AUTHOR INDEX

Abaza, A., 320, 336 Abe, K., 446, 455, 458 Abood, L.G., 11, 13 Acara, M., 502, 511 Adam, K., 318, 341 Adams, H.E., 199,200,201,202 Adams, R.D., 144, 154,215,228,231 Ad hoc committee on hypoglycemia,

226,231 Aghajanian, G.K., 130, 138,238,250,

374,383,385,386,408,409,410, 415,416,439,440,442,484,492, 509,521,522,530

~d,Y.,272,298,407,408,409,410, 412,415,419,435,441

Ahmed, A., 398, 415 Albaum, H.G., 224, 231 Albizzati, M., 433 Ali, N., 402, 413, 420 Allen, R.P., 518, 531 Allen, R.P., 11,13,33,44,200,204,

207,213,238,250,402,414,422 Alpern, HP., 177,184,201,202,288,

298 Alpert,M.,15,30,64, 72,122,129,138 AIson, L., 383, 386 Amatruda, T.T., 277, 282, 293, 304, 313,

314,336 Ambani, L., 376, 377, 385,

393, 398, 399, 415, 424 Anden, N.E., 17,29,374,375,382,383,

384,385,386,395,396,404,409, 411,415,424,435,439,440

Andersen, P., 284, 291,293 Anderson,J.R., 238, 249 Anderson, M.H., 293, 303, 439, 443 Andersson, S.A., 284, 291,293 Andreoli, V.M., 433, 434 Andrews, H.L., 320, 336 Anfred, T., 439, 440 Angrist, B.M., 382, 386 Anonymous editorial (1977), 230, 231 Ansell, G.B., 75, 76, 80,103,116,132,

138,206,212,465,480,484,485, 494,504,515,516,517,518,527, 531

Antebi, R.N., 59, 60, 69, 71

Aoki, K., 463, 480 Appel, S.H., 155,171,230,234 Aprison, M.H., 110,119,196,201,208,

212,270,291,299,486,512 Aquilonius, S.M., 20, 29, 60,76,79,80,

81,87,88,97,103,104,105,106, 114,116,158,166,170,380,386, 401,414,415,435,440,483,484, 490,492,495,496,497,499,502, 503,504,507,516,518,527,534, 537,538

Arab, A., 228, 229, 231 Araguete, A., 200, 204,207,213 Arnfred, T., 47,50,383,386,401,403,

415 Arregui, A., 102, 116 Arvidsson, J., 398, 403, 415 Asberg, M., 41,42 Asnis, G.M., 108, 116 Asper, H., 378, 392,413,415 Atack, C., 409, 419, 436, 440, 464, 480 Atkinson, R.C., 238, 239, 249 Atsev, E., 277, 301 Atweh, S., 484, 492,512, 524, 527, 531 Augustinsson, K.B., 65, 71 Avemo, A., 404, 424 Avemo, E., 404, 424 Avigan, J., 143, 153 Awad, 0., 277, 301 Axelrod, J., 199,203 Ayala, G.F., 278, 297 Ayd, F.J., Jr., 399,415 Azcurra, J.M., 288, 308 Babb, M., 283,287,293 Babb, T.L., 283, 287, 293 Bacha, J.C., 448, 456 Bachelard, H.S., 223, 234 Backerman, I.A., 40, 44 Bacq, S.M., 181,201 Baddeley, A.D., 239, 249 Baden, M.M., 70, 74 Baez, L.A., 404, 415 Baggliolini, M., 413,415 Bailey, J., 41,43 Bain, J.A., 379, 389,494,507 Bak, I.J., 375, 389,400,409,415 Baker, W.W., 280, 287, 293, 294, 376,

549

550

386,398,417 Baldessarini, R.J., 15,29.33,42,109,

118,119,121,122,129,131,136, 140,142,238,250,377,378,390, 392,397,401,404,409,413,419, 420,423,424,439,440,541,547

Baldi, V.,407,416 Bales, P.D., 276, 297 Balfour, D.J.K., 447, 456 Ban, T., 276, 293 Banerjee, U., 280, 293 Banerjie, S.P., 382, 392 Barbeau, A., 160, 170,227,231,376,

378,381,386,398,407,415,421, 426,427,433,434,483,495,497, 498,499,504

Barchas, J.D., 15, 16, 18,20,29,53,61, 64,71,73,76,81,87,88,97,103, 104,106,109,110,115,117,122, 137, 139, 166, 170, 260,261,312, 338,379,380,388,401,414,417, 435,441,447,456,483,495,496, 497,498,499~500,502,503,506, 533,534,537,541,547

Barchas, J.L., 438, 440 Barker, L.A., 218,220,222,231,484,

493,504,515,517,520,521,522, 523,524,525,526,527,528,529

Barnes, C., 282, 294,301 Barnes, L., 274, 294, 298 Baro, F., 426,433 Barraclough, B., 41,42 Barrett, R.J., 486,513 Barros, A., 287, 298 Barrows, C.H., 206, 212, 253, 261 Barry, M., 58, 59, 61 Bartfai, T., 156, 170 Bartholini, G., 11, 13,17,29,282,297,

312,337,374,392,397,407,408, 409,410,411,415,416,420,423, 435,440

Bartolini, A., 196,204,271,296 Basuray, B.N., 78, 80 Batsakis, J.D., 59, 61 Battig, W.F., 241, 249 Baxter, B.L., 278, 294, 313, 314, 336 Beach, R.C., 492,512 Beajouan, J.C., 408,415 Beani,L.,196,201,328,336,407,416 Beaton, J.M., 318, 341 Beaujouan, J .C., 272, 298, 404, 407,408,

AUTHOR INDEX

419,486,509,522,523,529,530 Beaulnes, A., 277,283,296 Beck, R.A., 362, 368, 369 Bedard,P.,375,385,409,415,435,440 Beigel, A., 5, 12 Beleslin, D., 288, 294,328,336 Behnaker, R., 7, 8 Ben-Arl, Y., 267, 268, 269, 287, 291,

294,396,416 Benda, P., 484,511 Benedeth, W.L., 449, 458 Benedict, F., 280, 287, 294 Bennett, G.W., 447, 456 Bennett, J.P., 96, 97, 102,103,106,116,

117,119,155,156,160,161,164, 165,166,167,170,171,172,206, 212,379,380,388,495,500,507

Bergen, D., 76, 82,131,137,141,379, 390

Berger, P.A., 6,7,12,15,16,18,19,20, 29,41,43,53,61,64,71,72,76,81, 87,88,97,103,104,106,109,110, 115, 117, 122, 131, 135, 137, 139, 166,170,255,257,260,261,357, 359,379,380,387,388,401,414, 417,418,435,438,440,441,447, 456,483,495,496,497,498,499, 500,502,503,506,533,534,537, 538,541,547

Berl, S., 220, 230, 231, 232 Berle, J.C., 271,294 Berman, R., 495,504 Bernheim, F., 326, 336 Bernheim, M.L.C., 326, 336 Bernheimer, H., 396, 397, 400, 416, 427,

433 Berry, C.A., 285, 302 Bertilsson, L., 41, 42, 206,207,213,

253,262 Berwald-Netter, Y., 486,509 Besson, M.J., 266, 298, 375, 388, 408,

409,410,412,417,418,435,441 Betz, E., 224, 235 Bevan, J., 39, 44,75,82,121,132,141 Bhargava, H.N., 321,334,336,342 Bhate, S., 402, 413, 420 Bhatnagar, S.P., 435, 440, 484, 504 Bianchi, C.P., 196,201,328,336,407

416 Bianchi, S., 408,417,502,503,505 Bickel, M.H., 11, 14,34,44

AUTHOR INDEX

Biederman, G.B., 177,201,202 Bigelow, L., 16,31,65, 73, 385, 391,

399,422 Bilezikjian, L., 410, 416 Billewicz-Stankiewicz, J., 11, 13 Binaglia, L., 76, 83 Bird, E.D., 96, 97, 102, 106, 116, 117,

130,138,160,161,164,165,170, 171,206,212,213,379,380,386, 388,389,391,400,405,414,416, 419,495,500,504,507

Bird, M.T., 427, 433 Birdsall, N.J.M., 156,172,267,294 Birket-Smith, E., 379, 386, 399, 416 Birkhauser, H., 65, 68, 69, 71 Birkmayer, W., 376, 386, 396, 397,400,

416,427,433 Birks, R., 486, 505,521, 528 Bishop, B.G., 77 80 Bite, A., 277,287,289,306 Bjegovic, M., 46,50, 78, 80 Bjorklund, A., 16,30 Bjornstad, P., 132, 139 Bjornsted, P., 103, 116 Blachut,K., 277, 301 Black, D.A., 277, 282, 293, 304, 313,

314,336 Black-Cleworth, P., 267,310 Blackmore, W., 39, 44, 75, 82, 121, 132,

141 Blackwood, G., 229, 232, 248, 249, 361,

369,497,499,505 Blake, C.A., 448, 449, 450, 455, 456,

458 Bland, B.H., 281,302 Blass, J.P., 143, 144, 146, 148, 153,

154,216,217,218,219,220,221, 222,224,226, 230, 231, 232, 233, 486,505,507,511

Blaustein,M.P.,493,505 Blessed, G., 70, 73, 206, 213, 229, 235,

253,262,402,413,420 Bligh, J., 484,501,505 Blonde, L., 77,83 Bloom, F.E., 373, 374, 386, 391, 404,

405,416,423 Bock, J., 321, 323, 342 Bockaert, J., 274, 300 Bockenheimer, S., 136, 137, 139 Bogdanski, D.F., 34, 39,42 Boggan, W., 287, 307

Bohdanechy, Z., 208, 211 Bohner, B., 288, 295 Boksa, P., 526, 530 Bokums, J.A., 274, 277, 287, 294 Bonnet, V., 276, 294 Booth, R.A., 76, 82, 218, 234, 379,

389,534,538,539 Borbely, A.A., 286, 294 Borison, R.L., 430, 434 Bosanquet, F.D., 425, 433 Bosma, J.F., 107, 119 Bossol0, P.A., 447,456 Botticelli, L.J., 487,505 Bouchard, M., 311,339 Boucher, R.L., 436, 439, 442 Boulding, J .E., 398,421 Boullin, D.J., 502, 507 Bourdois, P.S., 271,294 Bouttier, D., 107, 119 Bouvet, D., 278, 279, 303, 409, 410,

412,419,435,441 Bovens, B.R., 53, 61 Bovet, D., 276, 294 Bowden, C.L., 79, 83

551

Bowen,D.M., 70, 71,205,206,211,213, 228,229,230,232,235,236,253, 259,262

Bower, G.H., 238, 249 Bowers, J., 58, 61,67,69,70,72 Bowers, M.B., Jr., 4,12,18,29,39,42,

75, 80, 375, 376, 377, 385, 386, 393,398,399,409,415,416,424, 435,440

Boyarski, L.L., 288, 297 Boyd, W.D., 229, 232, 248, 249, 361,

369,497,499,505 Box, G.E.P., 246, 249 Bradbury, M.W.B., 446,455,456 Bradley, P.J., 276, 279, 294,492, 510 Braggaar-Schaap, P., 493,511 Brain, the late Lord, 144, 153 Bralower, M., 109, 119,401,424 Branisteanu, D.D., 45,50 Braswell, L.M., 196,203 Braun, L.D., 485, 494, 506, 510, 517,

530 Bremer, J., 75, 80,103,116,132,139,

276,286,294,465,480,515,528 Breton, G., 227, 231 Brezinova, V., 318, 341

552

Brizzee, K.R, 228, 229,232 Brodie,B.B.,11,14,34,39,42,44 Brooke, S., 400, 420 Brooks, D.C., 282, 295 Brown,C.P., 177, 178,204 Brown, G.B., 492,510 Brown, G.C., 181,201 Brown, H., 9,12 Browning, E.T., 75, 76, 80, 222, 232,

465,480,484,505,515,516,520, 528

Browning, R.A., 270, 273, 278, 287, 289,290,304

Brownstein, M., 375, 384, 391, 396, 411,421

Brucher, J .M., 426, 433 Brucke, F.T., 281, 295 Brummel, E., 69, 72 Bruyn, G.W., 100, 116, 379, 386, 426,

428,433 Buchsbaum, M.S., 320, 323, 324, 325,

336,340,342,360 Buchwald, N.A., 284, 285, 295 Bunch, J., 41,42 Bunney, B.S., 272, 273, 290, 307, 374,

383,385,386,408,409,410,415, 416,422,439,440

Bunney, W.E., Jr., 33, 41, 42, 312, 318,337,341

Burack, R, 318, 341 Burden, J., 446, 455, 456, 457 Bures, J., 208, 211 Buresova, 0., 208, 211 Burgen, A.S.V., 156, 172, 267, 294,

395,416,525,528 Burke, G., 525, 528 Burld, H.R, 17, 29, 378, 392, 413,

415 Burks, J .S., 402,416 Burn, J.H., 410,416 Burnett, G.R., 449,456 Burns, L.L., 279, 286, 304 Burt, A.M., 503, 505 Burt, D.R., 109, 116, 134, 139, 156,

170,374,378,382,386,387,429, 433

Buschke, H., 241, 245, 249, 255, 261 Butcher, L.L., 269, 295,375,386,396,

397,404,408,410,416,424,516,

AUTHOR INDEX

518,528 Butcher, S.G., 396, 397,404,408, 416,

424 Butcher, S.H., 375, 386, 516, 518, 528 Butler, R.N., 228, 232 Butterbaugh, G.G., 521,528 Butters, N., 380, 391 Butterworth, R.F., 227, 231 Bylubd, D., 379, 380, 388 Bylund, D.B., 96, 97,106, 117, 160,

161,164,165,167,171,206,212, 495,500,507

Cadilhac, J., 288, 304 Caffey, E., Jr., 402, 413, 420 Cahn, J., 277, 306 Caine, D.B., 122, 129, 139, 376, 387,

407,416,433,434 Camrnelli, E., 321,324,340 Campochiaro,P., 166, 170 Canepa, F.G., 326, 336 Cankat, T.F., 321,324,326,342 Caraceni, T., 502, 503,505 Carlo, D.J., 229, 234 Carlson, H.E., 311, 336 Carlsson, A., 16, 29, 109, 116, 230,

232,374,382,384,386,387,395, 396,397,409,415,416,417,419, 436,440,464,480

Carlton, P.L., 208,211,212,404,417 Carman, J.S., 312, 341 Caroll, B.J., 6, 12 Carpenter, D.O., 267,310 Carrasco, L.H., 206, 213, 229, 236,

253,259,262 Carrick, D.J., 130, 139 Carrol, P.T., 521,523,528 Carroll, B.J., 18,25,29,39,44, 129,

134,135,139,141,447,456 Carson, V.G., 484,505,526,528 Casella, C., 225, 235 Casella, G.A., 230, 232 Casey, D.E., 10, 12, 39,43, 76, 80,

109, 116, 122, 123, 125, 126, 128, 129,130, 131, 134,135,136, 137, 139,141,379,387

Casey,K.L., 319, 336 Casper, R.C., 64, 72 Castaneda, L., 16,31 Cavaunaugh, J., 382, 389 Caveness, W., 65, 66, 73

AUTHOR INDEX

Ceder, G., 484,504,516,527 Cederbaum, S.D., 143, 153, 226, 232 Celesia, G.C., 288, 295 Chabrol, J.G., 486,508 Chadwick, D., 107, 116 Chambers, R.A., 228, 231 Chandler, J.P., 76, 81,132,140,379,

388,485,494,500,506 Chang,M.M., 217,218, 224,233 Chang, S., 9,10,14,19,32,34,39,40,

41,44,49,51,75,76,83,87,97, 110, 115, 119, 131, 136, 142,257, 262,495,496,499,500,512,533, 534,539

Changeux, J.P., 155, 170, 196,202 Charlton, M., 381, 392 Chase, H.P., 224, 233 Chase, N., 49,50 Chase, P.M., 199,204 Chase, T.N., 102, 103, 107, 109, 116,

117,119,159,170,171,378,381, 391,392,397,401,417

Chatfield, P.O., 286, 287,295 Chatonnet, J., 276, 286, 294 Chau-Wong, M., 429, 434 Chavez-Ibana, G., 283, 299, 313, 338 Chaykin, S., 500, 508 Chen, D., 486,512 Chen, G., 288, 295,320,336 Cheney, D.L., 11, 14,206,207,213,

253,262,269,271,272,283,295, 309,327,331,340,343,374,384, 390,392,396,407,408,410,411, 412,417,424,483,486,488,490, 505,511,517,531

Cheng, M.N., 122, 129, 142 Cheng, S C., 216, 222, 230, 232, 235,

236,486,505,512 Cheramy, A., 273, 295, 375,387,408,

409,417 Chien, C., 109, 118, 122, 129,

140, 141, 378, 385, 387, 389, 401, 402, 417, 419

Chihara, K., 448, 449, 457 Chin, H.I., 224, 231 Chin, L.S., 77, 80 Chipman, L.M., 395, 416 Chippendale, T.J., 487, 489, 490, 491,

508,518,519,530 Chirillo, R., 69, 73

553

Cho, A.K., 375, 376, 386, 387, 484, 495,505,526,528

Choi, R.L., 76,82,103,117,218,234, 379,389,489,490,492,503,505, 516,517,518,528,529,534,538, 539

Choi, W.B., 400, 409, 415 Chorover, S.L., 186, 202 Chou, D., 34, 39,44, 75,83, 103,120,

132,133,142,379,393,494,513 Chou-Wong, M., 382, 392 Christensen, E.M., 320, 323, 336 Christiansen, E., 107,117 Chubb, I.W., 68, 71 Clark, C., 229, 233 Clark, W.C., 324, 336 Clarke, D.O., 220, 230,231,232 Clarke, P.A., 402,413,420 Claveria, L.E., 122, 129, 139,376,387 Clement-Cormier, Y.C., 374, 387 Clemente, C.D., 283, 285, 295, 308 Clody, D.E., 20, 30, 34, 39,43,60,61,

87, 97, 121, 132, 133, 140, 237, 250,260,261,379,389,488,489, 490,494,495,508,517,530,533, 539,541,547

Cocolas, G., 321, 326,335,337 Cohen, E.L., 20, 29, 34, 43, 60, 61,

76,79,80, 81, 87, 88, 97, 103, 104, 105, 106, 109, 114, 117, 118, 166,171,237,249,257,260,261, 379,380,381,387,389,465,466, 471,480,483,487,488,490,491, 495,496,499,500,505,507,517, 519,528,533,534,537,538,539, 541,546,547

Cohen, J.A., 53, 61 Cohen, L.H., 196,202 Cohen, M.M., 76, 81, 132, 140, 224,

225,232,379,388,485,494,500, 506

Coyle, J.T., 103, 119 Colasanti, B.K., 288, 289, 290, 299 Cole, J.O., 109, 118, 122, 129, 131,

136, 139, 140, 141,378,389,399, 401,402,413,419,421,423

Coleman, J.C., 281,295 Coleman, N., 40, 43 Collard, J., 15,29,75,80 Collier, B., 76, 81, 266, 296, 304, 494,

505,516,520,521,523,524,526, 528,530

554

Collier, H.O.J., 333, 334, 336 Collier, J., 225, 232 Colmenares, J.L., 464, 480 Colpaert, F .C., 404, 417 Committee on Nomenclature and Statis­

tics of the American Psychiatric Association, 54, 61

Connell, P.H., 382, 387 Connor, J.D., 373, 376,386,387,398,

405,406,417 Conrad, L.C.A., 375, 387 Conroy, C.A., 518, 531 Consolo, S., 374, 387,408,417, 502,

503,505 Contrera, J.T., 524, 531 Cools, A.R., 130, 139,373,380,387,

439,440,441 Cooper, H.P., 7,13,39,40,43 Cooper, J .R., 486, 507 Cooper, M.F., 76, 81 Cooper, S.0.,492, 505 Coppen, A., 41, 43 Cordeau, J.D., 277, 283,296 Cornblath, D.R., 287, 297 Cornford, E.M., 494,506 Correll, P.E., 284,301 Corrodi, H., 406, 409,417,435,441 Costa, E., 11, 14, 134,140,206,207,

213,253,262,269,271,272,295, 298,309,327,331,340,343,373, 374,384,386,390,391,392,393, 404,405,407,408,416,424,436, 441,483,505,520,529

Costall, B., 17,29,379,387,398,401, 402,403,404,410,417

Cote, L.J., 395, 418 Cotzias, G.C., 102, 117,376,387 Cowell, E.B., 238, 250 Coyle, J.T., 166,170,399,417 Cox, B., 321,336 Cox,T., 208, 209, 212 Cozanitis, D.A., 446, 455,456 Crabbe, J.C., 184, 202 Cragg, B.G., 197,202 Crmg,C.R., 288, 289, 290, 299 Craine, A.M., 526, 529 Crane, G.E., 107 109,117,122,135,

