aubrey de grey's slide - nigeria ict fest 2015
TRANSCRIPT
Aubrey D.N.J. de Grey, Ph.D.Chief Science Officer
SENS Research [email protected]
http://www.sens.org/
Most infectious diseases have been easily prevented
Sanitation Vaccines Antibiotics Carrier control
Age-related diseases have not. Why not?
reduced light adaptationreduced ethanol metabolismaltered drug pharmacokineticssomatopauseloss of cardiac adaptabilityincontinenceimpaired wound healingidiopathic axonal polyneuropathyautonomic neuropathyarrhythmiachronic obstructive pulmonary disorderbenign prostatic hypertrophymenopauseleukoaraiosisstrokevascular dementiafrontotemporal dementiaimmunosenescenceanosmiacachexiaanorexia of agingsystolic hypertensionageusiaerectile dysfunctionorthostatic hypotensionimpaired adaptive beta-cell proliferationfibroblast collapseanergic T-cell clonescellular senescencevascular calcificationimpaired transdermal absorptionimpaired thermoregulationreduced tactile acuityimpaired vasoconstrictionloss of neuromuscular junctionsdelayed withdrawal reflex
impaired pH maintenancereduced chemical clearancealtered dermal immune cell residence and functionaberrant allergic and irritant reactionsloss of skin elasticityimpaired vitamin D synthesisreduced renal reserverenal cortex atrophygut dysbiosisloss of jejunal villus heightimpaired response to vaccinationimpaired thirstlentigo senilisthinning hairimpaired proprioceptionimpaired balancereduced vital capacityreduced cardiorespiratory enduranceimpaired sweat responseimpaired blood distributionnutrient malabsorptiondiverticular diseasepresbyphagiaincreased refluxalveolar lossneuronal losssenile emphysemadegenerative disc diseasejoint calcificationpineal calcificationaberrant differentiationgait instabilityfrontal demyelinationaxonal atrophyimpaired functional connectivityimpaired working memory
presbycusisosteoporosisosteoarthritisautoimmunitygreying hairpresbyopiacataractglaucomatemporal arteritispolymyalgia rheumaticawrinklingAlzheimer's diseasePick's diseasecorticobasal degenerationprogressive supranuclear palsyParkinson's diseasemultiple system atrophydementia with Lewy bodiessarcopeniaglomerulonephritissenile cardiac amyloidosisatherosclerosisarteriosclerosisage-related macular degenerationcardiomyopathydiastolic heart failurecancersystemic inflammationoxidative stressreduced coronary blood flowloss of cardiac reserveandropausethymic involutionreduced plasma renin activityreduced aldosteronereduced melatonin diurnal rhythm
Aging is:
The life-long accumulation of “damage” to the body that occurs as an intrinsic side-effect of the body’s normal operation.
The body can tolerate some damage, but too much of it causes disease and disability.
PathologyMetabolism Damage(life-long) (late life)
Diseases AgingCommunicable Congenital Chronic
TuberculosisMalaria
HIV…
Tay-SachsMELAS
Li-Fraumeni...
Alzheimer’sCancer
Atherosclerosis…
FrailtySarcopenia
Immunosenescence…
Diseases AgingCommunicable Congenital Specific General
TuberculosisMalaria
HIV…
Tay-SachsMELAS
Li-Fraumeni...
Alzheimer’sCancer
Atherosclerosis…
FrailtySarcopenia
Immunosenescence…
Pathology
Geriatrics
Metabolism Damage(life-long) (late life)
Pathology
Gerontology Geriatrics
Metabolism Damage(life-long) (late life)
Pathology
Gerontology Geriatrics
Metabolism Damage
Maintenance
(life-long) (late life)
Cell loss, cell atrophy
Division-obsessed cells
Death-resistant cells
Mitochondrial mutations
Intracellular junk
Extracellular junk
Extracellular matrix stiffening
No new type of damage
confirmed since 1982
And, I’ve said so without challenge
since 2002
Damage type
Why? That was easy
How? That’s where we have a new plan
What? That’s where we show you it’s a good plan (can be done, is being done)
Cell loss, cell atrophy
Division-obsessed cells
Death-resistant cells
Mitochondrial mutations
Intracellular junk
Extracellular junk
Extracellular matrix stiffening
Cell therapy, mainly
Telomerase/ALT gene deletion plus periodic stem cell reseeding
Suicide genes, immune stimulation
Allotopic expression of 13 proteins
Transgenic microbial hydrolases
Phagocytosis by immune stimulation
AGE-breaking molecules/enzymes
Damage type The maintenance approach
Total synthesis of glucosepane, allowing identification of antibodies and degraders (Science, 2015)
Modified bacterial enzyme protects cells from atherogenic oxysterols (Biotech Bioeng, 2012)
Catalytic antibodies cleave cardiotoxic amyloid (J Biol Chem, 2014)
Much more ongoing in our research centre and funded labs
See their names, their awesome credentials and their hard-hitting endorsement of our research approach at
www.sens.org/about/leadership/research-advisory-board
Cell loss, cell atrophy
Division-obsessed cells
Death-resistant cells
Mitochondrial mutations
Intracellular junk
Extracellular junk
Extracellular matrix stiffening
Cell therapy, mainly
Telomerase/ALT gene deletion plus periodic stem cell reseeding
Suicide genes, immune stimulation
Allotopic expression of 13 proteins
Transgenic microbial hydrolases
Phagocytosis by immune stimulation
AGE-breaking molecules/enzymes
Damage type The maintenance approach
Endothelial cell
Lipid-engorged lysosome
Foamcell
Mathieu et al., Biotechnol. Bioeng. 2012; 109(9):2409-2415
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