J.Pharmac. 1081, 73 , P. 137

187. Regulation of acetycholine receptors. A.S.V. Burgen Advances in Pharmacology (Proceedings of the Eighth Internat. Cong. Pharmacology, Tokyo, 1981).

188. Effects of coenzyme binding on histidine residues in L.casei Dihydrofolate reductase.A. Gronenborn, B. Birdsall, E.I. Hyde, G.C.K.Roberts, J.Feeney and ASV Burgen. Biochemistry 1981, 20 ,1717

189. Direct observation by NMR of two coexisting conformations of an enzyme - ligand complex in solution A. Gronenborn, B. Birdsall, E.I. Hyde, C.C.K. Roberts, J. Feeney and A.S.V. Burgen Nature, 1981, 290, P. 273

190. Membrane receptors - the nature of the muscarinic receptors in the heart A.S.V. Burgen, E.C. Hulme, CP Berrie and N.J.M. Birdsall in Godfraind and Meyer (eds.) Cell membrane in function and dysfunction of vascular tissue. Elsevier/North-Holland Biomedical Press, 1981.

191. Muscarinic receptor binding: modulation by nucelotides and ions E.C. Hulme, N.J.M. Birdsall, C.P. Berrie and ASV Burgen. Proceedings of EMBO workshop on drug receptors in the central nervous system, 1980,

192. The antisecretory agent pirenzepine shows an original

spectrum of binding properties to muscarinic receptors NJM Birdsall, EC Hulme, ASV Burgen, CP Berrie and R. Hammer. Hepatogastroenterology, 1980, Suppl. 173

193. 1H and 31 P NMR characterisation of two conformations of the

trimethoprim-NADP - dihydrofolate reductase complex A. Gronenborn, B Birdsall, El Hyde, GCK Roberts, J. Feeney, and ASV Burgen Molecular Pharmacology 1981, 20, 145.

194. Interactions of muscarinic receptors with guanine nucleotides and adenylate cyclase. EC Hulme, NJM Birdsall, CP Berrie, and ASV Burgen in Drug receptors and their effectors. ed. NJM Birdsall, London Macmillan, 1981.

195. ‘Binding states' of muscaranic receptors.

NJM Birdsall, CP Berrie, ASV Burgen, EC Hulme, J. Stockton Proceedings of an International Colloquium on Cholinergic Mechanisms. ed. G. Pepeu, New York, Plenum, 1981

196. The effects of N-bromosuccinimide modification on the binding of ligands to dihydrofolate reductase JWThomson, GCK Roberts ind ASV Burgen Biochemical Journal, 1980, 137, 501.

197. Perturbations of rnuscarinic receptor binding by p-chloromercuribenzoate EHF Wong, NJM Birdsall, ASV Burgen and EC Hulme Federation Proceedings: 1980, 39, 610.

198. Demonstration and characterization of two co-existing

conformations of an enzyme complex by NMR. B. Birdsall, A. Gronenborn, El Hyde, CCK Roberts, J. Feeney and ASV Burgen. Biochemical Sec. Transactions, 1980, 8, 637

199. Conformational changes and drug action. ASV Burgen

Federation Proc. 1981,40, 2727.

200. The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart .N.J.M. Birdsall, ASV Burgen, EC Hulme, JM Stockton and MJ Zigmond. Br.J.Pharmac 1983, 78, 257.

201. Use of Transferred Nuclear Overhauser Effect:Measurements to Compare Binding of Coenzyme Analogues to Dihydrofolate Reductase. J. Feeney, B. Birdsall, GCK Roberts and ASV Burgen. Biochemistry, 1983, 22, 628.

202*. Modification of the Binding Properties of Muscarinic Receptors by Gallamine . JM Stockton, NJM Birdsall, ASV Burgen, EC Hulme Molecular Pharmacology 1983, 23, 551.

203. The effect of p-chloromercuribenzoate on structure-binding relationships of muscarinic receptors in the rat cerebral cortex. NJM Birdsall, ASV Burgcn, EC Hulme, EHF Wong. Brit.J.Pharmac 1983, 80. 197.

