autophagy - medchemexpress.com...catabolism with another key protein degradation pathway, the...

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Autophagy

Autophagy is a conserved cellular degradation and recycling processin the lysosome. In mammalian cells, there are three primary types ofautophagy: microautophagy, macroautophagy, andchaperone-mediated autophagy (CMA). Microphagy captures cargoesby means of invaginations or protrusions of the lysosomal membranedirectly, CMA uses chaperones to identify cargo proteins and thenunfolds and transfers them into the lysosomal, while macroautophagysequesters cargo by autophagosomes-de novo synthesized ofdouble-membrane vesicles-and subsequently transport it to thelysosome.Macroautophagy is the best studied and it occurs at a low level

constitutively and can also be further induced under stress conditions, such as nutrient or energy starvation with asalient feature of autophagy protein degradation. Stress-induced macrophagy plays an important role in proteincatabolism with another key protein degradation pathway, the ubiquitin–proteasome system (UPS).As the study progressed, autophagy gains its importance under basal, nutrient-rich conditions, and is now recognizedas a critical housekeeping pathway in catabolism of diverse cellular constituents, such as protein aggregates(aggrephagy), lipid droplets (lipophagy), iron complex (Ferritinophagy) and carbohydrate. Except for macromolecules,autophagy can also target several organelles and structures, such as mitochondria (mitophagy), peroxisome(pexophagy), endoplasmic reticulum (reticulophagy or ER-phagy), ribosome (ribophagy), spermatozoon-inheritedorganelles following fertilization (allophagy), secretory granules within pancreatic cells (zymophagy) and intracellularpathogens (xenophagy).Autophagy and its dysfunction are associated with a variety of human pathologies, including ageing, cancer,neurodegenerative disease, heart disease and metabolic diseases, such as diabetes. Plenty of drugs and naturalproducts are involved in autophagy modulation through multiple signaling pathways. Small molecules that canregulate autophagy seem to have great potential to intervene such diseases in animal models or clinical courses.

https://www.MedChemExpress.com/Targets/Autophagy.html

Purity: 99.84%Clinical Data: No Development ReportedSize: 50 mg, 100 mg, 200 mg, 500 mg

Purity: 98.74%Clinical Data: Phase 4Size: 10mM x 1mL in DMSO,

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Purity: >98%Clinical Data: Phase 2Size: 10 mg, 50 mg


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Purity: 99.16%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

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5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 5g

Autophagy Inhibitors & Modulators

Bioactivity: (+)-JQ-1 is a inhibitor, with s of 77BET bromodomain IC50and 33 nM for the first and second bromodomain ( )BRD4(1/2)

. (+)-JQ-1 also activates .[1] autophagy [2]

Bioactivity: Epicatechin gallate inhibits cyclooxygenase-1 ( ) withCOX-1an of 7.5 μM.IC50

Bioactivity: (-)-Epigallocatechin (EGCG) is the most abundant flavonoid ingreen tea, can bind to unfolded native polypeptides andprevent conversion to amyloid fibrils.

Bioactivity: (-)-Epigallocatechin Gallate is a tea flavonoid with potentantioxidant, antiinflammatory, and anticarcinogenicproperties. (-)-Epigallocatechin Gallate is reported toinhibit signaling and thereby exert anticancer effects.EGFR

Bioactivity: (E)-Daporinad (FK866) is an effective inhibitor ofnicotinamide phosphoribosyltransferase ( ) with anNMPRTase

of 0.09 nM.IC50

Bioactivity: (R)-(-)-Gossypol (AT-101) is the levorotatory isomer of anatural product Gossypol. AT-101 is determined to bind to

, and proteins with s of 260±30 nM,Bcl-2 Mcl-1 Bcl-xL Ki170±10 nM, and 480±40 nM, respectively.

Bioactivity: (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) is thelevorotatory isomer of a natural product Gossypol. AT-101 isdetermined to bind to , and proteins withBcl-2 Mcl-1 Bcl-xL

s of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.Ki

Bioactivity: 2-Methoxyestradiol is an inhibitor and angiogenesis apoptosisinducer with potent antineoplastic activity.2-Methoxyestradiol also destablize .microtubules

Bioactivity: 3,3'-Diindolylmethane is a strong, pure androgen receptor(AR) antagonist.

Bioactivity: 3-Methyladenine is a inhibitor. 3-Methyladenine is aPI3Kwidely used inhibitor of via its inhibitory effectautophagyon class III PI3K.

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

(+)-JQ-1 (JQ1) Cat. No.: HY-13030

(-)-Epicatechin gallate (ECG; Epicatechin gallate; (-)-Epicatechin 3-O-gallate) Cat. No.: HY-N0002

(-)-Epigallocatechin (EGC; Epigallocatechin; l-Epigallocatechin) Cat. No.: HY-N0225

(-)-Epigallocatechin Gallate (EGCG; Epigallocatechol Gallate) Cat. No.: HY-13653

(E)-Daporinad (FK866; APO866) Cat. No.: HY-50876

(R)-(-)-Gossypol (AT-101; R-(-)-gossypol acetic acid) Cat. No.: HY-15464

(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid);

(-)-Gossypol acetic acid; (R)-Gossypol acetic acid) Cat. No.: HY-15464A

2-Methoxyestradiol (2-ME2; NSC-659853) Cat. No.: HY-12033

3,3'-Diindolylmethane (DIM; Arundine; HB 236) Cat. No.: HY-15758

3-Methyladenine (3-MA) Cat. No.: HY-19312

https://www.MedChemExpress.com/Targets/Autophagy.html

https://www.MedChemExpress.com/__addition__-JQ-1.html

https://www.MedChemExpress.com/_-_-Epicatechin-gallate.html

https://www.MedChemExpress.com/_-_-Epigallocatechin.html

https://www.MedChemExpress.com/_-_-Epigallocatechin-Gallate.html

https://www.MedChemExpress.com/FK866.html

https://www.MedChemExpress.com/AT-101.html

https://www.MedChemExpress.com/AT-101-acetic-acid.html

https://www.MedChemExpress.com/2-Methoxyestradiol.html

https://www.MedChemExpress.com/3,3_acute_-Diindolylmethane.html

https://www.MedChemExpress.com/3-Methyladenine.html



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Purity: 99.65%Clinical Data: No Development ReportedSize: 10mM x 1mL in Water,

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Purity: 98.0%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

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Purity: 96.0%Clinical Data: LaunchedSize: 50 mg, 100 mg, 500 mg


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Bioactivity: 3BDO is a new activator which can also inhibitmTOR.autophagy

Bioactivity: 5-Aminolevulinic acid HCl is an intermediate in hemebiosynthesis in the body and the universal precursor oftetrapyrroles. Target: Others 5-Aminolevulinic acid is anon-fluorescent prodrug that leads to intracellularaccumulation of fluorescent porphyrins in malignant gliomas-a…

Bioactivity: 5-Azacytidine is a nucleoside analogue of cytidine thatspecifically inhibits DNA methylation by trapping DNA

.methyltransferases

Bioactivity: 6-Mercaptopurine is a purine analogue which acts as anantagonist of the and has been widely usedendogenous purinesas antileukemic agent and immunosuppressive drug.

Bioactivity: 6-Thioguanine (Thioguanine) is an anti-leukemia andimmunosuppressant agent, acts as an inhibitor of SARS and MERScoronavirus papain-like proteases ( ) and also potentlyPLprosinhibits activity, with s of 25 μM and 40 μM forUSP2 IC50Plpros and recombinant human USP2, respectively.

Bioactivity: A-317491 is a non-nucleotide P2X3 and P2X2/3 receptorantagonist, which inhibits calcium flux mediated by thereceptors. IC50 value: Target: P2X2/3 It is known that P2X3and P2X2/3 receptors stimulate the pronociceptive effects ofATP upon activation. Studies indicate that the P2X3 receptor…

Bioactivity: A-317491 is a non-nucleotide P2X3 and P2X2/3 receptorantagonist, which inhibits calcium flux mediated by thereceptors. IC50 value: Target: P2X2/3 receptor It is knownthat P2X3 and P2X2/3 receptors stimulate the pronociceptiveeffects of ATP upon activation. Studies indicate that the P2X3…

Bioactivity: A-867744 is a positive allosteric modulator of α7 nAChRs (IC50values are 0.98 and 1.12 μM for human and rat α7 receptorACh-evoked currents respectively, in X. laevis oocytes).Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. IC50value: ~ 1 uM Target: α7 nAChR Target:

Bioactivity: ABT-737 is a selective and BH3 mimetic , Bcl-xL and inhibitor with Bcl-2 Bcl-ws of 78.7 nM, 30.3 nM and 197.8 nM, respectively.EC50

Bioactivity: ABT-751(E 7010) is a novel bioavailable tubulin-binding andantimitotic sulfonamide agent with IC50 of about 1.5 and 3.4μM in neuroblastoma and non-neuroblastoma cell lines,respectively. IC50 Value: 1.5 μM(neuroblastoma); 3.4μM(non-neuroblastoma) Target: Microtubule/Tubulin in vitro:…

3BDO Cat. No.: HY-U00434

5-Aminolevulinic acid hydrochloride (ALA; 5-ALA) Cat. No.: HY-N0305

5-Azacytidine (Ladakamycin; 5-AzaC; Azacitidine) Cat. No.: HY-10586

6-Mercaptopurine (Mercaptopurine; 6-MP) Cat. No.: HY-13677

6-Thioguanine (Thioguanine2-Amino-6-purinethiol) Cat. No.: HY-13765

A-317491 Cat. No.: HY-15568

A-317491 sodium salt hydrate Cat. No.: HY-15568A

A-867744 Cat. No.: HY-12149

ABT-737 Cat. No.: HY-50907

ABT-751 (E7010) Cat. No.: HY-13270

https://www.MedChemExpress.com/3BDO.html

https://www.MedChemExpress.com/5-aminolevulinic-acid-hydrochloride.html

https://www.MedChemExpress.com/5-Azacytidine.html

https://www.MedChemExpress.com/6-Mercaptopurine.html

https://www.MedChemExpress.com/6-Thioguanine.html

https://www.MedChemExpress.com/A-317491.html

https://www.MedChemExpress.com/A-317491-sodium-salt-hydrate.html

https://www.MedChemExpress.com/A-867744.html

https://www.MedChemExpress.com/abt-737.html

https://www.MedChemExpress.com/ABT-751.html

Purity: 99.92%Clinical Data: Phase 3Size: 10mM x 1mL in Water,

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Bioactivity: Aceglutamide is a psychostimulant and nootropic, used toimprove memory and concentration.

Bioactivity: Acetazolamide is a ( ) inhibitor withcarbonic anhydrase CA IXan of 30 nM for . Diuretic effects .IC50 hCA IX [1] [4]

Bioactivity: Acetylcholine (chloride) is a common foundneurotransmitterin the central and peripheral nerve system.

Bioactivity: Actinomycin D inhibits with an of 0.42 μM.DNA repair IC50

Bioactivity: Adenosine is a nucleoside composed of a molecule of adenineattached to a ribose sugar molecule (ribofuranose) moiety viaa β-N9-glycosidic bond. Target: Nucleosideantimetabolite/analog Adenosine plays an important role inbiochemical processes, such as energy transfer — as adenosine…

Bioactivity: Afatinib (BIBW 2992) is an irreversible family inhibitorEGFRwith s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR ,IC50

wt

EGFR , EGFR and HER2, respectively.L858R L858R/T790M

Bioactivity: Afatinib dimaleate is an irreversible family inhibitorEGFRwith s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR ,IC50

wt

EGFR , EGFR and HER2, respectively.L858R L858R/T790M

Bioactivity: AG-490 is a tyrosine kinase inhibitor that inhibits ,EGFR and .Stat-3 JAK2/3

Bioactivity: AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation withIC50 of 7 μM, less potent to IR with IC50 of 57 μM. IC50value: 7 uM (IGF-1R autophosphorylation); 57 uM (IR) [1]Target: IGF-1R; IR in vitro: AG-1024 blocks the IGF-1 receptorand IR autophosphorylation with IC50 of 7 μM and 57 μM,…

Bioactivity: AICAR is a cell-permeable AMP-activated protein kinase () activator.AMPK


Aceglutamide (α-N-Acetyl-L-glutamine; N2-Acetylglutamine) Cat. No.: HY-B1065

Acetazolamide Cat. No.: HY-B0782

Acetylcholine chloride (Ach; ACh chloride) Cat. No.: HY-B0282

Actinomycin D (Dactinomycin; Actinomycin IV) Cat. No.: HY-17559

Adenosine (Adenine riboside; D-Adenosine) Cat. No.: HY-B0228

Afatinib (BIBW 2992) Cat. No.: HY-10261

Afatinib dimaleate (BIBW 2992MA2) Cat. No.: HY-10261A

AG-490 (Tyrphostin AG 490) Cat. No.: HY-12000

AG1024 (Tyrphostin AG 1024) Cat. No.: HY-10253

AICAR (Acadesine; AICA Riboside) Cat. No.: HY-13417

https://www.MedChemExpress.com/Aceglutamide.html

https://www.MedChemExpress.com/Acetazolamide.html

https://www.MedChemExpress.com/Acetylcholine-chloride.html

https://www.MedChemExpress.com/Actinomycin-D.html

https://www.MedChemExpress.com/Adenosine.html

https://www.MedChemExpress.com/Afatinib.html

https://www.MedChemExpress.com/Afatinib-dimaleate.html

https://www.MedChemExpress.com/AG-490.html

https://www.MedChemExpress.com/AG1024.html

https://www.MedChemExpress.com/AICAR.html



1 g, 5 g

Purity: >98%Clinical Data: LaunchedSize: 5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg

Purity: 97.70%Clinical Data: No Development ReportedSize: 100 mg, 500 mg

Purity: >98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg


5 mg, 10 mg

Purity: 99.47%Clinical Data: LaunchedSize: 10mM x 1mL in Water,

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Bioactivity: AICAR phosphate is an activator of AMP-activated proteinkinase ( ).AMPK

Bioactivity: Alisertib (MLN 8237) is an oral active and selective Aurora A inhibitor with an of 1.2 nM.kinase IC50

Bioactivity: Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of1.5 nM. IC50 value: 1.5 nM [1] Target: renin in vitro:Aliskiren hemifumarate appears to bind to both the hydrophobicS1/S3-binding pocket and to a large, distinct subpocket thatextends from the S3-binding site towards the hydrophobic core…

Bioactivity: Aliskiren hemifumarate(CGP 60536 hemifumarate) is a directrenin inhibitor with IC50 of 1.5 nM. IC50 value: 1.5 nM [1]Target: renin in vitro: Aliskiren hemifumarate appears to bindto both the hydrophobic S1/S3-binding pocket and to a large,distinct subpocket that extends from the S3-binding site…

Bioactivity: Alisol A is a natural product. Bioactivity: ALLO-1, an autophagy receptor, is essential for autophagosomeformation around paternal organelles and directly binds to theworm LC3 homologue LGG-1 through its LC3-interacting region(LIR) motif .[1]

Bioactivity: Aloe emodin is a hydroxyanthraquinone present in Aloe veraleaves, has a specific in vitro and in vivo antitumoractivity. IC50 value: Target: in vitro: aloe-emodin treatmentled to the dissociation of heat shock protein 90 (HSP90) andER α and increased ER α ubiquitination. Protein fractionation…

Bioactivity: AM580 is a selective agonist with and of 8RARα IC50 EC50nM and 0.36 nM, respectively.

Bioactivity: Amiodarone is an antiarrhythmic drug for inhibition ofATP-sensitive potassium channel with an IC of 19.1 μM.50

Bioactivity: Amiodarone is an antiarrhythmic drug for inhibition ofATP-sensitive potassium channel with IC50 of 19.1 μM. IC50Value: 1.5 uM ( inhibit TBARS, LOOH and FPL formation)[1] invitro: It was found that 10 uM amiodarone induces accumulationof ethidium bromide (5 ug/ml) in Saccharomyces cerevisiae…

AICAR phosphate (Acadesine phosphate; AICA Riboside phosphate) Cat. No.: HY-13417A

Alisertib (MLN 8237) Cat. No.: HY-10971

Aliskiren (CGP 60536; CGP60536B; SPP 100) Cat. No.: HY-12176

Aliskiren hemifumarate (CGP 60536 (hemifumarate); CGP60536B

(hemifumarate); SPP 100 (hemifumarate)) Cat. No.: HY-12177

Alisol A (Alisol-A) Cat. No.: HY-N0853

ALLO-1 Cat. No.: HY-121546

Aloe emodin (Rhabarberone; 3-Hydroxymethylchrysazine) Cat. No.: HY-N0189

AM580 (CD336; NSC608001; Ro 40-6055) Cat. No.: HY-10475

Amiodarone Cat. No.: HY-14187

Amiodarone hydrochloride Cat. No.: HY-14188

https://www.MedChemExpress.com/AICAR-phosphate.html

https://www.MedChemExpress.com/Alisertib.html

https://www.MedChemExpress.com/Aliskiren.html

https://www.MedChemExpress.com/Aliskiren-hemifumarate.html

https://www.MedChemExpress.com/Alisol-A.html

https://www.MedChemExpress.com/allo-1.html

https://www.MedChemExpress.com/Aloe-emodin.html

https://www.MedChemExpress.com/AM580.html

https://www.MedChemExpress.com/Amiodarone.html

https://www.MedChemExpress.com/Amiodarone-hydrochloride.html


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg


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10 mg, 50 mg, 100 mg, 200 mg, 500 mg


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100 mg, 500 mg


200 mg, 1 g

Purity: >98%Clinical Data: LaunchedSize: 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 500 mg

Bioactivity: Amsacrine (m-AMSA) is an inhibitor of , andtopoisomerase IIacts as an antineoplastic agent which can intercalates intothe DNA of tumor cells.

Bioactivity: Amsacrine hydrochloride (mAMSA hydrochloride) is an inhibitorof , and acts as an antineoplastic agenttopoisomerase IIwhich can intercalates into the DNA of tumor cells.

Bioactivity: Ancitabine (hydrochloride) is an important antileukemia drugs. Bioactivity: Andrographolide is a inhibitor, which inhibits NF-κBNF-κBactivation through covalent modification of a cysteine residueon in endothelial cells without affecting IκBαp50degradation or p50/p65 nuclear translocation.

Bioactivity: Apatinib is a highly selective inhibitor with an VEGFR2 IC50of 1 nM. Apatinib also potently suppresses the activities ofRet, c-Kit and c-Src with IC s of 13, 429 and 530 nM,50respectively.

Bioactivity: Apigenin is a competitive inhibitor with a of 2 μM.CYP2C9 Ki

Bioactivity: Apocynin is a selective inhibitor with an ofNADPH-oxidase IC5010 μM.

Bioactivity: Arctigenin is a lignan found in certain plants of theAsteraceae; it has shown antiviral and anticancer effects inglass; it is the aglycone of arctiin. IC50 value: Target:anticancer agent Arctiin and its aglucone, arctigenin from thefruits of Arctium lappa L. showed potent in vitro antiviral…

Bioactivity: AS-605240 is a specific and orally active inhibitor of the, with an of 8 nM, and a of 7.8 nM.PI3Kγ IC50 Ki

Bioactivity: AS1842856, a specific inhibitor ( =30 nM), potentlyFoxo1 IC50

suppresses . AS1842856 inhibits FoxO1 activityautophagy [1]

by suppressing the expression of SIRT1. AS1842856 only reducesthe activity of FoxO1 by binding with it, without affect…


Amsacrine (m-AMSA; acridinyl anisidide) Cat. No.: HY-13551

Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) Cat. No.: HY-13551A

Ancitabine hydrochloride (Cyclocytidine hydrochloride;

Cyclo-CMP hydrochloride; Cyclo-C) Cat. No.: HY-N0093

Andrographolide (Andrographis) Cat. No.: HY-N0191

Apatinib (YN968D1) Cat. No.: HY-13342

Apigenin (4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural

Yellow 1) Cat. No.: HY-N1201

Apocynin (Acetovanillone) Cat. No.: HY-N0088

Arctigenin ((-)-Arctigenin) Cat. No.: HY-N0035

AS-605240 Cat. No.: HY-10109

AS1842856 Cat. No.: HY-100596

https://www.MedChemExpress.com/Amsacrine.html

https://www.MedChemExpress.com/amsacrine-hydrochloride.html

https://www.MedChemExpress.com/Ancitabine-hydrochloride.html

https://www.MedChemExpress.com/andrographolide.html

https://www.MedChemExpress.com/Apatinib.html

https://www.MedChemExpress.com/Apigenin.html

https://www.MedChemExpress.com/Apocynin.html

https://www.MedChemExpress.com/Arctigenin.html

https://www.MedChemExpress.com/AS-605240.html

https://www.MedChemExpress.com/AS1842856.html



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5 mg, 10 mg, 50 mg, 100 mg


100 mg


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100 mg


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2 mg, 5 mg, 10 mg, 50 mg, 100 mg


1 g, 5 g

Bioactivity: Aspirin is a non-selective and irreversible inhibitor of and with s of 5 and 210 μg/mL.COX-1 COX-2 IC50

Bioactivity: AT9283 is a multitargeted kinase inhibitor which potentlyinhibits , ( =1.2 nM, 1.1 nM).aurora kinase A/B JAK2/3 IC50

Bioactivity: Atorvastatin hemicalcium salt is a potent HMG-CoA inhibitor with an value of 8 nM.reductase IC50

Bioactivity: Atropine sulfate monohydrate is a competitive muscarinicacetylcholine receptor antagonist. Target: mAChR Atropine is anaturally occurring tropane alkaloid extracted from deadlynightshade (Atropa belladonna), Jimson weed (Daturastramonium), mandrake (Mandragora officinarum) and other…

Bioactivity: Autophinib is a potent inhibitor, which can inhibitautophagyautophagy induced by starvation or rapamycin by targeting thelipid kinase VPS34 with s of 90, 40 and 19 nM,IC50respectively.

