attention-deficit / hyperactivity disorder
DESCRIPTION
Attention-Deficit / Hyperactivity Disorder. Ross Andelman, M.D. Contra Costa Children’s Mental Health CCRMC Noon Lecture Series September 8 th 2009. ADHD Diagnosis - PowerPoint PPT PresentationTRANSCRIPT
Attention-Deficit / Hyperactivity Disorder
Ross Andelman, M.D.Contra Costa Children’s Mental
Health
CCRMC Noon Lecture SeriesSeptember 8th 2009
ADHD Diagnosis
“A persistent pattern of inattention and/or hyperactivity-impulsivity that is more frequent and severe than is typically observed in individuals at comparable level of development.”
DSM IV, APA 1994
ADHD: Current Perspective
Highly prevalent in community studiesExtremely prevalent in clinical samplesDevelopmental disorder Presents in childhood (before age 7) Persists into adolescence and into adulthood
Neurobiological disorder Disorder of executive functionSpectrum ‘heterogeneous’ disorderHighly inheritableResponsive to appropriate treatment
ADHD Etiology-Genetics
Up to 92% concordance in monozygotic twinsHeritability - .75 (twin studies) Comparable to schizophrenia Panic - .48; Height - .92
Siblings - 26-50% in full; 9% in halfFirst degree family members – 20-25%Dopamine transporter gene (DAT1), chr 5Dopamine receptor D4 (DRD4*7), chr 11
ADHD: D/O of Executive Fxn
Shifting from one mindset to another - flexibilityOrganization - anticipating needs & problemsPlanning - goal settingWorking memory (short-term) - receiving, storing, retrieving informationSeparating affect from cognition - detaching emotions from reasonInhibiting and regulating verbal and motoric action - jumping to conclusions too quickly, difficulty waiting in line in an appropriate fashion
ADHD, DSM IV Diagnosis 6 of 9 Sxs of inattention and/or
6 of 9 Sxs of hyperactivity-impulsivity
Sxs present for more than 6 months
Presence of some Sxs before age 7
Impairment in 2 or more settings
Clear evidence of significant social, academic, or occupation impairment
Symptoms not secondary to other Dx
ADHD, DSM IV–Inattentive Symptoms
Fails to give close attention; makes careless mistakes Has difficulty sustaining attention Does not seem to be listening when spoken to Does not follow through; fails to finish tasks Difficulty organizing tasks Avoids tasks requiring sustained mental effort Often loses things Easily distracted by extraneous stimuli Forgetful in daily activities
ADHD, DSM IV-Hyperactivity-Impulsivity
Symptoms Fidgets or squirms
Unable to stay in seat
Runs and climbs excessively
Difficulty playing quietly
On the go (driven by a motor)
Talks excessively
Blurts out answers
Difficulty waiting turn
Interrupts or intrudes on others
ADHD, Presentation-Preschool
Hyperactivity the rule Frequent temper tantrums Impulsive aggression toward peers Fearlessness with frequent injuries Noncompliance with preschool rules & decorum Demanding and argumentative with parents Sleep disturbance Delays in motor-language development
ADHD, Presentation-Elementary Age
Difficulty, especially with challenging work Homework disorganized, messy, with careless errors
Easily distracted, unable to sustain attention Difficulty forming & keeping peer relationships Denny Cantwell's 'lack of social savoir-faire' Perceived as poorly controlled, disrespectful, disruptive, class clown, immature, bad Impulsivity and noncompliance now result in trips to the principal's office
ADHD, Presentation-Adolescence
From 'on the go' to fidgety and restless
School performance inconsistentIf not yet diagnosed, likely to be intelligentPoor organization & poor follow through
Persistent high risk behaviorBike and auto accidentsDrug and alcohol use
Lack of social skills now impacts on both same-sex and opposite-sex
relationships
Failure to meet educational and career goals
Poor organization, time management, and Procrastination
Interpersonal instability at home and at work
Poor social skills 'grown up‘Short fuse, irritabilityInability to maintain long-term relationships
May still be restless or fidgety May be drawn to high risk activities &
substance abuse May have legal problems May have low self-esteem
ADHD, Presentation-Adults
ADHD - Assessment
Diagnostic Bottom Line Diagnostic interviews with parents &
child or adult +/- spouse/ co-worker Rating scales – e.g. SNAP, Vanderbilt,
Conners, & Adult ADHD checklists
Frills and Extras Observation of behavior in natural
contexts Medical and / or neurological evaluation Cognitive, psycholinguistic, and psycho-
educational testing
ADHD, Initial Assessment-Goals
Determine presence of core symptoms (Sxs)
Rule out alternate explanations for symptoms
Assess for co-morbid conditions
Obtain baseline ratings of symptom severity and functional impairment
Educate family about disorder
Dispel myths and normalize condition
ADHD, Initial Assessment-Interview and History
Symptom & impairment history How long / how bad / where / when Family’s understanding of problem What has helped? What has not?
