Copyright Dr Marc Halpern and the

California College of Ayurveda

Definition and Introduction The role of the immune system

To keep the body healthy by destroying that which it perceives to be non-self

Autoimmune Disease

The body mistakes normal tissue for non-self and begins to attack the tissue in an attempt to destroy it

Epidemiology

Prevalence 3 -9 of US population afflicted with tissue specific or systemic autoimmune disease (111)

Number of diseases 80+

Male Femle Woman have a much higher incidecenwith some conditions occuring 80 ndash 90 in woman 85 of sjogrens syndrome thyroiditis lupus and

systemic sclerosis

Common Autoimmune Diseases Rheumatoid Arthritis

Systemic Lupus

Hyper and Hypo Thyroid

Multiple Sclerosis

Pernicious and hemolytic anemias

Diabetes Mellitus

Vitiligo

Psoriasis

Chronersquos disease

Ulcerative Colitis

Celiac Disease

Possible Autoimmune Components

Fibromyalgia

Lymersquos Disease

What is the causeA Western Perspective

Micro-organisms

Hidden

Cross Reactivity

Strept throat and Rheumatic heart disease

Alterations in Normal Tissue

Radiation chemical toxicity viruses

B-lymphocyte Malfunction due to alteration from radiation etc

Genetic tendencies activated by drug use or micro-organisms or stress

Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)

Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells

should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)

Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)

Abnormal function of T helper cells Alterations in cytokine production

Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity

What Happens The reaction triggers abnormal reactions within the

tissues resulting in (1)

Inflammation and or tissue destruction

Excessive growth

Altered function

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Definition and Introduction The role of the immune system

To keep the body healthy by destroying that which it perceives to be non-self

Autoimmune Disease

The body mistakes normal tissue for non-self and begins to attack the tissue in an attempt to destroy it

Epidemiology

Prevalence 3 -9 of US population afflicted with tissue specific or systemic autoimmune disease (111)

Number of diseases 80+

Male Femle Woman have a much higher incidecenwith some conditions occuring 80 ndash 90 in woman 85 of sjogrens syndrome thyroiditis lupus and

systemic sclerosis

Common Autoimmune Diseases Rheumatoid Arthritis

Systemic Lupus

Hyper and Hypo Thyroid

Multiple Sclerosis

Pernicious and hemolytic anemias

Diabetes Mellitus

Vitiligo

Psoriasis

Chronersquos disease

Ulcerative Colitis

Celiac Disease

Possible Autoimmune Components

Fibromyalgia

Lymersquos Disease

What is the causeA Western Perspective

Micro-organisms

Hidden

Cross Reactivity

Strept throat and Rheumatic heart disease

Alterations in Normal Tissue

Radiation chemical toxicity viruses

B-lymphocyte Malfunction due to alteration from radiation etc

Genetic tendencies activated by drug use or micro-organisms or stress

Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)

Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells

should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)

Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)

Abnormal function of T helper cells Alterations in cytokine production

Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity

What Happens The reaction triggers abnormal reactions within the

tissues resulting in (1)

Inflammation and or tissue destruction

Excessive growth

Altered function

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Epidemiology

Prevalence 3 -9 of US population afflicted with tissue specific or systemic autoimmune disease (111)

Number of diseases 80+

Male Femle Woman have a much higher incidecenwith some conditions occuring 80 ndash 90 in woman 85 of sjogrens syndrome thyroiditis lupus and

systemic sclerosis

Common Autoimmune Diseases Rheumatoid Arthritis

Systemic Lupus

Hyper and Hypo Thyroid

Multiple Sclerosis

Pernicious and hemolytic anemias

Diabetes Mellitus

Vitiligo

Psoriasis

Chronersquos disease

Ulcerative Colitis

Celiac Disease

Possible Autoimmune Components

Fibromyalgia

Lymersquos Disease

What is the causeA Western Perspective

Micro-organisms

Hidden

Cross Reactivity

Strept throat and Rheumatic heart disease

Alterations in Normal Tissue

Radiation chemical toxicity viruses

B-lymphocyte Malfunction due to alteration from radiation etc

Genetic tendencies activated by drug use or micro-organisms or stress

Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)

Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells

should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)

Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)

Abnormal function of T helper cells Alterations in cytokine production

Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity

What Happens The reaction triggers abnormal reactions within the

tissues resulting in (1)

Inflammation and or tissue destruction

Excessive growth

Altered function

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Common Autoimmune Diseases Rheumatoid Arthritis

Systemic Lupus

Hyper and Hypo Thyroid

Multiple Sclerosis

Pernicious and hemolytic anemias

Diabetes Mellitus

Vitiligo

Psoriasis

Chronersquos disease

Ulcerative Colitis

Celiac Disease

Possible Autoimmune Components

Fibromyalgia

Lymersquos Disease

What is the causeA Western Perspective

Micro-organisms

Hidden

Cross Reactivity

Strept throat and Rheumatic heart disease

Alterations in Normal Tissue

Radiation chemical toxicity viruses

B-lymphocyte Malfunction due to alteration from radiation etc

Genetic tendencies activated by drug use or micro-organisms or stress

Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)

Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells

should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)

Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)

Abnormal function of T helper cells Alterations in cytokine production

Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity

What Happens The reaction triggers abnormal reactions within the

tissues resulting in (1)

Inflammation and or tissue destruction

Excessive growth

Altered function

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

What is the causeA Western Perspective

Micro-organisms

Hidden

Cross Reactivity

Strept throat and Rheumatic heart disease

Alterations in Normal Tissue

Radiation chemical toxicity viruses

B-lymphocyte Malfunction due to alteration from radiation etc

Genetic tendencies activated by drug use or micro-organisms or stress

Sequestered antigens Lymphoid cells that are not exposed to certain self-antigens during their development and so never develop tolerance (4)

Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells

should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)

Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)

Abnormal function of T helper cells Alterations in cytokine production

Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity

What Happens The reaction triggers abnormal reactions within the

tissues resulting in (1)

Inflammation and or tissue destruction

Excessive growth

Altered function

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Etiology and Pathology Thymus Dysfunction Self-reacting lymphoid cells

should be negatively selected if they are sensitive to self antigens They should undergo apoptosis (programmed cell death) - Called Failure of Clonal Deletion (4)

Fewer Suppressor T-cell Failure to regulate immune responses Some patients have fewer of these cells (4)

Abnormal function of T helper cells Alterations in cytokine production

Xenoestrogens may result in suppression of cell mediated immunity and stimulation of humeral immunity

What Happens The reaction triggers abnormal reactions within the

tissues resulting in (1)

Inflammation and or tissue destruction

Excessive growth

Altered function

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

What Happens The reaction triggers abnormal reactions within the

tissues resulting in (1)

Inflammation and or tissue destruction

Excessive growth

Altered function

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Factors Increasing Your Risk Cigarette smoking RA+

SLE (varies per country) Atopic allergies Psychosocial Stress ndash 5

years period (Relationship job financial) (RA)

Use of private well-water Hair dye Hep B Vaccination (SLE) EBV Herpes Viral

infections (SLE)

Pneumonia (RA) Pre-eclampsia (RA + SLE) Cystaline Silica Exposure

(General) Drugs and contaminants

of Canola oil Tryptophan procainamide interferon

Xenoestrogen exposure (BPA DDT TTCD (tetrachlorodioxin)

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Factors Decreasing Risk Breast Fed

Protects against RA and SLE

Past Urinary Tract Infections

Protects against RA

Past Rubella Infection (German Measles)

Protects against RA

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Most Common Tissues Affected Red Blood Cells

Pernicious Anemia Hemolytic anemia

Blood Vessels

Vasculitis

Endocrine Glands (Thyroid Adrenal Pancreas)

Hashimottorsquos Thyroiditis Graversquos Disease Addisonrsquos Disease Diabetes Mellitus

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Most Common Tissues Affected Muscle Nerve

Multiple sclerosis Myesthenia gravis Joints

Rheumatoid Arthritis SLE Skin and muscle

Dermatomyositis Psoriasis Vitiligo Organ Disease

Digestive system Chronersquos disease Celiac disease Ulcerative

colitis

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Generalized SymptomsCommon symptoms