204. Muscarinic Receptor Subclasses: Evidence from Binding Studies. NJM Birdsall, EC Hulme, J. Stockton, ASV Burgen, CP Berrie,R. Hammer, EHF Wong and MJ Zigmond in Mandel and DeFeudis (eds) CNS Receptors - from Molecular Pharmacology to Behaviour Raven Press, New York, 1983.

205. The Stereochemistry of Binding to Receptors. ASV Burgen in Ariens, Soudijn and Timmermans (eds) Stereochemistry and Biological Activity of Drugs, Blackwell Scientific Publications, Oxford, 1983.

206. The effect of sulphydryl block on.'the binding of H 1 antagonists to the muscarinic receptor A.S.V. Burgen and C.J. Harbird Brit. J. Pharmacol. 1983, 80, 600.

207. Muscarinic receptors - an overview. ASV Burgen

Trends in Pharmacol. Science, 1984, 1. 208. Trimethoprim Binding to Bacterial and Mammalian Dihydrofolate

Reductase: A comparison by Proton and Carbon-l3 Nuclear Magnetic Resonance. Birdsall B, Roberts G.C.K., Feeney J. Dann J.G., and Burgen A.S.V. Biochemistry 1983, 22, 5597.

209. Topics in Molecular Pharmacology ed. Burgen A.S.V. and Roberts G.C.K. Volume I (1983) Elsevier

210. Topics in Molecular Pharmacology ed. Burgen A.S.V. and Roberts G.C.K. Volume II (1983) Elsevier

211. Ab initio Molecular orbital calculations of electron distribution

in tetramethylammonium ion Barrett A.N., Roberts G.C.K., Burgen A.S.V. and Clore G.M. Mol. Pharmacol. 1983, 24, 443.

212. International Co-operation in Science. A.S.V. Burgen Trans. of Royal

Society Canada,Series IV, 1984,VolumeXXII . 213. Gaddum's Pharmacology. Ninth Edition. Burgen A.S.V. and Mitchell J.F.,

Oxford University Press. 1985. 214. The road to rational drug design. Burgen A.S.V. in Innovative approaches in drug research.ed. A.F. Harris, 1986,9, Elsevier, Amsterdam 215. The effect of ionic strength on cardiac muscarinic receptors. A.S.V.

Burgen. Br. J. Pharmac 1986, 88, 451 . 216. Drug Receptors & Dynamic Processes in Cells. Alfred Benzon

Symposium 22. ed. J.S. Schou, A. Geisler, S. Norn, Munksgaard Copenhagen 1986

217. Topics in Molecular Pharmacology

ed. Burgen A.S.V. and Roberts G.C.K..Volume III ,1986, Elsevier

218.Topics in Molecular Pharmacology ed. Burgen A.S.V., Roberts C.C.K., and Anner B.M.Volume IV ,1987, Elsevier

219. History and basic properties of the muscarinic receptor

in The Muscarinic Receptors ed.J.Heller Brown. Humana, New Jersey.

220. Some consideration of receptor specificity in

Subtypes of Muscarinic Receptors IV ed. Ruth Levine,,N.J.M.Birdsall, Elsevier,Cambridge

221. Evolution and acetylcholine receptors

Progress in Brain Research 1993, 98 , 129. 222 Goals and purposes of higher education in the 21st century. ed Arnold Burgen. Jessica Kingsley,1996. 223, The Idea of Progress. ed, A.Burgen,P.Mclaughlin& J Mittelstrass. De Gruyter, 1997. 224. Growing up with Science. ed. K Harnqvist & A.Burgen. Kingsley, 1997. 225. Information flow in the Nervous system, European Review,1993, 1,31. 226. Francois Magendie and the New Science of Drugs. European Review, 1996, 4, 165. 227. Progress in Pharmacology. Clin Pharmac. Ther. 1995, 57, 1. 228. The background of the Muscarinic system. Life Sciences 1995, 56, 801. 229. Obecne modele organizacji nauki w Europie zachodniej. Nauka, 1997, 1, 11. 230. What does my left hand know? European Review 1999, 7, 53-7. 231. Exact numbers.

European Review 2000, 8, 498-502. 232. Is this a new sociology of science? European Review, 2002, 10, 417-422. 233. St.Anthony’s Gift. European Review, 2003, 11, 27-36. 234. An explosive study. European Review, 2004, 12, 209-216 235. Tobacco. European Review, 2005, 13, 577-591