Past mental health history Birth, development, and medical history Social and educational history Family and home environment Family psychiatric history Individual and family strengths and resources
ADHD, Treatment-Goals
Reduce core symptoms of ADHD Establish individual target symptoms
Improve functioning in all areas of impairment Assess for and attend to co-occurring conditions Minimize adverse effects of therapy
ADHD, TreatmentTreatment is Multimodal!
Psycho-Education Psycho-Pharmacology Psycho-Social Educational Interventions Parent Training and Support Social Skills Training Recreational Mainstreaming Individual and Group Psychotherapies
ADHDPsychopharmacology
ADHD, Treatment-Psychopharmacology
Symptoms likely to respond to medication Inattention Impulsivity Hyperactivity Non-compliance with authority Impulsive aggression Social deficits Academic performance
ADHD, Treatment-Psychopharmacology
ADHD, Treatment-Psychopharmacology
Psychostimulants MPH, dextroamphetamine, mixed amphetamines>200 double-blind random controlled trials (RCTs)Typical investigations of efficacy usually quite brief
Other medications found effective in RCTs Tricyclic Antidepressants (>18 trials)AtomoxetineBuproprionalpha-2 agonists
Promising, efficacy not yet fully establishedVenlafaxine, Nicotine, modafinil, donepezil
ADHD, Psychopharmacology
-? Adverse effects of stimulants
Weight loss; Sleep disturbance; Mood lability ? Risk of sudden death ? Induce tics ? Height suppression ? Dependence ? Drug abuse
ADHD, Psychopharmacology
-Stimulants The Andelman (Cantwell-UCLA) Algorithm Trial of one of the long-acting formulations,
titrating dose weekly, and monitoring benefits and side effects through parent and child interviews, and teacher serial checklists Concerta 18mg – 36 mg – 54 mg qAM; Metadate CD 20mg – 40 mg - 60mg qAM; Dexadrine Spansule 10 mg – 20 mg - 30mg qAM; Adderall XR 10 mg – 20 mg -30mg qAM Vyvance 20mg – 30 mg – 40 mg – 50 mg qAM
ADHD, Psychopharmacology
-Beyond Stimulants
Atomoxetine (Strattera) Initiate 0.5mg/kg/D qAM or 10mg Titrate alt weekly to 1.2mg/kg or 80mg Max
Bupropion (Wellbutrin [SR]) Initiate 3mg/kg/D qAM to TID [BID for SR] Titrate weekly to 7mg/kg/D or 400mg Max
Clonidine (Catapres) or Guanfacine (Tenex) Initiate 0.05mg qHS (.5mg Guanfacine) Titrate weekly to .05mg TID (.5mg Guanfacine),
then to .1mg TID Max (1mg TID Guanfacine)
ADHD, Treatment-Psychosocial interventions
• Behavioral parent support & training• Bibliotherapy / Organizational support
• Behavioral classroom interventions
• Social skills group therapy
• Individual psychotherapy• Unfortunately not all that useful
ADHD, Treatment-Parent training
ADHD, Psychosocial Treatment
-Parent Training
Normalize hygiene – food and sleep Consistency in expectations / discipline Positive reinforcement Homework & Chores
Provide structure and predictability Modeling good organizational skills Home-school-clinician communication Exercise & relaxation
ADHD, Psychosocial Treatment
-Parent Training –Behavioral Mod Positive attending
Catch the child doing good: Be specific!
Contingency contracting Identifying “target behaviors”
Establishing behavioral baseline Ignoring low-level negative behaviors
Creating positive reward systems Selected use of “punishment” Shaping, cueing, modeling
Parent Training-Creating positive rewards
Parent Training-Creating positive rewards
-Parent TrainingSelective ignoring
ADHD, Psychosocial Treatment
-School-based interventions
ADHD, Psychosocial Treatment
- Self Discipline (Adult)
Normalize hygiene Food and sleep Exercise & relaxation
Structure and predictability Developing good organizational skills Attention to schedule, deadlines, &
priorities
ADHD, Treatment-Psycho-Education:
Bibliotherapy Driven to Distraction: Recognizing and Coping with
Attention Deficit Disorder from Childhood through Adulthood,
Hallowell and Ratey, 1995. Attention Deficit Hyperactivity Disorder: What Every
Parent Wants To Know, Wodrich, 1994. ADHD 102: Practical Strategies for Reducing the
Deficit, Frank and Smith, 2001.
Getting a Grip on ADD: A Kids Guide to Understanding and Coping With Attention Disorders, Frank and Smith, 1994.
I Would If I Could : a Teenagers Guide ADHD Hyperactivity, Gordon, 1992.
ADHD Treatment
QUESTIONS?