139 Cravens, J., 318, 338 Crawford, J.M., 287, 296 Creese, I., 109, 116, 134, 139, 156,

170,374,378,382,386,387,429,

AUTHOR INDEX

433, Critchley, M., 100, 117 Crossland, J., 199, 204, 288, 307, 312,

327,330,336,341 Crossman, A.R., 409,417,439,441 Crow, T.J., 207,212,267,310 Cuatrecasas, P., 155, 170, 171 Curran, D.J., 135, 139 Curran, P.F., 493,511 Currier, S.F., 525, 528 Curtis, D.R., 287, 296 Curtis, G.C., 129, 139,447,456 Cutler, R.P., 8,12 Dahl, H., 177, 202 Dahlberg, L., 494, 506 Dahlstrom, A., 320, 323, 326, 336,

383,386,395,415 Daly, R., 122, 141,378,391 Daniels, J.C., 288, 296 Danysz, A., 34, 39, 43, 132, 133, 134,

139,494,506 Dawson, S., 282, 292,308,315,342,

347,358,360 Dauterman, W.C., 525, 528 Daves, E., 321,326,335,337 David, E., 399,418 Davidson, L., 376, 390, 397, 420 Davies, D.L., 227,232 Davies, P., 68,70,71,206,212,229,

232,253,261 Davis, B.M., 357, 359 Davis, J.M., 3, 4, 5, 6, 7, 8, 9,10,12,13,

14,15,16,17,18,19,30,32,33,34, 39,40,41,42,43,44,45,47,49,50, 51,64,72,75,76,77,82,83,87, 97,107,110,115,117,119,122, 129, 131, 136, 140, 142, 192,200, 202,204,230,232,257,261,262, 318,338,385,387,388,389,402, 419,435,439,441,447,457,495, 496,499,500,508,512,533,534, 539,541,547

Davis,K.L.,6, 7,9,11,12,15,17,18, 19,20,29,30,31,40,41,43,49,50, 53,61,64,72,76,81,87,88,97, 103,104,106,109,110,115,117, 122,131,135,137,139,166,170, 200,202,207, 212, 238, 239, 248, 250,253,254,357,358,359,361, 362,368,369,370,379,380,387, 388,401,414,417,418,435,438, 439,440,441,447,456,483,495,

AUTHOR INDEX

496,497,498,499,500,502,503, 506,533,534,537,538,541,547

Davis, R, 266, 302 Davison, A.N., 70, 71, 205, 211, 228,

229,230,232,235 Deadwyler, S.A., 396, 397, 407,420 De Bellis, A.M., 321, 324, 340 De Braganza, B., 495,509 De Feudis, F.V., 47, 50, 270, 296 De Fraites, E.G., 6, 7, 12, 131, 139,

255,257,261,435,441,447,456, 483,500,506

Deguchi, T., 288, 290, 299 De Jong, D.K., 321,336 De La Huerga, J., 105, 117, 500, 506 Delgado, J.M.R., 288, 309 Demaret, A., 15,29,75,80 Dement, W.C., 283, 299, 311,314,315,

336,338,340,341 Demirgian, E., 399,413,418 Dempsey, E.W., 284, 286, 287, 295,

296 Denham, J., 130, 139 Denisenko, P.P., 321,337 Denney, D., 10, 12, 76,80, 109, 116,

122, 123, 125, 126, 128, 129, 131, 134,135,139,379,387

Dennis, S.G., 189,202 De Robertis, E., 197, 202, 267, 296,

396,418 Desbarats-Schonbaum, M.L., 525, 528 Deshimoru, M., 229, 235 Desi, I., 277,296 De Silva, L., 109, 117, 135, 140,379,

388 Dettbarn, W.D., 69, 72,466,481,487,

490,491,492,502,503,507,510, 513

Dettinger, E., 224, 235 Deutsch, J.A., 177, 178, 181, 183,

185,186,202,204,208,209,212, 237,247,249,250,251

Dewey, W.L., 321, 326, 328, 331, 332, 335,337,338,341

De Wied, D., 447, 457 Dexheimer, P., 40, 43 Diamond, I., 122, 129, 138,430,434,

485,506,517,521,528,529 Dickinson, G., 333, 339 Dill, RE., 166, 170 DiMascio, A., 40, 43,64,72,385,387,

399,402,413,417,418,421

555

Dirnov, S., 277 , 301 Dingledine, R., 267, 268, 287, 291,

294 Di Pietro, D., 486, 506 Do Amaral, J.R., 495, 498, 499, 500,

502,503,506,537,538 Dolezalova, H., 312, 337, 342 Dolivo, M., 225, 232 Domino, E.F., 39,43,53,58,59,61,

64, 67, 68, 69, 70, 72, 208, 213, 271,272,276,278,280,282,287, 296,301,304,306,310,314,315, 327,329,330,337,339,340,341, 503,509

Doneen, B.A., 326, 340 Donnalley, T.E., 155, 156, 171 Donoso, 'A.a., 448, 456 Doon, R, 426,433 Dormand, Y., 132, 140,494,506 Dorris, R.L., 166, 170 Dowdall, M.J., 515, 52i, 525,527,529 Drachman, D.A., 200, 202, 207, 212,

227,232,233,238,250,253,261, 361,369,402,414,418,483,506

Dray, A., 375, 388, 409, 418 Dren, A.T., 276, 278, 296, 314, 315, 337 Dreyfus, P., 486,506 Dross, K., 76, 81, 484,506,516,517,

518,529,538,539 Drucker-Colin, R.R., 283, 307, 312,

314,337 Druckman, R., 107, 117 Duane, D.P., 155, 171 Ducey, J., 398, 418 Dudar,J.D., 271, 296 Dudler, L., 312, 340 Duffy, M.J., 375, 388 Duffy, T.E., 224, 233 Dulska, E., 411,424 Dun, N.J., 63, 72, 266, 267, 268, 290,

291,296,297,301 Duncan, W.C., 311,337 Dundee, J.W., 207, 212, 320,337 Dunner, D.L., 78, 79, 81 Dura, G., 277,296,297 Du Vigneaud, V., 76, 81,132,140,379,

388,485,494,500,506 Duvoisin, R.C., 69, 72, 143, 153,377,

388,398,399,418,502,503,507 Early, D.F., 69, 72 Eccles, J .C., 268, 290,291, 297 Echlin,F.A., 278, 297

556

Eckemas, S.A., 20, 29, 76, 79,80,81, 87,88,97,103,104,105,114,116, 158,166,170,257,261,414,415, 483,489,490,492,495,496,497, 499,503,504,507,517,518,520, 529,533,534,537,538,539,541, 545,547

Edwards, A.L., 367, 369 Edwards, D.J., 282, 292,302 Edwardson, J.A., 447, 456 Ehringer, H., 376, 388 Eichenberger, E., 17, 29 Elias, S.B., 155, 171 Elkes, J., 276, 279, 294 Elliot, K.A.C., 287, 306 Elliott, G.R., 15, 16,29,64, 71,312,338 Elliott, H.W., 274, 277,287,294 EI-Yousef, J.K., 257, 261 EI-Yousef, M.K., 3, 4, 5, 7, 8, 9, 10,

12, 13, 15, 16, 17, 18,30,33,34, 39,40,41,43,45,47,49,50,64, 72,75,77,82,131,140,318,338, 385,388,389,402,419,435,439, 441,447,457,500,508,541,547

Endroczi, E., 277, 297,445,446,456 Engel, G.L., 357, 360 Engel, W.K., 143, 144, 153 English, D.C., 33, 43 Enna, S.J., 96, 97, 106, 117, 160, 161,

164, 165, 167, 171,206,212,213, 379, 380,388,495, SOD, 507

Ensor, C.R., 288, 295 Erecinska, M., 220, 236 Ericksen, S.E., 40, 41, 44, 76, 83, 87,

97,110,115,119,136,142,495, 496,499,500,510,533,534,539

Erill, S., 315, 341 Emst, A.M., 383, 388,411,423 Escalar, G., 69, 72 Escobar, J.I., 109,117,135,140,379,

388 Eskridge, N.K., 404, 415 Essig, C.F., 276, 297 Essman, W.B., 288, 297 Euvrard, C., 274,300 Everett, G.M., 276, 297 Everett, J.W., 449,458 Fahn,S., 102, 117,395,399,401,418 Fahrney, D., 176,196,203 Fainrnan, F., 509

AUTHOR INDEX

Fairchild, M.D., 274, 277,279,281,297 Fairweather, R., 312, 342 Fann, W.E., 76, 81, 96, 97,107,109,

117,122,129,131,135,140,379, 388

Famebo, L.O., 399, 418 Farringather, R., 312, 337 Fatt, P., 268, 290, 297 Faull, K., 438, 440 Faurbye, A., 107, 109, 117, 119, 122,

129,142 Featherstone, R.M., 326, 327, 343 Fedele, C.A., 53, 61 Fedorov, V.S., 197,202 Feighner, J.P., 20, 30, 54, 61 Feinberg, I., 229,234,311,337 Feldberg, W., 266, 280, 293, 297, 398,

418 Feldman, R.G., 380, 391 Feltz, A., 198,202 Feltz, P., 375, 388,409,418,439,441 Fencl, V., 312, 341 Ferguson, J.H., 287, 289, 297 Fernstrom, J.D., 266, 310, 461, 464,

466,469,480,481 Ferrari, E., 447, 456 Ferrendelli, J.A., 156, 171,217,218,

224,233 Ferris, S.H., 229, 233 Ferry, C.B., 410, 418 Feuer, G., 492,505 Fex, J., 198,202 Fibiger, H.C., 7, 13, 39, 40,43, 102,

118,326,341,375,380,389,390, 396,397,400,406,407,408,409, 414,418,419,420,421,439,442, 495,510

Fields, J.Z., 165, 171, 380, 391,429, 433

Fieve, R.R., 41,43,58,59,61,78,79, 81,82

Figard, P.H., 132, 139 Filbert, M.G., 53, 61 Fink, M., 287,288,293,297,361,369 Finley, W.W., 311, 339 Finnerty, R., 40, 43 Fiorindo, R.P., 449, 455, 457 Fischer-Williams, M., 289, 290, 298 Fiscus, R.R., 275, 276, 277, 283, 287,

309

AUTHOR INDEX

Fisher, R., 381, 388 Fitzgerald, G.G., 486,507 FjaI1and, B., 377,378,388 Flanigan, S., 287 304 Fleishhauer, K., 280, 297 Flemenbaum, A., 49,50 Flentge, F., 518, 527 Floodmark, S., 320, 323, 337 Floris, V., 278, 297 Flynn, J.P., 287, 304 Flynn, V.P., 280, 293 FonnumF., 266, 297,484,493,507,

526,529 Food and Drug Administration Task

Force, American College of Neuro­psychopharmacology, 107, 117

Fortemps, E., 135, 141, 166, 171 Foster, F.G., 77, 78, 79, 81, 83, 257,

261,311,339,483,502,503,508, 513,541,547

Fothergill, L., 326, 338 Foulkes, R.G., 398,421 Fox, R.A., 184,202 Fram, D., 311, 342 Francis, D.L., 333, 334, 336 Franck, H.P., 76, 82 Frankel, B.L., 311, 337 Frankenberg, L., 525, 529 Frattola, L., 433, 434 Frazer, A., 6,12,18,25,29 Frazier, D.T., 288, 297 Fredrickson, R.C.A., 327, 333, 341 Freedman, D.X., 34, 39,44,132, 133,

134,141,287,307,379,391,494, 510

Freedman, G., 486,508 Freeman, J.J., 76,81, 103, 117, 132,

140,464,480,484,485,489,490, 494,503,505,507,516,517,518, 528,529,538,539

Frey,P.A., 216, 234 Freyhan, F.A., 228, 229, 233 Friede, R.L., 229, 233 Friedhoff, A.J., 15, 30, 64, 72, 122,

129,138,321,323,340 Fries, E.D., 19,30 Froissart, C., 79, 82 Frumin, J.J., 320, 340 Frygyesi, T.L., 286, 306 Fuchinoue, T., 501,510

Fujiwara, H., 277, 305 Fulcher, J.H., 15,30 Fuld, P.A., 241, 245, 249, 255, 261 Fuxe, K., 383, 386, 395, 396, 399,

557

404,406,409,415,417,418,424, 435,441

Fyro, D.G., 21, 22, 24, 25, 26, 28, 31 Gadea-Ciria, M., 11, 13, 17, 29, 282,

297,312,337,374,392,407,408, 411,423

Gaechter, R., 312,340 Galeone, F., 501,511 Gaffney, T.E., 503, 509 Gair, D.S., 398,418 Gala, R.R., 448, 457,458 Gallagher, W., 15,30,39,44, 75, 82,

121,132,141,485,494,500,511 Galli, G., 69, 72 Garattini, S., 374, 387 Garau, L., 196, 204, 327, 329, 337 Gardiner, J.E., 517, 529 Gardner, C.R., 288, 297 Garrattini, S., 274, 298 Gardos, G., 131, 136, 139,140 Gastaut, R., 289, 290, 298 Gautier, J., 16,30,402,418 Gelato, M., 448, 457 Gelenberg, A.J., 107,115,117 Gelhard, R.E., 378, 391 Gellene, R., 102, 117 Geofrrey, G., 227, 231 George, R., 282, 298, 313, 314, 315, 337 Gerber, C.J., 96, 97,109,117,122,129,

131,140 Gerlach, J., 41, 43, 87, 97, 109, 118,

122,129, 131, 140,378,379,388, 399,401,418

Gerner, R.H., 312, 341 Gershon, M.D., 282, 295 Gershon, S., 4,6,13,15,18,30,31,34,

39,43,45,49,50,65,72,75,81, 107,118,229,233,317,382,384, 386,388

Gessa, G.L., 435, 442 Ghoneim, M.M., 200, 202, 238, 250 Giacobini, E., 314, 337 Giarman, N.J., 34, 39, 44, 132, 133,

134,141,328,337,379,391,494, 510

Gibson, C.J., 464,480

558

Gibson, G.E., 143,153,216,217,218, 219,220,221,222,224,230,231, 233,486,505,507

Gibson, P .H., 70, 73 Gibson, W.C., 398,421 Gilka, L., 381,388 Gillette, J.R., 379, 389 Gillin, J .C., 207, 213, 253, 262, 282,

292,308,311,312,315,317,318, 320,323,324,325,336,337,338, 340,341,342,347,358,360,361, 368,370,436,441

Gillo-Joffroy, L., 378, 381,386 Gilman, A., 3, 4,13 Ginsburg, S., 196,203 Giorguieff, M.F., 266, 298, 375, 388,

410,412,418,435,441 Giunta, F., 278, 303 Glasgow, A.M., 224, 233 Glasser, G., 288, 309 Glen, I., 229, 232, 248, 249, 361, 369,

497,499,505 Glick, S.D., 526, 529 Glisson, S.N., 274, 298 Glover, V.A.S., 484, 493, 507 Glowinski, J., 266, 272, 273, 274, 295,

298,300,301,375,387,388,404, 407,408,409,410,412,415,417, 418,419,435 441,522,523,529, 530

Gochfeld, L., 131,136,141 Goenczi, C., 277 297 Goetz, C.G., 292, 301 Gogolak, G., 278, 308 Goldberg, A.M., 34, 39, 43,132,133,

140,379,388,471,481,484,494, 507,509,523,526,528,530

Goldblatt, D., 381,392 Goldmacher, D., 311,343 Goldman, B.D., 447, 458 Goldring, J .M., 493, 505 Goldstein, L., 40, 44, 347, 359, 362,

368,369,370 Goldstein, M., 399, 418 Gommeren, W., 429, 434 Gonczi, L., 277, 296 Goodhardt, M.J., 206, 213, 229, 235,

236,253,259,262 Goodman, E., 4,12,18,29,39,42,75,

80

AUTHOR INDEX

Goodman, L.S., 3, 4,13 Goodman, R., 199,203 Goodman, S., 68, 71 Goodwin, F.K., 11, 12, 15,30,41,42,

312,318,337,341,357,359,436, 438,441,442

Gorden, P., 311,336 Gordon, E.K., 11, 12,357,359,436,

438,441,442 Gorny, D., 11, 13 Goracci, G., 76, 83 Gothelf, B., 277, 301 Gottfries, C.G., 229, 233 Goyne, T.J., 375, 388 Graham-White, J., 229, 232, 248, 249,

361,369,497,499,505 Granacher, R.P., 109, 118, 122, 129,

136,139,140,238,250,401,419 Grandison, L., 448, 455,457 Gray, E.G., 521,529 Green, A.R., 502,507 Green, J.P., 526, 529 Green, R.E., 276, 310,484, 505 Greengard,P., 155,156,171,199,203,

374,387,388 Greenberg, D.M., 17,32,75,80,130,

132,139,142,158,172,382,392, 395,396,399,405,407,423,424, 429,434,465,480,515,521,528, 531

Greenfield, J.G., 144, 153, 425, 433 Greer, C.A., 288, 298 Gregoire, M., 320, 336 Grewaal, D.S., 109, 118, 374, 390,

407,408,418,419,421 Grieu, E., 267,310 Griffith, J.D., 382, 389 Grinspoon, L., 311, 342 Grob, D., 317, 338,346,359,362,

369 Gros, F.,486, 509 Gross, E.G., 320, 323, 326, 327, 336,

343 Groth, D.P., 379, 389,494,507 Groves, P.M., 409, 419, 439, 441 Grove-White, I.G., 207, 212 Growdon, J.H., 60, 61, 76,79,81,83,

87,88,97,103,104,105,106,109, 110, 111, 113, 114, 115, 118, 120, 122,129,140,166,171,379,380,

AUTHOR INDEX

381,389,401,414,419,465,466, 467,470,471,480,481,483,489, 490,495,496,499,500,507,508, 517,519,530,531,533,534,537, 539

Grumbach, L., 333, 338 Gubler, C.J., 486,505 Guerrero-Figueroa, R., 287, 298 Guggenheimer, E.H., 271,298 Guha, D., 278, 286, 298 Guidotti, A., 384, 393 Gulevich, G., 311, 338 Gurdjian, E.S., 224, 233 Gustafson, L., 228, 233 Guyenet, P.G., 272, 298, 404, 407,

408,415,419,522,523,529,530 Guynn, R.W., 493,511 Guze, S.B., 20, 30, 54, 61 Gwee, M.C.E., 517, 529 Gyorgy, L., 277, 287, 289, 306 Haas, H.L., 46, 50 Haba, R., 287, 288, 305 Hackett, J.T., 285,304 Haefely, W., 273, 283, 299, 307 Haga, T., 466, 480, 484, 507, 521,522,

523,529 Hagen, P.B., 196,202 Haggendal, J., 374, 386 Hain, R.F., 228, 235 Halaris, A.E., 312, 313, 339 Hall, R.C., 282, 298,516,531 Haltoris, T., 439, 442 Hamberger, B., 399, 418 Hamburg, D., 64, 73 Hamburg, M.D., 177, 202, 203, 237,

247,249,250 Hammer, W.,435,441 Hammond, K.B., 500, 508 Hampson, J .L., 276, 297 Handler,P., 197,204 Hanigan, W.C., 288, 298 Hanin, I., 34, 39,44, 75,76, 77, 78, 79,

80,82,83,103,120,132,133,134, 140,142,257,261,271,272,298, 309,379,393,494,501,502,503, 507,508,513,518,520,529,541, 547

Hansen,S., 102, 103,119,160,172, 379,391,400,422

Hanson, H.M., 65, 72

Hara, M., 501,510 Hara, T., 317, 342

559

Haranath, P.S.R.K., 283, 298, 312, 338

Haraszti, J.S., 9,10,14,34,39,40,44, 49,51,75,83, 110, 119, 122, 129, 131,142,257,262,496,499,500, 512

Hannatz, J .S., 255, 262 Hanns, M.S., 518, 528 Harper, S.T., 312, 313, 339 Harpur, R.P., 216, 233 Harris, C.A., 78, 80 Harris, J.E., 409, 419 Harris, L.S., 53, 61, 320, 321, 326,

328,331,332,335,337,338,341, 374,389

Harris, S.H., 226, 232 Hartmann, E., 318,338 Hartmann, G., 277,297 Harvey, A.M., 346, 359, 362, 369 Harvey, J.C., 317, 338 Harvuszti, J .S., 19,32 Harwood, C.T., 454, 457 Haskayne, L., 122, 129, 139 Haslett, W.L., 282, 298, 313, 314, 315,