Tissue specific Inflammation and or destruction

Generalize Fatigue dizziness weakness

Possible low Grade Fever

Specific Symptoms

Vary with the individual disease

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Most Important General Blood Tests

ESR and CRP

These measure inflammation in the body The numbers rise as tissue destruction becomes more active

Can be used to monitor the condition and assess the success of treatment

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Common Western Drug TreatmentImmune Suppressive Drugs

Anti-inflammatory Corticosteroids such as prednisone

Non-steroidal anti-inflammatory drugs

Immune suppressive drugs cyclophosphamide azathioprine cyclosporine

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

General CourseAs a group they tend to be chronic

Prone to remission and flare -ups

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

General ComplicationsDisability due to impaired tissue

function

Complications of immune suppression secondary to drugs

Increased incidence of Infections and cancers

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Lymes Disease Microrganism B berdorferi (spirochete type

bacteria)

Cross reactivity

T-cells and antibodies appear to a host of self-antigens may be responsible for chronic arthritis neurological dysfunction and other symptoms 131415

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Trust the Laws of Nature First Then Trust Science

The Laws of Nature Never Change The Conclusions of Science are always

changing

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Generalized Diagnostic ApproachSeek an understanding of the nidana

Determine the doshic nature of the disease

Understand the samprapti Dhatu and srotas involved

To what degree is ama present

What is the state of ojas

Determine the imbalances of the mind (state of prana-tejas and ojas)

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

The Role of Ama and Dosha

Ama and Dosha combined to enter the dhatu and disturb formation and function

Unstable Dhatu

DhatuAgni

New Dhatu and Upadhatu are

formed

Dhatu agni vitiation results in Amaformation which enters the tissues

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

The Role of Ojas

Ojas is the foundation of a stable immune system

Protects against vitiated dosha and disturbances of prana and tejas

Shukra DhatuTrans-

mutation Ojas

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

The Role of Cellular Intelligence

There is a failure of the intellect on a cellular level resulting in abnormal immune physiology

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

The 3 Keys to protecting ojasaccording to Charaka

The practice of non-violence

Nothing destroys ojas faster than a violent act

Preservation of shukra

The foundation of ojas

Attainment of knowledge

Knowledge of how live harmoniously and nourish ourselves properly

Knowledge of how to sustain the 3 pillars of life

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

The Science of Rasayana The rebuilding of the systems of the body

Follows the three phases of panchakarma

Purva Karma

Pradhan Karma

Praschat Karma

Use of rasayana herbs during praschat karma

Proper lifestyle sustained throughout praschatkarma

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Management of the Annamaya kosha

Rest and Sleep Support a healthy sleep rhythm

Normalize diet and digestion Proper diet in accordance with vikruti

Follow the guidelines for health eating

Create a health daily routine Asana in accordance with onersquos level of ojas

Self abhyanga in accordance with onersquos level of ama

General care practices

Avoid sexual activity

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Management through thePranamaya kosha

Abdominal Breathing

Create a steady healthy relaxed abdominal breathing practice

Pranayama

Choose the proper pranayama based on vikruti

`Minimize if the patient is very weak

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Management through the Manomaya Kosha

Interleukins levels change with emotion

Anxiety raises pro-inflammatory IL ndash 6 and decreases cortisol (Brain Behav Immun 2010 Mar 18 )

IL-6 increases when we feel helpless and in pain Pessimism increases inflammation

All immune cells have receptors on them to neuropeptides chemicals produced in the brain in response to emotions

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Care for the Manomaya Kosha Balance prana-tejas and ojas

Create a beautiful and supportive sensory environment

Surround yourself with nurturing people with a cheery and positive disposition

Reduce extreme sensory stimuli

Expose yourself to light-hearted stimuli that makes you laugh

Role of a caregiver

Positive Thinking

Yoga Nidra

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Management through theVijnanamaya kosha

Cultivation of discernment through intellectual study and spiritual teachings in accordance to the state of ojas