Bioactivity: Avermectin B1 (Abamectin) is a widely used insecticide andanthelmintic. IC50 Value: N/A Target: Antiparasitic AvermectinB1 is a mixture of avermectins containing more than 80%avermectin B1a and less than 20% avermectin B1b. These twocomponents, B1a and B1b have very similar biological and…

Bioactivity: AZ304 is an ATP-competitive dual kinase inhibitor,BRAFpotently inhibits wild type BRAF, V600E mutant BRAF and wildtype CRAF, with s of 79 nM, 38 nM and 68 nM, respectively.IC50AZ304 also has significant effect on other kinases, such…

Bioactivity: Azathramycin is an antibiotic.

Bioactivity: AZD 6482 is a potent and selective inhibitor with p110β IC50of 0.69 nM.

Bioactivity: AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiplemechanisms of acquired resistance to crizotinib. IC50 Value:Target: ALK/IGF1R

Aspirin (ASA; Acetylsalicylic Acid) Cat. No.: HY-14654

AT9283 Cat. No.: HY-50514

Atorvastatin hemicalcium salt (CI-981; Atorvastatin hemicalcium) Cat. No.: HY-17379

Atropine sulfate monohydrate (Atropine sulfate hydrate) Cat. No.: HY-B0394

Autophinib Cat. No.: HY-101920

Avermectin B1 (Abamectin; Avermectin B1a-Avermectin B1b mixt.) Cat. No.: HY-15311

AZ304 Cat. No.: HY-117273

Azathramycin (Azaerythromycin A; Desmethyl Azithromycin) Cat. No.: HY-17442

AZD 6482 (KIN 193) Cat. No.: HY-10344

AZD-3463 (ALK/IGF1R inhibitor) Cat. No.: HY-15609

https://www.MedChemExpress.com/aspirin.html

https://www.MedChemExpress.com/at9283.html

https://www.MedChemExpress.com/atorvastatin-hemicalcium-salt.html

https://www.MedChemExpress.com/Atropine-sulfate-monohydrate.html

https://www.MedChemExpress.com/Autophinib.html

https://www.MedChemExpress.com/Avermectin-B1.html

https://www.MedChemExpress.com/AZ304.html

https://www.MedChemExpress.com/Azathramycin.html

https://www.MedChemExpress.com/AZD-6482.html

https://www.MedChemExpress.com/azd-3463.html


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100 mg, 500 mg, 1 g, 5 g

Purity: 99.0%Clinical Data: No Development ReportedSize: 100u g


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Purity: >98%Clinical Data: LaunchedSize: 50 mg, 100 mg


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5 mg, 10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg, 100 mg, 200 mg

Bioactivity: AZD-8055 is a novel ATP-competitive inhibitor of mTORkinase with an of 0.8 nM. AZD-8055 inhibits bothIC50

and .mTORC1 mTORC2

Bioactivity: AZD1208 is a novel, orally bioavailable, highly selective kinases inhibitor.PIM

Bioactivity: Azithromycin is a macrolide antibiotic useful for thetreatment of a number of bacterial infections.

Bioactivity: Azithromycin hydrate is a macrolide antibiotic useful for thetreatment of a number of bacterial infections.

Bioactivity: Bafetinib is a tyrosine kinase inhibitor withLyn and Bcr-Ablpotential antineoplastic activity.

Bioactivity: Bafilomycin A1, a macrolide antibiotic isolated from the species, is a specific inhibitor ofStreptomyces

. Bafilomycin A1 inhibitsvacuolar-type H+ ATPase (V-ATPase) .autophagy [1]

Bioactivity: Baicalin is a flavonoid glycoside isolated from Scutellaria. Baicalin reduces the expression of .baicalensis NF-κB

Bioactivity: Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) isa synthetic triterpenoid compound with potentialantineoplastic and anti-inflammatory activities, acting as anactivator of the pathway and an inhibitor of the Nrf2 NF-κBpathway.

Bioactivity: BAY 11-7082 is a inhibitor which decreases NF-κB byNF-κBinhibiting TNF-α-induced phosphorylation of IκB-α. BAY 11-7082inhibits ubiquitin-specific protease and withUSP7 USP21

s of 0.19 μM and 0.96 μM, respectively.IC50

Bioactivity: Belinostat is a potent inhibitor with an of 27 nMHDAC IC50in HeLa cell extracts.


AZD-8055 Cat. No.: HY-10422

AZD1208 Cat. No.: HY-15604

Azithromycin (CP 62993) Cat. No.: HY-17506

Azithromycin hydrate (CP-62993 dihydrate) Cat. No.: HY-17506A

Bafetinib (INNO-406; NS-187) Cat. No.: HY-50868

Bafilomycin A1 ((-)-Bafilomycin A1) Cat. No.: HY-100558

Baicalin (Baicalein 7-O-β-D-glucuronide) Cat. No.: HY-N0197

Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) Cat. No.: HY-13324

BAY 11-7082 (BAY 11-7821) Cat. No.: HY-13453

Belinostat (PXD101; PX105684) Cat. No.: HY-10225

https://www.MedChemExpress.com/AZD-8055.html

https://www.MedChemExpress.com/AZD1208.html

https://www.MedChemExpress.com/Azithromycin.html

https://www.MedChemExpress.com/azithromycin-hydrate.html

https://www.MedChemExpress.com/Bafetinib.html

https://www.MedChemExpress.com/Bafilomycin_A1.html

https://www.MedChemExpress.com/Baicalin.html

https://www.MedChemExpress.com/Bardoxolone-methyl.html

https://www.MedChemExpress.com/BAY-11-7082.html

https://www.MedChemExpress.com/Belinostat.html



2 mg, 5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 50 mg


50 mg, 100 mg, 500 mg


100 mg, 200 mg, 500 mg


2 mg, 5 mg, 10 mg, 50 mg


1 g, 5 g


5 g



200 mg, 500 mg

Bioactivity: Berbamine dihydrochloride is an inhibitor of activityNF-κBwith remarkable anti-myeloma efficacy.

Bioactivity: Berberine chloride is an alkaloid isolated from the Chineseherbal medicine Huanglian, as an . Berberine chlorideantibioticinduces reactive oxygen species ( ) generation andROSinhibits . Antineoplastic propertiesDNA topoisomerase

.[1]

Bioactivity: Berberine chloride hydrate is an alkaloid isolated from theChinese herbal medicine Huanglian, as an . Berberineantibioticchloride hydrate induces reactive oxygen species ( )ROSgeneration and inhibits . AntineoplasticDNA topoisomeraseproperties .[1]

Bioactivity: Bergapten is a natural anti-inflammatory and anti-tumor agentisolated from bergamot essential oil, other citrus essentialoils and grapefruit juice. Bergapten is inhibitory towardsmouse and human isoforms.CYP

Bioactivity: Bergenin, a polyphenol, is a potent antinarcotic agent withantioxidant action. IC50 value: < 2.5 μM (antiplasmodial)[3] Target: In vitro: The naloxone-precipitated withdrawalsymptom (jumping frequency) was significantly ameliorated (50%of control group) by administration of bergenin (20 mg/kg) in…

Bioactivity: Betulinic acid is a natural pentacyclic triterpenoid, acts asa eukaryotic inhibitor, with an of 5topoisomerase I IC50μM, and possesses anti-HIV, anti-malarial, anti-inflammatoryand anti-tumor properties.

Bioactivity: Bexarotene (LGD1069) is a selective retinoid X receptors (RXR)agonist for the treatment of cutaneous T-cell lymphoma.

Bioactivity: BGT226 (NVP-BGT226) is a (with s of 4 nM, 63 nM and 38PI3K IC50nM for , and )/ dual inhibitor whichPI3Kα PI3Kβ PI3Kγ mTORdisplays potent growth-inhibitory activity against human headand neck cancer cells .[1] [2]

Bioactivity: BGT226 maleate (NVP-BGT226 maleate) is a (with s of 4PI3K IC50nM, 63 nM and 38 nM for , and ) / dualPI3Kα PI3Kβ PI3Kγ mTORinhibitor which displays potent growth-inhibitory activityagainst human head and neck cancer cells .[1] [2]

Bioactivity: BI-D1870 is an ATP-competitive inhibitor of isoforms,RSKwith s of 31 nM/24 nM/18 nM/15 nM for RSK1/SK2/SK3/SK4,IC50respectively.

Berbamine dihydrochloride Cat. No.: HY-N0714A

Berberine chloride (Natural Yellow 18 (chloride)) Cat. No.: HY-18258

Berberine chloride hydrate (Natural Yellow 18 (chloride hydrate)) Cat. No.: HY-17577

Bergapten (5-Methoxypsoralen) Cat. No.: HY-N0370

Bergenin (Cuscutin) Cat. No.: HY-N0017

Betulinic acid (Lupatic acid; Betulic acid) Cat. No.: HY-10529

Bexarotene (LGD1069) Cat. No.: HY-14171

BGT226 (NVP-BGT226) Cat. No.: HY-13334A

BGT226 maleate (NVP-BGT226 (maleate)) Cat. No.: HY-13334

BI-D1870 Cat. No.: HY-10510

https://www.MedChemExpress.com/Berbamine-dihydrochloride.html

https://www.MedChemExpress.com/Berberine-chloride.html

https://www.MedChemExpress.com/Berberine-chloride-hydrate.html

https://www.MedChemExpress.com/5-Methoxypsoralen.html

https://www.MedChemExpress.com/Bergenin.html

https://www.MedChemExpress.com/Betulinic-acid.html

https://www.MedChemExpress.com/Bexarotene.html

https://www.MedChemExpress.com/BGT226.html

https://www.MedChemExpress.com/nvp-bgt226.html

https://www.MedChemExpress.com/BI-D1870.html

Purity: >98%Clinical Data: No Development ReportedSize:


10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg


10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 25 mg, 50 mg


100 mg, 200 mg, 500 mg, 1 g, 5 g

Bioactivity: Bicalutamide is a non-steroidal inhibitor.androgen receptor Bioactivity: Bicyclol(SY 801) is a anti-hepatitis drug. Target: HBV Oraladministration of bicyclol normalized the elevated serumtransaminases (ALT, AST) by approximately 50% in chronic viralhepatitis B and C, and also showed certain level of inhibitingHBV and HCV replication. No noticeable adverse reaction has…

Bioactivity: BIIB021 is an orally available, fully synthetic inhibitor of with and of 1.7 nM and 38 nM, respectively.HSP90 Ki EC50

Bioactivity: Bilobalide is a biologically active terpenic trilactonepresent in Ginkgo biloba. An increasing number of studies havedemonstrated its neuroprotective effects. IC50 Value: 3.33(pIC50 Value) [1] Target: neuroprotective in vitro: Inhibitionby BB and GB was abolished in mutant receptors containing T6'S…

Bioactivity: Binimetinib (MEK162) is an oral and selective MEK1/2inhibitor with an of 12 nM.IC50

Bioactivity: Bisdemethoxycurcumin(Curcumin III; Didemethoxycurcumin) is anatural derivative of curcumin with anti-inflammatory andanti-cancer activities. IC50 value: Target: Anticancer naturalcompound in vitro: BDMC-induced apoptosis was mediated by acombinatory inhibition of cytoprotective proteins, such as…

Bioactivity: BIX-01294 is an inhibitor of G9a Histone Methyltransferasewith an of 1.9 μM. BIX-01294 also inhibits ATF3IC50expression.

Bioactivity: Bortezomib (PS-341) is a potent inhibitor20S proteasomewith a of 0.6 nM.Ki

Bioactivity: Bosutinib is a dual inhibitor with s of 1.2 nM andSrc/Abl IC501 nM, respectively.

Bioactivity: BRD5631 is an enhancer, enhances throughautophagy autophagyan mTOR-independent pathway. BRD5631 affects several cellulardisease phenotypes previously linked to autophagy, includingprotein aggregation, cell survival, bacterial replication, andinflammatory cytokine production .[1]


Bicalutamide Cat. No.: HY-14249

Bicyclol (SY801) Cat. No.: HY-B0766

BIIB021 (CNF2024) Cat. No.: HY-10212

Bilobalide ((-)-Bilobalide) Cat. No.: HY-N0076

Binimetinib (MEK162; ARRY-162; ARRY-438162) Cat. No.: HY-15202

Bisdemethoxycurcumin (Curcumin III; Didemethoxycurcumin) Cat. No.: HY-N0007

BIX-01294 Cat. No.: HY-10587

Bortezomib (PS-341; Brotezamide; DPBA; LDP 341; MG 341;

Radiciol; NSC 681239) Cat. No.: HY-10227

Bosutinib (SKI-606) Cat. No.: HY-10158

BRD5631 Cat. No.: HY-125197

https://www.MedChemExpress.com/Bicalutamide.html

https://www.MedChemExpress.com/Bicyclol.html

https://www.MedChemExpress.com/BIIB021.html

https://www.MedChemExpress.com/Bilobalide.html

https://www.MedChemExpress.com/MEK162.html

https://www.MedChemExpress.com/Bisdemethoxycurcumin.html

https://www.MedChemExpress.com/BIX-01294.html

https://www.MedChemExpress.com/Bortezomib.html

https://www.MedChemExpress.com/Bosutinib.html

https://www.MedChemExpress.com/brd5631.html



5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


10 mg, 50 mg


2 mg, 5 mg, 10 mg, 50 mg, 100 mg


50 mg, 100 mg, 200 mg


5 g, 10 g


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: Brefeldin A is a specific inhibitor of whichprotein traffickingblocks the protein transport from the endoplasmic reticulum tothe Golgi complex.

Bioactivity: Brivanib is an ATP-competitive inhibitor against withVEGFR2 of 25 nM, and has moderate potency against VEGFR-1 andIC50

FGFR-1, but >240-fold against PDGFR-β.

Bioactivity: Brivanib alaninate is an ATP-competitive inhibitor against with an of 25 nM; has moderate potency againstVEGFR2 IC50

VEGFR-1 and FGFR-1, but more than 240-fold against PDGFRβ.

Bioactivity: Bromhexine Hydrochloride is a medication prescribed for coughswhich works by dissolving hard phlegm. Target: OthersBromhexine is a mucolytic agent used in the treatment ofrespiratory disorders associated with viscid or excessivemucus. In addition, bromhexine has antioxidant properties.…

Bioactivity: Bromocriptine mesylate is a potent dopamine D2/D3 receptoragonist, which binds D2 dopamine receptor with ofpKi8.05±0.2.

Bioactivity: Butein, a plant polyphenol isolated from Rhus verniciflua,inhibit the activation of protein tyrosine kinase and EGFR.target: EGFR [1] In vitro: 1) Butein inhibited the activationof AKT, extracellular signal-regulated kinase (ERKs) and p38kinases in the presence of cisplatin.[2] 2) FoxO3a and its…

Bioactivity: C646 is a selective and competitive histone acetyltransferase inhibitor with of 400 nM, and is less potent forp300 Ki

other acetyltransferases.

Bioactivity: CA-5f is a potent late-stage macroautophagy/autophagyinhibitor via inhibiting autophagosome-lysosome fusion. CA-5fincreases LC3B-II (a marker to monitor autophagy) and SQSTM1protein both in A549 cells and HUVECs. Anti-tumor activity

.[1]

Bioactivity: Cabazitaxel is a semi-synthetic derivative of the naturaltaxoid 10-deacetylbaccatin III with potential antineoplasticactivity.

Bioactivity: Cabergoline is an ergot derived-dopamine D -like receptor2agonist that has high affinity for , , and D2 D3 5-HT2Breceptors ( =0.7, 1.5, and 1.2, respectively).Ki

Brefeldin A (BFA; Cyanein; Decumbin) Cat. No.: HY-16592

Brivanib (BMS-540215) Cat. No.: HY-10337

Brivanib alaninate (BMS-582664) Cat. No.: HY-10336

Bromhexine hydrochloride Cat. No.: HY-B0372A

Bromocriptine mesylate (CB-154) Cat. No.: HY-12705A

Butein (2’,3,4,4’-tetrahydroxy Chalcone) Cat. No.: HY-16558

C646 Cat. No.: HY-13823

CA-5f Cat. No.: HY-112698

Cabazitaxel (XRP6258; RPR-116258A; taxoid XRP6258) Cat. No.: HY-15459

Cabergoline (FCE-21336) Cat. No.: HY-15296

https://www.MedChemExpress.com/Brefeldin-A.html

https://www.MedChemExpress.com/Brivanib.html

https://www.MedChemExpress.com/brivanib-alaninate.html

https://www.MedChemExpress.com/Bromhexine-hydrochloride.html

https://www.MedChemExpress.com/Bromocriptine-mesylate.html

https://www.MedChemExpress.com/Butein.html

https://www.MedChemExpress.com/C646.html

https://www.MedChemExpress.com/CA-5f.html

https://www.MedChemExpress.com/Cabazitaxel.html

https://www.MedChemExpress.com/Cabergoline.html


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg


100 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg



100 mg, 500 mg


50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 500u g, 1 mg, 5 mg

Bioactivity: Calcineurin substrate is a peptide from the regulatory RIIsubunit of cAMP-dependent protein kinase. It can be used inthe calcineurin activity assay.

Bioactivity: Capivasertib (AZD5363) is a potent kinase inhibitorpan-AKTwith of 3, 7 and 7 nM for , and ,IC50 Akt1 Akt2 Akt3

respectively.

Bioactivity: Capsaicin is a agonist with an of 0.29 μM inTRPV1 EC50HEK293 cells.

Bioactivity: Carbamazepine, a sodium channel blocker, is an anticonvulsantdrug. Target: Sodium channel Carbamazepine inhibits thebinding of [3H]batrachotoxinin A 20-α-benzoate (BTX-B) to areceptor site of voltage-sensitive sodium channel with IC50 of131 μM, to decrease the activation of sodium channel ion flux…

Bioactivity: Carboplatin (NSC 241240) is a inhibitor whichDNA synthesisbinds to DNA, inhibits replication and transcription andinduces cell death. Carboplatin (NSC 241240) is a derivativeof CDDP and a potent anti-cancer agent.

Bioactivity: Carfilzomib is an irreversible inhibitor with anproteasome of 5 nM in ANBL-6 and RPMI 8226 cells.IC50

Bioactivity: Carvedilol(BM14190) is a non-selective beta blocker/alpha-1blocker with an IC50 of 3.8 μM for inhibition of LDLoxidation. IC50 Value: 3.8 μM ( inhibition of LDL oxidation)Target: beta Adrenergic Receptor Carvedilol is anonselective-blocking agent and is used in the treatment of…

Bioactivity: CCT128930 is a potent and selective inhibitor of ( Akt2 IC506 nM) with 28-fold selectivity over the closely related PKAkinase (IC 168 nM), as well as 20-fold selectivity over50p70S6K (IC 120 nM).50

Bioactivity: Cediranib (AZD2171) is a highly potent, orally available tyrosine kinase inhibitor with s of <1, <3,VEGFR IC50

5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit,respectively.

Bioactivity: Cediranib maleate (AZD-2171 maleate) is a highly potent,orally available inhibitor with s of <1, <3,VEGFR IC505, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit,respectively.


Calcineurin substrate Cat. No.: HY-P0228

Capivasertib (AZD5363) Cat. No.: HY-15431

Capsaicin ((E)-Capsaicin; 8-Methyl-N-vanillyl-trans-6-nonenamide) Cat. No.: HY-10448

Carbamazepine (CBZ; NSC 169864) Cat. No.: HY-B0246

Carboplatin (NSC 241240) Cat. No.: HY-17393

Carfilzomib (PR-171) Cat. No.: HY-10455

Carvedilol (BM 14190) Cat. No.: HY-B0006

CCT128930 Cat. No.: HY-13260

Cediranib (AZD2171) Cat. No.: HY-10205

Cediranib maleate (AZD-2171 maleate) Cat. No.: HY-13049

https://www.MedChemExpress.com/Calcineurin_substrate.html


https://www.MedChemExpress.com/Capsaicin.html

https://www.MedChemExpress.com/Carbamazepine.html

https://www.MedChemExpress.com/Carboplatin.html

https://www.MedChemExpress.com/Carfilzomib.html

https://www.MedChemExpress.com/carvedilol.html

https://www.MedChemExpress.com/CCT128930.html

https://www.MedChemExpress.com/Cediranib.html

https://www.MedChemExpress.com/Cediranib-maleate.html



50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


50 mg, 100 mg

Purity: 99.83%Clinical Data: LaunchedSize: 1 g, 5 g


100 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: CGI-1746 is a potent and highly selective inhibitor ofthe with of 1.9 nM.Btk IC50

Bioactivity: Chelerythrine Chloride is a potent, cell-permeable inhibitorof , with an of 660 nM.protein kinase C IC50

Bioactivity: CHIR-99021 is a inhibitor with an of 10 and 6.7GSK-3α/β IC50nMshowing 500-fold selectivity over its closest homologs CDC2and ERK2, as well as other protein kinases.