337,376,387 Hassler, 0., 229, 233 Hassler, R., 375, 389,400,409,415,

439,442 Hattori, T., 375, 389, 396, 397, 407,

408,409,413,414,419,421 Haubrich, D.R., 20, 30, 34, 39,43,

60,61,76,81,87,97,121, 132, 133,140,237,250,260,261,379, 389,466,480,487,488,489,490, 491,494,495,508,517,518,519, 530,533,539,541,547

Havill, J.H., 77,80 Hawkins, R.A., 220, 234 Hawthorne, J.N., 197,203 Hayes, A.H., 238, 250 Hazra, J., 315,338 Heath, R.C., 287, 298 Hebb, C.O., 395, 396, 419, 526, 530 Hedge, G.A., 447,457 Heimburger, G., 525, 529 Heinrich, C.P., 486, 508 Heiser, J.F., 77,82 Heisler, S., 135, 142

560

Heitz, Ph., 397, 410, 420 Held, J., 382, 389 Hemphill, R.E., 68, 69,72,73 Hemsworth, B.A., 288, 298 Henriksen, SJ., 283, 299 Herken, H., 328, 338 Hernandez-Peon, R., 278, 283, 298,

299,309,313,338,340 Hen, A., 284, 299, 320, 321, 324,

325,338,340,405,419 Heyl, W.C., 374, 389 Heywood, D.M., 228, 231 Hickey, S.W., 206, 212 Higgins, T., 500, 508 Hiley, C.R., 160, 171,206,213,229,

236,253,259,262,376,379,380, 384,389,390,399,407,421

Hiley, R., 405, 414, 419 Hill, P., 446, 457 Hill, R.C., 280, 299 Hillarp, N.A., 395, 396, 415 Hillhouse, E.W , 446, 455, 456, 457 Hilliard, L.T., 231,233 Himmellioch, J J., 46, 50 Himwich, H.E., 225, 233, 269, 270,

276,277,279,290,297,307 ~gen,J.N.,208,212,270,291,299 Hippius, H., 122, 140 Hirai, K., 446, 447,458 Hirose, K., 399, 420 Hirose, T., 446, 447, 455, 458 Hirsch,MJ., 76, 79, 81, 83,87, 88, 97,

103,106,110,111,112,113,114, 115,118,120,122,129,140,266, 293,309,379,389,401,414,419, 465,466,467,470,471,472,475, 480,481,487,489,490,491,492, 495,496,497,499,501,507,508, 512,513,517,519,530,531,533, 534,539

Hitch, G., 239, 249 Hitri, A., 430, 434 Hobbit, P.R., 199, 201 Hobson, J.A., 270, 273, 277, 278, 282,

283,293,299,304,308,312,313, 314,318,336,338

Hoehn, M., 103, 120, 137, 142, 166, 172,380,393

Hoelzl, J., 76, 82 Hoffer, BJ., 405, 423

AUTHOR INDEX

Hoffman, R.R., 401, 418 Hohorst, H.J., 224, 235 Hojo, M., 276, 293 Hokfelt, T., 274, 299, 375, 389 Holden, O.M.C., 16,30 Hollander, J., 206, 212, 253, 261 Hollenberg, M., 155, 170 Hollister, L.E., 6, 7,9,11,12,15,17,18,

19,20,29,30,40,41,43,49,50, 53,61,64,72,76,81,87,88,97, 103,104,106,109,110, 115,117, 122,131,135,137,139,166,170, 200,202,207,212,238,239,248, 250,253,254,255,257,260,261, 357,358,359,361,362,368,369, 370,379,380,387,388,401,414, 417,418,435,438,439,441,447, 456,483,495,496,497,498,499, 500,502,503,506,533,534,537, 538,541,547

Hollunger, E.G., 53, 61 Holman, R.B., 312, 338 Holmstedt, B., 69, 276, 299, 376, 389 Honig, W.M.M., 17, 31, 383, 391,439,

440,441 Hoover, D.B., 288, 289, 290, 299 Hoover, V., 448, 458 Hoppe, J .0.,280,303 Hornykiewicz, 0., 102, 118, 376, 386,

388,390,395,396,397,400,413, 416,419,420,425,427,433,434

Horwath, F.E., 285, 295 Hosein, E.A., 486, 508 Houser, F.L., 320, 323, 338 Houser, V.P., 320, 323, 338 Howes, J.F., 328, 338 Hrbek, J., 207, 212 Huang,C.Y., 109,117,135,140,379,

388 Hubbard, B.J., 3,13 Huestis, W.H., 79, 82 Hughes, J., 326, 338 Hulme, E.C., 267, 294 Humbert, J .R., 500, 508 Hunger, J., 8,10, 13, 16, 18,31,75,82 Hunger, R.B., 6, 8, 13 Hunt, R.D., 433, 434 Huntington, G., 100,118 Hunch, C.J., 311, 339 Hyde, P.R., 318, 341

AUTHOR INDEX

Hysert, P., 502, 511 Ichikawa, K.P., 76, 83 Ichiro, Y., 321,324,326,342 Ikeda, M., 464, 480 Ikeda, T., 439, 442 Ikonomoff, S.I., 289, 299 llahi, MM., 425, 434 rues, 1.,277,297 rues, P.,46, 51,78,83 lllingworth, D.R., 76, 82, 484, 508,

516,517,530 lllis, L.S., 197, 203 llson, D., 266,296,524,526,528,530 llyutchenok, R.Y., 208, 212 Imura, H., 448, 449, 457 Indira, G., 283, 298 Ingerson, A., 274, 294 Ingram, W.R., 284, 301 Ingvar, D.H., 228, 233 Innes, I.R., 227,234,447,457 Inoshita, H., 439,442 Inoue, S., 312, 340 Ireson, J.D., 321,338 Iriki, M., 312, 340 Irmi, S.F., 281,299 Israel, M., 485,508 Itil, T M., 16,30 Itoh, T., 216,234 Iversen, L.L., 96, 97, 102, 106, 116,

117,155,160,161,164,165,167, 170,171,206,212,379,380,386, 388,400,414,416,495,500,504, 507

Iwamoto, E.T., 334, 342 Iwata, N., 288, 290, 299 Jacobowitz, D.M., 273, 283, 299, 305,

384,389 Jacobs, B.L., 283, 299 Jacobson, G., 131, 136, 140 Jalfre, M., 273,283,299,307 Jalowiec,J.E., 283, 299 Janowsky, D.S., 3, 4,5,6,7,8,9,10,12,

13,15,16,17 18,30,33,34,39,40, 41,43,45,46,47,48,49,50,64, 72,75,77,82,107,117,131,140, 192,204,257,261,318,338,385, 388,389,402,419,435,439,441, 457,500,508,541,547

Janssen, H.J., 373, 387 Janssen, P.A.J., 383, 389

561

Jarvick, M.E., 208,211 Jasper, H.H., 282, 287, 288, 289, 295,

297,299,306,310,312,339 Jaussi, A.W., 486, 505 Javoy,F.,272, 274, 298,300,407,408,

409,410,412,415,419,435,441 Jellinger, K., 396, 397, 400, 416 Jenden, D.J., 20, 64, 72, 76, 77, 81,

82,103, 117, 119, 132, 140,218, 220,221,222,233,234,271,274, 277,279,281,282,297,298,300, 313,314,315,337,376,379,386, 389,464,466,480,481,483,484, 485,486,489,490,492,493,494, 495,500,501,502,503,505,507, 508,509,511,513,516,517,518, 524,526,528,529,530,531,534, 538,539

Jenkins, G.M., 246, 249 Jenney, E.H., 15,31,39,40,44,64,

73,75,82,121,132,141,347,359, 362,368,370,385,391,402,422, 485,494,500,511

Jeuser, G., 284, 295 Jewett, R.E., 282, 300,314,339 Jhamandas, K., 327, 328, 329, 333, 339 Jimerson, D.C., 312, 341 Joh, T.H.,40,43, 137, 141 Johannessen, J.N., 281,309 Johannsson, H., 224, 225, 235 Johnson, A., 7,9, 12, 19,29,40,43,

200,202,207,212,238,239,248, 250,260,261,359

Johnson, J.E., 229, 232 Johnson, L., 49, 50 Johnson,P.C., 160, 165,167,171,172,

380,391,393,500,513 Johnson, S., 53, 61, 503, 509 Jones, B.E., 312, 313, 339 Jones, M.S., 59, 61 Jones, M.T., 446, 455,456,457 Jonsson, L.E., 502, 509 Jope, R.S., 143, 153, 216, 217, 220,

222,233,234,484,486,492,493, 494,495,500,502,509,513,524, 530

Jouvet, M., 273, 282, 283, 300, 306, 312,314,339

Joynt, R.J., 381,392 Judd, L.L., 46, 48, 50

562

Jung, E., 396, 420 Jus, AX., 16, 30,121,122,140,311,

339,402,418 Justo, G., 449, 457 Kaack, B., 229, 235 Kahlson, G.,486 509 Kaibara, K., 268, 296, 297 Kaita, A.A., 471, 481 Kalberer, M., 284, 286, 305 Kaloianova, F., 277,301 Kalsbeek, F., 53,61 Kamat, U., 321,323,339 Kammerer, E., 237, 250 Kanapa, D.J., 134, 142,541,547 Kanazawa, I., 267, 268, 287, 291, 294 Kandel, E.R., 175, 203 Kanematsu, S., 449, 456, 457 Kaplanski, J., 447,457 Karacan, I., 311, 339 Karczmar, A.G., 63, 72,208,213,237,

250,266, 267,268, 270, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281,282,283,284,285,286,287, 288, 289, 290, 291, 292, 293, 294, 296,297,298,300,301,305,309, 314,319,339,345,357,358,359, 360,362,370,407,409,419

Kariya, T., 287, 309 Kark, R.AP., 143, 144, 146, 148, 153,

154,226,232 Karnovsky, M., 312, 314, 341 Karoum, F., 436, 441 Kartzinel, R., 102, 119,381,392,433,

434 Kase, Y., 314, 339 Kasparian, G., 402,413,421 Kassil. G.N., 78, 82 Kataoka, K., 375, 389 Kato, A.C., 486,509 Kato, M., 287,288,302,305 Kato, Y., 448, 449,457 Katz, B., 198, 203 Katz, H.S., 523, 528 Katz, R.,49, 50,143,153 Katzman, R., 229, 236 Kawaguchi, S., 284 307 Kawamura, H., 271,278,296,301 Kawamura, S., 439, 442 Kay, S.R., 16,31,385,392,402,414,

423

AUTHOR INDEX

Kazamatsuri, H., 109, 118, 122, 129, 140,141,378,389,401,419

Keane, P.E., 273, 282,298,306 Kebabian, J.W., 374, 387 Keet, J.P., 206, 213, 229, 236, 253,

259,262 Kehr, W., 409, 419, 436, 440, 464, 480 Keller, H.H.,411, 416, 440 Kellerth, J.~., 375, 389 Kelly, J.S., 267,268,287,291,294 Kelly, P.H., 379, 389, 404, 419 Kemp, G.E., 492,510 Kemp, J., 396, 420 Kemp, K.F., 109, 117, 135, 140,379,

388 Kemp,P., 197,203 Kennedy,J., 160, 172 Keskiner, A., 16,30 Kessler, J.A., 436, 441 Ketchum, J.S., 238, 250 Kety, S.s., 228, 229, 233 Kewitz, H., 75, 76, 81, 82,465, 481,

484,494,506,509,516,517,529, 538,539

Key, B.J., 283,301 Khinkova, L., 277,301 Khromov-Borisov, N.V., 198,203 Khyllar, A.K., 447,456 Kidokoro, Y., 288, 301,302 Kilbinger, H., 502, 503, 510 Killam, E.K., 39, 44, 75, 82, 121, 132,

141 Killam, K.F., 39, 44, 64, 72, 75, 82,121,

132,141 Kiloh, L.G., 401,420 Kim, C., 287,304,398,423 Kim, J.S., 375, 389 Kimura, H., 218, 234 King, J., 59, 60, 69, 71 Kingsley, R.E., 282, 301 Kipnis, D.M., 156, 171 Kirkland, R.J.A., 520,531 Kirman, B.H., 231, 233 Kirshner, N., 487, 510 Kitai, S.T., 405, 420 Kitz, R.J., 196,203 Kjallquist, A., 229, 233 Klassen, A.C., 229, 234 Klatzo, L., 230, 234 Klava, P., 229, 232

AUTHOR INDEX

Klawans, H.L., 17,30,41,43, 76,82,87, 97, 102, 103, 108, 109, 118, 122, 129,131, 134, 137, 141, 142, 143, 153,166, 171,292,301,377,378, 379,380,389 390,391,397,399, 400,401,402,403,414,420,422, 425,426,428,430,434,435,439, 441,442,541,547

Klein, D.F., 131, 136, 141,397,422 Klemm, W.R., 280, 281, 301 Klett, CJ., 402, 413, 420 Kloster,M., 102, 119,379,391,400,422 Knapp, D.R., 503, 509 Knapp, S.,II,13 Kneffel, Z., 277, 296 Knispel, J.D., 267, 310 Knoll, J., 46,51,78,83 Knott, J.R., 284, 301 Kobayauu, H., 198,199,203 Kobayauu, R.M., 384, 391,396,411,

421 Koch-Weser, J., 227, 234 Kocmierska~rodzka, D., 34, 39, 43,132,

133,134,139,494,506 Kocsis, JD., 405, 420 Koehn, G.L., 274, 286, 294, 301 Koelle, G.B., 53, 61, 237, 238 250,

266,268,271,301 Koelle, W.A., 266, 302 Kohl, H.8., 288, 308 Koketsu, K., 268, 290, 297 Kokmen, E., 129, 139 Koller, W.C., 285, 302 Komenda, S., 207, 212 Kopec, J., 286, 307 Kopell, B.S., 207, 212,253,254,260,

261,358,359 361,362,368,369, 370,435,441

Kopin, IJ., 49,50,436,441,487,509 Kopp, U., 76, 77 78, 79, 80, 81, 83,

257,261,502,503,508,541,547 Koreny,C.,101,120 Korey, S.R., 229, 236, 495, 509 Korf, J., 4Q9, 411, 424, 435, 443 Korsak, RJ., 277, 302 Koski, G., 312, 341 Koslow, S.H., 384, 390 Kosower,E.M., 195,197,203 Kosterlitz, H.W., 328,339,342 Kostowski, W., 277 302

563

Kostro, B., 34, 39, 43, 132, 133, 134, 139,494,506

Kramis, R., 281, 302 Krause, R.R., 58, 61, 64, 67, 69, 70, 72 Krebs, H.A., 220, 236 Krell, R.D., 484, 509,526,530 Kremzner, L.T., 196,203 Krespan, B., 220, 231, 521, 523, 525,

526,528 Krieger, D.T., 445, 446, 447, 457 Krieger, H.P., 445, 446, 447, 457 Krip, G., 288,289,309 Kripke,D.F., 311, 343 Krishnamurthy, A., 283, 298 Kr~enc,K.,267,268,269, 281,302 Krop, S., 276, 310 Krueger, J., 312, 341 Krupp, P., 284, 286, 305 Kruszewska, J., 34, 39, 43, 132, 133,

134,139,494,506 Krzywoskinski, L., 283, 301 Kubota, K., 288, 301, 302 Kuhar, M.J., 70, 72,74,158,172,205,

213,253,259,262,269,270,302, 384,390,395,396,405,408,411, 420,422,424,484,492,509,512, 522,523,524,525,527,530,531

Kumagai, H., 280, 302 Kumar, B.B., 135,137,141 Kumar, S., 230, 232 Kumbaraci, T., 41, 43, 58, 59, 61,

78,79,81,82 Kuntscherova, J., 486, 488, 490, 491,

495,509 Kuo, J.F., 155, 156, 171 Kupfer, D.J., 77, 78, 79, 81, 83,257,

261,282,292,302,311,339,483, 502,503,508,513,541,547

Kurland, H.D., 8,12 Kurokawa, M., 287,288,302,305,315,

342 Kurouji, K.I., 446, 447, 458 Kutarski, A., II, 13 Kvetnansky, R., 487, 509 Laaksonen, H., 396, 397,422 Labrecque, G., 327, 329, 339, 340 Lachance, R., 121, 122, 140, 311, 339 Lacki, M.,411, 424 Ladinsky, H., 374, 387, 408, 417, 502,

503,505

564

Laduron, P.M., 429, 434 Lake, C.R., 109, 117,122,129,131,

140,379,388 Lal, H., 404, 417, 424 Lal, S., 122, 129,141 Lalley, P.M., 376, 386 Lamaire, S., 326, 340 Lamb, S.I., 495, 505 Lane, J.D., 520, 531 Lane, M.H., 229, 234 Lang, R.W., 229, 234 Langlois, J.M., 284, 285, 302 Langworthy,O.R., 346,359,362,369 Lanrin,C.,277,283,296 Larin, F., 266, 310 Larsson, K., 395, 396, 415 Lasagna, L., 16,31,402,422 Lassen, N.A., 228, 229, 234 Laterre,E.C., 135, 141, 166, 171 Lauener, H., 413, 415 Lauprecht, C.W., 284, 295 Laverty, R., 435, 442 Lavine, R., 324, 340 Lawson, D.M., 448, 457 Leavitt, J., 200, 202, 207, 212, 227,

232,233,238,250,253,261,361, 369

Lecoq, R., 15,29,75,80 Ledda, F.,407, 416 Lee, C.W.G., 106, 118 Lee, G., 78, 79, 82 Lee, J.F., 281, 309 Lee, L.W., 224, 236 Lee, M., 59, 61 Lee, T., 382, 392, 397,422,429,434 Lee, T .P., 155, 156, 171 Le Fevre, H.F., 283, 295, 396,410,411,

412,417 Le Floch, M.L., 266, 298, 375, 388,

410,412,418,435,441 Lefresne, P., 486 509,522,523,529,

530 Le Fur, J.M., 132, 140,494,506 Leibowitz, S.F., 181,203 Lemieux, B., 227,231 Lenaerts, F.M., 383, 389 Lenke, D., 320, 340 Lennon, V.A., 155, 171, 198, 203 Leonard, C.M., 375, 387 Leopold, N., 96, 97,122,129,142,166,

AUTHOR INDEX

172,379,380,392,399,401,424 Leslie, G.B., 320, 325, 340 Lesny, I.,346,359, 362,370 Levenson, S.M., 466, 481, 487, 491,

510 Levin, H.S., 208, 213, 238, 250, 253,

262 Levinger, I.M., 271,298 Levitt, M., 464, 480 Levron, J.C., 132, 140,494,506 Levy,J., 276,302,484, 510 Lewander, T.,4O,43, 137,141 Lewis, C.A., 216, 232 Lewis, J., 40, 43,103,120,137,142,

166,172,327,340,380,393 Lewis, P.R., 268, 269, 270, 294, 303,

308,319,342,396,406,407,416, 423

Leysen, J.E., 429, 434 L'Herrnite, P., 484, 510 Li, C.H., 326, 340 Liao, C.L., 224, 236 Libertun, C., 448, 449, 450, 455, 457,

458 Libet, B., 198, 199,203,268,290,303 Licata, S.M., 46,50 Lidbrink, P., 406,409, 417, 435,441 Lilienthall, J.L., Jr., 346, 359, 362,

369 Lindquist, M., 397, 409, 416, 417, 419,

436,440,464,480 Lindsley, D.B., 281,295 Lindstrom,J.M., 155,171 Lindvall, 0.,16,30 Ling, G.M., 277,310 Lingsch, C., 78, 79, 82 Lipinski, J., 15, 16,30 Lipp, J.A., 288, 303 Lipton, M.A., 64, 72 lissak, K., 277, 297,445,446, 456 Livett, B.G., 273, 291, 303 Livingston, K.E., 65, 66, 73 Ljundahl, H., 399, 418 Ljungberg, T., 404, 424 Ljungdahl, A., 399,418 Ljunggren, B., 224, 225, 235 lloyd, F.G., 435, 440 lloyd, K.G., 11, 13, 17,29,266,282,

297,303,312,337,374,376,390, 392,397,407,408,410,411,415,

AUTHOR INDEX

416,420,423 Lobanova, N.A., 78, 83 Lodge-Patch, I.C., 122, 129, 139 Loew, D., 320, 340 Loe~,O.,176,203,288,303 Logemann, G., 122, 140 Loh, H.H., 334, 342 Loizzo, A., 281,293,303 Long, V.P., 66, 72 Longden, A., 447, 456 Longo, V.G., 276, 277, 278, 279, 281,

