Ask Not What the NIH Can Do For You; Ask What You Can Do For the NIH Philip E. Bourne Ph.D.

Associate Director for Data ScienceNational Institutes of Health

http://www.slideshare.net/pebourne

The Backdrop…

To foster an ecosystem that enables biomedical research to be conducted as a digital enterprise that enhances

health, lengthens life and reduces illness and disability

So what can you do for the NIH?First, some background

a) We believe what you are doing in discovery informatics to be very important to the ADDS mission

b) We have defined 5 thematic areas to pursue so how can you help?

Here are the areas….

Associate Director for Data Science

CommonsTrainingCenter

BD2KModifiedReview

Sustainability* Education* Innovation* Process

• Cloud – Data & Compute

• Search• Security • Reproducibility

Standards• App Store

• Coordinate• Hands-on• Syllabus• MOOCs

• Community• Centers• Training Grants• Catalogs• Standards• Analysis

• Data Resource Support

• Metrics• Best

Practices• Evaluation• Portfolio

Analysis

The Biomedical Research Digital Enterprise

Communication

Collaboration

Programmatic Theme

Deliverable

Example Features • IC’s• Researchers• Federal

Agencies• International

Partners• Computer

Scientists

Scientific Data Council External Advisory Board

* Hires made

Lets take each area one at a time

1. Sustainability & the Commons

Source Michael Bell http://homepages.cs.ncl.ac.uk/m.j.bell1/blog/?p=830

What The Commons Is and Is Not

Is Not:– A database

– Confined to one physical location

– A new large infrastructure

– Owned by any one group

Is:– A conceptual framework

– Analogous to the Internet

– A collaboratory

– A few shared rules

• All research objects have unique identifiers

• All research objects have limited provenance

http://video.open-bio.org/video/23/biomedical-research-as-an-open-digital-enterprise

The Commons (Vivien Bonnazi & George Komatsoulis (NCBI))

What we beginning to do:• Establishing public/private partnership

• Working with IC’s, NCBI, CIT, the community to identify and run pilots in the cloud, HPC centers, institutions

• Porting DbGAP to the cloud

• Experimenting with new funding strategies

• Evaluating

Sustainability and Sharing: The Commons

Data

The Long Tail

Core Facilities/HS Centers

Clinical /Patient

The Why:Data Sharing Plans

TheCommons

Government

The How:

DataDiscoveryIndex

SustainableStorage

Quality

Scientific Discovery

Usability

Security/Privacy

Commons == Extramural NCBI == Research Object Sandbox == Collaborative Environment

The End Game:

KnowledgeNIHAwardees

PrivateSector

Metrics/Standards

Rest ofAcademia

Software StandardsIndex

BD2KCenters

Cloud, Research Objects,Business Models

What Does the Commons Enable?

Dropbox like storage

The opportunity to apply quality metrics

Bring compute to the data

A place to collaborate

A place to discover

http://100plus.com/wp-content/uploads/Data-Commons-3-1024x825.png

[Adapted from George Komatsoulis]

One Possible Commons Business Model

HPC, Institution …

1. So What Can You Do for the Commons?

Contribute to the discussion on research object identifiers

Contribute to the discussion on provenance for research objects

Propose and implement pilots in the commons

Apply for FY15 RFAs associated with the commons

Critique it!

2. Training (Michelle Dunn)2. Training (Michelle Dunn)

Training Goals:

– Develop a sufficient cadre of researchers skilled in data science

– Elevate general competencies in data usage and analysis across the biomedical research workforce

– Combat the Google bus

How:

– Traditional training grants

– Non-traditional funding mechanisms

– Work with IC’s on a needs assessment

– Work with institutions on raising awareness

– Training center(s)

2. What Can You Do for Training?

Propose new models for training at the intersection of the disciplines

Address the question, are training centers a good idea?

Propose new funding models for training around prizes, challenges, hackathons etc.

Data Discovery Index Coordination Consortium (U24) (under review; FY14)

Centers (under review; FY14)

Metadata standards (under development; FY15)

Targeted Software Development (FY14;FY15)

Workshops (FY14, FY15)

3. BD2K Innovation (Jennie 3. BD2K Innovation (Jennie Larkin and Mark Guyer)Larkin and Mark Guyer)

3. What Can You Do for BD2K/Innovation?

Apply to the RFAs

Respond to the RFIs

Participate in the workshops

Talk to us about what we should be doing in the extramural community to foster the ecosystem

Other?

4. Process

What this involves:

– Policies and procedures

– Grant management and review

– Communicating with the community …

4. What Can You Do for Process?

– Make research object citation a reality

– Support machine readable data sharing plans?

– Support open review?

– Support micro funding?

– Support standing data committees to explore best practices?

– Support Crowd sourcing?

– [your ideas here….]

5. Collaboration

Between funding agencies

Between different branches of the federal government

Between countries / geographic regions

Between communities / disciplines

5. What Can You Do for Collaboration?

Continue to do what you are doing

Encourage interagency funding initiatives

Suggest workshops that bring folks together

Suggest mechanisms for making the collaborations stick

Suggest ways to stimulate communities

Your ideas here ….

That’s enough for you to do for one day…

Thanks for listening and acting as I know you will (no pressure)

Some Acknowledgements

Eric Green & Mark Guyer (NHGRI)

Jennie Larkin (NHLBI)

Leigh Finnegan (NHGRI)

Vivien Bonazzi (NHGRI)

Michelle Dunn (NCI)

Mike Huerta (NLM)

David Lipman (NLM)

Jim Ostell (NLM)

Andrea Norris (CIT)

Peter Lyster (NIGMS)

All the over 100 folks on the BD2K team

NIHNIH……Turning Discovery Into HealthTurning Discovery Into Health

philip.bourne@nih.gov