Bioactivity: CHIR-99021 monohydrochloride is a inhibitor withGSK-3α/β of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3IC50

versus its closest homologs CDC2 and ERK2, as well as otherprotein kinases.

Bioactivity: CHIR-99021 trihydrochloride is a inhibitor with GSK-3α/β IC50of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versusits closest homologs CDC2 and ERK2, as well as other proteinkinases.

Bioactivity: Chloroquine (diphosphate) is an antimalarial andanti-inflammatory drug widely used to treat malaria andrheumatoid arthritis. Chloroquine is an inhibitor of

and .autophagy toll-like receptors (TLRs)

Bioactivity: Chlorpromazine Hydrochloride is an antagonist of the, , and dopamine D2 5HT2A potassium channel sodium

. Chlorpromazine binds with D2 and 5HT2A with s of 363channel KinM and 8.3 nM, respectively.

Bioactivity: Ciclopirox (Penlac) is a synthetic antifungal agent. Target:Antifungal Ciclopirox is a synthetic antifungal agent fortopical dermatologic treatment of superficial mycoses. It ismost useful against Tinea versicolor. The mechanism of actionof ciclopirox is poorly understood [1]. However, loss of…

Bioactivity: Cilengitide is a potent and selective inhibitor for αintegrinβ and α β receptor, with s of 4 and 79 nM,v 3 v 5 IC50

respectively.

Bioactivity: Cilostazol(OPC 13013; OPC 21) is a potent inhibitor of PDE3A,the isoform of PDE 3 in the cardiovascular system (IC50=0.2uM). IC50 Value: 0.2 uM [1] Target: PDE3A in vitro: Cilostazolcaused a concentration-dependent increase in the cAMP level inrabbit and human platelets with similar potency. Furthermore,…

CGI-1746 Cat. No.: HY-11999

Chelerythrine Chloride Cat. No.: HY-12048

CHIR-99021 (CT99021) Cat. No.: HY-10182

CHIR-99021 monohydrochloride (CT99021 monohydrochloride) Cat. No.: HY-10182A

CHIR-99021 trihydrochloride (CT99021 trihydrochloride) Cat. No.: HY-10182B

Chloroquine diphosphate Cat. No.: HY-17589

Chlorpromazine hydrochloride Cat. No.: HY-B0407A

Ciclopirox (HOE296b) Cat. No.: HY-B0450

Cilengitide (EMD 121974) Cat. No.: HY-16141

Cilostazol (OPC 13013; OPC 21) Cat. No.: HY-17464

https://www.MedChemExpress.com/CGI-1746.html

https://www.MedChemExpress.com/Chelerythrine-Chloride.html

https://www.MedChemExpress.com/CHIR-99021.html

https://www.MedChemExpress.com/CHIR-99021-monohydrochloride.html

https://www.MedChemExpress.com/CHIR-99021-trihydrochloride.html

https://www.MedChemExpress.com/Chloroquine-diphosphate.html

https://www.MedChemExpress.com/Chlorpromazine-hydrochloride.html

https://www.MedChemExpress.com/Ciclopirox.html

https://www.MedChemExpress.com/Cilengitide.html

https://www.MedChemExpress.com/Cilostazol.html


100 mg, 500 mg


200 mg, 500 mg


1 g


10 mg, 50 mg


1 g, 5 g


100 mg, 200 mg, 500 mg


100 mg, 200 mg, 500 mg


10 mg, 50 mg, 100 mg


25 mg, 50 mg, 100 mg


5 mg, 10 mg

Bioactivity: Cinobufagin, a kind of Chinese materia medica with antitumoreffect, is widely used in clinical practice, especially inanti-liver cancer. IC50 value: Target: In vitro: Cinobufagininhibited proliferation of cancer cells at doses of 0.1, 1, or10 μM after 2–4 days of culture. Cytotoxicity of cinobufagin…

Bioactivity: Cisatracurium Besylate (51W89) is a nondepolarizingneuromuscular blocking agent, antagonizing the action ofacetylcholine by inhibiting neuromuscular transmission.

Bioactivity: Citalopram hydrobromide is an antidepressant drug of theselective serotonin reuptake inhibitor (SSRI) class. It has USFDA approval to treat major depression.

Bioactivity: Clarithromycin is a macrolide antibiotic and a CYP3A4inhibitor. Target: Antibacterial; CYP3A4 Clarithromycin is amacrolide antibiotic used to treat pharyngitis, tonsillitis,acute maxillary sinusitis, acute bacterial exacerbation ofchronic bronchitis, pneumonia (especially atypical pneumonias…

Bioactivity: Clemastine (fumarate) (HS-592 (fumarate)) is a selectivehistamine H1 receptor antagonist with IC of 3 nM.50

Bioactivity: Clioquinol(Iodochlorhydroxyquin) is an antifungal drug andantiprotozoal compound that shows effectivity for Alzheimer'sdisease treatment and induce cancer cell death.

Bioactivity: Clofarabine(Clolar; Clofarex) inhibits the enzymaticactivities of ribonucleotide reductase (IC50 = 65 nM) and DNApolymerase. IC50 Value: 65 nM Target: in vitro: Clofarabine isa second generation purine nucleoside analog withantineoplastic activity. It is phosphorylated intracellularly,…

Bioactivity: Clotrimazole is an imidazole derivative, an antifungalcompound and is a CYP (cytochrome P450) inhibitor. Target:Antifungal; CYP Clotrimazole (brand name Canesten or Lotrimin)is an antifungal medication commonly used in the treatment offungal infections (of both humans and other animals) such as…

Bioactivity: Colchicine is a inhibitor and a tubulin microtubuledisrupting agent. Colchicine inhibits microtubulepolymerization with an of 3 nM.IC50

Bioactivity: Colistin sulfate is a polypeptide antibiotic which inhibits by binding to lipopolysaccharides andgram-negative bacteria

phospholipids in the outer cell membrane of gram-negativebacteria.


Cinobufagin (Cinobufagine) Cat. No.: HY-N0421

Cisatracurium besylate (51W89) Cat. No.: HY-13596

Citalopram hydrobromide ((±)-Citalopram hydrobromide; Lu 10-171) Cat. No.: HY-B1287

Clarithromycin Cat. No.: HY-17508

Clemastine fumarate (HS-592 (fumarate); Meclastine (fumarate)) Cat. No.: HY-B0298A

Clioquinol (Iodochlorhydroxyquin) Cat. No.: HY-14603

Clofarabine Cat. No.: HY-A0005

Clotrimazole Cat. No.: HY-10882

Colchicine Cat. No.: HY-16569

Colistin sulfate (Polymyxin E Sulfate) Cat. No.: HY-A0089

https://www.MedChemExpress.com/Cinobufagin.html

https://www.MedChemExpress.com/Cisatracurium-besylate.html

https://www.MedChemExpress.com/Citalopram-hydrobromide.html

https://www.MedChemExpress.com/Clarithromycin.html

https://www.MedChemExpress.com/Clemastine-fumarate.html

https://www.MedChemExpress.com/Clioquinol.html

https://www.MedChemExpress.com/clofarabine.html

https://www.MedChemExpress.com/Clotrimazole.html

https://www.MedChemExpress.com/Colchicine.html

https://www.MedChemExpress.com/Colistin-sulfate.html



5 mg, 10 mg, 25 mg, 50 mg


10 mg, 50 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


1 g


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg


5 mg, 10 mg


5 mg, 10 mg


10 mg, 25 mg, 50 mg

Bioactivity: Cordycepin, which is a nucleoside derivative isolated from, inhibits IL-1β-induced and Cordyceps MMP-1 MMP-3

expression in rheumatoid arthritis synovial fibroblasts(RASFs) in a dose-dependent manner.

Bioactivity: Corosolic acid isolated from the fruit of Cratoeguspinnatifida var. psilosa, was reported to have anticanceractivity.

Bioactivity: Corynoxine is an enantiomer of Corynoxine B; induces autophagyin different neuronal cell lines, including N2a and SHSY-5Ycells.

Bioactivity: Corynoxine B is an oxindole alkaloid isolated from Uncariarhynchophylla (Miq.) Jacks (Gouteng in Chinese); aBeclin-1-dependent autophagy inducer.

Bioactivity: Crenolanib is a potent and selective inhibitor of wild-typeand mutant isoforms of the class III receptor tyrosine kinases

and with s of 0.74 nM and 2.1 nM/3.2 nM,FLT3 PDGFRα/β Kdrespectively.

Bioactivity: Cresol is organic compoundis a widely occurring natural andmanufactured group of aromatic organic compounds.

Bioactivity: Crizotinib is a potent inhibitor of and with anc-Met ALK of 11 nM and 24 nM in cell-based assays, respectively.IC50

Bioactivity: Crizotinib hydrochloride is a potent inhibitor of andc-Met with s of 11 nM and 24 nM in cell-based assays,ALK IC50

respectively.

Bioactivity: Cryptotanshinone is a natural compound extracted from the rootof Bunge that shows antitumorSalvia miltiorrhizaactivities. Cryptotanshinone inhibits with an ofSTAT3 IC504.6 μM.

Bioactivity: Cucurbitacin B belongs to a class of highly oxidizedtetracyclic triterpenoids; could repress cancer cellprogression. IC50 value: Target: anticancer natural compoundin vitro: Cucurbitacin-B inhibited growth and modulatedexpression of cell-cycle regulators in SHSY5Y cells. At the…

Cordycepin (3'-Deoxyadenosine) Cat. No.: HY-N0262

Corosolic acid (Colosolic acid; Corsolic acid; Glucosol) Cat. No.: HY-N0280

Corynoxine Cat. No.: HY-N0901

Corynoxine B Cat. No.: HY-N0901A

Crenolanib (CP-868596) Cat. No.: HY-13223

Cresol (Cresol mixture of isomers; Hydroxytoluene; Tricresol;

Methylphenol) Cat. No.: HY-B0969

Crizotinib (PF-02341066) Cat. No.: HY-50878

Crizotinib hydrochloride (PF-02341066 hydrochloride) Cat. No.: HY-50878A

Cryptotanshinone (Cryptotanshinon; Tanshinone c) Cat. No.: HY-N0174

Cucurbitacin B Cat. No.: HY-N0416

https://www.MedChemExpress.com/Cordycepin.html

https://www.MedChemExpress.com/Corosolic-acid.html

https://www.MedChemExpress.com/Corynoxine.html

https://www.MedChemExpress.com/Corynoxine-B.html

https://www.MedChemExpress.com/crenolanib.html

https://www.MedChemExpress.com/Cresol.html

https://www.MedChemExpress.com/Crizotinib.html

https://www.MedChemExpress.com/Crizotinib-hydrochloride.html

https://www.MedChemExpress.com/Cryptotanshinone.html

https://www.MedChemExpress.com/Cucurbitacin-B.html


10 mg, 50 mg


5 mg, 10 mg, 50 mg


50 mg, 100 mg



100 mg, 500 mg, 1 g


5 g


200 mg, 500 mg



100 mg, 500 mg


5 mg, 10 mg

Bioactivity: Cucurbitacin E is a natural compound which from the climbingstem of . Cucurbitacin E significantlyCucumic melo Lsuppresses the activity of the / complex.cyclin B1 CDC2

Bioactivity: Curcumin (Turmeric yellow) is a natural phenolic compound withdiverse pharmacologic effects including anti-inflammatory,antioxidant, antiproliferative and antiangiogenic activities.Curcumin is an inhibitor of p300 histone acetylatransferase (

) and also shows inhibitory effects on and…HATs NF-κB

Bioactivity: CX546 is a selective positive AMPAR modulator; theprototypical ampakine agent. IC50 value: Target: AMPAR agonistin vitro: Treatments with the ampakine CX614 markedly andreversibly increased brain-derived neurotrophic factor (BDNF)mRNA and protein levels in cultured rat entorhinal/hippocampal…

Bioactivity: Cycloheximide (Naramycin A) is an eukaryote protein synthesisinhibitor, with s of 532.5 nM and 2880 nM for proteinIC50synthesis and RNA synthesis , respectively.in vivo

Bioactivity: Cysteamine Hydrochloride is an agent for the treatment ofnephropathic cystinosis and an antioxidant. Target: OthersCysteamine has been shown to increase intracellularglutathione levels in cystinotic cells, thus restoring thealtered redox state of the cells. Also increased rates of…

Bioactivity: Cytarabine, a nucleoside analog, causes S phase cell cyclearrest and inhibits . Cytarabine inhibitsDNA polymerase

with an of 16 nM.DNA synthesis IC50

Bioactivity: Cytarabine hydrochloride, a nucleoside analog, causes S phasecell cycle arrest and inhibits . CytarabineDNA polymeraseinhibits with an of 16 nM.DNA synthesis IC50

Bioactivity: D-Glutamine is a cell-permeable D type stereoisomer ofGlutamine.

Bioactivity: D4476 is a potent, selective and cell-permeable inhibitor ofcasein kinase 1( ) with an value of 0.3 μM .CK1 IC50 in vitro

Bioactivity: Dacinostat is a potent inhibitor, with an of 32 nM;HDAC IC50Dacinostat also inhibits with an of 9 nM, and usedHDAC1 IC50in cancer research.


Cucurbitacin E (α-Elaterin; α-Elaterine) Cat. No.: HY-N0417

Curcumin (Turmeric yellow; Natural Yellow 3; Diferuloylmethane) Cat. No.: HY-N0005

CX546 Cat. No.: HY-12505

Cycloheximide (Naramycin A; Actidione; CHX) Cat. No.: HY-12320

Cysteamine hydrochloride (β-Mercaptoethylamine Hydrochloride;

2-Aminoethanethiol Hydrochloride; …) Cat. No.: HY-77591

Cytarabine (Cytosine β-D-arabinofuranoside; Cytosine

Arabinoside; Ara-C) Cat. No.: HY-13605

Cytarabine hydrochloride (Cytosine β-D-arabinofuranoside

hydrochloride; Cytosine Arabinoside hydrochloride; …) Cat. No.: HY-13605A

D-Glutamine Cat. No.: HY-100587

D4476 (Casein Kinase I Inhibitor) Cat. No.: HY-10324

Dacinostat (NVP-LAQ824; LAQ824) Cat. No.: HY-13606

https://www.MedChemExpress.com/Cucurbitacin-E.html

https://www.MedChemExpress.com/Curcumin.html

https://www.MedChemExpress.com/CX546.html

https://www.MedChemExpress.com/Cycloheximide.html

https://www.MedChemExpress.com/Cysteamine-Hydrochloride.html

https://www.MedChemExpress.com/Cytarabine.html

https://www.MedChemExpress.com/cytarabine-hydrochloride.html

https://www.MedChemExpress.com/D-Glutamine.html

https://www.MedChemExpress.com/D4476.html

https://www.MedChemExpress.com/Dacinostat.html



100 mg, 200 mg, 500 mg


5 mg, 10 mg, 50 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


100 mg, 200 mg, 500 mg


100 mg


10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg, 100 mg


50 mg, 100 mg, 200 mg, 500 mg

Purity: 99.13%Clinical Data: Phase 2Size: 50 mg, 100 mg, 200 mg, 500 mg

Bioactivity: Dactolisib (BEZ235) is a dual pan-class I and PI3K mTORkinase inhibitor with s of 4 nM/5 nM/7 nM/75 nM, and 20.7IC50nM for / / / and ,p110α p110γ p110δ p110β mTORrespectively. Dactolisib (BEZ235) inhibits both andmTORC1

.mTORC2

Bioactivity: Dactolisib (BEZ235) Tosylate is a dual and kinasePI3K mTORinhibitor with values of 4, 75, 7, 5 nM for PI3Kα, β, γ,IC50δ, respectively. Dactolisib (BEZ235) Tosylate inhibits

and .mTORC1 mTORC2

Bioactivity: Danshensu, an active ingredient of Salvia, shows wide cardiovascular benefit bymiltiorrhiza

activating signaling pathway.Nrf2

Bioactivity: Danshensu (sodium salt) is odium salt of danshensu from thewidely used Chinese herb Danshen. It can inhibitedphenylephrine- and CaCl2-induced vasoconstriction in Ca2+-freemedium. In vitro: Sodium danshensu showed a biphasic effectson vessel tension. While low dosage of sodium danshensu…

Bioactivity: Danthron is a natural product extracted from the traditionalChinese medicine . Danthron functions in regulatingrhubarbglucose and lipid metabolism by activating .AMPK

Bioactivity: Dantrolene sodium hemiheptahydrate is a skeletal musclerelaxant which acts by blocking muscle contraction beyond theneuromuscular junction. Dantrolene sodium hemiheptahydrate isa inhibitor of calcium channel proteins, inhibiting therelease of Ca2+ from the sarcoplasm.

Bioactivity: Danusertib is a pyrrolo-pyrazole and inhibitoraurora kinasewith of 13, 79, and 61 nM for Aurora A, B, and C,IC50respectively.

Bioactivity: Daphnetin (7,8-dihydroxycoumarin), one coumarin derivativeisolated from plants of the , is a Genus Daphne protein kinaseinhibitor, with of 7.67 μM, 9.33 μM and 25.01 μM forIC s50

EGFR, PKA and PKC , respectively . Daphne…in vitro [1] [2]

Bioactivity: DAPT is a inhibitor with s of 115 and 200 nMγ-secretase IC50for total Aβ and Aβ42, respectively.

Bioactivity: Dasatinib (BMS-354825) is a dual and familyBcr-Abl Srctyrosine kinase inhibitor with s of 0.6, 0.8, 79 and 37 nMIC50

for Abl, Src, c-Kit and c-Kit , respectively.D816V

Dactolisib (BEZ235; NVP-BEZ235) Cat. No.: HY-50673

Dactolisib Tosylate (BEZ235 (Tosylate); NVP-BEZ 235 (Tosylate)) Cat. No.: HY-15174

Danshensu (Dan shen suan A; Salvianic acid A) Cat. No.: HY-N1913

Danshensu sodium salt (Sodium Danshensu; (±)-DanShenSu sodium sal) Cat. No.: HY-N0106

Danthron (Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone) Cat. No.: HY-B0923

Dantrolene sodium hemiheptahydrate (Dantrolene sodium hydrate) Cat. No.: HY-12542A

Danusertib (PHA-739358) Cat. No.: HY-10179

Daphnetin (7,8-Dihydroxycoumarin) Cat. No.: HY-N0281

DAPT (GSI-IX) Cat. No.: HY-13027

Dasatinib (BMS-354825) Cat. No.: HY-10181

https://www.MedChemExpress.com/BEZ235.html

https://www.MedChemExpress.com/BEZ235-Tosylate.html

https://www.MedChemExpress.com/Danshensu.html

https://www.MedChemExpress.com/Danshensu-sodium-salt.html

https://www.MedChemExpress.com/Danthron.html

https://www.MedChemExpress.com/Dantrolene-sodium-hemiheptahydrate.html

https://www.MedChemExpress.com/Danusertib.html

https://www.MedChemExpress.com/Daphnetin.html

https://www.MedChemExpress.com/DAPT.html

https://www.MedChemExpress.com/Dasatinib.html


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg, 100 mg

Purity: 98.46%Clinical Data: Phase 3Size: 10 mg, 50 mg


100 mg, 500 mg


2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 25 mg, 50 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg



100 mg, 200 mg, 500 mg

Bioactivity: Dasatinib hydrochloride is a potent and dual / AblWT Srcinhibitor of 0.6 nM/0.8 nM respectively; also inhibitsIC50

/ with of 79 nM/37 nM.c-KitWT c-KitD816V IC50

Bioactivity: Daunorubicin (RP 13057, Daunomycin, Rubidomycin) is a inhibitor with potent antineoplastictopoisomerase II

activities. Daunorubicin inhibites inDNA and RNA synthesissensitive and resistant Ehrlich ascites tumor cells.

Bioactivity: Daunorubicin Hydrochloride is a inhibitortopoisomerase IIwith potent antineoplastic activities. DaunorubicinHydrochloride inhibites in sensitive andDNA and RNA synthesisresistant Ehrlich ascites tumor cells.

Bioactivity: Daurisoline is a inhibitor and also an hERG autophagyblocker.

Bioactivity: DBeQ is a selective, potent, reversible, and ATP-competitive inhibitor, with an value of 1.5 μM and 1.6 μM forp97 IC50

p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4with an of 11.5 μM.IC50

Bioactivity: DC661 is a potent palmitoyl-protein thioesterase 1 ( )PPT1inhibitor, inhibits , and acts as an anti-lysosomalautophagyagent. Anti-cancer activity .[1]

Bioactivity: Deferoxamine mesylate is an iron chelator that binds free ironin a stable complex, preventing it from engaging in chemicalreactions.

