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Superior bio-friendly systems for enhanced wood durability
Patrycja KwaśniewskaThe Institute of Wood Chemical Technology
Poznan University of Life Science
ALKALOIDS AS POTENTIAL
FUNGISTATIC SUBSTANCES
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Superior bio-friendly systems for enhanced wood durability
WHAT ARE AN ALKALOIDS?
They are characterized by three key features: The nitrogen atom is usually present in a ring system
The compounds are of natural origin
The compounds manifests significant physiological effects
on human and animal organisms
caffeine
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Superior bio-friendly systems for enhanced wood durability
caffeine
nicotine
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Superior bio-friendly systems for enhanced wood durability
Examples of well-known alkaloids
morphine nicotine
quinine
codeine
cocaine
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Superior bio-friendly systems for enhanced wood durability
Nature is an almost infinite
source of chemicals.
Frequency (%) of chemical compounds types with fungicidal activity
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Superior bio-friendly systems for enhanced wood durability
Nature is an almost infinite
source of chemicals.
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Superior bio-friendly systems for enhanced wood durability
Examples of alkaloids with fungicidal activity Arecoline Berberastine Berberine Canthin-6-one Chelerythrine Dehydroglaucine Dictamnine Emetine Frangufoline Isoboldine Jatrorrhizine Liriodenine Lupanine Methoxybrassitin Reticuline Rubijervine Sanguinarine Serpentine Solamargine Solanine Solasodine Theaflavin Tomatine Tryptanthrin
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Superior bio-friendly systems for enhanced wood durability 8
THE SIMPLEST DIVISION OF ALKALOIDS
Because of the diversity in terms of chemical structure,
origin and pharmacological
activity can be many ways of classification.
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Superior bio-friendly systems for enhanced wood durabilityPatrycja Kwaśniewska 9
New active ingredient registrations for
conventional pesticides from 1997 to 2010 organized by
source.
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Superior bio-friendly systems for enhanced wood durability 10
TLC - Bioautography
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Superior bio-friendly systems for enhanced wood durability
References:[1] Pelletier S.W., The Nature and Definition of an Alkaloid, Department of Chemistry The University of Georgia, (1998)
[2] Aniszewski T., Alkaloids - Secrets of Life: Alkaloid Chemistry, Biological Significance, Applications and Ecological Role, Elsevier Science & Technology, (2007) 100
[3] Wink M., Quinolizidine Alkaloids: Biochemistry, Metabolism and Function in Plant and Cell Suspension Cultures, Planta medica, (1987) 509 – 513
[4] Dewick, P.M., Medicinal Natural Products, 3rd. Ed. Wiley, (2009) 310
[5] Boulogne I., Petit P., Ozier-Lafontaine H., Desfontaines L., Loranger-Merciris G., Insecticidal and antifungal chemicals produced by plants: a review, Environ Chem Lett 10, (2012) 325–347
[6] M. K Kathiravan et al. , The biology and chemistry of antifungal agents: A review, Bioorg. Med. Chem. 20 (2012) 5678–5698
[7] Verpoorte R., Pharmacognosy in the New Millennium: Leadnding and Biotechnology , J. Pharm. Pharmacol. 52, (2000) 253-262
[8] Mosby, Saunders, Netter & more, Alkaloids in Pharmacopoeial and related drugs of biological origin, Evanston, USA, (1995) 26, 353-359
[9] Cantrell C.L., Dayan F.E., Duke S.O., Natural Products As Sources for New Pesticides, J. Nat. Prod. 75, (2012) 1231−1242
[10] Choma I.M., GrzelakE.M., Bioautography detection in thin-layer chromatography, Journal of Chromatography A 1218, (2011) 2684-2691