282,283,284,289,293,294,301, 303,314,339

Longoni, R., 288, 303 Lord, J.T., 287, 295 Lorenz, E.G., 378, 393 Losey, N.A., 277, 303 Lovat, S., 266, 296, 526, 528 Lowry, O.H., 224, 233 Lucas, P.A., 396, 397,407,420 Lucius, G., 136, 137, 139 Luduena, FP., 280, 303 Lundgren, G., 376, 389 Lundholm,B.,272,303 Lust, W.D., 230, 234 Lutzky, H., 181,202 Lying-Tunnell, U., 484,504, 516,527 Lyle, P.T., 78, 79 82 Lynch, G.S., 7, 13,39 40,43,396,

397,407,420 Lynch, H.D., 293, 303 Lytle, L.D., 487 505 Maas, J.W., 34, 41,43 Macakova, J., 207,212 Machiyama, Y., 287,302 Machne, K., 276, 278, 287,303 MacIntosh, F .C., 266, 304, 484, 486,

494,504,505,509,516,520,521, 523,528

MacKay, A.V P., 379,386 MacLean, P., 287, 304, 398 423 MacLeod, P.M., 103,119 MacMillan, V., 224, 234 Macphail, E.M., 277,304 Macri, J., 494,495,509 Magee, K.R., 229, 233 Magherini, P.C., 282, 304, 314, 340, 342 Magnusson, T., 397, 409,417, 419,436,

440,464,480 Magoun, H.W., 270, 280, 305, 308

Mahler, H.R., 53, 61 Mahuke, J .H., 283, 287, 293 Maibauer, D., 328, 338 Maier, P.F., 312, 340 Maiti, A., 287,304 Maitre, L., 384, 393 Major, M., 277, 297 Makara, G.B., 447,458 Maldonado, M.E., 216, 234 Maler, L., 439, 442 Mallart, A., 198,202

565

Malmlund, H.O., 484, 504, 516, 527 Maloney, A.J.F., 206, 212, 229, 232,

253,261 Manaka, S., 501, 510 Mancall, E.L., 144, 154 Mancia, M., 277, 296 Mandel, P., 79, 82 Mandell, A.J., 11,13 Mandybur, T.I., 229, 234 Mano, T., 399, 420 Manschreck, T., 131,136,140 Mantovani, P., 271,306 Mao, C.C., 384, 390 Marchetti, P., 196,201,328,336 Marco, E., 384, 390 Marconcini, I., 288, 303 Marczynski, T.J., 270, 271, 272, 273,

277,278,279,280,283,285,286, 287,289,290,304,310

Markee, J.E., 449, 458 Markham, C.H., 143, 153,502,503,513 Markiewicz, B., 208, 212 Marley, E., 277, 304 Marriott, J.G., 177,201 Mars, H., 378, 381,386 Marsden, C.D., 107, 116, 378, 390,

397,404,409,411,413,420,422, 424

Marshall, P.B., 398,415 Martin, K., 78, 79,82,502,510 Martin, L., 449, 457 Martinelli, I., 447,456 Martini, L., 449,455,457 Maslova, A.F., 78,82 Mason, H.L., 226, 236 Mason, I.W., 454,457 Massarelli, R., 79, 82, 502, 507 Matousek, M., 351, 359, 370 Matsuda, Y., 284, 286, 307

566

Matsumoto, 1.,455,458 Matsuzaki, M., 314, 340 Mathew, P., 134, 135, 141 Matthews, J.D., 327,329,340 Matthies, H., 237, 250 Matthysse, S., 15, 16, 30, 382, 390,

409,420 Matz, R., 107,118 Maulsby, R.L., 286,304 Mauss, E.A., 69, 73 Mautner, H.G., 525, 528 Maxey, G., 320 322,341 Mayer-Gross, W., 382, 390 Maynert, E.W., 270, 273, 278, 287,

289,290,304,328,340 Mazzuchelli-O'Flaherty, A.C., 313, 338 Mazzuchelli-O'Flaherty, A.L., 313, 340 McBride, W.J., 520, 531 McCall, A.L., 103.119 McCandless, D.W.,486, 512 McCann, SM., 448, 449, 450, 455,

457,458 McCarley, R.W., 277,282, 293, 304,

312,313,314,318,336,338 McClelland, H.A., 402, 413, 420 McDonald, J., 278, 297 McDough, D.B., 156, 171 McDowell, F.H., 143, 153 McEachern, D., 287, 309, 503, 512 McFarland, R.A., 225, 234 McGaugh, J.L., 186, 203, 237, 250 McGeer, E.G., 67 68,70,72,102,109,

118,161,171,205,213,229,234, 253,374,375,377,380,389,390, 396,397,399,400,406,407,408, 409,410,413,414,419,420,421, 439,442,495,510

McGeer, P.L., 67, 68, 70, 72,102,109, 118,161,171,205 213,229,234, 253,262,374,375,377,380,389, 390,396,397,398,399,400,406, 407,408,409,410,413,414,419, 420,421,439 442,495,510

McGinty, D.J., 313, 342 McGregor, P., 311 , 343 Mcllwain, H., 223, 234 McKendall, R.R., 109, 118, 122, 129,

141,378,389 McKenna, T M., 277, 282, 293, 304,312,

313,314,318,336,338

AUTHOR INDEX

McKenzie, G.M., 17,30,76,81,96,97, 109,117,122,129,131,135,140, 379,388

McLean, B.K., 448,455,458 McLean, P., 135, 137, 141, 378, 391 McLennan, H., 373, 390,405,406,407,

421 McMenemy, W.H., 101, 119 McMurty, J.G., 286,306 McNair, J .L., 439,442 McNamara, B.P., 276,310 McNamara, J.~., 230, 234 McQueen, J., 229, 232, 248, 249, 361,

369,497,499,505 McWhirter, W.R., 77, 83 Meath, J.A., Jr., 65, 73 Meckelnberg, K.L., 280, 308 Meduna, L.J., 11, 13 Meek, J.L., 206, 207, 213, 253, 262 Mehler, W.R., 439, 442 Mehrotra, K.N., 525, 528 Mehta, D., 134, 135, 141 Mehta, S., 134, 135,141 Meites, J., 448, 455, 457 Melancon, S., 227, 231 Meldrum, B., 409, 424 Mendels, A., 6,12 Mendels, I., 447, 456 Mendels, J., 18,25,29 Mendelson, G., 402, 421 Mendelson, W.B., 312, 315, 317, 337,

338,340,342 Menon, N., 143, 153,226,232 Mergner, T., 282, 304 Merikangas, J.R., 77, 78, 79, 81,257,

261,502,503,508,541,547 Merlis, S., 376, 392 Merry, J., 41,43 Mettler, C.C., 382,390 Mettler, F .A., 382, 390 Metys, J., 321,324,325,340 Metysova, J., 321,324,325,340 Mewaldt, S.P., 200, 202, 238, 250 Meyers, B., 208, 213 Michaelson, LA., 520, 531 Michel-Ber, E., 276, 302 Michelson, M.J., 197, 198,203 Mickey, M.R., 274, 277, 279, 281, 297 Migdal, W., 320, 340 Milfay, D., 521, 529

AUTHOR INDEX

Miller, AL., 220,234 Miller, E., 76, 82, 122, 131, 134, 135,

137,141 Miller, P.L., 204 Miller, R.D., 76, 81,109,117,135,140,

379,388 Miller, R.F., 276, 304 Miller, R.I., 376, 379,384,389,390,

399,404,407,419,421 Millington, W.R., 103, 119 Milner, B., 239, 250 Milson, J., 404, 420, 422 Milstoc, M., 41, 43,58,59,61,78,79,

81,82 Minota, S., 288, 290, 305 Minvielle, J., 288 304 Mirotvorskaia, G.N., 289, 304 Mishkin,MM., 401, 418 Mitchell,J.F., 271, 294, 328, 340, 374,

390 Mitchell, K., 206, 212 Mitchell, P., 221,235 Mitler, MM., 314, 315, 340 Mittag, T.W., 220, 231, 484, 493,504,

521,522,523,525,526,527,528, 529,531

Mittal, C., 218, 234 Miyakawa, T., 229, 235 Miyata, T., 314, 339 Mizuno, N., 284, 307 Modak, A.T., 79, 83,484, 503, 512,

516,531 Modestin,J.I., 6, 8,10,13,16,18,31,

75,82 Mohan, KJ., 135, 139 Mohler, H., 397, 410, 420 Mohs, R., 207, 212, 253, 254, 260,

261,358,359,361,362,368,369, 370,435,441

Molenaar,P.C., 218, 235,493, 511, 522, 523,531

Molina, F., 177, 194, 204 Moline, R., 131, 136, 141 Moller, J.E., 107, 117 Moller-Nielsen, I., 377,378,388 Monnier, M., 284, 286, 305, 312, 340 Montague,W.E., 241, 249 Monti, J .M., 449,458 Montplaisir, J.Y., 277,286,305 Mookerjee, B., 502, 511

Moore, A., 317,342 Moore, J., 320, 337

567

Moore, K.E., 377, 378, 390, 404, 424 Moore, R.Y., 16,30 Moore, W.J., 53, 61 Mooser, G., 196,203 Moreau, A., 277,283,296 Morel, M.N., 486,510 Morgan, B., 326, 338 Morgane, P.J., 283, 299, 313, 338 Morgenroth, V.H., 472, 481, 487,510 Morison, R.S., 284, 296 Morley,B.J., 492, 510 Morocutti, G., 278, 297 Moroni, F., 327,331,340 Morpurgo, C., 403, 404, 421 Morrell, F., 278,305 Morris, A.A., 287,306 Moruzzi, G., 276, 280, 305 Moskovitz, C., 402, 420 Moss, D.E., 176, 177, 192, 194, 195,

196,203,204 Mostafapour, S., 266, 310 Motta, M., 449, 457 Moyer, A.W., 132, 140,379,388,485,

494,500,506 Mrsulja, B., 320, 234 Madgill, L., 321,323,340 Mueller, R.A., 199,203 Mulas, A., 288,303,305 Mulas, M.L., 196,204,327,329,337 Mulder, A.H., 522,530 Mulhall, D., 375, 388 Muller,P.,119 Muller, S., 328, 338 Munal, H.D., 320, 326, 342 Munch, 0., 228, 234 Munkvad, 1.,17,31,383,3.90 Munoz, C., 40, 44, 347, 359, 362, 368,

370 Munoz, R., 20, 30, 54, 61 Munsell, D.W., 320, 323, 326, 342 Murad, F., 218, 234 Murayama, E., 229, 235 Murphree, H.B., 40, 44, 347, 359, 362,

368,370 Murphy, D.L., 5, 12, 15, 30,41,42 Murray, K.E., 106, 118 Murrin, L.C., 439, 442, 472, 481, 484,

487,492,509,510,523,524,530

568

Muscholl, E.,41O, 421 Muzio, J.N., 311,341 Myers, R.D., 270, 277, 278, 280, 287,

291,305 Nachmansohn, D., 215, 216, 235, 495,

504,509 Nagasaki, H., 312, 340 Nagaswami, S., 135, 139 Nagle, A.F., 266, 302 Nagler, A.L., 466, 481, 487, 491,510 Nakamura, R., 216, 222, 235, 486,

505 Naruse, H., 216, 222,235,287,288,305 Nashold, B.S., 376, 390 Nasrallah, H., 402, 422 Nasu, T., 287,309 Naumenko, E.V., 445, 446, 458 Nausieda, P.A., 430, 434 Nauta, W J.H., 283, 305, 439, 442 Naylor, R.J., 17,29,31,379,387,401,

403,404,410,417 Neal, MJ., 288, 298 Neil,F., 46,50 Nelson, B., 41,42 Nelson, S.R., 224, 233 Nesse, R., 39,44, 134, 135, 141 Nevin, S., 4,13,16,18,31,34,39,44,

65,73,75,83,346,360,362,370, 385,391,402,422

Newton, R.W., 77,82 Ng, L.K.Y., 378, 391 Ngo, T., 227,231 Nicholl, R.M., 320, 337 Nickerson M., 227, 234, 447,457 Nicklas, W.J., 230, 232 Nicoll, R.A., 288, 290, 305 Nicotera, M., 501, 511 Niemegeers, C., 383, 389, 404, 417, 424 Nieoullon, A., 273, 295, 375, 387,409,

417 Niimi, K., 439, 442 Nikitovitch-Winer, M.B., 448, 455, 458 Niklasson, B.H., 53, 61 Nilsson, G., 375, 389,525,529 Nishi,S.,266,267,271,288,290,305 Nistri, A., 271 , 305, 306, 321,324, 340 Nixon, R.A., 314, 341 Noda, H., 466, 480, 484, 507, 521,

522,523,529 Noell, W.K., 224, 231

AUTHOR INDEX

Nogeire, C., 311,343 Nola, E., 155, 171 Norberg, K., 224, 225,235 Nordberg, A., 483, 492,510 Norman, R.L., 448, 449, 450, 455, 456 Norris, J.W., 381, 388 Norton, S., 282,300,314,339 Nosari, 1.,447,456 Nose, T., 435, 442 Nowycky, M.C., 436, 442 Nyback, H., 374, 391 Nystrom, B., 60, 105,106, 116,502,

503,504 Oakley, N.R., 375, 388,409,418 Oates, J.A., 382, 389 Obrador, S., 278, 305 Oderfeld-Novak, B., 288, 303 Oesch, F., 199,203,487,510 O'Flaherty, J.J., 313, 338,340 Ogashiwa, M., 501,510 Ogushi, T., 66, 73 Oh, D., 107, 118 Oh, K.J., 216, 234 Ohgo, S., 448, 449, 457 Ohlsson, W.G., 288, 308 Ohta, M., 429,434 Oishi, R., 277,305 Oka, H., 284, 286, 307 Okada, J., 501,510 Okada, V., 439, 442 Okada, Y., 375, 389 Okamoto, S., 399, 420 O'Keefe, R., 375, 391, 409, 421, 435,

442 Okonek, S., 277, 307, 347, 357, 359,

362,370,502,503,510 Okuma, T., 284, 295 Olariu, J., 65, 72 Oldendorf, W.H., 463, 465, 466, 481,

485,494,506,510,517,518,530 OIds, M.E., 39, 43 Olivecrona, H., 231, 235 Olivier, A., 396,409,421 Olley, J .E., 17,31,398,402,403,404,

410,417 Olson, L., 395, 415 Ombrato, M., 501,511 Onodera, K., 45,50 Op den Velde, W., 68, 73 Ordy, J.M., 229, 235

AUTHOR INDEX

Orlov, P., 402, 413, 421 Orzeck, A., 407,421 Ostfeld, A.M., 200, 204, 207,213 Osuide, G., 495,510 Osumi, Y., 277,305 Osuntokun, B.O., 226, 235 Oswald, I., 318, 341 Otegui, J.T., 449,458 Otsuka, K., 446, 447,458 Otsuka, Y., 280, 302 Ott, J.E., 402,416 Ott, T., 237, 250 Otten, U., 199, 203 Overall, J., 7, 9,12,19,20,29,31,40,

43,49,50,200,202,207,212,238, 239,248,250,260,261,359

Paalzow, L., 320, 323, 326, 336 Pakkenberg, H., 383, 390 Palkovits, M., 273, 283, 305, 375, 384,

389,391,396,411,421 Pallis, C.A., 122, 129, 139 Pandit, S.K., 207, 212 Pandey,G.N., 122, 129, 142 Panksepp, J., 283, 299 Papavasiliou, P.S., 102, 117 Papeschi, R., 436, 439, 442 Pappano, A.J., 46,50 Pappenheimer, J.R., 312, 341 Pardridge, W.M., 463, 464, 465, 466,

481,485,510,517,518,530 Parent, A., 396, 409, 420 Parikh, I., 155, 171 Parkes, J.D., 404, 420 Parsons, J .C., 320, 326, 342 Passonneau, J .V., 230, 234 Passouant, M., 288,304 Patel, B.C., 17,30,401,403,420 Paton, W.D.M., 197, 204, 328, 341,

517,529 Patrick,J., 155, 171 Patrick, R.L., 487,510 Pauling, P., 326, 336 Paulson, G.W., 426, 427, 433, 434 Pearce,G.W., 206, 212 Pechnick, R., 46, 48,50 Pedata, F., 288, 305,519,530 Pedigo,N.W., 321, 326, 331, 332,341 Pegram, G.V., 318, 341 Pelchat, G., 121, 122, 140 Pellandra, C.L., 319, 320, 323

Penaloza-Rojas, J .H., 278, 305 Penfield, W., 287,306

569

Pepeu, G., 34, 39,44, 132, 133, 134, 141,196,204,269,270,271,288, 303,305,306,321,324,327,379, 391,494,510,519,530

Peregrino de Iraldi, A., 396, 418 Perez-Cruet, J., 435, 442 Pernow, B., 375, 389 Perri, V., 225, 235 Perry, E.K., 70, 73, 206, 213, 229,

235,253,262 Perry, R.H., 70, 73, 206, 213, 229,

235,253,262 Perry, T.L., 102, 103, 119, 160,172,

379,391,400,422 Persseon, T., 382, 387 Pert, A., 319, 320,322,323,325,326,

341 Pert, C.B., 326, 341 Peters, B.H., 208, 213, 238, 250, 253,

262 Peters, H., 122,141,378,391 Peterson, M.R., 383,392 Peterson, R.C., 238, 250 Petrie, A., 122, 129,139 Petsche, H., 281, 306 Petterson, U., 21,22,24,25,26,28,31 Pettigrew, K.D., 311,337 Petzold, G.L., 374, 387 Pfaff, D.W., 375, 387 Pfefferbaum, A., 207, 212, 253, 254,

260,261,358,359,361,362,368, 369,435,441,541,547

Pfeiffer, C.C., 15,30,31,39,40,44,64, 73,75,82,121,132,141,347,359, 362,368,370,379,385,389,391, 402,422,485,494,500,507,510, 511

Phan, D.V., 277, 287, 289, 306 Phillips-Thonnard, 1.,166, 170 Phillis, J.W., 156, 171,267,291,306,

328,339 Pieklik, J.R., 493,511 Pieron, H., 312, 341 Pierre, R., 277,306 Pijnenburg, A.J.J., 17,31,383,391,

439,440,441 Pilar, G., 492, 493,512,521,524,531 Pineau, R., 121, 122, 140

570

Pinski, C., 327, 328, 333, 339, 341 Piorier, L.J., 436, 439,442 Piot, Cl., 107, 119 Pires, P., 16, 30, 121, 122, 140,402,

418 Pitts, F.N., Jr., 41,44 Pletscher, A., 408, 409, 410, 411, 415,

416,440 Pleul, 0., 75, 82,465,481,484,494,

509 Pleuvy, B.J., 321,323,341 Ploeg, R.A.V., 326, 327, 343 Plum, C.M., 69, 73 Plum, F., 224, 228,231, 235, 236 Poirier, L.J., 396, 409, 412, 421, 422 Polak, R.L., 218, 235, 288, 294, 328,

336,493,511,522,523,531 Polocki, B., 34, 39, 43, 132, 133, 134,

139, 494, 506 Poloni, A., 69, 73 Pompeiano, 0., 282, 294, 304, 306,

314,340,342 Poncy, M., 324,340 Poon, P., 76, 81 Pope, A., 65,66, 73,287,289,306,310 Popper, H., 105,117,500,506 Porcellati, G., 76, 83 Porter, J .C., 447,458 Portig, P.J., 436, 439, 442 Portman, O.W., 76, 82,484, 508, 516,

517,530 Posner, J.B., 228, 235 Post, R.M., 312, 318, 337, 341, 436,

442 Postman, L., 239, 250 Potter, L.T., 484,493,507 Poulen, U., 229, 233 Poussart, Y., 284- 285, 302 Powell, D., 375, 388 Powell, T .P.S., 396, 420 Power, M.H., 226, 236 Pradhan,R.,321,323,339 Pradhan, S.N., 278, 286, 298 Prange, A.J., 449, 456 Precht, W., 375, 391,439,443 Price, M.T.C., 326, 341 Procter, E., 487, 491, 508, 518, 530 Pryor, G.T., 287, 306 Puca, G.A., 155, 171 Puerto, A., 177, 194,204

AUTHOR INDEX

Pull, E., 268, 302 Pujol, J.F., 273, 274, 282, 298, 306 Purpura, D.P., 286, 306 Pycock, C., 404, 409, 420, 422, 424 Quastel, J.H., 216, 233, 234, 235,485,

486,511 Quitkin, F., 131, 136, 141, 397,422 Rabassini, A., 69, 73 Rabin, A., 439, 443 Rabsztyn, T., 286, 307 Racagni, E., 269, 295 Racagni, G., 11, 14, 272, 283, 295,

309,327,331,343,374,384,390, 392,396,407,408,410,411,412, 417,424,483,488,490,505,511, 517,531