Bioactivity: Deforolimus (AP23573; MK-8669) is a potent and selective inhibitor; inhibits ribosomal protein S6mTOR

phosphorylation with an of 0.2 nM in HT-1080 cells.IC50

Bioactivity: Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB)inhibitor, directly inhibiting DUB activity of USP9x, USP5,USP14, and UCH37. Degrasyn has been shown to downregulate theantiapoptotic proteins and .Bcr-Abl JAK2

Bioactivity: Deguelin, a naturally occurring rotenoid, is a potent PI3K/AKTinhibitor.


Dasatinib hydrochloride (BMS 354825 hydrochloride) Cat. No.: HY-10181A

Daunorubicin (RP 13057; Daunomycin; Rubidomycin) Cat. No.: HY-13062A

Daunorubicin Hydrochloride (RP 13057 (Hydrochloride);

Daunomycin (Hydrochloride); Rubidomycin (Hydrochloride)) Cat. No.: HY-13062

Daurisoline ((R,R)-Daurisoline) Cat. No.: HY-N0221

DBeQ (JRF 12) Cat. No.: HY-15945

DC661 Cat. No.: HY-111621

Deferoxamine mesylate (Desferrioxamine B mesylate; DFOM) Cat. No.: HY-B0988

Deforolimus (AP23573; MK-8669; Ridaforolimus) Cat. No.: HY-50908

Degrasyn (WP1130) Cat. No.: HY-13264

Deguelin ((-)-Deguelin; (-)-cis-Deguelin) Cat. No.: HY-13425

https://www.MedChemExpress.com/Dasatinib-hydrochloride.html

https://www.MedChemExpress.com/daunorubicin.html

https://www.MedChemExpress.com/Daunorubicin-Hydrochloride.html

https://www.MedChemExpress.com/Daurisoline.html

https://www.MedChemExpress.com/DBeQ.html

https://www.MedChemExpress.com/DC661.html

https://www.MedChemExpress.com/Deferoxamine-mesylate.html

https://www.MedChemExpress.com/Deforolimus.html

https://www.MedChemExpress.com/WP1130.html

https://www.MedChemExpress.com/deguelin.html



10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg, 100 mg


50 mg, 100 mg, 200 mg, 500 mg


10 mg, 50 mg, 100 mg


100 mg


5 mg, 10 mg, 50 mg


1 g, 5 g


1 g, 5 g


5 mg, 10 mg, 50 mg

Bioactivity: Demethoxycurcumin(Curcumin II) is a major active curcuminoid;possess anti-inflammatory properties; also exert cytotoxiceffects in human cancer cells via induction of apoptosis. IC50value: Target: in vitro: DMC significantly decreased NOsecretion by 35-41% in our inflamed cell model. Decrease in NO…

Bioactivity: Dexamethasone is a agonist.glucocorticoid receptor

Bioactivity: Dexamethasone acetate is a agonist.glucocorticoid receptor Bioactivity: Dexmedetomidine Hydrochloride is an agonist of adrenergicalpha-2 receptor, which is used in veterinary medicine for itsanalgesic and sedative properties. Target: Adrenergic alpha-2Receptor Dexmedetomidine, acting at alpha(2A) adrenoceptors,must be present during the encoding process to decrease…

Bioactivity: Diazoxide is an ATP-sensitive activator ;potassium channelcan be used to treat hyperinsulinism.

Bioactivity: Dienogest(STS-557) is a specific progesterone receptor agonistwith potent oral endometrial activity and is used in thetreatment of endometriosis. Target: progesterone receptoragonist Dienogest is an orally active synthetic progesterone(or progestin). It is available for use as an oral…

Bioactivity: Dihydroartemisinin is a potent agent.anti-malaria Bioactivity: Dihydromyricetin is a potent inhibitor with an of 48 μMIC50on . Dihydromyricetin can activatedihydropyrimidinaseautophagy through inhibiting signaling.mTORDihydromyricetin suppresses the formation of mTOR complexes (

/ ).mTORC1 2

Bioactivity: Dioscin(CCRIS 4123; Collettiside III) is a natural steroidsaponin derived from several plants, showing potentanti-cancer effect against a variety of tumor cell lines. IC50value: Target: Anticancer agent in vitro: dioscin (1, 2 and 4μmol/L) could significantly inhibit the viability of LNCaP…

Bioactivity: DMH-1 is a potent and selective inhibitor with s ofBMP IC5027/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively.

Demethoxycurcumin (Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin)Cat. No.: HY-N0006

Dexamethasone (Hexadecadrol; Prednisolone F) Cat. No.: HY-14648

Dexamethasone acetate (Dexamethasone 21-acetate) Cat. No.: HY-14648A

Dexmedetomidine hydrochloride ((+)-Medetomidine

hydrochloride; (S)-Medetomidine hydrochloride) Cat. No.: HY-17034A

Diazoxide (Sch-6783; SRG-95213) Cat. No.: HY-B1140

Dienogest (STS 557) Cat. No.: HY-B0084

Dihydroartemisinin (Dihydroqinghaosu; β-Dihydroartemisinin; Artenimol) Cat. No.: HY-N0176

Dihydromyricetin (Ampeloptin; Ampelopsin) Cat. No.: HY-N0112

Dioscin (Collettiside III; CCRIS 4123) Cat. No.: HY-N0124

DMH-1 Cat. No.: HY-12273

https://www.MedChemExpress.com/Demethoxycurcumin.html

https://www.MedChemExpress.com/Dexamethasone.html

https://www.MedChemExpress.com/Dexamethasone-acetate.html

https://www.MedChemExpress.com/Dexmedetomidine-hydrochloride.html

https://www.MedChemExpress.com/Diazoxide.html

https://www.MedChemExpress.com/Dienogest.html

https://www.MedChemExpress.com/Dihydroartemisinin.html

https://www.MedChemExpress.com/Dihydromyricetin.html

https://www.MedChemExpress.com/Dioscin.html

https://www.MedChemExpress.com/DMH-1.html


5 mg, 10 mg, 25 mg, 50 mg


10 mg, 50 mg


10 mg, 50 mg


10 mg, 50 mg


50 mg, 100 mg, 200 mg, 500 mg, 1 g



500 mg, 1 g


5 mg, 10 mg, 50 mg, 100 mg



50 mg, 100 mg, 200 mg, 500 mg

Bioactivity: DMOG (Dimethyloxallyl Glycine) is a cell-permeable andcompetitive inhibitor of .HIF-1α prolyl hydroxylase (HIF-PH)

Bioactivity: Dorsomorphin (BML-275; Compound C) is a potent and selective inhibitor, that is competitive with ATP, with =109AMPK Ki

nM in the absence of AMP . Dorsomorphin inhibits BMP[1]

pathway by targeting the type I receptors , , …ALK2 ALK3

Bioactivity: Dorsomorphin dihydrochloride (BML-275 dihydrochloride;Compound C dihydrochloride) is a potent, selective andATP-competitive inhibitor, with a of 109 nM .AMPK Ki

[1]

Dorsomorphin dihydrochloride inhibits BMP pathway by target…

Bioactivity: Doxazosin mesylate(UK 33274) is a quinazoline-derivative thatselectively antagonizes postsynaptic α1-adrenergic receptors.Target: α1-adrenergic receptor Doxazosin (mesylate) is themesylate salt form of doxazosin, which is a long-lastinginhibitor of α1-adrenoceptors that is widely used to treat…

Bioactivity: Doxorubicin is a cytotoxic anthracycline antibiotic for thetreatment of multiple cancers. The possible mechanisms bywhich doxorubicin acts in the cancer cell are intercalationinto DNA and disruption of -mediated DNAtopoisomerase-IIrepair.

Bioactivity: Doxorubicin hydrochloride is a cytotoxic anthracyclineantibiotic for the treatment of multiple cancers. The possiblemechanisms by which doxorubicin acts in the cancer cell areintercalation into DNA and disruption of

-mediated DNA repair.topoisomerase-II

Bioactivity: Dronedarone (SR 33589) is a newer therapeutic agent with astructural resemblance to amiodarone and a better side effectprofile; it is a multichannel blocker with antiadrenergicproperties and has been evaluated in both rate and rhythmcontrol strategies in the management of AF.

Bioactivity: Dronedarone hydrochloride is a non-iodinated amiodaronederivative that inhibits , and currents.Na+ K+ Ca2+

Bioactivity: Dynasore is a cell-permeable inhibitor with an dynamin IC50of 15 μM.

Bioactivity: E-64 is a potent irreversible inhibitor against general with of 9 nM for .cysteine proteases IC50 papain


DMOG (Dimethyloxallyl Glycine) Cat. No.: HY-15893

Dorsomorphin (BML-275; Compound C) Cat. No.: HY-13418A

Dorsomorphin dihydrochloride (BML-275 dihydrochloride; Compound C dihydrochloride) Cat. No.: HY-13418

Doxazosin mesylate (UK 33274 mesylate) Cat. No.: HY-B0098A

Doxorubicin (Hydroxydaunorubicin) Cat. No.: HY-15142A

Doxorubicin hydrochloride (Hydroxydaunorubicin (hydrochloride)) Cat. No.: HY-15142

Dronedarone (SR 33589) Cat. No.: HY-A0016

Dronedarone Hydrochloride Cat. No.: HY-75839

Dynasore Cat. No.: HY-15304

E-64 (Proteinase inhibitor E 64) Cat. No.: HY-15282

https://www.MedChemExpress.com/DMOG.html

https://www.MedChemExpress.com/dorsomorphin.html

https://www.MedChemExpress.com/Dorsomorphin-dihydrochloride.html

https://www.MedChemExpress.com/Doxazosin-mesylate.html

https://www.MedChemExpress.com/Doxorubicin.html

https://www.MedChemExpress.com/Doxorubicin-hydrochloride.html

https://www.MedChemExpress.com/Dronedarone.html

https://www.MedChemExpress.com/Dronedarone-Hydrochloride.html

https://www.MedChemExpress.com/Dynasore.html

https://www.MedChemExpress.com/E-64.html



5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 2g, 5 g


5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg


50 mg, 100 mg


50 mg, 100 mg, 200 mg


Purity: >98%Clinical Data: No Development ReportedSize: 1 mg


5 mg, 10 mg, 50 mg


Bioactivity: Ebselen is a small-molecule capsid Inhibitor of HIV-1replication. Target: Ebselen is an organoselenium compound, asan inhibitor of HIV-1 capsid CTD dimerization. Ebseleninhibits early viral postentry events of the HIV-1 life cycleby impairing the incoming capsid uncoating process. [1]…

Bioactivity: Efavirenz is a potent inhibitor of the wild-type HIV-1 reverse with a of 2.93 nM and exhibits an of 1.5transcriptase Ki IC95

nM for the inhibition of HIV-1 replicative spread in cellculture.

Bioactivity: Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) is an inhibitor, exerts antitumor activity as a singleautophagy

agent in ovarian cancer cells .[1]

Bioactivity: Emetine dihydrochloride hydrate is an anti-protozoal drugpreviously used for intestinal and tissue amoebiasis.

Bioactivity: Emodin is a broad-spectrum anticancer agent. Emodin inhibits II (CKII) activity with of 2 μM.casein kinase IC50

Bioactivity: Enalaprilat (dihydrate) (MK-422) is an angiotensin-convertingenzyme (ACE) inhibitor with IC of 1.94 nM.50

Bioactivity: Entinostat is an oral and selective class I inhibitor,HDACwith s of 243 nM, 453 nM, and 248 nM for , ,IC50 HDAC1 HDAC2

and , respectively.HDAC3

Bioactivity: Entrectinib is a potent and orally available , , andTrk ROS1 inhibitor; inhibits TrkA, TrkB, TrkC, ROS1 and ALK withALK values of 1, 3, 5, 12 and 7 nM, respectively.IC50

Bioactivity: Enzalutamide (MDV3100) is an androgen receptor (AR)antagonist with an of 36 nM in LNCaP prostate cells.IC50

Bioactivity: Enzastaurin is a potent and selective inhibitor with anPKCβ of 6 nM, showing 6- to 20-fold selectivity over PKCα,IC50

PKCγ and PKCε.

Ebselen (SPI-1005; PZ-51; CCG-39161) Cat. No.: HY-13750

Efavirenz (DMP 266; EFV; L-743726) Cat. No.: HY-10572

Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) Cat. No.: HY-15184

Emetine dihydrochloride hydrate Cat. No.: HY-B1479B

Emodin (Frangula emodin) Cat. No.: HY-14393

Enalaprilat dihydrate (MK-422) Cat. No.: HY-B0231

Entinostat (MS-275; SNDX-275) Cat. No.: HY-12163

Entrectinib (NMS-E628; RXDX-101) Cat. No.: HY-12678

Enzalutamide (MDV3100) Cat. No.: HY-70002

Enzastaurin (LY317615) Cat. No.: HY-10342

https://www.MedChemExpress.com/Ebselen.html

https://www.MedChemExpress.com/Efavirenz.html

https://www.MedChemExpress.com/Elaiophylin.html

https://www.MedChemExpress.com/Emetine-dihydrochloride-hydrate.html

https://www.MedChemExpress.com/Emodin.html

https://www.MedChemExpress.com/Enalaprilat-dihydrate.html

https://www.MedChemExpress.com/Entinostat.html

https://www.MedChemExpress.com/Entrectinib.html

https://www.MedChemExpress.com/Enzalutamide.html

https://www.MedChemExpress.com/Enzastaurin.html

Purity: 98.79%Clinical Data: LaunchedSize: 5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg


100 mg, 200 mg, 500 mg



10 mg, 50 mg, 100 mg


200 mg


1 g, 5 g, 10 g



100 mg, 500 mg


100 mg, 500 mg

Bioactivity: Erlotinib is a medication for the treatment of non-small celllung cancer. It inhibits purified kinase with an ofEGFR IC502 nM.

Bioactivity: Erlotinib Hydrochloride inhibits purified kinase with anEGFR of 2 nM.IC50

Bioactivity: Erlotinib mesylate inhibits purified kinase with an EGFR IC50of 2 nM.

Bioactivity: Erythromycin, an oral macrolide antibiotic produced byStreptomyces erythreus, reversibly binds to the 50S ribosomeof bacteria, and inhibits protein synthesis. Target:Antibacterial Erythromycin is a macrolide antibiotic that hasan antimicrobial spectrum similar to or slightly wider than…

Bioactivity: Erythromycin Ethylsuccinate is an antibiotic useful for thetreatment of a number of bacterial infections, has anantimicrobial spectrum similar to or slightly wider than thatof penicillin.

Bioactivity: Esmolol Hydrochloride is a beta adrenergic receptor blocker.Target: Adrenergic receptor Esmolol Hydrochloride is thehydrochloride salt form of Esmolol, a short and rapid-actingbeta adrenergic antagonist belonging to the class IIanti-arrhythmic drugs and devoid of intrinsic sympathomimetic…

Bioactivity: Esomeprazole Magnesium trihydrate is a proton pump inhibitorwhich reduces acid secretion through inhibition of the H+ / K+ATPase in gastric parietal cells. IC50 value: Target: protonpump Esomeprazole sodium (Nexium) is the S-isomer ofomeprazole and acts as a proton pump inhibitor and gastric…

Bioactivity: Etoposide (VP-16; VP-16-213), a chemotherapy medication usedfor the treatments of a number of types of cancer, inhibits

by forming a complex with topoisomerase II andDNA synthesisDNA. Etoposide arrests cell cycle in G2 and induces apoptos…

Bioactivity: Eupatilin, a lipophilic flavonoid isolated from Artemisiaspecies, is a agonist, and possesses anti-apoptotic,PPARαanti-oxidative and anti-inflammatory activities.

Bioactivity: Everolimus (RAD001) is a potent inhibitor that bindsmTORto FKBP-12 to generate an immunosuppressive complex.


Erlotinib (CP-358774; NSC 718781; OSI-774) Cat. No.: HY-50896

Erlotinib Hydrochloride (CP-358774 (Hydrochloride); NSC

718781 (Hydrochloride); OSI-774 (Hydrochloride)) Cat. No.: HY-12008

Erlotinib mesylate (CP-358774 (mesylate); NSC 718781

(mesylate); OSI-774 (mesylate)) Cat. No.: HY-12008A

Erythromycin Cat. No.: HY-B0220

Erythromycin Ethylsuccinate (Erythromycin ethyl succinate; EES) Cat. No.: HY-B0957

Esmolol hydrochloride Cat. No.: HY-B1392

Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) Cat. No.: HY-17022

Etoposide (VP-16; VP-16-213) Cat. No.: HY-13629

Eupatilin Cat. No.: HY-N0783

Everolimus (RAD001; SDZ-RAD) Cat. No.: HY-10218

https://www.MedChemExpress.com/erlotinib.html

https://www.MedChemExpress.com/Erlotinib-Hydrochloride.html

https://www.MedChemExpress.com/erlotinib-mesylate.html

https://www.MedChemExpress.com/Erythromycin.html

https://www.MedChemExpress.com/Erythromycin-Ethylsuccinate.html

https://www.MedChemExpress.com/Esmolol-hydrochloride.html

https://www.MedChemExpress.com/esomeprazole-magnesium-trihydrate.html

https://www.MedChemExpress.com/etoposide.html

https://www.MedChemExpress.com/Eupatilin.html

https://www.MedChemExpress.com/Everolimus.html



100 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg



5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


5 g, 10 g


10 mg, 50 mg


200 mg, 500 mg



10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Bioactivity: Ezetimibe (SCH 58235) is a Niemann-Pick C1-like1 ( )NPC1L1inhibitor, and is a potent activator. Ezetimibe (SCHNrf258235) is a potent cholesterol absorption inhibitor.

Bioactivity: Fasudil (HA-1077; AT877), a potent inhibitor of with aROCK of 0.33 μM for ROCK1, which is also a potent Ki Ca channel2+

antagonist and vasodilator.

Bioactivity: Fasudil Hydrochloride (HA-1077 Hydrochloride; AT-877Hydrochloride), a potent inhibitor of with a of 0.33ROCK Ki

μM for ROCK1, which is also a potent antagonistCa channel2+

and vasodilator.

Bioactivity: Felodipine is a long-acting 1,4-dihydropyridine calciumchannel blocker. Target: Calcium Channel Felodipine is along-acting 1,4-dihydropyridine calcium channel blocker(CCB)b. It acts primarily on vascular smooth muscle cells bystabilizing voltage-gated L-type calcium channels in their…

Bioactivity: Fenofibrate is a agonist with an of 30 μM.PPARα EC50 Bioactivity: Fenretinide is a synthetic retinoid deriverative, binding tothe retinoic acid receptors ( ) at concentrationsRARnecessary to induce cell death.

Bioactivity: FIPI is a derivative of halopemide which potently inhibitsboth and with s of 25 nM and 20 nM,PLD1 PLD2 IC50respectively.

Bioactivity: Flavopiridol is a broad spectrum and competitive inhibitor of, inhibiting CDK1, CDK2, CDK4 with s of 30, 170, 100CDKs IC50

nM, respectively.

Bioactivity: Flavopiridol Hydrochloride is a broad inhibitor of ,CDKcompeting with ATP to inhibit CDKs including CDK1, CDK2, CDK4with s of 30, 170, 100 nM, respectively.IC50

Bioactivity: Flubendazole is a potent broad spectrum anthelmintic. Target:Antiparasitic Flubendazole is an anthelmintic. It is alsoavailable for human use to treat worm infections[1].

Ezetimibe (SCH 58235) Cat. No.: HY-17376

Fasudil (HA-1077; AT877) Cat. No.: HY-10341A

Fasudil Hydrochloride (HA-1077 (Hydrochloride); AT-877 (Hydrochloride)) Cat. No.: HY-10341

Felodipine Cat. No.: HY-B0309

Fenofibrate Cat. No.: HY-17356

Fenretinide (4-HPR) Cat. No.: HY-15373

FIPI (5-Fluoro-2-indolyl deschlorohalopemide) Cat. No.: HY-12807

Flavopiridol (L868275; HMR-1275; Alvocidib) Cat. No.: HY-10005

Flavopiridol Hydrochloride (HL 275; NSC 649890; MDL 107826A;

FLAVOPIRIDOL HCL; Alvocidib Hydrochloride) Cat. No.: HY-10006

Flubendazole Cat. No.: HY-B0294

https://www.MedChemExpress.com/Ezetimibe.html

https://www.MedChemExpress.com/fasudil.html

https://www.MedChemExpress.com/Fasudil-Hydrochloride.html

https://www.MedChemExpress.com/felodipine.html

https://www.MedChemExpress.com/Fenofibrate.html

https://www.MedChemExpress.com/Fenretinide.html

https://www.MedChemExpress.com/FIPI.html

https://www.MedChemExpress.com/Flavopiridol.html

https://www.MedChemExpress.com/Flavopiridol-Hydrochloride.html

https://www.MedChemExpress.com/flubendazole.html


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg


10 mg, 25 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg


1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg


50 mg, 100 mg


50 mg, 100 mg, 500 mg



100 mg

Bioactivity: Fludrocortisone Acetate is a synthetic mineralocorticoid, usedto control the amount of sodium and fluids in your body. It isused to treat Addison's disease by decreasing the amount ofsodium that is lost (excreted) in your urinealso used toincrease blood pressure.