Self- reflection and Inquiry

Expose yourself to inspirational ldquoTruthrdquo based parables and stories

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Management through theAnandamaya kosha

Meditation in accordance with ojas

Realization and the transformation of consciousness

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Yoga and Meditation Yoga and Autoimmune Disease

Asana 3X per week for 75 minutes for 10 weeks decreased pain depression and overall disability in patients with Rheumatoid Arthritis Mechanism is unknown(7)

Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Lifestyle Yoga and Meditation Complementary therapy use by persons with

multiple sclerosis benefits and research priorities (8)

Six most used therapies reflexology massage yoga relaxation meditation accupuncture and aromatherapy

25-40 reported that the therapies received were ldquoextremely helpfulrdquo

Authors point to this study to show the potential benefits of CAM procedures for patients with MS

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Lifestyle Yoga and Meditation Complementary and alternative medicine for multiple

sclerosis (9)

Survey of 1573 patients in Germany Main Reason for CAM use Low satisfaction with

conventional treatment and high side effects

More positive attitude toward CAM than allopathy

70 use or used at least 1 CAM approach

50+ nutritional supplementation

41 diet modification

26 homeopathy

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Lifestyle Yoga and Meditation Complementary and alternative medicine use in

rheumatoid arthritis in patients in India (10)

Study of 102 patients

82 used CAM therapies

28 used Ayurveda

20 used Homeopathy

17 yoga asana

12 pranayama

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Lifestyle Yoga and Meditation Review of the efficacy of meditation techniques as

treatments for medical illness

Performed University of Connecticut Medical School

Department of Psychiatry (11)

Review of 82 studies of which 20 were randomized controlled studies

Authorrsquos conclusion Review supports meditation as an effective treatment for four illnesses

Epilepsy

PMS

Mood disorders

Autoimmune disorders

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

When it Comes to MedicineEveryone Wants The Magic BulletThe One Medicine (or Herb) To

Make All Their Troubles Go Away

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

General Mechanisms for Herbs Impacting Autoimmune Disease

Modulation of Cytokine activity Interleukin (16) TNF and Interferon (Immunomodulators) High levels cause many of the problems associated with

autoimmune disease

Anti-inflammatory Actions Decrease secretion of lysosomal enzymes by macrophages

Ginger

COX inhibitor COX-2 most specific Most NSAIDrsquos work via this mechanism Turmeric ashwaganda guggul

Control the formation or release of pro-inflammatory mediators such as eicosanoids Curcumin capsacin bromelain

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Transcription Factors Transcription Factor A protein that activates genes

controls the transfer of genetic information from DNA to mRNA mRNA then carries information to sites of protein production (ribosomes)

NF KappaB Nuclear Factor Kappa B cells

Involved in the pathway for cellular production of cytokines It regulates the immune response to infections Poor regulation is linked to cancer development and autoimmune disease

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

The Most Famous Herbs for Rasayana

Vata Pitta Kapha

Amalaki Amalaki Amalaki

Gaduchi Gaduchi Gaduchi

Brahmi Brahmi Brahmi

Ashwaganda

Bala Bala

Haritaki

Bibhitaki

Shallijit

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Well-studied ImmunomodulatorHerbs from India

Turmeric

Gaduchi

Ashwaganda

Boswellia

Castor Oil

Guggulu

Ginger

Kutki

Licorice

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Arthritis an inflammation of the joints is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines and pro-inflammatory enzymes that mediate the production of prostaglandins (eg cyclooxygenase-2) and leukotrienes helliphellip

hellipNumerous agents derived from plants can suppress these cell

signaling intermediates including curcumin (from turmeric)

hellipsilymarin (artichoke) guggulsterone (guggul) boswellic acid

(frankincense) and withanolides (ashwagandha) Indeed several preclinical and clinical studies suggest that these agents have potential for arthritis treatment

Curr Opin Pharmacol 2007 Jun7(3)344-51 Epub2007 May 1

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Ashwagandha Latin Withania somnifera

Rasa Sweet bitter astringent

Virya Slightly warm

Vipaka Sweet

Dosha V-PK+ (Ex)