RadiI-Weiss, T., 281, 306 Ranai, A., 46,51 Rand, M.J., 410, 416 Randic, M., 46,50, 78, 80, 267, 306 Randrup, A., 17,31,41,43,47,50,

87,97,109,118,122,129,130,131, 140,141,142,378,379,383,386, 388,390,399,401,403,415,418, 422,439,440

Ranje, C., 404, 424 Raymondeaud, Cl., 107, 119 Rayner, C.N., 379, 386 Re, 0., 379, 391 Rea, A., 447,456 Rebec, G.V., 409, 419, 439, 441 Rech, R.H., 287, 306 Redman, W., 40, 43 Reeves, C., 287,306 Reid, J.L., 436, 441 Reid, W.D., 379, 389 Reiger, H., 347, 357,359,362,370 Reis, D.J., 40, 43,137,141 Reisby, N., 41, 43,87,97,109,118,

122, 129, 131, 140,378,379,388, 399,401,418

Reisine, T.D., 165, 171,206,213,380, 391,429,433

Reiss, M., 68, 69, 72, 73 Rengel, S.P., 425, 434 Rennick, B., 502, 511 Revuelta, A., 384, 390, 393 Reyes, P.L., 155,156,171 Reynolds, C.M., 41,43 Reynolds, E.H., 107, 116

AUTHOR INDEX

Reynolds, S.F., 486, 511 Richardson, D.L., 288, 301 Richardson, I.W., 271, 306 Richardson, J.D., 228, 231 Richardson, J.S., 273, 305 Richelson, E., 156, 171 Richter, D., 59, 61, 199, 204, 288,

307,312,341 Riciputl, R.H., 208, 213 Rick, W., 107, 118 Ridlon, S., 277,301 Rieger, H., 277, 307 Riekkinen, P., 396, 397,422 Rifkin, A., 131, 136, 141,397,422 Riives,J.,231,235 Rinaldi, R., 269, 270, 276, 277, 279,

290,307 Ringberger, V., 41,42 Ringel, S.P., 426, 434 Rinne, UK., 396, 397,422 Rivera-Ca1irnlim, L., 16, 31, 402, 422 Rizzo, F., 447,457 Roberts, E., 103, 119,288,308,381,

392 Roberts, K.R., 208, 213 Robins, R., 20, 30, 54, 61 Robinson, C.R., 318,341 Robinson, G.A., 267,308 Robinson, G.R., 492,510 Robinson, T.E., 281,310 Roch, M., 76, 82, 218, 234, 379, 389,

492,494,495,505,509,534,538, 539

Rodriguez-Budelli, M., 143, 144, 153, 154,226,232

Rodriguez de Lores Arnaiz, G., 396,418 Roffler-Tarlov, S., 436, 442 Roffwarg, H.P., 311,341 Rogers, J.B., 177, 178, 183, 186, 190,

192,194,195,203,204 Rojas-Ramirez, J .A., 283, 307 Romano, J., 357, 360 Rommelspacher, H., 408,422 Ronai, A., 78, 83 Roos, B.E., 229, 233, 382, 385, 387,

391,398,403,415,422 Rosen, AJ., 285, 304 Rosenblatt, J.E., 9, 13, 18,30,49, 50 Rosenblatt, J.R., 8,12 Rosenthal, R., 16, 31, 65, 73, 385,

571

391,399,422 Roshchina, L.F., 277 , 307 Rossi, G.V., 376, 386, 398,417 Rossier, J., 272, 298, 407, 419, 484,

511,522,523,529 Rossiter, R.J., 538, 539 Roth, M., 226, 231, 235, 382, 390 Roth, R.H., 272, 273,290,307,374,

375,386,408,409,410,416,422, 435,436,439,440,442,472,481, 484,487,492,509,510,521,522, 530

Rothwell, R.P.G., 77,80 Rowntree, D.W., 4, 13, 16, 18,31,34,

39, 44, 65, 73, 75, 83, 346, 360, 362,370,385,391,402,422

Rozanova, V.D., 204 Rubovits, R., 17,30,87,97, 103, 109,

118,122,129,134,141,143,153, 166,171,377,378,379,380,390, 391,400,401,403,414,420,422, 435,442,541,547

Ruch, W., 378,392,413,415 Ruch-Monachon, M.A., 273, 283, 299,

307 Rumack, B.H., 402, 416 Rump, S., 286, 307 Russell, R.W., 289, 310,494,495,509 Ryall, R.W., 46,50 Saavedra, J.M., 375, 384, 391,396,411,

421 Saba,P., 501, 511 Sacchi, 0., 225, 235 Saelens, J.K., 270, 308, 374, 392, 518,

531 Safer, D.J., 11, 13,33,44,200,204,207,

213,238,250,402,414,422 Safratova, V., 207, 213 Sahakian, B., 404, 419 Sahlstrom, L., 489, 490, 492, 507 Sagales, T., 315, 341 Sainsbury, P., 41, 42 Sakai, Y., 280, 288, 290, 299, 302 Sala, M.A., 449,458 Salehmoghaddam, S., 76, 81 Salford, L.G., 224, 234 Salganicoff, L., 396,418 Salmoiraghi, G.C., 373, 374, 386, 391,

404,405,416 Salvadorini, F., 501,511

572

Salzman, C., 255, 262 Salzman, P.M., 436, 442 Samanin, R., 274, 298 Samaras, G.M., 524, 531 Samples, J., 46, 48,50 Sandgarde, B., 436,442 Sano, K., 501,510 Santinoceto, L., 196, 201, 328, 336 Sarwer-Foner, G.J., 130, 141 Sasaki, K., 284, 286, 307, 315, 342 Sastry, P.S., 502, 511 Sathananthan, G., 15, 31, 229, 233 Sato, M.M., 277, 302 Sato, S., 122, 141,378,391 Savina, L.S., 78,83 Sawyer, C.H., 448, 449, 450, 455, 456,

457,458 Sayers, A.C., 17,29,378,392 Sax, D.S., 96, 97, 122, 129, 142, 166,

172,379,380,391,392,399,401, 424

Saxena, P.N., 320, 323, 342 Sazie, E., 277, 286, 305 Scally, M.C., 40, 44, 266, 293, 309,

462,465,474,476,477,478,479, 481,487,489,490,492,511,512

Scaramuzzi, R.J., 448,449,456 Scarf, T., 286,306 Schacht, J., 267, 296 Schaeppi, U., 278, 308 Schain, R.J., 69, 73, 502, 511 Schallert, T., 281, 310 Schapiro, S., 197,204 Schaumann, W., 328, 342 Scheel-Kruger, J., 130, 141,383,392,

401,403,422,542,547 Schein, R., 404, 415 Schelkunov, E.L., 404, 422, 541, 546,

547 Schenck, J.R., 76, 81 Schenker, S., 486,512,513 Schiffer, L.M., 376, 387 Schildkraut, JJ., 4,13, 15,31,33,41,

44 Schillekens, K.H.L., 383, 389 Schiller, P.H., 186,202 Schiorring, E., 130, 142 Schlesinger, K., 287, 307 Schless, A., 6,12,18,25,29 Schmahl, F.W., 224, 235

AUTHOR INDEX

Schmidt, D.E., 486, 490, 492, 513 Schmidt, J., 286, 307 Schmitt, H., 276, 308 Schneider, C., 333, 334, 336 Schneider, D., 220, 231 Schoenenberger, G.A., 312, 340 Schreiberg, G., 277, 297,445,446,456 Schuberth, J., 60, 76,81,83,103,105,

106,116,119,374,391,466,481, 484,485,494,500,502,503,504, 506,508,509,511,516,517,518, 527,529,531

Schulman, H., 196, 203 Schulman,J.,198,204 Schulman, M.P., 75, 80,465,480,515,

516,520,528 Schultz, S.G., 493,511 Schutz, F., 66, 73 Schwartz, R.B., 6, 8, 10, 13, 16, 18,

31, 75, 82, 103, 119, 166, 170 Schwarz,P., 231, 235 Scott de Carolis, A., 314, 339 Scudder, C.L., 288, 298,301 Sears, E., 103, 120, 137, 142, 166,

172,380,393 Sedvall, G., 21, 22, 24, 25, 26, 28, 31,

374,384,391,393,436,442 Seelinger, D., 107, 117 Seeman, P., 119,382,392,397,422,

429,434 Seifter, E., 466, 481,487,491,510 Seitelberger, F., 396,397,400, 416 Sekerke, H.J., 3,4,5,7,10,13,15,16,

17,18,30,33,34,39,40,41,43,45, 47,49,50,64,72,75,77,82,131, 140,318,338,385,388,389,402, 419,439,441,447,457,500,508, 541,547

Sekino, H., 501, 510 Seller, T.J., 277, 304 Sellinger, 0 .Z., 288, 308 Sequin, J.J., 314, 342 Sethy, V.H., 374, 376, 392, 407, 423,

484,492,509,521,522,530 Sevostyanova, G.A., 78, 83 Seybold, M.E., 155, 171 Shader, R.I., 255, 262 Shahani, B.T., 104, 119 Shapcott, D., 227, 231 Shapiro, S., 399, 423

AUTHOR INDEX

Shapman, D.R., 435, 442 Sharman, D.F., 375, 391,409,421,435,

436,442 Sharp, F M., 230, 235 Shaw, F.H., 4, 13, 18,30,34,39,43,

65,72,75,81,317,337 Shea, P.A., 110, 119, 486, 512, 520,

531 Sheppard, C., 376, 392 Sherwood, S.L., 66, 73 Sheth, U., 321,323,339 Shiffrin, R.M., 238, 239, 249 Shih, TM., 76, 77, 78, 79, 80, 81, 83,

257,261,502,503,508,541,547 Shimada, M., 218, 219, 222, 230, 233 Shimono,T.,286,307 ShopMn, B., 6, 13, 15,31,45,49,50,

192,204 Shoulson, 1.,102,103,119,159,171,

381,392 ~ute, C.C.D., 268, 269, 270, 294,

303,308,319,342,396,406,407, 416,423

Shuto, S., 288, 301 Sianska, J., 200, 204 Sica, V., 155, 171 Sidell, F.R., 238, 250 Siegel, JF.L., 463, 480 Siegel, JM., 313, 342 Siesjo, B.K., 224, 225, 234, 235 Siggins, G.R., 405, 423 Sigman, D.S., 196,203 Signorelli, A., 177,185,186,204,208,

209,213 Sigwald,J., 107, 119 Silbergeld, E.K., 34, 39,43, 132, 133,

140,379,388,494,507 Silver, A., 395, 396, 419, 503, 505 Silverberg, A.I., 447, 457 Silverman, R.W., 76, 82, 218, 234,

379,389,534,538,539 Silvestrini, G., 276, 279, 284, 289, 294,

303 Sim, V M., 4,12,18,29,39,42,75,80 Simard, H., 396, 409, 421 Simke, J.P., 270, 308, 374, 392 Simmonds, M.A., 280, 299, 409, 418 Simmonds, S., 76, 81, 132, 140, 379,

388,485,494,500,506 Simon, E.J., 521, 529

573

Simon, J.R., 484, 492,512,522,524, 525,527,530,531

Simon, R.P., 282, 295 Simonton, S., 257, 260, 261, 439, 441,

534,538 Simpson, G.M., 121, 136, 142,399,413,

423 Simpson, L.L., 46, 50 Singer, G., 177,178,204 Singer, K., 122, 129, 142 Singh, MM., 16,31,65, 73, 385, 392,

402,414,423 Singh, V.K., 374, 390, 396, 397,407,

408,409,413,414,419,421,439, 442

Sinke, J.P., 518, 531 Siroka, A., 207, 212 Sitaram, N., 207, 213, 253, 262, 282,

292,308,312,315,317,320,323, 324,325,337,338,342,347,358, 360,361,368,370

Sjogren, T., 226, 227, 235 Sjostrand, T., 278, 308 Sjostrom, R., 87, 97, 166, 170, 380,

386,401,415,435,440 Skinner, R.F., 77,81 Slater, E., 226, 231, 235, 382, 390 Slater, P., 288, 289, 308, 330, 336 Slater, P.C., 199,204 Slaughter, D., 320, 323, 326, 342 Smeets, R.A., 122, 139 Smelik, P.G., 411,423,447,457 Smialowski, A., 277, 308 Sminoff, R., 267, 306 Smith, A.D., 68, 71 Smith, C.B., 205, 211, 228, 229, 230,

232 Smith, E.L., 197,204 Smith, J.E., 520, 531 Smith, J.M., 16,31,65,73,385,392 Smith, R.C., 3,6,9, 10, 12, 14, 19,

32,34,39,40,41,44,49,51,75, 76,83,87,97,110,115,119,122, 129, 131, 136, 142,257,262,495, 496,499,500,512,533,534,539

Smith, R.P., 39, 44,75,82, 121,132, 141

Smith, S.J., 401,420 Smith, T., 326, 338 Smyrl, E.G., 266, 302

574

Smythies, J.R., 318, 341 Sniffen, C., 131,140 Snyder, B.D., 77, 83 Snyder, F., 311, 318, 336,337 Snyder, S.H., 11,13,17,19,31,32,70,

71,74,78,83,96,97, 102, 109, 116, 117, 130, 134, 139, 142, ISS, 156,157,158,160,161,164,165, 167,170,171,172,206,213,326, 341,374,378,379,380,382,386, 387,388,392,395,396,399,405, 407,417,423,424,429,433,434, 449,456,466,481,484,495,500, 507,513,521,522,523,525,530, 531

Sobotka, T.J., 287, 308 Sobue, I., 399,420 Soko~kaya,R.A., 78,82,83 Sokoloff, L., 228, 236 Somogyi, G.T., 271,294 Sonesson, B., 198,202 Sonninen, V., 396, 397, 422 Sorbo, B., 525, 529 Sorum, H., 326, 336 Soukupova,B.,207,213 Sourkes,T.L.,225,231,236,396,422,

436,439,442 Spanis, C.W., 312, 337 Spanner, S., 75, 76, 80, 301, 116, 132,

138,465,480,484,485,494,504, 515,516,517,518,527,531

Spano, P., 433 Sparf, B., 76, 83, 103, 119, 272, 303,

485,511,517,518,527,531 Speeg, K.V., 486,512 Spehlmann, R., 288, 296, 405, 406,

413,423 Spence, M.A., 144, 146, 148, 153 Spiker, D.G., 77, 78, 79, 81, 257,261,

502,503,508,541,547 Spillane, J .A., 229,235 Spina, L., 321,324,340 Spokes, E., 206, 213 Sproull, D.H., 288, 294 Squire, L.R., 176, 177,199,204 Stadian, EM., 229, 234 Stadler, H., 11, 13, 17,29,282,297,

312,337,374,392,407,408,411, 415,416,423,435,440,486,508

Stadnicki, S.W., 278, 308

AUTHOR INDEX

Stahl, S.M., 413, 423 Stahl, W.L., 102, 119,379,380, 392,

400,423,495,512 Stam, F.C., 68,73 Stancer, H.C., 502, 511 Stanes, M.D., 177,178,204 Stanley, M.E., 384, 393 Stark, E., 447, 458 Starzl, T.E., 270, 308 Stavinoha, W.B., 79, 83, 484,503,512,

516,531 Stavraky, G.W., 276, 304 Steg, G., 398, 403, 405, 406, 415,

422,423 Stein, L., 70, 74 Steinborn, J.A., 76, 82, 218, 234, 379,

389,534,538,539 Steiner, A.L., 156, 171 Stepita-Klavco, M., 312, 337, 342 Steriade, M., 270, 273, 277, 278, 282,

283,308 Sterman, M.B., 283, 285, 295, 308 Stern, L.Z., 160, 165, 167, 171, 172,

380,391,393,500,513 Stern, M., 311,342 Stern, W.C., 283, 299 Sternberg, S., 240, 241,250 Stevens, D.L., 100, 119 Stevens, J.R., 16,32,287,304,398,423 Stille, G., 413, 415 Stitcher, D.L., 374, 389 Stock, G., 384, 385,439,440 Stone,C.A.,65,72,280,287,308 Stone, W.E., 224, 233 Strange, P.G., 156,172 Straughan, D.W., 267, 280, 299, 306 Strauss, J., 402, 422 Strickland, K.P., 538, 539 Strohmayer, A., 277, 296 Struyker Boudier, H.A.J., 373, 387 Stubs, M., 220,236 Stumpf, C., 278, 281,295,308 Subramanian, M.G., 448, 458 Sugimori, M., 405, 420 Sullivan, J.L., III, 76, 81, 109, 117,

135,140,379,388 Sulser, F., 11, 14,34,39,42,44 Sumino, R., 288, 301 Surniyoshl, S., 229, 235 Sundbarg, G., 229, 233

AUTHOR INDEX

Sundwall, A., 60, 76, 83, 103, 105, 106, 116, 119, 158, 170,483,485, 502,503,504,510,511,518,527

Sung, J.H , 229, 234 Suszkiw, J.B., 492,493,512,521,531 Sutak, M., 327, 329, 339 Sutherland, E.W., 267, 308 Sutin, J., 439,442 Sutker, P.B., 199,201 Suzuki, J., 288, 302 Suzuki, K., 229, 236 Suzuki, T., 446, 447, 455, 458 Svenneby, G., 288, 308 Svensmark, 0., 53, 61 Swahn, C.G., 436,442 Swanson, P.O., 102, 119, 379, 380,

392,400,423,495,512 Swett, C., 399 423 Szabo, J., 277, 296, 439,443 Szerb, J .C., 266, 271, 296, 306, 308,

309 Taeschler, M., 320, 340 Takagi, S., 399, 420 Takahashi, R., 287,309 Takahashi, Y., 66, 73 Takaori, S., 277, 305 Takemori, A.E., 321, 324, 326, 342 Takemoto, H., 435, 442 Takeuchi, K., 501,510 Taliamonte, A., 435, 442 Tamminga, C., 3, 6, 9,10,12,14,19,32,

34,39,40,41,44,49,51,75,76, 83,87,97,110,115,119,122,129, 131,136,142,257,262,495,496, 499,500,512,533,534,539

Tamura, T., 287, 309 Tan, U., 280, 287,309 Tanaka, T., 198, 199, 203, 501, 510 Taneda, M., 317, 342 Tang, A.H., 319, 342 Tanner, T., 375, 388 Tarsy, D., 96,97, 109, 119, 121, 122,

129,142,166,172,377,378,379, 380,390,392,397,399,401,404, 413,420,422,423,424,439,440, 541,547

Taylor, C.W., 270, 308 Tebecis, A.K., 406, 424 Tecce, JJ., 363, 370 Tedesco, J., 429, 434

575

Tegerdine, P., 436, 442 Teitelbaum, H., 281, 309 Tennenbaum, M., 216, 235, 486, 511 Teodoru, C., 41, 43, 58, 59, 61, 79,

82 Tepper, J., 17,30,439,441,541,547 Terao, A., 396, 420 Terkel, J., 448, 458 Tessier, J., 282, 299, 312, 339 Teychenne, P.F., 122, 129, 139, 376,

387 Tha, S., 321, 336 Thacore, V.R., 318, 341 Thatch, B.T., 107, 119 Theobald, W., 404, 421 Thesleff, S., 198,202,203,204 Thiessen, M.M., 59, 61 Thoden, U., 282,304, 314,340 Thoenen, H., 199,203,472,481,487,

512 Thomas, R.K., Jr., 200, 202 Thompson, H., 107, 118 Thoren, P., 41,42 Thornburg, J.E., 377, 378, 390, 404,

424 Thulin, B., 107, 117 Timo-Iaria, C., 283, 299, 313, 338 Tinklenberg, J.R., 207, 212, 253, 254,

260,261,358,359,361,362,368, 369,370,435,441

Tittler, M., 429, 434 Tobey, J., 321, 323, 340 Tobias, M.A., 321, 323, 341 Tobler, HJ., 312, 340 Tod, H., 59, 61 Tolley, E.R., 228, 234 Tomlinson, B.E., 70, n, 206, 213,

229,235,253,262,380,391 Topel, J.L., 76, 82,131,137,141,379,

390 Torchiana, M.A., 280, 308 Torda, C., 318, 342 Torrey, E.F., 383, 392 Tower, D.B., 287, 309, 503, 512 Toyoda, J., 315, 342 Trabucchi, M., 11, 14, 272, 309, 374,

392,407,408,424,433,434,488, 490,511,517,531

Train,K.,7,9, 12, 19,29,40,43,49,50, 200,202,207,212,238,239,248,

576

250,260,261,359 Traskman, L., 41,42 Tretyakova, K.A., 78, 83 Trienzenberg, HJ., 378, 393 Tripod, J., 288, 309 Tsubokawa, T., 439, 442 Tucek, S., 216, 222, 236, 485, 486,