Bioactivity: Fluoxetine (LY-110140 free base) is a selective serotoninreuptake inhibitor ( ) class used for antidepressantSSRIresearch.

Bioactivity: Fluoxetine hydrochloride is an antidepressant and a selective inhibitor.serotonin reuptake

Bioactivity: Fluvastatin (XU 62320) sodium is a competitive inhibitor ofhydroxymethylglutaryl-coenzyme A reductase (HMGCR), used totreat hypercholesterolemia and to prevent cardiovasculardisease.

Bioactivity: FMK 9a is an inhibitor with values of 80 andautophagin-1 IC5073 μM in FRET and LRA assay.

Bioactivity: Forskolin is a potent activator, with andadenylate cyclase IC50 of 41 nM and 0.5 μM for ,EC50 type I adenylyl cyclase

respectively.

Bioactivity: Fulvestrant is a potent antagonist with anEstrogen Receptor of 9.4 nM.IC50

Bioactivity: Galangin is an agonist/antagonist ofthe arylhydrocarbon receptor, and also showsinhibition of activity.CYP1A1

Bioactivity: Gambogic acid is derived from the gamboges resin of the tree. Gambogic acid inhibits , ,Garcinia hanburyi Bcl-XL Bcl-2

, , and with s of 1.47 μM, 1.21Bcl-W Bcl-B Bfl-1 Mcl-1 IC50μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

Bioactivity: GANT 61 is an inhibitor of and targeting theGli1 Gli2Hedgehog/GLI pathway.


Fludrocortisone acetate (9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate) Cat. No.: HY-B1203A

Fluoxetine (LY-110140 (free base)) Cat. No.: HY-B0102

Fluoxetine hydrochloride (LY-110140) Cat. No.: HY-B0102A

Fluvastatin sodium (XU 62320 sodium) Cat. No.: HY-14664A

FMK 9a Cat. No.: HY-100522

Forskolin (Coleonol; Colforsin) Cat. No.: HY-15371

Fulvestrant (ICI 182780; ZD 9238; ZM 182780) Cat. No.: HY-13636

Galangin (Norizalpinin; 3,5,7-Trihydroxyflavone) Cat. No.: HY-N0382

Gambogic Acid (Beta-Guttiferrin) Cat. No.: HY-N0087

GANT 61 (NSC 136476) Cat. No.: HY-13901

https://www.MedChemExpress.com/Fludrocortisone-acetate.html

https://www.MedChemExpress.com/fluoxetine.html

https://www.MedChemExpress.com/fluoxetine-hydrochloride.html

https://www.MedChemExpress.com/Fluvastatin-sodium.html

https://www.MedChemExpress.com/FMK_9a.html

https://www.MedChemExpress.com/Forskolin.html

https://www.MedChemExpress.com/Fulvestrant.html

https://www.MedChemExpress.com/Galangin.html

https://www.MedChemExpress.com/Gambogic-Acid.html

https://www.MedChemExpress.com/GANT-61.html



5 mg, 10 mg


5 mg, 10 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


100 mg, 500 mg


50 mg, 100 mg


100 mg, 200 mg, 500 mg, 1 g


5 mg, 10 mg, 50 mg


100 mg, 200 mg, 500 mg, 1 g


100 mg, 500 mg, 1 g, 5 g


5 mg, 10 mg, 50 mg

Bioactivity: GDC-0349 is a potent and selective ATP-competitive mTORinhibitor with a of 3.8 nM. GDC-0349 inhibits of bothKi

and complexes.mTORC1 mTORC2

Bioactivity: Gefitinib (ZD1839) is a inhibitor, withEGFR tyrosine kinase of 2-37 nM in NR6wtEGFR cells.IC50

Bioactivity: Gemcitabine (NSC 613327;LY188011) is a inhibitorDNA synthesiswhich inhibits the growth of BxPC-3, Mia Paca-2, PANC-1, PL-45and AsPC-1 cells with s of 37.6, 42.9, 92.7, 89.3 andIC50131.4 nM, respectively.

Bioactivity: Gemcitabine elaidate(CP-4126; CO-101) is a lipophilic,unsaturated fatty acid ester derivative of gemcitabine (dFdC),an antimetabolite deoxynucleoside analogue, with potentialantineoplastic activity. IC50 value: Target: Gemcitabineanalog Upon hydrolysis intracellularly by esterases, the…

Bioactivity: Gemcitabine hydrochloride is a inhibitor withDNA synthesiss of 37.6, 42.9, 92.7, 89.3 and 131.4 nM in BxPC-3, MiaIC50

Paca-2, PANC-1, PL-45 and AsPC-1 cells, respectively.

Bioactivity: Genipin is a natural water soluble crosslinking reagent.

Bioactivity: Genistein, a soy isoflavone, is a multiple tyrosine kinasesinhibitor which acts as a chemotherapeutic agent againstdifferent types of cancer, mainly by altering apoptosis, thecell cycle, and angiogenesis and inhibiting metastasis.

Bioactivity: Genistin is the major isoflavonoid of soybeans and soyproducts.

Bioactivity: Ginsenoside Rb1, a main constituent of the root of Panaxginseng, inhibits activity with an ofNa , K -ATPase+ + IC506.3±1.0 μM. Ginsenoside also inhibits activation andIRAK-1phosphorylation of .NF-κB p65

Bioactivity: Ginsenoside Rh4 is a rare saponin obtained from Panax. Ginsenoside Rh4 activates , ,notoginseng Bax caspase 3

, and . Ginsenoside Rh4 also inducescaspase 8 caspase 9.autophagy

GDC-0349 Cat. No.: HY-15248

Gefitinib (ZD1839) Cat. No.: HY-50895

Gemcitabine (NSC 613327; LY188011) Cat. No.: HY-17026

Gemcitabine elaidate (CP-4126; CO-101; Gemcitabine 5'-elaidate) Cat. No.: HY-13538

Gemcitabine Hydrochloride (LY 188011 hydrochloride) Cat. No.: HY-B0003

Genipin ((+)-Genipin) Cat. No.: HY-17389

Genistein (NPI 031L) Cat. No.: HY-14596

Genistin (Genistine; Genistoside; Genistein

7-O-β-D-glucopyranoside) Cat. No.: HY-N0595

Ginsenoside Rb1 (Gypenoside III) Cat. No.: HY-N0039

Ginsenoside Rh4 Cat. No.: HY-N0905

https://www.MedChemExpress.com/gdc-0349.html

https://www.MedChemExpress.com/Gefitinib.html

https://www.MedChemExpress.com/Gemcitabine.html

https://www.MedChemExpress.com/Gemcitabine-elaidate.html

https://www.MedChemExpress.com/Gemcitabine-Hydrochloride.html

https://www.MedChemExpress.com/Genipin.html

https://www.MedChemExpress.com/Genistein.html

https://www.MedChemExpress.com/Genistin.html

https://www.MedChemExpress.com/Ginsenoside-Rb1.html

https://www.MedChemExpress.com/Ginsenoside-Rh4.html


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


50 mg


1 g, 5 g


5 mg, 10 mg

Bioactivity: Glaucocalyxin B is an ent kaurane diterpenoid isolated fromthe Chinese traditional medicine withRabdosia japonicaanticancer and antitumor activity; decreases the growth ofHL-60 cells with an of approximately 5.86 μM at 24 h.IC50

Bioactivity: Glibenclamide is a selective inhibitor of ATP-sensitive K+

.channel

Bioactivity: Glucosamine (hydrochloride) is a natural product. IC50 value:Target: In vitro: Glucosamine hydrochloride exhibiteddose-dependent DPPH antioxidant activity [1]. Short-term (4 h)glucosamine hydrochloride treatment inhibited HIF-1α at theprotein level, decreased phosphorylation of p70S6K and S6,…

Bioactivity: GSK-690693 is an ATP-competitive inhibitor with span-Akt IC50of 2, 13, 9 nM for Akt1, Akt2 and Akt3, respectively.

Bioactivity: GSK2578215A is a potent and highly selective inhibitor,LRRK2which exhibits s of around 10 nM against both wild-typeIC50LRRK2 and the G2019S mutant.

Bioactivity: GSK2606414 is a cell-permeable and orally available proteinkinase R-like endoplasmic reticulum (ER) kinase (PERK)inhibitor with an of 0.4 nM.IC50

Bioactivity: GSK2656157 is a selective and ATP-competitive inhibitor ofprotein kinase R (PKR)-like endoplasmic reticulum kinase (

) with an of 0.9 nM.PERK IC50

Bioactivity: GSK343 is a highly potent and selective inhibitor withEZH2an of 4 nM.IC50

Bioactivity: GSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is asmall molecule chemical probe for the cell biology of thenuclear heme receptor Rev-erbα. IC50 value: 0.4 μM (EC50)Target: Rev-erbα in vitro: GSK4112 profiled as a Rev-erbagonist in cells to inhibit expression of the circadian target…

Bioactivity: GW 501516 is a agonist with an of 1.1 nM.PPARδ EC50


Glaucocalyxin B Cat. No.: HY-N2113

Glibenclamide (Glyburide) Cat. No.: HY-15206

Glucosamine hydrochloride (D-(+)-Glucosamine hydrochloride;

Chitosamine hydrochloride) Cat. No.: HY-N0733

GSK-690693 Cat. No.: HY-10249

GSK2578215A Cat. No.: HY-13237

GSK2606414 Cat. No.: HY-18072

GSK2656157 Cat. No.: HY-13820

GSK343 Cat. No.: HY-13500

GSK4112 (SR6452) Cat. No.: HY-14414

GW 501516 (GW 1516; GSK-516) Cat. No.: HY-10838

https://www.MedChemExpress.com/Glaucocalyxin-B.html

https://www.MedChemExpress.com/glibenclamide.html

https://www.MedChemExpress.com/Glucosamine-hydrochloride.html

https://www.MedChemExpress.com/GSK-690693.html

https://www.MedChemExpress.com/GSK2578215A.html

https://www.MedChemExpress.com/GSK2606414.html




https://www.MedChemExpress.com/GW-501516.html



Purity: 98.75%Clinical Data: No Development ReportedSize: 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g


5 mg, 10 mg, 50 mg, 100 mg

Purity: 98.0%Clinical Data: LaunchedSize: 100 mg, 500 mg, 1 g

Purity:Clinical Data: No Development ReportedSize: 10mM x 1mL in Water,

100 mg, 500 mg



1 g, 5 g


10 mg, 50 mg, 100 mg


Bioactivity: H-89 is a potent inhibitor of cyclic AMP-dependent proteinkinase ( ) with of 48 nM and has weakprotein kinase A IC50inhibition on PKG, PKC, Casein Kinase, and others kinases.

Bioactivity: H-89 dihydrochloride is a potent inhibitor of protein kinase A( ) with an of 48 nM and has weak inhibition on PKG,PKA IC50PKC, Casein Kinase.

Bioactivity: Hemin is an iron-containing porphyrin. Hemin is an Heme inducer.oxygenase (HO)-1

Bioactivity: Heparin is a highly sulfated glycosaminoglycan,that is widelyused as an injectable anticoagulant, and has the highestnegative charge density of any known biological molecule(50-400 U/Kg).

Bioactivity: Heparin Lithium salt is an anticoagulant which bindsreversibly to (50-400 U/Kg).antithrombin III (ATIII)

Bioactivity: Heparin sodium salt is an anticoagulant which binds reversiblyto and greatly accelerates the rateantithrombin III (ATIII)at which ATIII inactivates coagulation enzymes thrombin

and (50-400 U/Kg).factor IIa factor Xa

Bioactivity: Hesperadin is an ATP-competitive inhibitor of aurora Bkinase with an of 250 nM.IC50

Bioactivity: Hesperidin (HP) is a bioflavonoid that plays a role in plantdefense and is abundant in citrus species, such as grapefruit,lemon and orange. Hesperidin is used effectively as asupplemental agent in complementary therapy protocols, sinceit possesses biological and pharmacological properties as an…

Bioactivity: Hoechst 33342 is a DNA minor groove binder used fluorochromefor visualizing cellular .DNA

Bioactivity: Hoechst 33342 trihydrochloride is a membrane permeant bluefluorescent stain.DNA

H 89 (Protein kinase inhibitor H-89) Cat. No.: HY-15979

H-89 dihydrochloride (Protein kinase inhibitor H-89 dihydrochloride) Cat. No.: HY-15979A

Hemin (Hemin chloride) Cat. No.: HY-19424

Heparin Cat. No.: HY-17567

Heparin Lithium salt Cat. No.: HY-17567B

Heparin sodium salt (Sodium heparinate) Cat. No.: HY-17567A

Hesperadin Cat. No.: HY-12054

Hesperidin (Hesperetin 7-rutinoside) Cat. No.: HY-15337

Hoechst 33342 (bisBenzimide H 33342; HOE 33342) Cat. No.: HY-15559

Hoechst 33342 trihydrochloride (bisBenzimide H 33342

trihydrochloride; HOE 33342 trihydrochloride) Cat. No.: HY-15559A

https://www.MedChemExpress.com/H-89.html

https://www.MedChemExpress.com/H-89-dihydrochloride.html

https://www.MedChemExpress.com/Hemin.html

https://www.MedChemExpress.com/Heparin.html

https://www.MedChemExpress.com/Heparin_Lithium_salt.html

https://www.MedChemExpress.com/Heparin-sodium-salt.html

https://www.MedChemExpress.com/Hesperadin.html

https://www.MedChemExpress.com/Hesperidin.html

https://www.MedChemExpress.com/hoechst-33342.html

https://www.MedChemExpress.com/Hoechst-33342-trihydrochloride.html


100 mg, 200 mg, 500 mg, 1 g, 5 g


200 mg, 500 mg, 1 g, 5 g


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg


100 mg, 200 mg, 500 mg


1 g, 5 g


50 mg


50 mg, 100 mg, 200 mg

Bioactivity: Honokiol is a bioactive, biphenolic phytochemical thatpossesses potent antioxidative, anti-inflammatory,antiangiogenic, and anticancer activities by targeting avariety of signaling molecules. It inhibits the activation of

and enhances the phosphorylation of .Akt ERK1/ERK2

Bioactivity: Hydroxychloroquine sulfate is a synthetic drugantimalarialwhich can also inhibit ( )Toll-like receptor 7/9 TLR7/9signaling.

Bioactivity: Hydroxyurea is a cell apoptosis inducer that inhibit DNAsynthesis through inhibition of .ribonucleotide reductase

Bioactivity: Icariin is a flavonol glycoside. Icariin inhibits andPDE5 activities with s of 432 nM and 73.50 μM,PDE4 IC50

respectively. Icariin also is a activator.PPARα

Bioactivity: Icaritin(Anhydroicaritin) is a component of Epimediumflavonoid isolated from Herba Epimedii; enhances osteoblasticdifferentiation of mesenchymal stem cells (MSCs) while itinhibits adipogenic differentiation of MSCs by inhibitingPPAR-g pathway. IC50 value: Target: in vitro: Icaritin was…

Bioactivity: Idarubicin hydrochloride is an anthracycline antileukemicdrug. It inhibits the interfering with thetopoisomerase IIreplication of DNA and RNA transcription.

Bioactivity: Idelalisib (CAL-101) is a highly selective and orallybioavailable inhibitor with an of 2.5 nM, showingp110δ IC5040- to 300-fold selectivity for p110δ over other PI3K class Ienzymes.

Bioactivity: IITZ-01 is a potent lysosomotropic inhibitor withautophagysingle-agent antitumor activity, with an of 2.62 μM forIC50PI3Kγ.

Bioactivity: Imatinib (STI571) is a tyrosine kinases inhibitor thatinhibits , , and ( =100 nM) tyrosinec-Kit Bcr-Abl PDGFR IC50kinases.

Bioactivity: Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinasesinhibitor that inhibits , , and ( =100c-Kit Bcr-Abl PDGFR IC50nM) tyrosine kinases.


Honokiol (NSC 293100) Cat. No.: HY-N0003

Hydroxychloroquine sulfate (HCQ sulfate) Cat. No.: HY-B1370

Hydroxyurea (Hydroxycarbamide) Cat. No.: HY-B0313

Icariin (Ieariline) Cat. No.: HY-N0014

Icaritin (Anhydroicaritin) Cat. No.: HY-N0678

Idarubicin hydrochloride (4-Demethoxydaunorubicin hydrochloride) Cat. No.: HY-17381

Idelalisib (CAL-101; GS-1101) Cat. No.: HY-13026

IITZ-01 Cat. No.: HY-112897

Imatinib (STI571; CGP-57148B) Cat. No.: HY-15463

Imatinib Mesylate (STI571 (Mesylate); CGP-57148B (Mesylate)) Cat. No.: HY-50946

https://www.MedChemExpress.com/honokiol.html

https://www.MedChemExpress.com/Hydroxychloroquine_sulfate.html

https://www.MedChemExpress.com/hydroxyurea.html

https://www.MedChemExpress.com/Icariin.html

https://www.MedChemExpress.com/Icaritin.html

https://www.MedChemExpress.com/Idarubicin-hydrochloride.html

https://www.MedChemExpress.com/CAL-101.html

https://www.MedChemExpress.com/IITZ-01.html

https://www.MedChemExpress.com/Imatinib.html

https://www.MedChemExpress.com/Imatinib-Mesylate.html



10 mg, 50 mg


50 mg, 100 mg, 200 mg, 500 mg


50 mg, 100 mg, 200 mg, 500 mg


50 mg, 100 mg, 200 mg, 500 mg

Purity: >98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 20 mg


100 mg, 500 mg


1 g, 5 g




100 mg, 200 mg, 500 mg

Bioactivity: Imiquimod (R 837) is an immune response modifier that acts asa agonist.toll-like receptor 7

Bioactivity: Imiquimod hydrochloride is an immune response modifier thatacts as a agonist.toll-like receptor 7

Bioactivity: Imiquimod maleate is an immune response modifier that acts asa agonist.toll-like receptor 7

Bioactivity: Indomethacin is a potent and nonselective inhibitor of COX1and , with s of 18 nM and 26 nM for human COX-1 andCOX2 IC50COX-2, respectively, in CHO cells.

Bioactivity: Iohexol is a contrast agent. Target: Others Iohexol is acontrast agent. The osmolality of iohexol ranges from 322mOsm/kg-approximately 1.1 times that of blood plasma-to 844mOsm/kg, almost three times that of blood. Despite thisdifference, iohexol is still considered a low-osmolality…

Bioactivity: Ipsalazide is a novel sulfasalazine analog designed to release5-aminosalicylic acid and a nontoxic carrier molecule in thegastrointestinal tract.

Bioactivity: Irinotecan is a water soluble inhibitor,topoisomerase Ipreventing religation of the DNA strand by binding totopoisomerase I-DNA complex.

Bioactivity: Irinotecan hydrochloride is a water soluble topoisomerase Iinhibitor mainly used to treat colon cancer and rectal cancer.

Bioactivity: Irinotecan hydrochloride trihydrate is a water soluble inhibitor with antitumor activity.topoisomerase I

Bioactivity: Isoalantolactone is an inducer, which also acts as anapoptosisalkylating agent.

Imiquimod (R 837) Cat. No.: HY-B0180

Imiquimod hydrochloride (R 837 hydrochloride) Cat. No.: HY-B0180A

Imiquimod maleate (R 837 maleate) Cat. No.: HY-B0180B

Indomethacin (Indometacin) Cat. No.: HY-14397

Iohexol Cat. No.: HY-B0594

Ipsalazide Cat. No.: HY-101744

Irinotecan ((+)-Irinotecan; CPT-11) Cat. No.: HY-16562

Irinotecan hydrochloride (CPT-11 hydrochloride; Camptothecin 11 hydrochloride) Cat. No.: HY-16562A

Irinotecan hydrochloride trihydrate Cat. No.: HY-16568

Isoalantolactone ((+)-Isoalantolactone; Isohelenin) Cat. No.: HY-N0780

https://www.MedChemExpress.com/Imiquimod.html

https://www.MedChemExpress.com/imiquimod-hydrochloride.html

https://www.MedChemExpress.com/imiquimod-maleate.html

https://www.MedChemExpress.com/Indomethacin.html

https://www.MedChemExpress.com/iohexol.html

https://www.MedChemExpress.com/Ipsalazide.html

https://www.MedChemExpress.com/Irinotecan.html

https://www.MedChemExpress.com/Irinotecan-hydrochloride.html

https://www.MedChemExpress.com/irinotecan-hydrochloride-trihydrate.html

https://www.MedChemExpress.com/Isoalantolactone.html


5 mg, 10 mg, 25 mg, 50 mg


500 mg, 1 g


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


100 mg, 500 mg


10 mg, 50 mg, 100 mg


1 g, 5 g


5 g


100 mg


10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 25 mg

Bioactivity: Isobavachalcone(Corylifolinin) is a chalcone constituent ofAngelica keiskei, induces apoptosis in neuroblastoma. IC50value: Target: Isobavachalcone inhibits platelet aggregation.Inhibitor of Epstein-Barr virus early antigen (EBV-EA)induction. Isobavachalcone exhibits potent inhibitory effect…

Bioactivity: Isoliquiritigenin is an anti-tumor flavonoid from the root of, which inhibits with an Glycyrrhiza glabra aldose reductase IC50

of 320 nM.