Actions Anti-inflammatory immunomodulator and rasayana

Research

COX-2 inhibitor

Th1 adjuvant useful in chronic infectious disease in immune suppressed patients

Decrease stress Reduced cortisol

Suppressed pro-inflammatory cytokines TNF-alpha IL-1 beta IL12p40

Inhibited transcription factors NFKappaB and Ap-1

Reduces tumor cell proliferation

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Immunomodulator Plants Turmeric Latin Curcuma longa Rasa bitter pungent Virya warm Vipaka pungent Doshas VK-P+ (ex) Actions Antiviral anti-

inflammatory Research COX-2

inhibitor LOX inhibitor Source

Nutr Hosp 2009 May-Jun24(3)273-81

Adv Exp Med Biol 2007595213-26

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Immunomodulator Plants Gaduchi Latin Tinospora cordifolia Rasa Bitter astringent Virya Neutral Vipaka Sweet Dosha VPK- Action Adaptogen

Hepatoprotective Anti-inflammatory rasayana

Research Rat Reduced mast cell breakdown in Guinea pigs (Histomineand Cytokines)

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Immunomodulator Plants Frankincense Latin Boswellia serrata Rasa Astringent bitter

sweet Virya slightly warm Vipaka pungent Dosha KP-V+ Actions Anti-inflammatory

anti-allergy Research Inhibits

complement activity in animals and leukotriens in humans Reduces eosinophilcounts in humans

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Immunomodulator Plants Guggulu Latin Commiphora mukul Rasa pungent bitter Virya warm Vipaka pungent Dosha KV-P+ Actions Anti-

inflammatory pachana antimicrobial

Research Verification as a COX 12-inhibitor reducing inflammation

httpwwwayurvedicdietsolutionscomimagesCommiphora_Mukulj

pg

Castor oil Eranda Latin Ricinus communis Rasa Pungent sweet Virya Warm Vipaka Pungent Dosha V-PK+ Actions Anti-inflammatory

analgesic Research Inflammation

reduced (Decrease edema substance P) with repeated topical application ndashmechanism unknown

Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana

Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages

Source J Med Food 2010 Feb13(1)156-62

httpdiggingrifileswordpresscom200910ginger2jpg

Licorice Research

Increases phagocytosis of macrophages

induces IL-1 secretion Enhances NK activity

Enhances mitogen of B-lymphocytes

inhibits viral multiplication

induces IFN production from spleen cells

Reduces post-traumatic inflammation

Reduces mediators of colon cancer (11BetaHSD2)

Raises cortisol levels protecting against inflammation

Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic

Astragalus Latin Astragalus

membranaceus Part Used Root Action Immune Tonic Research Astragalus

injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments

May work through suppression of IL-6

Pictures httpopenendedquestionfileswordpressco

m200910astragalus-plant1jpg

Immunomodulator Plants Siberian Ginseng

Latin Eleutherococcussenticosus

Action Adaptogen anodyne immune modulator

Part used Root

Research Higher levels decrease IL-6

American Ginseng

Latin Panaxquinquefolius

Part Root

Action Adaptogen tonic anti-cancer

Research Increases natural killer cells

Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions

Adaptogen tonic antiinflammatory

Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Immunomodulator Plants Ginger Latin Zingiber officinale Rasa Pungent sweet Virya Hot Vipaka Pungent Actions Dipana

Research Mouse studies confirm anti-inflammatory effect involving the inhibition of macrophages

Source J Med Food 2010 Feb13(1)156-62

httpdiggingrifileswordpresscom200910ginger2jpg

Licorice Research

Increases phagocytosis of macrophages

induces IL-1 secretion Enhances NK activity

Enhances mitogen of B-lymphocytes

inhibits viral multiplication

induces IFN production from spleen cells

Reduces post-traumatic inflammation

Reduces mediators of colon cancer (11BetaHSD2)