508,512,520,531 Turner, B.B., 106, 118 Turner, W J., 69, 73 Tursky, B., 311, 324, 342 Tye,N., 208,209, 212 Uchizono, K., 312, 340 Udenfriend, S., 464, 480 Uhlendorf, B.W., 143, 153 Uhrbrand, L., 107, 109, 119, 122, 129,

142 Ulus, I.H., 40,44, 106, 119, 120, 137,

142,257,262,266,293,309,409, 424,466,472,474,475,476,477, 478,479,481,487,489,490,492, 511,512

Ungerstedt, U., 16, 32, 379, 383, 386, 393,395,404,405,415,423,424

Unna, K.R.W., 276, 278, 287, 303 Urquhart, N., 160, 172 Usdin, E., 64, 73, 266,309 Usunoff, K.G., 400, 409, 415 Vaca, K., 524, 531 Vailati, A., 447, 456 Van Andel, H., 64 73,75,83 Van Balgooy, J.N.A., 103, 119, 381,

392 Van der Heyden, J .A.M., 17, 31 Van der Poel, A.M., 208, 213 Vanderwolf, C.H., 281,302,309 Van Eich, A., 321,323,342 Van Gelder, M., 522, 523, 531 Vanhart, D.A., 320, 323, 338 Van Meter, W.G., 268, 274, 275, 276,

277,283,284,285,287,302,309, 345,358,360

Vannucci, R.C., 231,236 Van Rossum, J.M., 17,31, 130, 139,

373,376,383,387,391,393,439, 440,441

Van Woert, M.H., 76, 83, 374, 376, 377,385,392,393,398,399,407, 415,423,424,483,512

Vas, CJ., 288, 309

AUTHOR INDEX

Vasquez, A.J., 288, 289, 309, 327, 333, 341

Veech, R.L., 220, 234, 236 Velluti, R., 283, 309 Venkatakrishna-Bhatt, H., 312, 338 Vento, A.L., 257, 260, 261,439,441 Vernadakis, A., 206, 213, 253, 262 Verseano, M., 283,287,293 Verster, F., 287, 298 Victor, M., 144, 154, 215, 228, 231 Villeneuve, A., 16,30,311,339,402,

418 Villeneuve, R., 16,30,121,122,140,

402,418 Vizi, E.S., 46,51,78,83 Vlk, J., 486, 488, 490, 491, 495,509 Vogt, M., 375, 391, 409, 421, 435,

442 Vojta, V., 346, 359, 362, 370 Vojtechovsky, M., 200, 204, 207, 213 Volle, R.L., 45, 46,50 Von Berger, G.P., 278, 279, 303 Voneida, T.J., 439,443 Von Voigtlander, P.F., 378, 393 Voorhoens, P.E., 287, 296 Vorhees, C.V., 486, 513 Vost, M., 436, 439, 442 Vosu, H., 281, 287, 309 Votova, Z., 200, 204, 267, 310 Voydd,C.,328,338 Vulkovich, K.R., 197, 204 Wada, J .A., 396, 420 Wagner, A., 375, 389, 400, 409, 415 Wagner, N., 321,324,325,340 Wakefield, C., 285, 295 Waldmeier, P.C., 384, 393 Walinder, J., 382, 387 Walker, J.E., 103, 120, 137, 142, 166,

172,380,393,402,416 Walker, R.J., 409,417,439,441 Walters, J.R., 408, 409, 416, 439, 442,

443 Walton, J.N., 144, 153 Walton, K.G., 155, 156, 171 Wang, P.F.L., 20, 30, 34, 39,43,60,

61,76,81,87,97,121,132,133, 140,237,250,260,261,379,389, 466,480,487,488,489,490,491, 495,508,517,518,530,533,539, 541,547

AUTHOR INDEX

Ward, A.A., 289, 310 Warrington, E.K., 239, 251 Wastek,G.J., 160,167,171,172,380,

393,500,513 Watanabe, H., 399,420 Waterfield, A., 328, 342 Watkin, D., 436, 442 Watson, E., 384, 393 Watson, P.O., 324, 342 Watt, AJ., 328, 339 Wauquier, A., 404, 417, 424 Way, E.L., 321,334,336,342 Waziri, R., 45,51, 78,83 Webster, G.R., 76, 81 Webster, J.P., 224, 233 Webster, R.A., 288, 297 Wecker, L., 490, 492,513 Wedeking, P.W., 20, 30, 34, 39, 43,60,

61,76,81,87,97,121,132,133, 140,237,250,260,261,379,389, 466,480,487,488,489,490,494, 495,508,517,530,533,539,541, 547

Weight, F.F., 198,204 Weiler, M.H., 484, 486, 492, 493, 509,

513,524,530 Weiner, W.J., 17,30,87,88,97, 134,

142,380,390,401,403,414,419, 420,426,430,434,541,547

Weingartner, H., 207, 213, 253, 262, 361,368,370

Weinhouse, S., 486,506 Weinreich, P., 429, 434 Weintraub, M.I., 377, 393, 399, 424 Weintraub, S.T., 484, 512, 516, 531 Weise, V.K., 487,509 Weiser, H., 486, 508 Weiskrantz, L., 239, 251 Weiss, B.L., 77, 83,483, 513 Weiss, T., 208, 211 Weitzman, E.D., 311,343 Welsh, M.J., 502, 503, 513 Wenthold, R.J., 53, 61 Werdinius, B., 382, 385 Werman, R., 268, 302 Wescoe, W.C., 276, 310 Westerink, B.H.C., 409, 411, 424, 435,

443 Westfall, T.C., 410,418,435,441 Westheimer, R., 292, 301

577

Wheatley, A.H.M., 216, 235, 486, 511 Whishaw, I.Q., 281,310 White, A., 197,204 White, H.L., 493, 513 White, P., 205, 206, 211, 213, 228,

229,230,232,235,236,253,259, 262

White, T .C., 17, 29 Whittaker, M., 58, 59, 61 Whittaker, V.P., 515, 520, 521, 527,

529,531 Whittier,J.R., 101, 120 Whittingham, S., 155, 171 Wickson, V., 102, 118,396,397,406,

407,421 Widroe, H.J., 135,142 Wiener, N., 177,200,204,237,247,

249,251 Wiener, W., 76,81,122,129,140,471,

480,495,496,499,507,533,534, 539

Wieraszko, A., 519, 530 Wiesel, F.A., 384, 393, 436, 442 Wikler, A., 280, 281,282,310 Wilber, J.F., 447, 458 Wilbert, D.E., 77, 82 Wilder, R.M., 226, 236 Wilk, S., 15,31,384,393 Williams, D., 289,310 Williams, I.E.I., 206, 213, 229, 236,

253,259,262 Williams, R.D., 226, 236 Williams, R.L., 311,339 Williams, S.E., 401,420 Willis, A., 276, 297 Wills, J.H., 277, 287, 310 Wilson, A., 4, 13, 34, 39, 44, 65, 73,

75, 83, 272, 296, 327, 330, 337, 346,360,362,370,385,391,402, 422

Wilson, C.J., 409, 419, 439, 441 Wilson, D.F., 220, 236 Wilson, E.C., 449,456 Wilson, LB., 196,203,495,504 Wilson, V.J., 287, 296 Winbladh, B., 502, 504 Winokur, G., 20, 30,41,44,54,61 Wise, C.D., 70, 74 Wise, R.A., 281,287,309 Woelk, H., 76, 83

578

Wolf, H., 286, 307 Wolfarth, S., 411,424 Wolff, V.H., 288, 289, 310 Wong, K., 382, 392,429,434 Woodford, R.B., 228,229,233 Woodruff, G.N., 409, 417, 439, 441 Woodruff, R.A., 20, 30, 54, 61 Woody, C.D., 267, 310 Woonton, G.A., 276, 304 Wramner, T., 320, 323, 337 Wu,J.C.,493,513 Wurtman, R.J., 20, 29, 34, 40, 43, 44,

60,61,76,79,80,81,83,87,88, 97, 103, 104, 105,106,109,110, 111,113,114,115,117,118,119, 120, 122, 129, 137, 140,142, 166, 171,237,249,257,260,261,262, 266,293,309,310,379,380,381, 387,389,401,409,414,419,424, 461,462,464,465,466,467,469, 470,471,472,474,475,476,477, 478,479,480,481,487,488,489, 490,491,492 495,496,497,499, 500,501,505,507,508,511,512, 513,517,519,528,530,531,533, 534,537,538,539,541,546,547

Wyatt, R.J., 71, 282, 292, 308, 311, 312,315,317,318,337,338,340, 342,343,347,358,360,436,441

Wyers, E.J., 284, 285,295 Wynder, E.L., 446, 457 Wyrwicka, W., 285,295,308 Yabe, T., 287,288, 305 Yaksh, T.L.,53,61,329,343 Yamaguchi, N., 277, 310 Yamakawa, K., 45, 50 Yamamoto, K., 276, 278, 280, 282,

286,296,307,310,314,315,337 Yamamura, H.I., 11, 13, 17, 19,31,32,

53,61,70,72,74,78,83,96,97, 102,106,116,117,130,142,156, 157,158,160,161,164,165,167, 171,172,206212,213,253,254, 259,261,269,270,302,329,343, 379,380,382,384,388,390,391, 392,393,395,396,399,405,407, 411,420,423,424,429,433,434, 466,481,484,495,500,507,513, 521,522,523,525,530,531

Yamashiro, D., 326, 340

AUTHOR INDEX

Yatsu, F.M., 224, 236 Yavin, E., 494, 513 Yesavage, J .A., 361,368,370 Yim, G.K.W., 319, 342 York, D.H., 267, 291, 306, 373, 390,

405,406,407,421,424,428,434 Yoshida, M., 375, 391,439,442,443 Yoshio, H., 446, 447, 458 Young, A.B., 156, 172 Young, D.C., 326, 327, 343 Young, R., 40, 43,104,119 Young, S.J., 409, 419,439, 441 Yu, J.S., 106,118 Zahniser, H.R., 257, 261 Zahniser, N., 34, 39,44, 75, 77, 78,

79, 81, 83, 103, 120, 132, 133, 142,397,393,494,502,503, 508,513,541,547

Zajqczkowska, M., 11,13 Zand, R., 288, 308 Zarcone, V., 311, 338, 343 Zeidenweber, J., 278, 305 Zeimal, E.V., 197, 198,203 Zeimis, E.J., 197,204 Zelena, J., 198, 202 Zetler, G., 319, 343,403,424 Zieglgansberger, W., 284, 299, 405,

419 Zieher, L.M., 396, 418 Zigmond, R.E., 269, 294, 396, 416 Zimmerman, H., 521,529 Zivkovic, B., 384, 393 Zolovick, A.J., 283, 299 Zsilla, G., 206, 207, 213, 253, 262,

327,331,343 Zwilling, G., 318, 338

ACh

AChE

AChR

ACTH

AMP

AMPT

CAT

Ch

ChE

CNS

DA

DFP

DOPAC

ECS

EEG

EKG

GABA

GAD

HD

HVA

L-DOPA

LTM

QNB

RBC

STM

TD

TH

SUBJECf INDEX

Abbreviations

acetylcholine

acetylcholinesterase

cholinergic receptor

adrenocorticotropine hormone

adenosine monophosphate

alpha-methyl-para-tyrosine

choline acetyltransferase

choline

cholinesterase

central nervous system

dopamine

diisopropylfluorophosphate

dihydroxyphenylacetic acid

electroconvulsive shock

electroencephalogram

electrocardiogram

gamma aminobutyric acid

glutamic acid decarboxylase

Huntington's disease

homovanillic acid

levodopa

long-term memory

3-quinuclidinyl benzilate

red blood cell

short-term memory

tardive dyskinesia

tyrosine hydroxylase

579

580

Acetate, in Ach synthesis, 486 Acetoacetate, 486

as ACh precursor; 216 Acetylcholine. See ACh Acetylcholinesterase. See AChE Acetylcoenzyme A, 63

in ACh synthesis, 216, 220-21,222, 266,465,483,484,485-86

and Ch loading, 493 precursors of, 485-86

Acetyldeanol,495 ACh,64,87,215-16,220

and AChE inhibitors, 4 and affective disorders, 34 and analgesia, 319-35

and opiate antagonists, 331-32, 335 "bound" and "free" forms in nervous

tissues, 218 Ch and biosynthesis of, 465-71 CH as precursor of, 99, 103, 115,

266,486-94 and cholinergic

pathways, 268-71 transmission, 265-68

content and morphine, 328, 330 and naxolone, 328 and opiates, 328, 330

and deanol, 34, 39,132, 133, 138 distribution in basal ganglia, 395-96 and EEG de synchronization, 277 ,278 effect on

anterior pituitary hormone secretion, 445-55

growth hormone, 448-49 hypothalamo-hypophyseal-adrenal

axis, 446 luteinizing hormone, 449-50

enzymes hydrolizing, 63 and extrapyramidal tremor, 376 and gonadotropin secretion, 449 hemicholinium induced depletion of,

and opiates, 330 hydrolysis of, slowed by anticholine­

sterase,181-82 impairment of function, compared to

hypoxia effects, 225, 228-30

interaction with DA, in TD, 121, 122-23, 127, 128, 129, 130-31,

SUBJECT INDEX

132, 138 interaction with lithium, 45-49 levels

in brain, effect of choline on, 257, 518-20

and choline, 472 in CSF, 502, 503 effect of dietary manipulation on,

491 erythrocytes, 502 plasma, 502 platelets, 502 whole blood, 502-3

and memory animal studies of, 175-201 disorders, 205-11

metabolism, 501 neurochemistry of

and morphine, 326-35 and opiates, 326-35

neurons, and HD, 102 "open-loop" formation of, 461 in Parkinson's disease, 397-98 precursor loading

clinical evidence, 395-501 experimental evidence, 486-95 as therapeutic strategy, 483-503

precursors of, 11,216,220-22, 483-86 and depression, 9-10 and HD, 96 and TD, 96, 379

and prolactin levels, 448 QNB binding inhibited by, 157, 162 rate of destruction of, reduced by

anticholinesterase, 179 and regulation of affect, 11 release, 270-71

and cholinergic synaptic change, 195-96

and DA receptors, 374 and morphine, 328-29, 330 and nalorphine, 329 and naxolone, 328, 329 and opiates, 328-30

role in centrally mediated disease states,

75-76 REM sleep, 312-18

and schizophrenia, 3, 16

SUBJECT INDEX

synthesis, 266,483-84 and acetylcoenzyme A, 483, 484,

485-86 in brain, 75-76 and carbohydrate oxidation, 215-23,

230-31 and CAT, 222, 483-84,526 and Ch, 222, 483, 484-85

availability and transport, 515-26 cellular localization, 520-21 loading, 492-94 uptake by nerve endings, 517,

521-25 conditions decreasing, 143 and DA receptors, 374 and glucose oxidation, 215 and pyruvate oxidation, 143

turnover, 269, 271-72 and EEG seizures, 288 and morphine, 331 and opiate analgesia, 327 and opiates, 331

as type I neurotransmitter, 76,461-62 AChE, 63,103,266

ACh in brain, 471 synthesis, 468

age related changes in, 205-6, 206-7 architectonic distribution in frontal

isocortex, 66 in blood, 503 brain, 53 as brain cholinesterase, 64 and choline chloride, 60 in cholinergic mapping, 268-69 inCNS,65 CSF, 64, 68-69

and choline, 58, 59 diurnal variations in, 57,58 and HD, 54, 55, 60 and physostigmine, 56, 57-58, 60 and probenecid, 55, 57-58

elevated after ECS treatment, 199-200 and etiology of affective disorders,

75-76 inhibitors, 131

and behavioral effects of ACh, 4 and depression, 4, 39 effect on animal memory, 208,

209-10

and mania, 4 and schizophrenia, 15-16

in limbic system, 384 in neostriatum, 395-96 and Parkinson's disease, 397 plasma total, 58, 59, 60 in red blood cells, 58-59

of schizophrenics, 64 regulation, and cholinergic synaptic

change, 196 and synaptic blockade, 181-82

AChR,155

581

changes in, and cholinergic synaptic 197-98

ACTH,454 cholinergic activation of, 445, 446-47

S-adenosylmethionine, 485, 515 Adenosine monophosphate. See AMP Adenylate cyclase, and DA receptors, 374 j3-adrenergic agents, in Huntington's

chorea, 380 Adrenocorticotropine hormone.

See ACTH Akathisia, 130 Alcohol abuse, deanol therapy for, 35,

36,37,38,41 Alert Non-Mobile Behavior, 280, 281,

289,292 Alpha-methyldopa, 4 Alpha methyl paratyrosine, 109,314

and animal EEG, 345,346 and chorea, 427 and Huntington's chorea, 380 and Parkinson's disease, 397 and REM sleep, 318 and schizophrenia, 382 and TD, 378

Alzheimer's disease, 68, 70 and changes in CAT activity, 206,

253 and Ch administration, 361,497 and impaired carbohydrate catabolism,

228-29 muscarinic receptor binding in, 206,

253 Amitriptyline, Ch levels in plasma and

RBCs, 78, 79 Ammonium chloride, 487 Amnesia, 199-201 Amobarbital, 15

582

AMP, 155 effect of hypoxia on, 230

AMPT. See Alpha methyl paratyrosine Amphetamine, 11, 17,40, 109

and ACh, 374 and dopaminergic activity, 378 effect on human EEG, 347 andHD,400 and motor activity in limbic system,

383 and rotational behavior, 404 and schizophrenia, 382-83 and stereotyped behavior, 403 and TD, 378

d-amphetamine, and Huntington's chorea, 380

Analgesia and ACh, 319-35 effect of cholinergic and anticholiner­

gic drugs on, 319-26 morphine, and ACh, 326-35 opiate

and ACh release, 327 and anticholinergic and cholinergiC

drugs, 319, 320-21 Anoxia, 224 Anticholinergics,4

analgesic activity of, 319-26 as anti-parkinsonian agents, 376 and catalepsy, 402-3 and cortisol levels, 447 EEG effects of, 279-80 effect on animal learning of, 208 effect on cognitive functions of, 227-

228,237-38,249,253,361 effect on memory of, 177, 179, 180-

81, 188-89, 191 andHD,401 and human LTM, 208 and luteinizing hormone, 449 and morphine abstinence syndrome,

333-34 and morphine withdrawal syndrome,

333 and Parkinson's disease, 398 and rotational behavior, 404 and schizophrenia, 16,383,385 and stereotyped behavior, 403 and synapse, 179-80 and TD, 108, 122,379,401-2

Anticholinesterase, 503 ACh

SUBJECT INDEX

hydrolysis slowed by, 181-82 rate of reduction reduced by, 179

activity in morphine, 326-27 agents, and analgesia, 319, 320-26 and caudate stimulation, 285 "cholinergic rebound" following treat-

ment with, 192 EEG

desynchronization, 284-87 effects, 274, 276-77, 278, 279,

346-59,362 seizures, 287-88, 289, 290

effect on memory, 177, 180, 181-84, 201 consolidation, 186-89 transient disruption, 185-86 weakened,189-92

Antihistamines, 398 Antimuscarinic drugs

and schizophrenia, 385 and toxic confusional state, 384-85 in treatment of drug-induced parkin-

sonism, 376 Apomorphine, 11, 17

and ACh, 374 andDA

-ACh interaction, 378-79 receptor binding, 430,431

and dopaminergic activity, 378 and schizophrenia, 382-83 stereotypy induced by, 403,541-42

effect of choline chloride on, 534, 542-43,544-47

and TD, 122, 129 animal model of, 541-42

Arecoline, 15 and analgesia, 320-21,323 EEG effects of, 278 effect on ACh turnover of, 272 effect on LTM of, 207 effect on STM of, 207 and prolactin, 448 and REM sleep, 317 and schizophrenia, 64-65, 385, 402

Ataxia and abnormalities of pyruvate

metabolism, 143,152-53 diagnosis of, 144

SUBJECT INDEX

evaluation of, 144-45 Friedreich's, 266, 227

and choline chloride administration, 498

and physostigmine, 143-44,145-53 spinocerebellar, 226-27

Atropine,S, 6, 7,9,19,70, 176,376, 439,492 and analgesia, 320-21,323,325,326 as anticonvulsant, 288 and antiepileptic properties of cho-

linergic system, 289 and Ch uptake, 524 and coma therapy, 292-93 and corticotrophin releasing factor,

446 and cortisol levels and secretion, 447 and OA turnover, 375 depressant effect of OFP counteracted

by,18 and depression, 292 dose level of, effect on LTM and STM,

207 EEG effects of, 272, 278, 279-80,

288,289,292-93,346 effect on ACh turnover, 272 effect on cognitive functions, 227 and luteinizing hormone, 449, 450 and mania, 292 and morphine abstinence syndrome,