Bioactivity: Isoniazid is an antibacterial agent used primarily as atuberculostatic. Target: Antibacterial Isoniazid is a prodrugand must be activated by a bacterial catalase-peroxidaseenzyme that in M. tuberculosis is called KatG [1]. KatGcouples the isonicotinic acyl with NADH to form isonicotinic…

Bioactivity: Isosorbide is used as a diuretic used mainly to treathydrocephalus and is also used to treat glaucoma.

Bioactivity: Isosorbide mononitrate(Isosorbide-5-mononitrate) is anitrate-class compound used for angina pectoris; acts bydilating the blood vessels so as to reduce the blood pressure.

Bioactivity: Isradipine(Dynacirc) is a calcium channel blocker with an IC50of 34±8 μM. Target: Calcium Channel Isradipine(Dynacirc) is acalcium channel blocker with an IC50 of 34±8 μM.It is usuallyprescribed for the treatment of high blood pressure in orderto reduce the risk of stroke and heart attack[1]. Isradipine…

Bioactivity: Itraconazole is a triazole antifungal agent. IC50 Value: N/ATarget: antifungal in vitro: Itraconazole is pharmacologicallydistinct from other azole antifungal agents in that it is theonly inhibitor in this class that has been shown to inhibitboth the hedgehog signaling pathway and angiogenesis[1, 2].…

Bioactivity: IU1 is a special inhibitor with of 4-5 μM.Usp14 IC50

Bioactivity: Ivermectin (MK-933) is a widely used antiparasitic agent inhuman and veterinary medicine. It is a positive allostericeffector of and the α7 neuronal nicotinic acetylcholineP2X4receptor ( ).nAChRs

Bioactivity: Ixazomib (MLN2238) is a selective, potent, and reversible inhibitor, which inhibits the chymotrypsin-likeproteasome

proteolytic (β5) site of the 20S proteasome with an ofIC503.4 nM ( of 0.93 nM).Ki


Isobavachalcone (Corylifolinin; Isobacachalcone) Cat. No.: HY-13065

Isoliquiritigenin (GU17; ISL; Isoliquiritigen) Cat. No.: HY-N0102

Isoniazid (INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide) Cat. No.: HY-B0329

Isosorbide (D-Isosorbide; Dianhydro-D-glucitol) Cat. No.: HY-B1469

Isosorbide mononitrate (Isosorbide-5-mononitrate) Cat. No.: HY-B0642

Isradipine (PN 200-110) Cat. No.: HY-B0233

Itraconazole (R51211) Cat. No.: HY-17514

IU1 Cat. No.: HY-13817

Ivermectin (MK-933) Cat. No.: HY-15310

Ixazomib (MLN2238) Cat. No.: HY-10453

https://www.MedChemExpress.com/Isobavachalcone.html

https://www.MedChemExpress.com/Isoliquiritigenin.html

https://www.MedChemExpress.com/Isoniazid.html

https://www.MedChemExpress.com/Isosorbide.html

https://www.MedChemExpress.com/Isosorbide-mononitrate.html

https://www.MedChemExpress.com/isradipine.html

https://www.MedChemExpress.com/Itraconazole.html

https://www.MedChemExpress.com/IU1.html

https://www.MedChemExpress.com/Ivermectin.html

https://www.MedChemExpress.com/MLN2238.html



1 g, 5 g


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


50 mg, 100 mg


50 mg, 100 mg


50 mg, 100 mg, 200 mg, 500 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: 98.67%Clinical Data: No Development ReportedSize: 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: Ixazomib citrate (MLN9708) is a reversible inhibitor of thechymotrypsin-like proteolytic β5 site of the 20S

with an of 3.4 nM and a of 0.93 nM.proteasome IC50 Ki

Bioactivity: JPH203 is a potent and selective L-type amino acid transporter1 ( ) inhibitor.LAT-1

Bioactivity: JPH203 Dihydrochloride is a tyrosine analog, acts as aselective inhibitor of L-type amino acid transporter 1 (

), and is used in cancer research.LAT1

Bioactivity: Kaempferide is an O-methylated flavonol, a type of chemicalcompound. It can be found in Kaempferia galanga (aromaticginger). The enzyme kaempferol 4'-O-methyltransferase usesS-adenosyl-L-methionine and kaempferol to produceS-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.

Bioactivity: Kaempferol inhibits expression in breastestrogen receptor αcancer cells and induces apoptosis in glioblastoma cells andlung cancer cells by activation of MEK-MAPK.

Bioactivity: Ketanserin is a selective antagonist.5-HT receptorKetanserin also blocks hERG current ( ) in aIhERGconcentration-dependent manner ( =0.11 μM).IC50

Bioactivity: Ketanserin tartrate is a selective antagonist.5-HT receptorKetanserin tartrate also blocks hERG current ( ) in aIhERGconcentration-dependent manner ( =0.11 μM).IC50

Bioactivity: KU-55933 is a potent inhibitor with an and ofATM IC50 Ki12.9 and 2.2 nM, respectively, and is highly selective for ATMas compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

Bioactivity: L-779450 is a potent and selective kinase inhibitorB-Rafwith a K of 2.4 nM.d

Bioactivity: Lamotrigine(BW430C) is a novel anticonvulsant drug forinhibition of 5-HT and sodium channel Target: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes byblockade of voltage-dependent sodium channels, thus preventingthe release of excitatory neurotransmitters, particularly…

Ixazomib citrate (MLN9708) Cat. No.: HY-10452

JPH203 (KYT-0353) Cat. No.: HY-100868

JPH203 Dihydrochloride Cat. No.: HY-U00445

Kaempferide (Kaempferol 4'-O-methyl ether) Cat. No.: HY-15449

Kaempferol (Robigenin; Kempferol) Cat. No.: HY-14590

Ketanserin (R41468) Cat. No.: HY-10562

Ketanserin tartrate (R41468 tartrate) Cat. No.: HY-10562A

KU-55933 Cat. No.: HY-12016

L-779450 Cat. No.: HY-12787

Lamotrigine (LTG; BW430C) Cat. No.: HY-B0495

https://www.MedChemExpress.com/MLN9708.html

https://www.MedChemExpress.com/JPH203.html

https://www.MedChemExpress.com/JPH203_Dihydrochloride.html

https://www.MedChemExpress.com/kaempferide.html

https://www.MedChemExpress.com/Kaempferol.html

https://www.MedChemExpress.com/Ketanserin.html

https://www.MedChemExpress.com/Ketanserin-tartrate.html

https://www.MedChemExpress.com/KU-55933.html

https://www.MedChemExpress.com/L-779450.html

https://www.MedChemExpress.com/Lamotrigine.html


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


100 mg, 200 mg, 500 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg



5 mg, 10 mg, 25 mg


50 mg, 100 mg, 500 mg, 1 g


50 mg, 100 mg, 500 mg, 1 g


10 mg

Bioactivity: Lanatoside C is a cardiac glycoside, can be used in thetreatment of congestive heart failure and cardiacarrhythmia.Lanatoside C has an IC50 of 0.19 μM for denguevirus infection in HuH-7 cells. Target: in vitro:Dose-dependent reduction in dengue viral RNA and viral…

Bioactivity: Lapatinib (GW572016) is a potent and inhibitorEGFR ErbB2with s of 10.2 and 9.8 nM, respectively.IC50

Bioactivity: Lapatinib ditosylate is a potent and inhibitorEGFR ErbB2with of 10.2 and 9.8 nM, respectively.IC50

Bioactivity: Lasalocid is an antibacterial agent and a coccidiostat, usedin the feed additives

Bioactivity: In vitro: Lasalocid sodium treatment led to an increase incell wall thickness, whilst the quantity and sugar compositionof the cell wall remained unchanged in BY-2 cells. Lasalocidsodium treatment enhances enzymatic saccharificationefficiency in both BY-2 cells and Arabidopsis plants. [1]

Bioactivity: Latrepirdine dihydrochloride is a neuroactive compound withantagonist activity at histaminergic, α-adrenergic, andserotonergic receptors. Latrepirdine stimulates amyloidprecursor protein (APP) catabolism and ( )amyloid-β Aβsecretion.

Bioactivity: Leonurine is an alkaloid isolated from , withHerba leonurianti-oxidative and anti-inflammatory.

Bioactivity: Leonurine hydrochloride is an alkaloid isolated from Herba, with anti-oxidative and anti-inflammatory.leonuri

Bioactivity: Letrozole is an inhibitor with an of 1-13aromatase IC50nM.

Bioactivity: Levobupivacaine hydrochloride is a local anaesthetic compoundbelonging to the amino amide group; long-acting localanesthetic.


Lanatoside C Cat. No.: HY-B1030

Lapatinib (GW572016) Cat. No.: HY-50898

Lapatinib ditosylate (GW-572016 ditosylate) Cat. No.: HY-50898A

Lasalocid (Antibiotic X-537A; Lasalocid-A; X-537A; Ionophore X-537A) Cat. No.: HY-B1071

Lasalocid sodium (Sodium lasalocid) Cat. No.: HY-B1071A

Latrepirdine dihydrochloride (Dimebolin dihydrochloride) Cat. No.: HY-14537

Leonurine (SCM-198) Cat. No.: HY-N0741

Leonurine hydrochloride (SCM-198 hydrochloride) Cat. No.: HY-N0741A

Letrozole (CGS 20267) Cat. No.: HY-14248

Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) Cat. No.: HY-B0653A

https://www.MedChemExpress.com/Lanatoside-C.html

https://www.MedChemExpress.com/Lapatinib.html

https://www.MedChemExpress.com/Lapatinib-ditosylate.html

https://www.MedChemExpress.com/Lasalocid.html

https://www.MedChemExpress.com/Lasalocid-sodium.html

https://www.MedChemExpress.com/Latrepirdine-dihydrochloride.html

https://www.MedChemExpress.com/Leonurine.html

https://www.MedChemExpress.com/Leonurine-hydrochloride.html

https://www.MedChemExpress.com/Letrozole.html

https://www.MedChemExpress.com/Levobupivacaine-hydrochloride.html



10 mg, 50 mg


100 mg, 500 mg


5 mg, 10 mg


200 mg, 500 mg


1 g, 5 g


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg, 250 mg, 1 g



5 mg, 10 mg, 50 mg, 100 mg


100 mg, 500 mg

Bioactivity: Levosimendan (OR1259) is a calcium sensitiser used in themanagement of acutely decompensated congestive heart failure.

Bioactivity: Licochalcone A, a flavonoid isolated from the famous Chinesemedicinal herb Glycyrrhiza uralensis Fisch, presents obviousanti-cancer effects. The IC50 value is 0.97 μM for UGT1A1.

Bioactivity: Ligustilide is an effective constituent extracted fromAngelica sinensis. IC50 value: Target: In vitro: Toinvestigate the neuroprotective of ligustilide (LIG) againstglutamate-induced apoptosis of PC12 cells, cell viability wereexamined by MTT assay. Pretreatment with ligustilide (1, 5, 15…

Bioactivity: Linagliptin is a highly potent, selective inhibitorDPP-4with of 1 nM.IC50

Bioactivity: Linifanib (ABT-869) is a multi-targeted inhibitor of andVEGF receptor family with s of 3, 4, 66, 4 nM for KDR,PDGFR IC50

Flt-1, PDGFRβ and FLT3, respectively.

Bioactivity: Lithocholic acid is a toxic secondary bile acid, causesintrahepatic cholestasis, has tumor-promoting activity.Target: Others Lithocholic acid has been used in a study toassess cholestasis and its action on several organs andtissues in rats. It has also been used in a study to…

Bioactivity: Lomustine (CCNU) is a agent, with antitumorDNA alkylatingactivity.

Bioactivity: Lonafarnib is an orally bioavailable farnesyl proteintransferase ( ) inhibitor for H-ras, K-ras and N-rasFPTasewith of 1.9 nM, 5.2 nM and 2.8 nM, respectively.IC50

Bioactivity: Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an agonist for the treatment of diarrhea.opioid receptor

Bioactivity: Losmapimod is a selective, potent, and orally active p38 inhibitor with s of 8.1 and 7.6 for p38α and p38β,MAPK pKi

respectively.

Levosimendan (OR1855; OR1259) Cat. No.: HY-14286

Licochalcone A (Licochalcone-A) Cat. No.: HY-N0372

Ligustilide Cat. No.: HY-N0401

Linagliptin (BI 1356) Cat. No.: HY-10284

Linifanib (ABT-869; AL-39324) Cat. No.: HY-50751

Lithocholic acid (3α-Hydroxy-5β-cholanic acid) Cat. No.: HY-B0172

Lomustine (CCNU; NSC 79037) Cat. No.: HY-13669

Lonafarnib (Sch66336) Cat. No.: HY-15136

Loperamide hydrochloride (R-18553 (hydrochloride)) Cat. No.: HY-B0418A

Losmapimod (GSK-AHAB; GW856553X; SB856553) Cat. No.: HY-10402

https://www.MedChemExpress.com/Levosimendan.html

https://www.MedChemExpress.com/Licochalcone-A.html

https://www.MedChemExpress.com/Ligustilide.html

https://www.MedChemExpress.com/Linagliptin.html

https://www.MedChemExpress.com/linifanib.html

https://www.MedChemExpress.com/Lithocholic-acid.html

https://www.MedChemExpress.com/Lomustine.html

https://www.MedChemExpress.com/Lonafarnib.html

https://www.MedChemExpress.com/Loperamide-hydrochloride.html

https://www.MedChemExpress.com/Losmapimod.html


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg


10 mg, 50 mg, 100 mg, 500 mg

Purity: 99.14%Clinical Data: Phase 2Size: 5 mg, 10 mg, 25 mg, 100 mg, 200 mg, 500 mg



1 mg, 5 mg, 10 mg, 20 mg

Bioactivity: Lucanthone is an endonuclease inhibitor of Apurinicendonuclease-1 ( ).APE-1

Bioactivity: Lumefantrine is an antimalarial drug, used in combination withArtemether. The artemether-lumefantrine (AL) as the first- andsecond-line anti-malarial drugs.

Bioactivity: Luminespib (NVP-AUY922) is a potent inhibitor withHSP90s of 7.8 and 21 nM for HSP90α and HSP90β, respectively.IC50

Bioactivity: Luteolin (Luteolol) is a falconoid compound, which exhibitsanticancer properties.

Bioactivity: LV-320 is a potent inhibitor with an of 24.5µM.ATG4B IC50 Bioactivity: LX2343 is a enzyme inhibitor with an value ofBACE1 IC5011.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3Kinhibitor with an of 15.99±3.23 μM. LX2343 stimulatesIC50

in its promotion of clearance.autophagy Aβ

Bioactivity: LY2109761 is an orally active, selective TGF-β receptor type inhibitor with s of 38 nM and 300 nM, respectively.I/II Ki

Bioactivity: LY294002 is a broad-spectrum inhibitor of with s ofPI3K IC500.5, 0.57, and 0.97 μM for , and , respectivelyPI3Kα PI3Kδ PI3Kβ

. LY294002 also inhibits with an of 98 nM .[1] CK2 IC50[2]

Bioactivity: LY3009120 is a pan inhibitor which inhibits BRAF ,RAF V600E

BRAF and CRAF with s of 5.8, 9.1 and 15 nM,WT WT IC50respectively.

Bioactivity: LY3023414 potently and selectively inhibits class I PI3Kisoforms, , and with s of 6.07 nM, 77.6DNA-PK mTORC1/2 IC50nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ,PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. LY3023414potently inhibits / at low nanomolar…mTORC1 2


Lucanthone Cat. No.: HY-B2098

Lumefantrine (Benflumetol) Cat. No.: HY-B0803

Luminespib (NVP-AUY922; AUY922; VER-52296) Cat. No.: HY-10215

Luteolin (Luteolol; Digitoflavone; Luteoline) Cat. No.: HY-N0162

LV-320 Cat. No.: HY-112711

LX2343 Cat. No.: HY-111383

LY2109761 Cat. No.: HY-12075

LY294002 (NSC 697286; SF 1101) Cat. No.: HY-10108

LY3009120 (DP-4978) Cat. No.: HY-12558

LY3023414 Cat. No.: HY-12513

https://www.MedChemExpress.com/Lucanthone.html

https://www.MedChemExpress.com/Lumefantrine.html

https://www.MedChemExpress.com/NVP-AUY922.html

https://www.MedChemExpress.com/Luteolin.html

https://www.MedChemExpress.com/LV-320.html

https://www.MedChemExpress.com/LX2343.html

https://www.MedChemExpress.com/LY2109761.html






1 g, 5 g


1 g, 5 g


100 mg, 500 mg


100 mg, 200 mg, 500 mg


100 mg, 500 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg


Bioactivity: Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50of 1.2μM in Hey1B cell. IC50: 1.2μM (Hey1B cell)[2] Invitro:Lycorine (hydrochloride) executed an anti-melanomavasculogenic effect by inhibiting VE-cadherin gene expressionin C8161 cells and caused a decrease in cell surface exposure…

Bioactivity: LYN-1604 is a potent UNC-51-like kinase 1 ( ) agonistULK1with an of 18.94 nM.EC50

Bioactivity: LYN-1604 hydrochloride is a potent activator with anULK1 of 18.94 nM.EC50

Bioactivity: Lys01 trihydrochloride (Lys05) is a novel lysosomal inhibitor with values of 3.6, 3.8, 6 and 7.9autophagy IC50

μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTTassay.

Bioactivity: Magnolol, a natural lignan isolated from the stem bark of, is a dual agonist of both andMagnolia officinalis RXRα

, with values of 10.4 µM and 17.7 µM,PPARγ EC50respectively.

Bioactivity: Maprotiline HCl is a selective noradrenalin re-uptakeinhibitor and a tetracyclic antidepressant. Target: OthersMaprotiline (sold as Deprilept, Ludiomil, Psymion) is atetracyclic antidepressant (TeCA). However, Maprotiline'sfourth ring is spurious, as formed by a bridge across the…

Bioactivity: Matrine (Matridin-15-one) is an alkaloid found in plants fromthe Sophora genus. It has a variety of pharmacologicaleffects, including anti-cancer effects, and action as a kappaopioid receptor and u-receptor agonist.

Bioactivity: Mefloquine hydrochloride is a quinoline antimalarial drug thatis structurally related to the antiarrhythmic agent quinidine.IC50 Value: 1 microM ( for K+ channel) [1] Target:Antiparasitic Mefloquine is widely used in both the treatmentand prophylaxis of Plasmodium falciparum malaria. MQ can…

Bioactivity: Megestrol Acetate is a synthetic progesteronal agent with anIC50 of 260 μM for the inhibition of HegG2. Target:Progesterone Receptor Megestrol acetate, also known as17α-acetoxy-6-dehydro-6-methylprogesterone, and sometimesabbreviated as MGA or MA, is a steroidal progestin and…

Bioactivity: Melatonin is a hormone made by the pineal gland that canactivates . Melatonin plays a role inmelatonin receptorsleep and possesses important antioxidative andanti-inflammatory properties.

Lycorine hydrochloride Cat. No.: HY-N0289

LYN-1604 (LYN1604; LYN 1604) Cat. No.: HY-101923

LYN-1604 hydrochloride Cat. No.: HY-101923A

Lys01 trihydrochloride (Lys05) Cat. No.: HY-12855A

Magnolol Cat. No.: HY-N0163

Maprotiline hydrochloride Cat. No.: HY-B0444

Matrine (Matridin-15-one; Vegard; α-Matrine) Cat. No.: HY-N0164

Mefloquine hydrochloride (Mefloquin hydrochloride) Cat. No.: HY-17437A

Megestrol Acetate Cat. No.: HY-13676

Melatonin (N-Acetyl-5-methoxytryptamine) Cat. No.: HY-B0075

https://www.MedChemExpress.com/Lycorine-hydrochloride.html

https://www.MedChemExpress.com/LYN-1604.html

https://www.MedChemExpress.com/LYN-1604_hydrochloride.html

https://www.MedChemExpress.com/Lys01__trihydrochloride_.html

https://www.MedChemExpress.com/Magnolol.html

https://www.MedChemExpress.com/maprotiline-hydrochloride.html

https://www.MedChemExpress.com/Matrine.html

https://www.MedChemExpress.com/mefloquine-hydrochloride.html

https://www.MedChemExpress.com/Megestrol-Acetate.html

https://www.MedChemExpress.com/Melatonin.html


100 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg



10 mg, 50 mg


500 mg


100 mg, 500 mg


10 g, 50 g

Purity: 99.36%Clinical Data: LaunchedSize: 10 mg, 100 mg


1 g, 5 g


100 mg, 500 mg

Bioactivity: Meloxicam is a non-steroidal antiinflammatory agent, inhibits activity, with s of 0.49 µM and 36.6 µM for COX-2 andCOX IC50

COX-1, respectively.

Bioactivity: Memantine (hydrochloride) (D-145 (hydrochloride)), anamantadine derivative with low to moderate-affinity for NMDAreceptors, inhibit CYP2B6 and CYP2D6 with K of 0.51 nM andi94.9 μM, respectively.