Raises cortisol levels protecting against inflammation

Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic

Astragalus Latin Astragalus

membranaceus Part Used Root Action Immune Tonic Research Astragalus

injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments

May work through suppression of IL-6

Pictures httpopenendedquestionfileswordpressco

m200910astragalus-plant1jpg

Immunomodulator Plants Siberian Ginseng

Latin Eleutherococcussenticosus

Action Adaptogen anodyne immune modulator

Part used Root

Research Higher levels decrease IL-6

American Ginseng

Latin Panaxquinquefolius

Part Root

Action Adaptogen tonic anti-cancer

Research Increases natural killer cells

Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions

Adaptogen tonic antiinflammatory

Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Licorice Research

Increases phagocytosis of macrophages

induces IL-1 secretion Enhances NK activity

Enhances mitogen of B-lymphocytes

inhibits viral multiplication

induces IFN production from spleen cells

Reduces post-traumatic inflammation

Reduces mediators of colon cancer (11BetaHSD2)

Raises cortisol levels protecting against inflammation

Latin Glycyrrhiza glabraRasa Sweet BitterVirya CoolVipaka SweetDosha VP-K+ (ex)Action Hepatoprotective anti-inflammatory antiviral anti-cancer tonic

Astragalus Latin Astragalus

membranaceus Part Used Root Action Immune Tonic Research Astragalus

injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments

May work through suppression of IL-6

Pictures httpopenendedquestionfileswordpressco

m200910astragalus-plant1jpg

Immunomodulator Plants Siberian Ginseng

Latin Eleutherococcussenticosus

Action Adaptogen anodyne immune modulator

Part used Root

Research Higher levels decrease IL-6

American Ginseng

Latin Panaxquinquefolius

Part Root

Action Adaptogen tonic anti-cancer

Research Increases natural killer cells

Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions

Adaptogen tonic antiinflammatory

Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Astragalus Latin Astragalus

membranaceus Part Used Root Action Immune Tonic Research Astragalus

injections in patients with SLE Enhanced cortiscosteroid and immunosuppressive actions of standard drug treatment suggesting the benefit of combining treatments

May work through suppression of IL-6

Pictures httpopenendedquestionfileswordpressco

m200910astragalus-plant1jpg

Immunomodulator Plants Siberian Ginseng

Latin Eleutherococcussenticosus

Action Adaptogen anodyne immune modulator

Part used Root

Research Higher levels decrease IL-6

American Ginseng

Latin Panaxquinquefolius

Part Root

Action Adaptogen tonic anti-cancer

Research Increases natural killer cells

Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions

Adaptogen tonic antiinflammatory

Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Immunomodulator Plants Siberian Ginseng

Latin Eleutherococcussenticosus

Action Adaptogen anodyne immune modulator

Part used Root

Research Higher levels decrease IL-6

American Ginseng

Latin Panaxquinquefolius

Part Root

Action Adaptogen tonic anti-cancer

Research Increases natural killer cells

Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions

Adaptogen tonic antiinflammatory

Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

American Ginseng

Latin Panaxquinquefolius

Part Root

Action Adaptogen tonic anti-cancer

Research Increases natural killer cells

Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions

Adaptogen tonic antiinflammatory

Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Immunomodulator Plants Asian Ginseng Latin Panax ginseng Part Root (flower) Rasa Pungent bitter sweet Virya Warm Vipaka Sweet Dosha VK-P+ Related Actions

Adaptogen tonic antiinflammatory

Research Flowers inhibited pro-inflammatory cytokines (IL-1 and TNF) Decreased COX-2

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Immunomodulator Plants Pineapple Stem Latin Ananus comosus Contains Bromelain Action anti-tumor

(metastisis) anti-inflammatory

Research Intraperitonealadministration induces tumor necrosis factor-a interleukin (Il)-1beta Il-6 and Il-8 Oral admin modulates arachadonicacid cascade

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Immunomodulator Plants Garlic (Lasuna) Latin Allium sativum Rasa Pungent Virya Warm Vipaka Pungent Dosha VK-P+ Related Actions

Shukrajanana shothahara antimicrobial rasayana

Research Inhibits Th1 and inflammatory cytokines Increase IL-10 ndash Possibly beneficial in IBD