333-34 and prolactin, 448 QNB binding inhibited by, 157,162 and REM sleep, 282, 292, 314 and rigidity, 403 and rotational behavior, 404 and schizophrenia, 292 and tyrosine hydroxylase, 474

Atropine methyl-nitrate, 345 Azidomorphine, 331 Barbiturates, effect on ChE activity, 66 Belladonna alkaloids, and Parkinson's

disease treatment, 397-98 Benign essential tremor, effect of deanol

on,34 Benzodiazepines, in HO treatment, 101 Benztropine, 37,103

and analgesia, 320-21 antiparkinsonian effect of, 399 and TO, 123, 125, 127, 129

583

Betaine, 538 Bethanechol, and corticotrophin releasing

factor, 446 Blood brain barrier, 64-65 Bromocriptine

and OA receptor sites, 433 and Parkinson's disease, 376

a-bungarotoxin, 70, 267 andCh,492

Butaclamol, 430,431 Butyrophenones

and OA receptor blockage, 374 and Huntington's chorea, 380 and Parkinson's disease, 375,376,397 and schizophrenia, 383, 385 and TD, 377,401

Butyrylcholine, 64 Butyrylcholinesterase, 63, 67,266

activity CSF, 64, 68-69 in epileptics given barbiturates, 66

inCNS,65 14C-ACh,67-68 Carbachol, 17, 176

and analgesia, 320-21,323 and cortisol production, 445-46, 447 and EEG de synchronization, 277, 278 and extrapyramidal tremor, 376 and REM sleep, 282, 313-14, 315

Carbaryl,176 Carbidopa, and ACh, 374 Carbohydrate catabolism, 222-23, 225,

486 and Alzheimer's disease, 228-29 inborn errors of, 226-27 and senile dementia, 228-29

Carbohydrate oxidation and ACh synthesis, 215-23,230-31

in vitro studies of, 216-16 in vivo studies of, 217-18 mechanisms in, 220-22 physiological significance of, 218-20 relevance of, 222-23

impairment of and impairment of cholinergic func­

tion, 215, 216-23 clinical studies of, 225-27 and effect on neurotransmitters,

230-31 inhibitors of cerebral, 226

584

in senile dementia, 228-29 Carbon monoxide, 226 CAT, 60, 103,462,524

andACh concentrations, 471 formation, 483-84 synthesis, 222, 266, 465, 468,526

in Ch loading and regulation, 492, 493-94

activity, 162, 165-66 in Alzheimer's disease, 206, 253 age related changes in, 205, 206-7,

2f1, 253 .-brain, 158, 164 and HD, 161, 164 and schizophrenia, 69-70 and Ch administration, 471,477 in cholinergic mapping, 269 CSF,503 decrease of, in senile dementia, 229 and high affinity transport system of

Ch analogs, 525-26 in HD, 102,400 and Huntington's chorea, 380, 381 in limbic system, 384 in neostriatum, 395-96 in nerve endings of cell, 520 in parkinsonian brain, 377 and Parkinson's disease, 397 and reserpine, 477,487

Catecholaminergic interactions and cho­linergic synaptic change, 198-99

Catalepsy, ACh-DA interactions in, 402-3

Catecholamine activity, and affective disorders, 33-

34 and antirecruitment of cholinergics,

284 andCh,476 synthesis of, and oxygen impairment,

230-31 "Caudate loop," 284-85 Caudate nucleus, in lID, 101, 102, 160-

61,163 Central nervous system. See CNS Ch,19,439

and ACh biosynthesis, 465-71 and ACh brain levels, 461,518-20 as ACh metabolite, 501

SUBJECT INDEX

asACh precursor, 99,103,115,266, 462,484-85,501 loading, 486-94, 495-500

in ACh synthesis, 222,468,483,484, 485,515-26 cellular localization, 520-21 uptake by nerve endings, 521-25 uptake by synaptosomes, 521-25

and Alzheimer's disease, 497 analogs, 525-26 and aspartate in brain, 520 blood brain gradient in, 538 blood level and sources, 103,105,106 brain free, 516-20 brain levels of, dependent on levels in

blood,103 and catecholamine, 476 and cholinergic system and mechanisms,

19,20,26,257,369 and cholinergic function, 472-80 cognitive effects in normal humans,

237,243-47,248,249 biphasic, 248

compared to deanol, 99 compared to physostigmine, 99, 533,

541 CSF,502 and CSF AChE, 55, 58, 59, 60 and DA in brain, 520 and depression, 9-10,19,39,40,49,

131 dosage, and plasma Ch concentration,

534-38 effect on Alzheimer's disease, 361 effect on apomorphine-induced stereo­

typy,534,542-43,544-47 with haloperidol, 543, 545, 546-47

effect on brain ACh, 87, 257, 541, 546

effect on CAT of, 471,477 effect of deanol on, 132, 133, 134,

138 effect on human EEG, 347 in the elderly, 361-69 effect on methylphenidate-induced

stereotypy, 542, 543, 544, 546 erythrocyte levels, 502 and flutarnate in brain, 520 and Friedreich's ataxia, 498 and GADA in brain, 520

SUBJECT INDEX

and Gilles de la Torrette syndrome, 498

and glycine in brain, 520 and HD, 87-88, 88-89, 90, 94, 95,

96,99,100,103-6,115,116,166, 260,380-81,495,496-98 side effects in treatment, 105-6

and 6-hydroxydopamine, 478 and LTM in elderly, 253-60 and insulin, 479 and mania, 24, 28,498 metabolism in CNS, 515-21 and morphine withdrawal syndrome,

333 and norepinephrine in brain, 520 not synthesized by brain, 465 plasma

concentration of, and choline chloride dosage, 534-38

free, 517-18 levels, 77-78, 79

precursors, 485 RBC, 77-78, 79

and affective disorders, 75-80 as marker of some mental illnesses,

78, 79 and schizophrenia, 23-24, 26-27,

498,541 serum

effect of choline chloride and lecithin on, 470

levels, and diet, 467 side effects of large doses of, 500 sources of, 485 synthesis of, 132 and TD, 87, 88, 89, 90, 91, 92, 96, 99,

100, 109-16, 129, 137,257,260, 379,495,496-98,533,534,541, 546

side effects, 115 and therapy for age related memory

changes, 257,259 in treating disease in which only

neurons using ACh are involved, 100 and tyrosine hydroxylase, 472, 473,

474,475,477,478,479 and urinary epipinephrine levels, 472,

474,475 use for neuropsychiatric disease treat­

ment, 99-100

ChE activity, 58-59

in blood, 64 in brain, 64, 65-68 CSF,64 effect of barbiturates on, 66

in catabolic function, 266

585

chemical variables influencing, 63-64 CSF, 68-69, 503 enzymes, 63 inhibitors, 4, 11

and depression, 18 effect on learning of, 208 and mania, 18 morphine as, 66 and REM sleep, 314

not synthesized de novo in brain, 75-76

in parkinsonian brain, 377 plasma total, 59-60 quantitative cytotechtonic distribution

of, in schizophrenia, 65-66 Chloral hydrate, 20, 89 Chlorpromazine, 16,378

and chorea, 426 andDA

receptor blockage, 374 turnover, 384

effect on ACh turnover, 272 and rigidity, 403

Choline. See Ch Choline acetyltransferase. See CAT Cholinergic

activity effects of choline chloride and

physostigmine on, compared, 533, 541

regulated by dopaminergic activity, 406-8

agents and age related memory impairment,

361-69 animal studies of

administered immediately before recall test, 177-85

administered immediately before training and/or recall test, 189-

93 administered immediately before

training, 186-89

586

administered one or more days before recall test, 185-86

dosage of, and memory function, 207 effect on human EEG, 346 effect on hypothalamo-hypophyseal­

adrenal axis, 445-47 effect on memory consolidation, 186-

89 transient vs. permanent effects of,

176-77 agonists, 271

and cholinergic synaptic sensitivity, 179-80

EEG effects of, 274-79, 280-83, 284-88,289,290-91

effect on ACh turnover, 272 effect on cortisol or corticosterone

production, 445-46, 447 and LTM, 361 and REM sleep, 282,314

antagonists and cholinergic synaptic sensitivity,

179-80 effect on ACh turnover, 272 and REM sleep, 314

brain enzymes, in schizophrenia, 63-71

desynchronization, 284-87 -dopaminergic interactions, 16-17

in animal behavioral studies, 402-4 in CNS diseases, 373-85 in corpus striatum, 382-83,435-

36,439 in HO, 400-1,435 439 in Huntington's chorea, 377,379-

82 in limbic system, 383-85,411-12 mechanisms of, 404-11 in Parkinson's disease, 375-77,

398-99 and physostigmine, 436-40 in prolactin release, 448 in schizophrenia, 382-85, 402 in substantia nigra, 435-36, 439 in TO, 377-79, 401-2, 435, 439

drugs analgesic activity of, 319-26 and catalepsy, 402-3 and morphine abstinence syndrome,

333-34

SUBJECT INDEX

and morphine withdrawal syndrome, 333

and Parkinson's disease, 398 and schizophrenia, 383,402

function, and Ch, 472-80 mechanisms

in cognitive functions, 237-43 and prolactin, 447-48 and REM sleep, 313-16, 317-18 in serum cortisol variations, 447

neurones, loss of, in senile dementia, 229

neurons, 131 in TO, 109, 110

pathways, 268-71,291 "rebound," 192 receptor agonists

forHO,96 for TO, 96

receptors, 70-71 regulation of dopaminergic activity,

408-11 sensitivity, and memory, 180-81 synaptic change

and ACh release, 195-96 and AChE regulation, 196 and AChR changes, 197-98 and catecholaminergic interactions,

198-99 neurophysiological bases for, 195-

99 synaptic excitability, 179-80 synaptic transmission, 265-68 system

and EEG, 289-91 neurochemical and neurophysio­

logical interaction, and other bio­amine systems, 273-74

and "open loop" system between blood and brain, 75-76

and REM sleep, 280, 282-83 role in cognitive function, 227-31 role in memory, 227-31 and slow sleep, 283 and synaptic changes associated with

memory, 176 and theta waves, 280, 281

transmission, and hypoxia and hypo­glycemia, 225

underactivity, and affective disorders,

SUBJECT INDEX

17-19 Cholinergic receptor. See AChR Cholinesterase. See ChE Cholinomimetics

and analgesia, 319-26 and apomorphine- and amphetamine­

induced stereotypy, 439 and basal cortisol and corticosterone

production, 445-46 effect on animal EEG of, 362 effect on cognitive functions of, 237-

38,248-49,253-54 and HD, 166 and luteinizing hormone, 449 and TD, 439-40

Chorea and bromocriptine, 433 Ch treatment for, 103-6 andDA

excess, 102 receptor sites, 430, 433

dopaminergic mechanisms in, 425-29,430,433

and HD, 100, 101,102-3 and increases in ACh released in

striatum, 103 pathophysiology of, 425-26 "senile," 107, 108 and TD, 107-8

Citrate, in ACh synthesis, 486 Clozapine, 16, 17 376

and ACh turnover, 272 and DA turnover, 384 extrapyramidal effects of, 399 and schizophrenia, 385 and rD, 107

Cocaine, 382 Coenzyme A, 484 Corticosteroid administration, and mania,

18 Corticotrophin releasing factor, 446-47 Cortisol

and cholinergic mechanisms, 445-47, 454-55

levels

CSF

effect of methscopolamine on, 451, 452,453

effect of physostigmine on, 450, 452-55

ACh levels, 502, 503 AChE,68-69 BChE, 68-69 CAT,503 Ch levels, 502

587

and HD treatment with Ch, 105, 106 ChE,64,68-69,503 DOPAC, effect of physostigmine on,

436-40 HV A, effect of physostigmine on,

436-40 TChE activity, 68, 69

C6NM, 523-24 Cyanide, 226 Cyclazocine, 331-32 Cyclic AMP, 267-68

and DA receptors, 374 Cyclic GMP, 198-99,267-68 Cycloheximide, 472 Cytidinediphosphorylcholine, 501 DA,15

agonists and depietors in TD, 122 distribution in basal ganglia, 395 excess, and chorea, 102 and HD, 101-2,400,426,29 interaction of, with ACh, in TD,

121,122-23,127,128,129,130-31,132,138

in limbic system, 383-85 and parkinsonism, 425 and Parkinson's disease, 375-76,

396-97 pathways, 16-17 receptors

and ACh synthesis and release, 373-75

and action of antipsychotics, 16-17 binding, 428-33 in frontal cortex, 165-66 striatal, evidence for two, 425-33

and REM sleep, 312 and schizophrenia, 16 and striatal neurons, 428 synthesis, 199 and rD, 121,122-23,127,401 turnover

and cholinomimetics, 439-40 and physostigmine, 438-39

as type I neurotransmitter, 462 Deanol, 76, 293

588

as ACh precursor, 39,132, 133, 134, 138

and ACh precursor loading, 494-95, 500-1

and affective mood changes, 34-38, 131

and alcohol abuse, 35, 36, 37, 38,41 and apomorphine-induced stereotypy,

541 and brain ACh, 34, 541 and brain Ch, 466 as cholinergic precursor, 39 compared to Ch, 99 and depression, 9-10,39-41 effect on Ch levels, 132, 133, 134,

138 effect on human EEG, 347, 362 effect on involuntary movement

disorders, 34 and HD, 103, 166,380,500 and hypomania, 40 and increased ACh, 39 as indirect Ch precursor, 485 pharmacological studies of, 132-34 physostigmine as predictive test for,

137,138 and prior history of affective

symptoms, 40-41 and schizophrenia, 37-38 as stimulant, 40 and TD,41, 109, 121, 122-23, 124,

125, 127-28, 131, 134-37, 138, 379,500

Dementia, 226-27 Depression

and AChE inhibitors, 4 and ACh precursors, 9-10 and atropine, 292 balance of adrenergic and cholinergiC

factors in, 3 catecholaminergic disequilibrium in,

33 and Ch, 49,131,500 and CNS cholinergiC activity, 39, 49 and CSF AChE, 54, 55 and deanol, 34-38, 39-41 and lithium carbonate, 49 and neostigmine, 4, 8 and physostigmine, 4,7-8,12,18-

19,49,131,292

SUBJECT INDEX

with marijuana, 8-9, 18-19 RBC Ch levels in, 78

Dexmnethasone, 447 Dexetirnide,162,165 Dextroamphetamine, 40

and hyperkinesia, 380 DFP, 4, 176,266

and analgesia, 320-21 and depression, 18 EEG effects of, 276, 346, 362 effect on animal learning of, 208,

209-10 effect on memory of, 177-79,185-

86,194 and morphine abstinence syndrome,

334 and schizophrenia, 16, 385, 402

Dimethylarninoethanol. See Deanol Dihydroxyphenylacetic acid. See DOPAC Diisopropylflourophosphate. See DFP Ditran, and schizophrenia, 16,65,385 Dopamine. See DA DOPACinCSF

and physostigmine, 436-40 and probenecid, 436, 437,438-39

Dopa decarboxylase, 472 and Parkinson's disease, 376

Dopaminergic activity regulated by cholinergiC

activity, 408-11 agonists, and ACh turnover, 272 -cholinergic interactions (see Cho­

linergic-dopaminergic interactions) pathways, and ACh synthesis and

release, 373-75 regulation of cholinergic activity,

406-8 Droperidol, in TO treatment, 123, 124,

125,126 DyskineSia, L-DOPA-induced, 76 Dystonia,130 EAO 1701, as cholinesterase inhibitor, 4 ECS

amnesia from, 199-200 therapy, 4, 45

EEG,265 andACh

release, 270 turnover, 272

animal,345-46,348,357,358,362

SUBJECT INDEX

cortical and subcortical, effect of cho­linergic agonists and anticholine­

sterase on, 274-79 desynchronization,288-91

mechanisms and sites, 284-87 effect of anticholinergic drugs on, 271 effect of anticholinesterase on, 346-

59,362 effect of atropine on, 279-80, 346 effect ofCh on, 347, 361-69 effect of cholinergic agents on, 271,

273-74,346 effect of cholinomimetics on, 362 effect of deanol on, 347, 362 effect of DFP on, 346, 362 effect of organophosphate poisoning

on, 347, 357,362 effect of physostigmine on, 274-77,

345-47,348-59,362 effect of scopolamine on, 279 and functional role of cholinergic

system, 289-91 seizure, 287-90

EKG,89 Electrocardiogram. See EKG Electroconvulsive shock. See ECS Electroencephalogram. See EEG Electrooculogram, effect of choline

chloride on, 363, 364, 365 Endorphin, 331

and ACh turnover, 327 Epipinephrine,476

and Ch, 472, 474, 475 Eserine, effect on human EEG, 346-47

See also Physostigmine Ethanolamine, 515-16 Ethopropazine,398 Fluphenazine, 20, 22, 25, 378 Fluphenazine decanoate, 37 Frontal cortex

DA receptors, 165-66 3H-QNB binding in, 157, 158, 159,

160 neurotransmitter binding in brain with

HD,165 GABA,65

and cholinergic-dopaminergic inter­action, 439

and DA release, 375 and HD, 102,379,381,382,400

589

-mediated neurons, 131 metabolism, and hypoxia, 230 -mimetics, and Huntington's chorea,

381 GABAergic neurons, and Huntington's

chorea, 379-80 GABA transaminase, 102-3

inhibitors, and Huntington's chorea, 381

GAD, 166 and HD, 102,379,400

Galanthamine, and serum cortisol con­centrations, 446

Gamma aminobutyric acid. See GABA Gilles de la Torrette syndrome, and Ch

administration, 498 Glucose

as ACh precursor, 216 and ACh synthesis, 218, 220-21,

222,486,520-21 oxidation, and ACh synthesis, 143,

215 Glutamate pyruvate transaminase activity,

69 Glutamic acid decarboxylase. See GAD Glycolysis, 216 GMP, 155,156

effect of hypoxia on, 230 Gonadotropin secretion, ACh in, 449 Growth hormone

cholinergic mechanisms in, 454-55 effect of ACh on, 448-49 levels

effect of methscopolamine on, 451 , 452,453

effect of physostigmine on, 450, 452-55

Guanethidine, 4 Haloperidol, 38, 45,378

and Ch uptake, 524 and chorea, 426 in DA receptor binding studies, 429 and DA turnover, 384 effect of choline chloride on

apomorphine-induced stereotypy in animals treated with, 543, 545, 546-47

effect on ACh turnover 272 andHD,101 and locomotor activity in limbic

590

system, 383 and rigidity, 403 and TD, 107, 109,129

HD,108 animal model of, 166-67 CAT activity in human brain, 161,

164 caudate nucleus in, 101, 102 and choline, 19,87-88,88-89,90,

94,95,96,99,100,103-6,115, 116,137,260,495,496-98,533, 541

and cholinomimetic drugs, 166 and CSF AChE, 54, 55, 60 and CSF Ch, 502 compared to Parkinson's disease, 426,

428 DA-ACh interaction in, 377, 379,-82, 400-1 and deanol, 34, 103, 137,500 functional cholinergic deficit in, 65 and L-DOPA, 102 muscarinic cholinergic receptor altera-

tions in, 159-66 and neuroleptic drugs, 101-2 neurologic features of, 100-1 neurotransmitter involvement in,

101-3 compared to Parkinson's disease, 101-

2,400 pathology of, 101 pathophysiology of, 426-28 and phenobarbital, 101 and physostigmine, 89, 90, 93, 96,

103,104,106,137,166,435,436, 533,541

rigid - a Kinetic vs. choreic form of, 428

and reserpine, 101 two forms of, 159

Hemicholinium and deanol, 494, 495 and morphine abstinence syndrome,

334 and REM sleep, 315

Hemicholinium-3, 176,376 and Ch uptake, 522, 523

3 H-DA binding, 430-33 3 H-dihydroalprenolol binding, 164 Hexamethonium, 326

SUBJECT INDEX

and release of corticotrophin releasing factor, 446

3H-GABA binding, 164 3H haloperidol, 378 Hippocampus, 3 H-QNB binding in, 157,

158,159,160 Histamine, as type I neurotransmitter,

462 Histidine, 462 Histidine decarboxylase, 462 Homocholine,525-26 Homovanillic acid. See HV A 3 H 3-quinuclidinyl benzilate e H-QNB),

156,157,384 binding

in frontal cortex, 157, 158, 159,160 in HD brain, 161, 163 in hippocampus, 157, 158, 159,

160 inhibited by dexetimide, 162, 165 in putamen, 157, 158, 159, 160 regional variation in, 157-58, 163