Bioactivity: Meprednisone is a glucocorticoid and a methylated derivativeof prednisone. Target: Glucocorticoid Receptor Meprednisone isa glucocorticoid and a methylated derivative of prednisone.The methylprednisone to MPL area under the curve ratiodecreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in…

Bioactivity: Metformin (hydrochloride) is an FDA approved first-line drugfor the treatment of type 2 diabetes. Metformin decreaseshepatic glucose production, mostly through a mild andtransient inhibition of the mitochondrial respiratory-chaincomplex 1.

Bioactivity: Methylprednisolone is a synthetic corticosteroid withanti-inflammatory and immunomodulating properties. Target:Glucocorticoid Receptor Methylprednisolone is typically usedfor its anti-inflammatory effects. Common uses includearthritis therapy and short-term treatment of bronchial…

Bioactivity: Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1hydroxylase activity and CYP11B1. Target: CYP11B1 Metyraponeis a drug used in the diagnosis of adrenal insufficiency andoccasionally in the treatment of Cushing's syndrome(hypercortisolism). Metyrapone blocks cortisol synthesis by…

Bioactivity: Mevastatin (Compactin; ML236B) inhibits HMGCR (HMG-CoAreductase) (Ki for acid form is 1 nM) which in turn inhibitsisoprenoid biosynthesis and therefore blocks proteinisoprenylation and reduces plasma cholesterol levels inhumans. IC50 value: 1 nM (Ki) Target: HMGCR Mevastatin induces…

Bioactivity: MG-132 is a potent, reversible, and cell-permeable 20S inhibitor which inhibits proteasomalproteasome

chymotrypsin-like peptidase activity with an of 24.2 nM.IC50

Bioactivity: MHY1485 is a cell-permeable activator. MHY1485 has anmTORinhibitory effect on the autophagic process by inhibition offusion between autophagosomes and lysosomes.

Bioactivity: Mifepristone is a ( ) andprogesterone receptor PR ( ) antagonist with s of 0.2 nMglucocorticoid receptor GR IC50

and 2.6 nM in assay.in vitro


Meloxicam Cat. No.: HY-B0261

Memantine hydrochloride (D-145 (hydrochloride)) Cat. No.: HY-B0365A

Meprednisone Cat. No.: HY-B0243

Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) Cat. No.: HY-17471A

Methylprednisolone (U 7532) Cat. No.: HY-B0260

Metyrapone (Su-4885) Cat. No.: HY-B1232

Mevastatin (Compactin; ML236B) Cat. No.: HY-17408

MG-132 Cat. No.: HY-13259

MHY1485 Cat. No.: HY-B0795

Mifepristone (RU486; RU 38486) Cat. No.: HY-13683

https://www.MedChemExpress.com/meloxicam.html

https://www.MedChemExpress.com/Memantine-hydrochloride.html

https://www.MedChemExpress.com/meprednisone.html

https://www.MedChemExpress.com/Metformin-hydrochloride.html

https://www.MedChemExpress.com/methylprednisolone.html

https://www.MedChemExpress.com/Metyrapone.html

https://www.MedChemExpress.com/mevastatin.html

https://www.MedChemExpress.com/MG-132.html

https://www.MedChemExpress.com/MHY1485.html

https://www.MedChemExpress.com/Mifepristone.html



5 mg, 10 mg, 50 mg, 100 mg


50 mg, 100 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: Phase 3Size: 5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: Milciclib (PHA-848125) is a potent, dual inhibitor of andCDK, with s of 45, 150,Tropomyosin receptor kinase (TRK) IC50

160, 363, 398 nM and 53 nM for cyclin A/CDK2, cyclin H/CDK7,cyclin D1/CDK4, cyclin E/CDK2, cyclin B/CDK1 and TRKA,respectively.

Bioactivity: Mitomycin C is an antitumor drug and antibiotic that showsextraordinary ability to inhibit . Mitomycin C isDNA synthesisa DNA cross-linking agent, which induces DNA damaging.

Bioactivity: MK 2206 dihydrochloride is an orally active allosteric Aktinhibitor with s of 5, 12 and 65 nM for , andIC50 Akt1 Akt2

, respectively.Akt3

Bioactivity: MK-5108 is a highly potent and specific inhibitor of Aurora A with an value of 0.064 nM.kinase IC50

Bioactivity: Mocetinostat (MGCD0103) is a potent, orally active andisotype-selective inhibitor with s ofHDAC (Class I/IV) IC500.15, 0.29, 1.66 and 0.59 μM for , , andHDAC1 HDAC2 HDAC3

, respectively. Mocetinostat shows no inhibition onHDAC11HDAC4, HDAC5, HDAC6, HDAC7, or HDAC8.

Bioactivity: Momelotinib (CYT387) is an ATP-competitive inhibitor of with a of 11 nM and 18 nM,respectively. CYT387JAK1/JAK2 IC50

shows much less activity against JAK3.

Bioactivity: Momelotinib Mesylate (CYT387 Mesylate) is an ATP-competitiveinhibitor of with of 11 nM/18 nM, appr 10-foldJAK1/JAK2 IC50selectivity versus JAK3.

Bioactivity: Momelotinib sulfate (CYT387 sulfate) is an ATP-competitiveinhibitor of with of 11 nM/18 nM, 10-foldJAK1/JAK2 IC50selectivity versus JAK3 (IC =155 nM).50

Bioactivity: Montelukast (sodium) (MK0476) is a potent, selective CysLT1receptor antagonist.

Bioactivity: MRT67307 is a dual inhibitor of the and with sIKKε TBK-1 IC50of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1and ULK2 with IC s of 45 and 38 nM, respectively.50

Milciclib (PHA-848125) Cat. No.: HY-10424

Mitomycin C (Ametycine) Cat. No.: HY-13316

MK 2206 dihydrochloride Cat. No.: HY-10358

MK-5108 (VX-689) Cat. No.: HY-13252

Mocetinostat (MGCD0103) Cat. No.: HY-12164

Momelotinib (CYT387) Cat. No.: HY-10961

Momelotinib Mesylate (CYT387 (Mesylate)) Cat. No.: HY-10963

Momelotinib sulfate (CYT387 (sulfate salt)) Cat. No.: HY-10962

Montelukast sodium (MK0476) Cat. No.: HY-13315

MRT67307 Cat. No.: HY-13018

https://www.MedChemExpress.com/PHA-848125.html

https://www.MedChemExpress.com/Mitomycin-C.html

https://www.MedChemExpress.com/MK-2206-dihydrochloride.html

https://www.MedChemExpress.com/MK-5108.html

https://www.MedChemExpress.com/Mocetinostat.html

https://www.MedChemExpress.com/CYT387.html

https://www.MedChemExpress.com/CYT387-Mesylate.html

https://www.MedChemExpress.com/CYT387-sulfate-salt.html

https://www.MedChemExpress.com/Montelukast-sodium.html

https://www.MedChemExpress.com/MRT67307.html


100 mg, 200 mg, 500 mg


1 g, 5 g, 10 g


1 g, 5 g


1 g, 5 g


5 mg, 10 mg, 25 mg, 50 mg


10 mg, 50 mg, 100 mg


200 mg, 10 g


5 g, 10 g


5 g, 10 g


50 mg, 100 mg, 200 mg, 500 mg

Bioactivity: Myricetin is a common plant-derived flavonoid with a widerange of activities including strong anti-oxidant, anticancer,antidiabetic and anti-inflammatory activities.

Bioactivity: Naproxen is a and inhibitor with s of 8.72COX-1 COX-2 IC50and 5.15 μM, respectively in cell assay.

Bioactivity: Naproxen sodium is a and inhibitor with s ofCOX-1 COX-2 IC508.72 and 5.15 μM, respectively in cell assay.

Bioactivity: Naringin is a major flavanone glycoside obtained fromtomatoes, grapefruits, and many other citrus fruits. Naringinexhibits biological properties such as antioxidant,anti-inflammatory, and antiapoptotic activities.

Bioactivity: Necrostatin-1 (Nec-1) is a potent, selective andcell-permeable inhibitor with an of 490 nMnecroptosis EC50in Jurkat cells. It acts by inhibiting the death domain kinaseRIP ( ) in the necroptosis pathway.RIP1

Bioactivity: Neferine is a major bisbenzylisoquinline alkaloid. Neferinestrongly inhibits activation.NF-κB

Bioactivity: Niacin (Vitamin B3) is a water-soluble vitamin and is part ofthe vitamin B group. Target: Others Niacin (also known asvitamin B3 and nicotinic acid) is an organic compound with theformula C6H5NO2 and, depending on the definition used, one ofthe 20 to 80 essential human nutrients. Not enough niacin in…

Bioactivity: Nicardipine Hydrochloride (YC-93 Hydrochloride) is a calciumchannel blocker that has been widely used to control bloodpressure in severe hypertension following events such asischemic stroke, traumatic brain injury, and intracerebralhemorrhage.

Bioactivity: Nifedipine (BAY-a-1040) is a potent blockercalcium channeland drug of choice for cardiac insufficiencies.

Bioactivity: Nilotinib is an orally available tyrosine kinaseBcr-Ablinhibitor with antineoplastic activity.


Myricetin (Cannabiscetin) Cat. No.: HY-15097

Naproxen ((S)-Naproxen) Cat. No.: HY-15030

Naproxen sodium Cat. No.: HY-15030A

Naringin (Naringoside) Cat. No.: HY-N0153

Necrostatin-1 (Nec-1) Cat. No.: HY-15760

Neferine ((-)-Neferine) Cat. No.: HY-N0441

Niacin (Nicotinic acid; Vitamin B3) Cat. No.: HY-B0143

Nicardipine Hydrochloride (YC-93 Hydrochloride) Cat. No.: HY-12515A

Nifedipine (BAY-a-1040) Cat. No.: HY-B0284

Nilotinib (AMN107) Cat. No.: HY-10159

https://www.MedChemExpress.com/Myricetin.html

https://www.MedChemExpress.com/Naproxen.html

https://www.MedChemExpress.com/Naproxen-sodium.html

https://www.MedChemExpress.com/Naringin.html

https://www.MedChemExpress.com/Necrostatin-1.html

https://www.MedChemExpress.com/Neferine.html

https://www.MedChemExpress.com/Niacin.html

https://www.MedChemExpress.com/Nicardipine-Hydrochloride.html

https://www.MedChemExpress.com/Nifedipine.html

https://www.MedChemExpress.com/Nilotinib.html




100 mg, 500 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


1 g

Purity: >98%Clinical Data: LaunchedSize: 10mM x 1mL in DMSO,

10 g


50 mg, 100 mg, 200 mg, 500 mg, 1 g


10 mg, 50 mg, 100 mg


100 mg, 500 mg


100 mg, 200 mg, 500 mg

Bioactivity: Nilotinib monohydrochloride monohydrate is a second generationtyrosine kinase inhibitor (TKI), is significantly more potentagainst than Imatinib, and is active against manyBCR-ABLImatinib-resistant BCR-ABL mutants.

Bioactivity: Nimodipine(Nimotop) is a dihydropyridine derivative and ananalogue of the calcium channel blocker nifedipine, withantihypertensive activity.Nimodipine decreases intracellularfree Ca2+,Beclin-1 and autophagy. Target: Calcium ChannelNimodipine is main use is in the prevention of cerebral…

Bioactivity: Nitazoxanide is a synthetic nitrothiazolyl-salicylamidederivative and an antiprotozoal agent. (IC50 for canineinfluenza virus ranges from 0.17 to 0.21 μM). Target: OthersNitazoxanide is a synthetic nitrothiazolyl-salicylamidederivative and an antiprotozoal agent. In vitro studies…

Bioactivity: Nitrendipine is a calcium channel blocker with markedvasodilator action. Target: Calcium Channel Nitrendipine is adihydropyridine calcium channel blocker. It is used in thetreatment of primary hypertension to decrease blood pressure.Nitrendipine blocked Ca2+ currents very potently, with…

Bioactivity: Nitroprusside disodium dihydrate is a potent vasodilatorworking through releasing NO spontaneously in blood. Target:Others Nitroprusside disodium dihydrate is a potentvasodilator. Sodium nitroprusside has potent vasodilatingeffects in arterioles and venules. Sodium Nitroprusside breaks…

Bioactivity: Nitroxoline is an antibiotic that has proven to be veryeffective at combating biofilm infections. Nitroxolinefunctions by chelating Fe2+ and Zn2+ ions from the biofilmmatrix.

Bioactivity: Nobiletin is a citrus flavonoid with anti-inflammatory,anti-cancer, cholesterol lowering, memory protectionactivities.

Bioactivity: Nocodazole is a rapidly-reversible inhibitor of. Nocodazole binds to β-tubulin and disruptsmicrotubule

microtubule assembly/disassembly dynamics, which preventsmitosis and induces apoptosis in tumor cells. Nocodazoleinhibits , activates .Bcr-Abl CRISPR/Cas9

Bioactivity: Nordihydroguaiaretic acid is a ( ) (5-lipoxygenase 5LOX=8±3 μM) and tyrosine kinase inhibitor.IC50

Bioactivity: Norepinephrine (Levarterenol; L-Noradrenaline) is a-selective agonist with of 5.37β1 adrenergic receptor EC50

μM.

Nilotinib monohydrochloride monohydrate (AMN107 (monohydrochloride monohydrate)) Cat. No.: HY-10159A

Nimodipine (BAY-e 9736) Cat. No.: HY-B0265

Nitazoxanide (NTZ; NSC 697855) Cat. No.: HY-B0217

Nitrendipine (BAY-E-5009) Cat. No.: HY-B0424

Nitroprusside disodium dihydrate (Sodium nitroprusside

dihydrate; Sodium Nitroferricyanide(III) Dihydrate) Cat. No.: HY-A0119

Nitroxoline (8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol) Cat. No.: HY-B1159

Nobiletin Cat. No.: HY-N0155

Nocodazole (Oncodazole; R17934) Cat. No.: HY-13520

Nordihydroguaiaretic acid (NDGA) Cat. No.: HY-N0198

Norepinephrine (Levarterenol; L-Noradrenaline) Cat. No.: HY-13715

https://www.MedChemExpress.com/Nilotinib-monohydrochloride-monohydrate.html

https://www.MedChemExpress.com/Nimodipine.html

https://www.MedChemExpress.com/nitazoxanide.html

https://www.MedChemExpress.com/Nitrendipine.html

https://www.MedChemExpress.com/Nitroprusside-disodium-dihydrate.html

https://www.MedChemExpress.com/Nitroxoline.html

https://www.MedChemExpress.com/Nobiletin.html

https://www.MedChemExpress.com/Nocodazole.html

https://www.MedChemExpress.com/nordihydroguaiaretic-acid.html

https://www.MedChemExpress.com/Norepinephrine.html


5 mg, 10 mg, 50 mg, 100 mg


2 mg, 5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg

Purity: >98%Clinical Data: No Development ReportedSize: 10mM x 1mL in DMSO,

5 mg, 10 mg


10 mg, 50 mg, 100 mg


100 mg, 500 mg


100 mg


50 mg

Purity: >98%Clinical Data: LaunchedSize: 500 mg, 1 g, 5 g


500 mg, 1 g, 5 g

Bioactivity: Norepinephrine bitartrate monohydrate (Levarterenol bitartratemonohydrate; L-Noradrenaline bitartrate monohydrate) is a

-selective agonist with of 5.37β1 adrenergic receptor EC50μM.

Bioactivity: Norepinephrine hydrochloride (Levarterenol hydrochloride;L-Noradrenaline hydrochloride) is a -selective β1 adrenergic

agonist with of 5.37 μM.receptor EC50

Bioactivity: Nortriptyline hydrochloride is a tricyclic antidepressant usedto relieve the symptoms of depression.

Bioactivity: Noscapine is an orally administrable drug used worldwide forcough suppression, primarily mediated by its σ-receptoragonist activity, and possess anticancer activity. Target:σ-receptor in vitro: Noscapine is a phthalideisoquinolinealkaloid from opium, is a recently discovered anticancer drug…

Bioactivity: Novobiocin Sodium is an antibiotic compound derived fromStreptomyces niveus. Target: Antibacterial Novobiocin, alsoknown as albamycin or cathomycin, is an aminocoumarinantibiotic that is produced by the actinomycete Streptomycesniveus, which has recently been identified as a subjective…

Bioactivity: NS1643 is a potent human ether-a-go-go related gene (hERG)KV11.1 channel activator (EC50 = 10.5 μM). IC50 value: Target:HERG activator in vitro: NS1643 enhanced the magnitude ofwild-type hERG current in a concentration- andvoltage-dependent manner with an EC(50) of 10.4 microM at -10…

Bioactivity: NSC 185058 is an inhibitor of , a major ATG4B cysteine. NSC185058 markedly attenuates activityprotease autophagic

.[1]

Bioactivity: Nutlin 3a is an active enantiomer of Nutlin-3, acts as amurine double minute ( ) antagonist that inhibitsMDM2

interactions and stabilizes the p53 protein, andMDM2-p53thereby induces cell cycle arrest and apoptosis.

Bioactivity: NVP-AEW541 is a potent inhibitor of with of 0.15IGF-1R IC50μM, also inhibits , with of 0.14 μM.InsR IC50

Bioactivity: Obatoclax is an inhibitor of the family proteins. ItBCL-2binds to with a of 220 nM.BCL-2 Ki


Norepinephrine bitartrate monohydrate (Levarterenol

(bitartrate monohydrate); …) Cat. No.: HY-13715B

Norepinephrine hydrochloride (Levarterenol (hydrochloride);

L-Noradrenaline (hydrochloride)) Cat. No.: HY-13715A

Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) Cat. No.: HY-B1417

Noscapine ((S,R)-Noscapine) Cat. No.: HY-13716

Novobiocin Sodium (Albamycin; Cathomycin) Cat. No.: HY-B0425A

NS1643 Cat. No.: HY-16916

NSC 185058 Cat. No.: HY-125169

Nutlin 3a (Nutlin-3a chiral) Cat. No.: HY-10029

NVP-AEW541 (AEW541) Cat. No.: HY-50866

Obatoclax (Obatoclax Mesylate; GX15-070) Cat. No.: HY-10969

https://www.MedChemExpress.com/Norepinephrine-bitartrate-monohydrate.html

https://www.MedChemExpress.com/Norepinephrine-hydrochloride.html

https://www.MedChemExpress.com/Nortriptyline-hydrochloride.html

https://www.MedChemExpress.com/Noscapine.html

https://www.MedChemExpress.com/novobiocin-sodium.html

https://www.MedChemExpress.com/NS1643.html

https://www.MedChemExpress.com/NSC_185058.html

https://www.MedChemExpress.com/Nutlin-3a.html

https://www.MedChemExpress.com/NVP-AEW541.html

https://www.MedChemExpress.com/Obatoclax.html




100 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg


100 mg, 500 mg


100 mg, 500 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 2 g


50 mg, 100 mg, 500 mg

Bioactivity: Olanzapine(LY170053) is a high affinity for 5-HT2 serotoninand D2 dopamine receptor antagonist. IC50 Value: Target: 5-HTReceptor Olanzapine is a thienobenzodiazepine that blocksespecially the serontonin (5-hydroxytryptamine [5-HT]) 5-HT2Aand the dopamine D2 receptors (Ki values are 4 and 11 nM…

Bioactivity: Olaparib (AZD2281;KU0059436) is a potent and oral PARPinhibitor with s of 5 and 1 nM for and ,IC50 PARP1 PARP2

respectively.

Bioactivity: Oleanolic acid (Caryophyllin) is a natural compound fromplants with anti-tumor activities.

Bioactivity: Omeprazole (H 16868) is a proton pump inhibitor used in thetreatment of dyspepsia.

Bioactivity: Omipalisib (GSK2126458) is a highly selective and potentinhibitor of with s of 0.019 nM/0.13 nM/0.024 nM/0.06 nMPI3K Kiand 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.

Bioactivity: Oprozomib (ONX 0912; PR047) is an orally bioavailableinhibitor for CT-L activity of 20S proteasome β5/LMP7 withIC50 of 36 nM/82 nM. IC50 value: 36 nM/82 nM(20S proteasomeβ5/LMP7) [1] Target: 20S proteasome The anti-MM activity ofOprozomib is associated with activation of caspase-8,…

Bioactivity: Oroxylin A is a natural active flavonoid with stronganticancer effects. IC50 value: Target: In vitro: Oroxylin Asuppressed the MDM2-mediated degradation of p53 viadownregulating MDM2 transcription in wt-p53 cancer cells [1].Oroxylin A remarkably reduced the generation of lactate and…

Bioactivity: OSI-027 is an ATP-competitive kinase activitymTORinhibitor with an of 4 nM. OSI-027 targets both IC50 mTORC1

and with s of 22 nM and 65 nM, respectively.mTORC2 IC50

Bioactivity: Ouabain Octahydrate is an inhibitor of , usedNa /K -ATPase+ +

for the treatment of congestive heart failure.Bioactivity: Oxaliplatin is a inhibitor. It causes DNADNA synthesis

crosslinking damage, prevents DNA replication andtranscription and causes cell death.