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Immunomodulator Plants

Kutki

Latin Picrorhizia kurrooa

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Anti-inflammatory and immune modulating

Research COX-2 inhibitor

httpwwwgreenchembizproductshtml

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Milk Thistle

Latin Silybummarianum

Action Anti-inflammatory antiviral cholegogue alterative

Rasa Bitter

Virya Cool

Viipaka Pungent

Dosha PK-V+

Research Most active ingrediant SilymarinAntiviralInhibits proinflammatorycytokinesDecreases NFKappaBDecreases IL-2

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Dandelion Root Latin Taraxacum

officinale

Rasa Bitter

Virya Cool

Vipaka Pungent

Dosha PK-V+

Actions Cholegogue alterative anti-inflammatory

Research

COX-2 inhibitor

Inhibits NFKappaB

Inhibits TNF-alpha

Inhibits IL-1beta

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

General Guidelines for the Management of Autoimmune Disease Vata

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic vata pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (Agni) and elimination (apanavayu)

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

General Guidelines for the Management of Autoimmune Disease

Pitta

Rest and Reduce Stress

Sexual abstinence for at least 30 days

Build ojas

Sattvic pitta pacifying diet

No alcohol coffee

Support Immune system with rasayanas

Support Digestive System (agni) and elimination (pachaka pitta)

Cool and purify the raktavaha srota (liver and blood)

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

General Guidelines for the Management of Autoimmune Disease Kapha ( Combines with Vata or Pitta)

As noted for the primary dosha

Sattvic VK or PK pacifying diet

Pacify appropriate kapha subdoshas particularly sleshaka and avalambaka

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

To Download a Copy of the Slides

Go to California College of Ayurveda

wwwayurvedacollegecom

Resources 1 Medline Plus Autoimmune Disease

httpwwwnlmnihgovmedlineplusencyarticle000816htm 2National Institute of Allergy and Immune disorders Lymes disease

httpwww3niaidnihgovtopicslymeDiseaseresearchautoimmunehtm 3 Merck Manual Online

httpwwwmerckcommmhesec16ch186ch186ahtml 4 Microbiology and Immunology online University of So Carolina School of

Medicine httppathmicromedscedughaffartolerance2000htm

5 Environmental epidemiology and risk factors for Autoimmune disease Medscape httpwwwmedscapecomviewarticle449854

International Journal of Molecular Science Effect of Xenoestrogens on T-lymphocytes Int J Mol Sci 2003 4 45-61 httpwwwmdpiorgijmspapersi4020045pdf

6 K Spellman Modulation of cytokine expression by traditional medicines a review of herbal immunomodulators Alternative Medicine Review June 2006 11(12) 128-50

Resources 7 Alternative Therapies in Health and Medicine 2009 Jul-Aug15(4)24-31

Functional and physiological effects of yoga in women with rheumatoid arthritis a pilot study Bosch PR Traustadoacutettir T Howard P Matt KSDepartment of Physical Therapy AT Still University USA

8 Complement Ther Clin Pract 2008 Aug14(3)176-84 Epub 2008 May 7Esmonde L Long AFSchool of Healthcare University of Leeds Baines Wing Leeds LS2 9UT UK

9 Mult Scler 2008 Sep14(8)1113-9 Epub 2008 Jul 16Schwarz S Knorr C Geiger H Flachenecker P Central Institute of Mental Health University of Heidelberg J 5 Mannheim 68159 Germany

10 Natl Med J India 2007 Sep-Oct20(5)236-9 Zaman T Agarwal S Handa R All India Institute of Medical Sciences New Delhi 110029 India

bull 11 J Altern Complement Med 2006 Oct12(8)817-32 Arias AJ Steinberg K Banga A Trestman RL Department of Psychiatry University of Connecticut Medical School Farmington CT USA ariaspsychiatryuchcedu

bull 11 httpwwwwrongdiagnosiscomaaiprevalencehtmprevalence_intro

Resources and References 13 Nature Medicine 5 1375 1999

14 J Peripheral Nervous System 9 165 2004 J Neuroimmunol 159 192 2005

15 J Clin Microbiol 43 850 2005