3 H-spiroperidol binding, 165-66 Huntington's chorea. See Huntington's

disease Huntington's disease. See HD HVA, 17,384

and administration of cholinomimetics, 436

CSF, and physostigmine, 436-40 and probenecid, 436, 437,438-39

inHD,400 fj-hydroxybutyrate,486

as ACh precursor, 216 6-hydroxydopamine,176

and Ch, 478 and dyskinesias, 378 and prolactin, 448 and TH, 487,492

5-hydroxyindoleacetic acid, 469 5-hydroxytryptophan, and REM sleep,

318 Hyperalgesia, 319, 320-21 Hyperkinesia, 380 Hyperkinesis, 40 Hypoglycemia

biochemical effects of, 224 clinical effects of, 225-26 experimental studies of, 224 and fall in ACh synthesis, 217-18

SUBJECT INDEX

physiological effects of, 225 Hypomania, and deanol, 40 Hypoxia, 230, 486

anemic, 224 and fall in ACh synthesis, 218, 219,

221 changes in mental function, compared

to those in ACh impairment and aging, 225, 228-30

effect on neurotransmitters, 230-31 and fall in ACh synthesis, 218,219,

221 graded,224-25

complete vs. partial, 224 histotoxic, 224

and fall in ACh synthesis, 218, 221 hypoxic, 224, 227 mechanisms of, and clinical implica­

tions, 231 THAM in treatment of, 222

Imidazole-4-acetic acid, 103 Imipramine, 38,40 Insulin

and Ch,479 and TH, 487,492

Isoleucine, 469 3-isopropylphenyl N-methyl carbamate,

176 Kainic acid, 166-69 Lactate, as ACh precursor, 216 Lavallorphan, 333 L-DOPA, 11, 108, 109 129, 346, 464

and ACh concentration, 374 and Ch administration, 472 and chorea, 428 and dyskinesias, 378, 399 andHD,102,4oo and Huntington's chorea, 380,427 and mania, 49 and parkinsonism, 428 and Parkinson's disease, 100, 102,

160,376,377,397,399 and REM sleep, 318 and rigidity, 403 and schizophrenia, 382 and stereotyped behavior, 403 and TD, 122, 123, 124, 125,129,

131,137,378,401 Lecithin,99 106,115,116,132,464,

466,515,516-17,518,538

and ACh levels, 461, 470 and Ch, 484

concentrations, 470 levels in serum and plasma; 465

as source of Ch, 485, 501 Leucine, 469 Levodopa. See L-DOPA

591

Lipoamide dehydrogenase, and ataxia, 143 Lithium, 7-8

chloride, and physostigmine, 46-49 cholinergic effects of, 45-49

Lithium carbonate, 41 Ch levels in RBCs and plasma, 78, 79 and mania and depression, 49

Long-term memory. See LTM LSD, and REM sleep, 318 LTM

and cholinergic agonists, 361 effect of anticholinergics on, 207,

238-39 effect of arecoline on, 253 effect of choline chloride on, 244--45

in aged, 255-60 effect of cholinomimetics on, 207-8,

238-39 effect of physostigmine on, 240--42,

243,247-48,253-54 dose-related, 260

effect of scopolamine on, 253 impairment in aged, 253-60

Luteinizing hormone cholinergic mechanisms in, 449-50,

454-55 levels

effect of methscopolarnine on, 451 , 452,453

effect of physostigmine on, 450, 452-55

Luteinizing-hormone releasing factor, 450 Lysolecithin, as Ch precursor, 484 Lysophosphatidylcholine, plasma, 516-

17,518 Mania

and AChE csp, 54, 55 inhibitors, 4

and atropine, 292 balance of adrenergic and cholinergic

factors in, 3 catecholaminergic disequilibrium in, 33

592

and ChE inhibitors, 18 and choline chloride, 24, 28,498 and deanol, 34 as disease of increased adrenergic

activity, 49 and L-DOPA, 49 and lithium carbonate, 49 and methylphenidate, 49 and neostigmine, 4, 5, 18 and physostigmine, 4,5-7, 12, 18,

22-23,24,25,26,131,292,435, 533

Marijuana, effect on depression, with physostigmine, 8-9, 18-19,49

Mecamylamine, 176, 325-26 and morphine abstinence syndrome,

333 and morphine withdrawal syndrome,

333 and prolactin levels, 448

Memory and ACh in animals, 175-201 consolidation, effect of cholinergic

agents on, 186-89 deficits, and physostigmine, 435 disorders

and ACh, 205-11 role of cholinergic systems in, 227-31 substrates of, 175-76 and synapses, 175-76, 193-95, 199,

249 and variations in cholinergic sensitivity,

180-81 Meperidine, 331 Metacholine, 64 Methantheline, 449 Methionine, 516 Methionine sulfoxamine, 287-88 3-methoxy-tyramine, and hyperkinesia,

380 Methscopolamine, 8,9,89,176,348

effect on anterior pituitary hormone secretion, 450, 451,452,453,455

and growth hormone, 448-49 and TD, 123

Methyl benactyzine, and analgesia, 320-21

Methylphenidate, 5, 39 and dopaminergic activity, 378 and mania, 49

SUBJECT INDEX

and physostigmine, 10,47-49 and schizophrenia, 16,382,385,

402 stereotypy induced by, 403

effect of choline chloride on, 542, 543,544,546

and TD, 378 Methylscopolamine, 315, 324, 436

and ataxia, 144, 145-46, 152 effect on cognitive functions of, 227

Microiontophoretic studies of DA-ACh interaction, 404-6

Monoamine oxidase inhibitors, 4 Monoethylcholine, 525-26 Morphine

andACh content, 328, 330 neurochemistry, 326-35 release, 328-29, 330 turnover, 272, 331

analgesic action of,326-27 as ChE inhibitor, 66

Morphine abstinence syndrome, 333-34 Morphine withdrawal syndrome, 333 Muscarinic

agonists, 271 EEG effects of, 276, 278, 287

antagonists, 271 EEG effects of, 278

cholinergic agents, and REM sleep, 314 antagonists, 156 receptors

alterations of, in HD, 159-66 in human brain, 156-59 in neostriatum, 396 use of QNB to study, 156, 157

receptors age related changes in, 206 binding

in Alzheimer's disease, 206, 253 in cholinergic mapping, 269 diminished with age, 253, 259 in Huntington's chorea, 380 in senile dementia, 206

in cholinergic transmission, 267, 268 in pain mechanisms, 325-26

Nalorphine, 332 and ACh release, 329

Naloxone

SUBJECT INDEX

and ACh analgesia, 332 content, 328 release, 328, 329

and morphine abstinence syndrome, 333

Naltrexone, 331 Neostigmine, 4, 176

and analgesia, 320-21,323,324 and depression, 4, 8 general effects of, 5 and mania, 18 and serum cortisol concentrations, 446

Neuroleptics, 11, 34, 65 and catalepsy, 402-3 and chorea, 426-27 in DA receptor binding studies, 429 effect on DA metabolism in limbic

system and striatum, 383-84 and HD, 88, 89,101-2 neurologic side effects of, 107 and parkinsonian symptoms, 376-77 and Parkinson's disease, 375,376,

397,425 and prolactin, 448 and rigidity, 403 and rotational behavior, 404 and schizophrenia, 15-16,382,385 and TD, 96,107,108,109,121-22,

377-78,541-42 a-neurotoxin, 176, 195 Neurotransmitters, 461-65

types, 462-63 type 1,462,464-65

Nicotinamide, and REM sleep, 318 Nicotine

and corticosterone levels, 447 EEG effects of, 278 and growth hormone, 449 and luteinizing hormone, 449, 450 and pain thresholds, 325-26 and prolactin, 448 and REM sleep, 282, 314 and serum cortisol levels, 446

Nicotinic agents, and REM sleep, 314 agonists, EEG effects of, 276, 278,

287 receptors, 155

in cholinergic mapping, 269

593

in cholinergic transmission, 267, 268 in pain mechanisms,325-26

Norepinephrine, 11, 15, 284, 476 receptor sites, 429 and REM sleep, 283 and schizophrenia, 382 as type I neurotransmitter, 462

Oligemia, 224 Opitate antagonists, and ACh analgesia,

331-32,335 Opiates

andACh content, 328, 330 neurochemistry, 326-35 release, 328-30 turnover, 331

Organophosphate poisoning, effect on human EEG, 347,357,362

Oromandibular dystonia, 34 Oxotremorine, 15,271,439

and ACh turnover, 272, 492 and analgesia, 320-21, 324,325,332 and DA-ACh interaction, 379 and DA synthesis, 374-75 EEG effects of, 276, 277 and extrapyramidal tremor, 376 and HD, 166 QNB binding inhibited by, 157, 162 and REM sleep, 313 stereotypy blocked by, 17

Paraoxon, 492 Parkinsonism, 3,130

compared to Huntington's chorea, 428 and DA receptor sites, 430, 433 dopaminergic mechanisms in, 425

Parkinson's disease, 108 ACh in, 397-98 compared to HD, 101-2,400 compared to Huntington's chorea,

426 CSF Ch in, 502 and DA, 396-97

-ACh interactions in, 17, 375-77, 398-99

and L-DOPA, 100, 160 Pentazocine, 332 Pentobarbital, 272 Peptides, as type II neurotransmitters,

462,463 "Pervagel," 447

594

Phenobarbital, 492 for HD, 101

Phenothiazines, 376 and ACh, 374 and HD, 101,380,400 and Parkinson's disease, 375, 376,

397,398 and schizophrenia, 382, 383, 385 and TD, 107, 109, 129,377,401

Phenoxybenzamine and REM sleep, 318 and TH, 487,492

Pheny~amine,464,469 Phosphatidylcholine. See Lecithin Phosphatidyldeanol,132 Phosphatidylethanolamine, 515

and sources of Ch, 485 Phosphoinositides, 197 Phospholipid hydrolase, 197 Phosphorylcholine, 516, 521, 538 Physostigmine, 4,36,176,293,439,523

andACh analgesia, 332 brain, 471 and fall in synthesis of, 218 turnover, 272

and analgesia, 319, 320-21,323, 324-25

and ataxia, 143-44, 145-53 block stereotypy, 17 and cholinergic mechanisms, 19,20,

25-26,87 and chorea, 103 cognitive effects in normal humans,

237,238,239-43,246-48,249, 358,359 biphasic, 248

compared to choline chloride in increasing cholinergic activity, 99, 533,541

and cortisol production, 445-46, 447 andDA

synthesis, 374-75 turnover, 438-39

and depression, 7-8,18-19,39,40 49,131,257 and marijuana, 8-9,18-19

dose-related effects of, 207, 260 and ECS amnesia, 200 EEG effects of, 274-77, 278, 289,

SUBJECT INDEX

292 animal, 345-46, 348, 357,358 human, 346-47,348-59,362

effect on animal learning, 208, 209-10

effect on anterior pituitary hormone secretion, 450-55

effect on caudato-cortical spindle, 285 effect on CSF

AChE, 56, 57-58,60 DOPAC,436-40 HVA,436-40

effect on memory, 177, 178, 180, 181,182,184,185-86,187-88, 189-90,191-92,194,238,435

effect on REM latency, 347, 358 sleep, 314,315-18,347, 358

electrophysiological effects of, in humans, 345-59

and extrapyramidal tremor, 376 general effects of, 5 and HD, 87, 89, 90, 93, 96,103,104,

106, 166, 380, 400-1, 435, 436, 439,533,541

and L-DOPA induced dyskinesias, 399 lethal drug dose, 192, 193 and lithium chloride, 46-49 and LTM, 207, 253-54, 260, 361 and luteinizing hormone, 449 and mania, 5-6, 18, 22-23, 24, 25,

26,131,292,435 and manic psychosis, 533 and methylphenidate, 10,47-49 and morphine abstinence syndrome,

333,334 with neuroleptics, effect on patients

resistant to DA antagonists, 65 and parkinsonian symptoms, 376, 377 and Parkinson's disease, 398-99 post-reinforcement synchronization

blocked by, 286 as predictive test for deanol, 137, 138 and prolactin, 448, 450, 452-55 rebound effects after administration of, 6-7

and rigidity, 403 and schizophrenia, 10, 15-16, 23,

26-27, 64-65, 292, 383, 385, 402,541

SUBJECT INDEX

and STM, 207, 260 and TO, 87, 89, 90, 93,109,110,115,

122,123,124,125,126,127,129, 130,131,379,401,435,436,533, 541

Pilocarpine and analgesia, 320-21,323 and DA synthesis, 374-75 EEG effects of, 278 and luteinizing hormone, 449 and prolactin, 448 QNB binding inhibited by, 157, 162 and REM sleep, 314

Pimozide, 129 Piperidine

and REM sleep and wAkefulness and sleep, 312-13

Post-reinforcement synchronization, 285-86

Probenecid andCSF

AChE, 55, 57-58 DOPAC,436,437,438-39 F.rVA,436, 437, 438-39

Prochlorperazine, 20, 22, 25, 348, 351 Prolactin

cholinergic mechanisms in, 447-48, 454-55

levels effect of methscopolamine on, 451,

452,453 effect of physostigmine on, 450,

452-55 Propantheline,500 PropanoIol, 4, 45 Prostigmine, 449 Pseudocholinesterase, 59, 60 Putamen

in HD brains, 160-61, 163 3 H-QNB binding in, 157, 158, 159,

160 Pyrrolidinocholine, 525-26 Pyruvate

and ACh synthesis, 218, 220-21,222 metabolism abnormalities, and ataxia,

143,152-53 oxidation

and ACh synthesis, 143, 216-17, 486

and Friedreich's ataxia, 227

595

as source of acetylcoenzyme A, 216 Pyruvate decarboxylase, and ataxia, 143 Pyruvate dehydrogenase, 485-86

and ataxia, 143 QNB, 70, 71, 267

in study of muscarinic cholinergic receptor, 156, 157

3-Quinuclidinyl benzilate. See QNB Red blood cell. See RBC REM

latency, 311,315 effect of physostigmine on, 347, 358

sleep, 289, 292 ACh role in, 312-18 and alpha-methylpara-tyrosine, 318 and arecoline, 317 and atropine, 314 and carbachol, 313-14, 315 and cholinergic

agonists and antagonists, 314 mechanisms, 313-16, 317-18 system, 280, 282-83

and dreaming, 317,318 "executive" cells for, 313 and hemicholinium, 315 and 5-hydroxytryptophan, 318 and L-DOPA, 318 and LSD, 318 neurochemical mechanisms in, 312 and nicotinamide, 318 and nicotine, 314 and nicotinic agents, 314 and nicotinic and muscarinic cholin-

ergic agents, 314-15 and oxotremorine, 313 and phenoxybenzamine, 318 and physostigmine, 314, 315-18,

347,358 and pilocarpine, 314

sleep and piperidine, 314 and reserpine, 318 and scopolamine, 315 andthymoxamine,318

Reserpine, 4, 10, 11,34,39,45,376 and animal EEG, 345, 346 and CAT, 477, 487 and cholinergic mechanisms in depres­

sion,19 and chorea, 426

596

and DA receptors, 378 and HD, 101,400 and Huntington's chorea, 380 and parkinsonism, 425 and Parkinson's disease, 375, 397 and prolactin, 448 and REM sleep, 282, 318 and rigidity, 403 and TD, 109,378 and TH,474,477,487,492

Retrograde amnesia, 186 and cholinergic insufficiency, 199-

200,201 and ECS treatment, 199

Rhythmical slow activity, 281 RS 86, and analgesia, 320-21 Schizophrenia

AChE activity, 64 CSF,54, 55,60 red cells, 64

adrenergic-cholinergic balance in, 10 and anticholinergics, 16 and arecoline, 64-65 and atropine, 292 brain CAT, 69-70 and choline chloride, 23-24, 26-27,

498,541 cholinergic

activity in, 64-65 brain enzymes in, 63-71 function in, 65 mechanisms in, 15-17

DA-ACh interactions in, 382-85,402 and DA receptor sites, 433 and deanol, 37-38 and Ditran, 65 EEG of, and DFP, 346 neuroanatomical site of

corpus striatum as, 382-83 limbic system as, 383-85

and physostigmine, 15-16,23, 26-27,64-65,292,541

quantitative cytotechtonic distribution of ChE in, 65-66

symptoms of, 3 and TChE activity, 65

Scopolamine,S, 7,46,176 and analgesia, 320-21,323,324,

325

SUBJECT INDEX

and ECS amnesia, 200 EEG effects of, 278, 279 effect on ACh turnover, 272 effect on cognitive functions, 227,

361 effect on memory, 177, 179, 180,

189,190-92,194,238,361 LTM,207,253 STM,207

lethal drug dose of, 192, 193 QNB binding inhibited by, 157, 162 and REM sleep, 315 and rotational behavior, 404 and TD, 109, 129

Senile dementia, 222,361 loss of cholinergic

cells in, 215 neurones in, 229

muscarinic receptor binding in, 206 role of carbohydrate oxidation in,

228-29 Serine, 515-16 Serotonin, 15, 196,461,464,466

and DA and ACh metabolism, 375 diet-induced changes in brain, 469 receptor binding, in Huntington's

chorea, 380 and sleep, 312 as type I neurotransmitter, 462

Short-term memory. See STM Sleep

and ACh, 311-18. See also REM sleep Slow system, and cholinergic system, 283 Soman, 523 Spinocerebellar degeneration, 34 STM

effect of anticholinergics and cholino­mimetics on, 238-39

effect of choline chloride on, 244 effect of dose level of cholinergic

agents on, 207 effect of physostigmine on, 239-40,

241,242,247 Substance P, 375 Sulfonyl fluorides, 196 Synapse

blockade, 181-84 and memory, 193-95,249

cholinergic, 199 substrates of, 175-76

SUBJECT INDEX

Synaptosomes Ch uptake and ACh synthesis, 521-25 uptake and acetylation of Ch analogs,

525-26 Tardive dyskinesia. See TO TO, 76, 526

and ACh precursor, 379 animal model of, 379

and choline chloride, 534, 542, 546 and neuroleptics, 541-42,546

choline chloride treatment for, 19, 87, 88,89,90,91,92,96,109-15,257, 260,533,534,541,546

cholinergic neurons in, 109, 110 receptor hypersensitivity in, 130

Ch treatment for, 9-10, 99, 100, 109-16,129,137,379,495,496-98

and cholinomimetics, 439-40 OA-ACh interactions in, 121, 122-23,

127,128, 129, 130-31, 132, 138, 377-79,401-2

OA agonists and depletors, 122 OA receptor supersensitivity, 122,129 deanol treatment for, 9-10, 34, 35,

36, 37, 41, 121, 122-23, 124, 125, 127-28, 131, 134-37, 138, 379,500

development of, and anticholinergic drugs, 108

epidemiology of, 107 exacerbating drugs, 109 growth hormone level and anticholin-

ergic medication in, 449 mimic disorders, 130-31 natural history of, 108 neuroleptic drugs as cause of, 107,

108,109,121-22,541-42 neurotransmitter involvement, 108-9 pharmacologic proflle of, 121-23 physostigmine treatment for, 89, 90,

93,115,379,435,436,439,533, 541

predisposing factors in, 121-22 symptomatology of, 107-8 temporary vs. permanent, 136

Tetrabenazine, 109 and HO,400 and Parkinson's disease, 397

and TO, 378 69-tetrahydrocannabinol, 9 Tetrodotoxin, 271 111,102,137,166,199,462,464

and atropine, 474

597

in caudate nucleus, and Ch administra­tion, 472, 473, 474, 475, 477, 478, 479

and Ch, 474, 477,478,487,492 and 6-hydroxydopamine, 487,492 and insulin, 487,492 and Parkinson's disease, 376 and phenoxybenzamine, 487, 492 and reserpine, 474, 477, 487, 492

THAM, 221-22, 223 Theta waves, 280, 281 Thiopropazate, and TO, 129 Thioridazine, 16, 17, 130,376

as antimuscarinic agent, 384 extrapyramidal effects of, 399 and schizophrenia, 385 and TO, 107

Thymoxamine, 318 Total cholinesterase (TChE) activity, 67-

68 CSF, 68, 69 in schizophrenics and psychotics, 65,

66-67 Tremorine, and analgesia, 320-21,323 Tricyclic

antidepressants, 4, 11,45 and cholinergic mechanisms in

depression, 19 and REM sleep, 292

drugs, 33-34, 41 Triethylcholine, 376, 525-26 Trihexyphenidyl, 38 Trimethylamine, 500 Trivastal, and ACh, 374 Tryptophan, 469

as serotonin precursor, 462, 464 Tryptophan hydroxylase, 462, 469 d-tubocuraine, 280 Tyrosine, 469

as OA precursor, 462, 464 as norepinephrine precursor, 462

Tyrosine hydroxylase. See TH Valine, 469