Olanzapine (LY170053) Cat. No.: HY-14541

Olaparib (AZD2281; KU0059436) Cat. No.: HY-10162

Oleanolic Acid (Oleanic acid; Caryophyllin) Cat. No.: HY-N0156

Omeprazole (H 16868) Cat. No.: HY-B0113

Omipalisib (GSK2126458; GSK458) Cat. No.: HY-10297

Oprozomib (ONX 0912; PR-047) Cat. No.: HY-12113

Oroxylin A (Baicalein 6-methyl ether; 6-Methoxybaicalein) Cat. No.: HY-N0560

OSI-027 Cat. No.: HY-10423

Ouabain Octahydrate (Acocantherine; G-Strophanthin) Cat. No.: HY-B0542

Oxaliplatin Cat. No.: HY-17371

https://www.MedChemExpress.com/Olanzapine.html

https://www.MedChemExpress.com/Olaparib.html

https://www.MedChemExpress.com/Oleanolic-Acid.html

https://www.MedChemExpress.com/Omeprazole.html


https://www.MedChemExpress.com/Oprozomib.html

https://www.MedChemExpress.com/Oroxylin-A.html

https://www.MedChemExpress.com/OSI-027.html

https://www.MedChemExpress.com/Ouabain-Octahydrate.html

https://www.MedChemExpress.com/Oxaliplatin.html


50 mg, 100 mg, 200 mg



100 mg, 500 mg


100 mg, 500 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


50 mg, 100 mg, 500 mg


10 mg, 50 mg


50 mg, 100 mg, 500 mg, 1 g


10 mg, 50 mg, 100 mg


50 mg, 100 mg, 200 mg, 500 mg, 1 g

Bioactivity: Oxidopamine (hydrobromide), an antagonist of the, is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons.

Bioactivity: Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is usedto be a laxative.

Bioactivity: Oxyresveratrol is neuroprotective and inhibits the apoptoticcell death in transient cerebral ischemia. It effectivelyscavenges H2O2, NO (IC50 = 45.3 μM), and the artificial freeradical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) Invitro: 1)oxyresveratrol exhibited more than 50% inhibition at…

Bioactivity: PAC-1 is an activator of induces apoptosis inprocaspase-3cancer cells with of 2.08 μM.EC50

Bioactivity: Paclitaxel (Taxol), a naturally occurring antineoplasticagent, stabilizes , resulting intubulin polymerizationarrest at the G2/M phase of the cell cycle and apoptotic celldeath .[1] [2]

Bioactivity: Panobinostat is a non-selective histone deacetylase ( )HDACinhibitor.

Bioactivity: Pantoprazole sodium salt(SKF96022; Protonix) is a proton pumpinhibitor drug used for short-term treatment of erosion andulceration of the esophagus caused by gastroesophageal refluxdisease. IC50 value: Target: proton pump inhibitor

Bioactivity: Paroxetine hydrochloride is a potent selective inhibitor, commonly prescribed as anserotonin-reuptake

antidepressant and has GRK2 inhibitory ability with ofIC5014μM.

Bioactivity: Paroxetine hydrochloride hemihydrate is a potent selective inhibitor, commonly prescribed as anserotonin-reuptake

antidepressant and has GRK2 inhibitory ability with ofIC5014μM.

Bioactivity: Parthenolide is a sesquiterpene lactone found in the medicinalherb Feverfew. Parthenolide exhibits anti-inflammatoryactivity by inhibiting activation; also inhibits NF-κB HDAC1protein without affecting other class I/II HDACs.


Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide)Cat. No.: HY-B1081A

Oxyphenisatin acetate Cat. No.: HY-101714

Oxyresveratrol (trans-Oxyresveratrol) Cat. No.: HY-N1430

PAC-1 (Procaspase activating compound 1) Cat. No.: HY-13523

Paclitaxel (Taxol) Cat. No.: HY-B0015

Panobinostat (LBH589; NVP-LBH589) Cat. No.: HY-10224

Pantoprazole sodium (BY1023 (sodium); SKF96022 (sodium)) Cat. No.: HY-17507A

Paroxetine hydrochloride (BRL29060 hydrochloride; BRL29060A) Cat. No.: HY-B0492

Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride

hemihydrate; BRL29060A hemihydrate) Cat. No.: HY-B0492A

Parthenolide ((-)-Parthenolide) Cat. No.: HY-N0141

https://www.MedChemExpress.com/Oxidopamine-hydrobromide.html

https://www.MedChemExpress.com/Oxyphenisatin_acetate.html

https://www.MedChemExpress.com/Oxyresveratrol.html

https://www.MedChemExpress.com/PAC-1.html

https://www.MedChemExpress.com/Paclitaxel.html

https://www.MedChemExpress.com/Panobinostat.html

https://www.MedChemExpress.com/Pantoprazole-sodium.html

https://www.MedChemExpress.com/Paroxetine-hydrochloride.html

https://www.MedChemExpress.com/Paroxetine-hydrochloride-hemihydrate.html

https://www.MedChemExpress.com/Parthenolide.html



50 mg, 100 mg


5 mg, 10 mg


10 mg, 50 mg, 100 mg


2 mg, 5 mg, 10 mg, 25 mg, 50 mg

Purity: 99.0%Clinical Data: No Development ReportedSize: 5 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


10 mg, 50 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Bioactivity: Pazopanib (GW786034) is a novel multi-target inhibitor of, , , , , , and VEGFR1 VEGFR2 VEGFR3 PDGFRβ c-Kit FGFR1 c-Fms

with s of 10, 30, 47, 84, 74, 140 and 146 nM,IC50respectively.

Bioactivity: Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novelmulti-target inhibitor of , , , ,VEGFR1 VEGFR2 VEGFR3 PDGFRβ

, , and with an of 10, 30, 47, 84, 74,c-Kit FGFR1 c-Fms IC50140 and 146 nM, respectively.

Bioactivity: PD 169316 is a potent, cell-permeable and selective p38 MAP inhibitor, with of 89 nM.kinase IC50

Bioactivity: PD166866 is a selective tyrosine kinase inhibitor withFGFR1an of 52.4 nM.IC50

Bioactivity: PD0325901 is a selective and cell permeable inhibitorMEKwith an of 0.33 nM.IC50

Bioactivity: PD146176 (NSC168807) is a inhibitor,15-Lipoxygenase (15-LO)which inhibits rabbit reticulocyte 15-LO with a of 197 nM.KiPD146176 (NSC168807) has a dramatic effect in reducingatherogenesis .[1]

Bioactivity: PD168393 is an potent, cell-permeable, irreversible EGFRinhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773,inactive against insulin, PDGFR, FGFR and PKC. target: EGFR IC50: 0.7 nM [1] (1) PD 168393 inhibite EGFr autophosphorylationin A431 human epidermoid carcinoma cells with >9-fold…

Bioactivity: PD98059 is a potent, selective and cell-permeable andMEK1 inhibitor with s of 4 μM and 50 μM respectively.MEK2 IC50

Bioactivity: Peiminine(Verticinone; Raddeanine) is a natural compound withanti-inflammatory activity. IC50 value: Target: Peiminine andDXS significantly reduced alveolar inflammation and pulmonaryinterstitial inflammation in rats with bleomycin-induced lunginjury. peiminine inhibits lung inflammation and pulmonary…

Bioactivity: Pemetrexed is a novel , the values of theantifolate Kipentaglutamate of LY231514 are 1.3, 7.2, and 65 nM forinhibits thymidylate synthase ( ), dihydrofolate reductaseTS( ), and glycinamide ribonucleotide formyltransferase (DHFR

), respectively.GARFT

Pazopanib (GW786034) Cat. No.: HY-10208

Pazopanib Hydrochloride (GW786034 (Hydrochloride)) Cat. No.: HY-12009

PD 169316 Cat. No.: HY-10578

PD-166866 Cat. No.: HY-101296

PD0325901 (PD325901) Cat. No.: HY-10254

PD146176 (NSC168807) Cat. No.: HY-103157

PD168393 Cat. No.: HY-13896

PD98059 Cat. No.: HY-12028

Peiminine (Verticinone; Raddeanine) Cat. No.: HY-N0213

Pemetrexed (LY231514) Cat. No.: HY-10820

https://www.MedChemExpress.com/Pazopanib.html

https://www.MedChemExpress.com/Pazopanib-Hydrochloride.html

https://www.MedChemExpress.com/pd-169316.html

https://www.MedChemExpress.com/PD166866.html


https://www.MedChemExpress.com/pd146176.html



https://www.MedChemExpress.com/Peiminine.html

https://www.MedChemExpress.com/pemetrexed.html


5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg



1 g


50 mg, 100 mg


100 mg, 500 mg


50 mg, 100 mg, 200 mg

Bioactivity: Pemetrexed disodium is a novel that inhibits theantifolatefolatedependent enzymes , thymidylate synthase dihydrofolate

, and reductase glycinamide ribonucleotide with s of 1.3, 7.2, and 65 nM,formyltransferase Ki

respectively.

Bioactivity: Pemetrexed disodium hemipenta hydrate is a novel ,antifolatethe values of the pentaglutamate of LY231514 are 1.3, 7.2,Kiand 65 nM for inhibits thymidylate synthase ( ),TSdihydrofolate reductase ( ), and glycinamideDHFRribonucleotide formyltransferase ( ), respectively.GARFT

Bioactivity: Penfluridol is a highly potent, first generationdiphenylbutylpiperidine antipsychotic.

Bioactivity: Pentoxifylline is a competitive nonselective phosphodiesteraseinhibitor. Target: PDE Pentoxifylline is a competitivenonselective phosphodiesterase inhibitor which raisesintracellular cAMP, activates PKA, inhibits TNF andleukotriene synthesis, and reduces inflammation and innate…

Bioactivity: Pepstatin is a specific inhibitor producedaspartic proteaseby actinomycetes, with s of 4.5 nM, 6.2 nM, 150 nM, 290IC50nM, 520 nM and 260 nM for hemoglobin-pepsin,hemoglobin-proctase, casein-pepsin, casein-proctase,casein-acid protease and hemoglobin-acid protease,…

Bioactivity: Perifosine is an oral inhibitor which inhibitsAktproliferation of different tumor cell lines with s ofIC500.6-8.9 μM.

Bioactivity: PF-04691502 is a potent and selective inhibitor of andPI3K. PF-04691502 binds to human PI3Kα, β, δ, γ and mTORmTOR

with s of 1.8, 2.1, 1.6, 1.9 and 16 nM, respectively.Ki

Bioactivity: PF-4708671 is a potent cell-permeable inhibitor with aS6K1 of 20 nM and of 160 nM.Ki IC50

Bioactivity: PFI-1 is a selective (bromodomain-containing protein)BETinhibitor for BRD4 with of 0.22 μM in a cell-free assay.IC50

Bioactivity: PFK-015 is an effective inhibitor of PFKFB3 with IC50 of 110nM (recombinant PFKFB3) and inhibits PFKFB3 activity in cancercells with IC50 of 20 nM. IC50 value: 110 nM (recombinantPFKFB3)[1] Target: PFKFB3 PFK-015 possesses compelling invitro properties, has satisfactory PK properties in rodents,…


Pemetrexed disodium (LY231514 disodium) Cat. No.: HY-10820A

Pemetrexed disodium hemipenta hydrate (LY231514 (disodium hemipenta hydrate)) Cat. No.: HY-13781

Penfluridol (R-16341) Cat. No.: HY-B1077

Pentoxifylline (BL-191; PTX; Oxpentifylline) Cat. No.: HY-B0715

Pepstatin (Pepstatin A) Cat. No.: HY-P0018

Perifosine (KRX-0401; NSC 639966; D21266) Cat. No.: HY-50909

PF-04691502 Cat. No.: HY-15177

PF-4708671 Cat. No.: HY-15773

PFI-1 Cat. No.: HY-16586

PFK-015 Cat. No.: HY-12204

https://www.MedChemExpress.com/Pemetrexed-disodium.html

https://www.MedChemExpress.com/Pemetrexed-disodium-hemipenta-hydrate_-1:2:2.5.html

https://www.MedChemExpress.com/Penfluridol.html

https://www.MedChemExpress.com/Pentoxifylline.html

https://www.MedChemExpress.com/Pepstatin.html

https://www.MedChemExpress.com/Perifosine.html

https://www.MedChemExpress.com/pf-04691502.html

https://www.MedChemExpress.com/PF-4708671.html

https://www.MedChemExpress.com/pfi-1.html

https://www.MedChemExpress.com/PFK-015.html



5 mg, 10 mg, 25 mg


10 mg


10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg, 100 mg, 200 mg


10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


1 g, 5 g


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: PFK-158 is a potent and selective inhibitor of PFKFB3 that iscurrently being investigated in a phase I study in patientswith advanced solid malignancies. Target: PFKFB3 in vitro:PFK-158 is the first6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3)…

Bioactivity: PHA-665752 is a potent, selective and ATP-competitive c-Metinhibitor with an of 9 nM.IC50

Bioactivity: Phenformin (hydrochloride) is a hydrochloride salt ofphenformin that is an anti-diabetic drug from the biguanideclass, can activate activity.AMPK

Bioactivity: PI-103 is a potent and inhibitor with s of 8PI3K mTOR IC50nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for , ,p110α p110β

, , , and . PI-103 also inhibitsp110δ p110γ mTORC1 mTORC2 with an of 2 nM.DNA-PK IC50

Bioactivity: PI-103 Hydrochloride is a dual and inhibitor withPI3K mTORs of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM forIC50

, , , , , and .p110α p110β p110δ p110γ mTORC1 mTORC2PI-103 also inhibits with an of 2 nM.DNA-PK IC50

Bioactivity: Piceatannol is a selective inhibitor of protein tyrosinekinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transientsand Na+-Ca2+ exchange except IK1. Shows multiple biologicalactivities such as anti-inflammatory, antiproliferative andimmunomodulatory effects. In vitro: The treatment of human…

Bioactivity: Pictilisib (GDC-0941) is a potent inhibitor of with anPI3Kα/δ of 3 nM, with modest selectivity against p110β (11-fold)IC50

and p110γ (25-fold).

Bioactivity: Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) isa potent inhibitor of with of 3 nM, with modestPI3Kα/δ IC50selectivity against p110β (11-fold) and p110γ (25-fold).

Bioactivity: Pifithrin-μ is an inhibitor of and , with antitumorp53 HSP70and neuroprotective activity.

Bioactivity: Pinocembrin ((+)-Pinocoembrin) is a flavonoid found inpropolis, acts as a competitive inhibitor of histidine

, and is an effective anti-allergic agent, withdecarboxylaseantioxidant, antimicrobial and anti-inflammatory properties

.[1]

PFK-158 Cat. No.: HY-12203

PHA-665752 Cat. No.: HY-11107

Phenformin hydrochloride (Phenethylbiguanide hydrochloride) Cat. No.: HY-16397A

PI-103 Cat. No.: HY-10115

PI-103 Hydrochloride Cat. No.: HY-10115A

Piceatannol (Astringenin; trans-Piceatannol) Cat. No.: HY-13518

Pictilisib (GDC-0941) Cat. No.: HY-50094

Pictilisib dimethanesulfonate (GDC-0941 (dimethanesulfonate) ; GDC-0941 (2 MeSO3H salt)) Cat. No.: HY-20180

Pifithrin-μ (PFTμ; 2-Phenylethynesulfonamide) Cat. No.: HY-10940

Pinocembrin ((+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone) Cat. No.: HY-N0575

https://www.MedChemExpress.com/PFK-158.html

https://www.MedChemExpress.com/PHA-665752.html

https://www.MedChemExpress.com/phenformin-hydrochloride.html

https://www.MedChemExpress.com/pi-103.html

https://www.MedChemExpress.com/PI-103-Hydrochloride.html

https://www.MedChemExpress.com/Piceatannol.html

https://www.MedChemExpress.com/GDC-0941.html

https://www.MedChemExpress.com/GDC-0941-dimethanesulfonate.html

https://www.MedChemExpress.com/Pifithrin-_mu_.html

https://www.MedChemExpress.com/Pinocembrin.html


100 mg, 200 mg, 500 mg


10 mg, 50 mg


10 mg, 50 mg


10 mg, 50 mg, 100 mg


100 mg, 200 mg, 500 mg


10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg



10 mg


200 mg, 1 g, 5 g

Bioactivity: Piperine, a natural alkaloid isolated from L,Piper nigruminhibits and activities with an P-glycoprotein CYP3A4 IC50value of 61.94±0.054 μg/mL in HeLa cell.

Bioactivity: Piperlongumine is a natural alkaloid isolated from Piper Linn , possesses ant-inflammatory,longum [1]

antibacterial, antiangiogenic, antioxidant, antitumor, andantidiabetic activities . Piperlongumine induces ROS, …[2]

Bioactivity: Pirarubicin is an anthracycline antibiotics, acts as a inhibitor, and is a widely used fortopoisomerase II

treatment of various cancers, in particular, solid tumors.

Bioactivity: Pirarubicin Hydrochloride is an anthracycline antibiotics,acts as a inhibitor, and is a widely usedtopoisomerase IIfor treatment of various cancers, in particular, solid tumors.

Bioactivity: Pitavastatin Calcium is a potent hydroxymethylglutaryl-CoA inhibitor. Pitavastatin inhibits(HMG-CoA) reductase

cholesterol synthesis from acetic acid with an of 5.8 nMIC50in HepG2 cells.

Bioactivity: Polydatin (Piceid), extracted from the roots of Polygonum Sieb, a widely used traditional Chinesecuspidatum

remedies, possesses anti-inflammatory activity in severalexperimental models.

Bioactivity: Ponatinib is a potent, orally available multi-targeted kinaseinhibitor with s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, andIC505.4 nM for , , , , and ,Abl PDGFRα VEGFR2 FGFR1 Srcrespectively.

Bioactivity: PR-619 is a broad-range inhibitor with of 3.93,DUB EC504.9, 6.86, 7.2, and 8.61 μM for , , , ,USP4 USP8 USP7 USP2and , respectively.USP5

Bioactivity: Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptoragonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L,D3, D4 receptor, respectively. IC50 Value: 3.9 nM(D2S); 2.2nM(D2L); 0.5 nM(D3); 5.1 nM(D4) Target: Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonist…

Bioactivity: Prazosin is an alpha-adrenergic blocker and is a sympatholyticdrug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. Target: Adrenergic Receptor Prazosin, is asympatholytic drug used to treat high blood pressure andanxiety, PTSD, andpanic disorder. It is an alpha-adrenergic…


Piperine (Bioperine; 1-Piperoylpiperidine) Cat. No.: HY-N0144

Piperlongumine (Piplartine) Cat. No.: HY-N2329

Pirarubicin (THP) Cat. No.: HY-13725

Pirarubicin Hydrochloride (THP Hydrochloride) Cat. No.: HY-13725A

Pitavastatin Calcium (Pitavastatin (hemicalcium); NK-104 (hemicalcium)) Cat. No.: HY-B0144

Polydatin (Piceid) Cat. No.: HY-N0120A

Ponatinib (AP24534) Cat. No.: HY-12047

PR-619 Cat. No.: HY-13814

Pramipexole dihydrochloride Cat. No.: HY-17355

Prazosin hydrochloride Cat. No.: HY-B0193A

https://www.MedChemExpress.com/Piperine.html

https://www.MedChemExpress.com/Piperlongumine.html

https://www.MedChemExpress.com/Pirarubicin.html

https://www.MedChemExpress.com/pirarubicin-hydrochloride.html

https://www.MedChemExpress.com/pitavastatin-calcium.html

https://www.MedChemExpress.com/Polydatin.html

https://www.MedChemExpress.com/Ponatinib.html

https://www.MedChemExpress.com/PR-619.html

https://www.MedChemExpress.com/pramipexole-dihydrochloride.html

https://www.MedChemExpress.com/Prazosin-hydrochloride.html



25 mg



5 mg, 10 mg, 50 mg, 100 mg


100 mg, 500 mg, 1 g


100 mg


100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg



1 g, 5 g

Bioactivity: Pregnenolone acts as a signaling-specific inhibitor of, reduces several effects ofcannabinoid CB1 receptor

tetrahydrocannabinol (THC).

Bioactivity: Pregnenolone monosulfate acts as a signaling-specificinhibitor of , reduces several effectscannabinoid CB1 receptorof tetrahydrocannabinol (THC).

Bioactivity: PRIMA-1 (NSC-281668) is a mutant reactivator, restoresp53the sensitivity of TP53 mutant-type thyroid cancer cells tothe histone methylation inhibitor 3-Deazaneplanocin A.

Bioactivity: PRIMA-1MET restores wild-type conformation and function tomutant , and triggers apoptosis in tumor cells. PRIMA-1METp53also targets the selenoprotein thioredoxin reductase 1 (

), a key regulator of cellular redox balance.TrxR1

Bioactivity: Procainamide hydrochloride is an anti-arrhythmic agent and isused to treat cardiac arrhythmia; induces rapid block of thebatrachotoxin(BTX)-activated sodium channels of the heartmuscle and acts as antagonist to long gating closures.

Bioactivity: Proflavine hemisulfate is an Acridine derivative, which is aslow-acting disinfectant with bacteriostatic action againstmany Gram-positive bacteria but less effective againstGram-negative organisms.

Bioactivity: Propranolol hydrochloride is a nonselective β-adrenergicreceptor ( ) antagonist with an of 12 nM.βAR IC50

Bioactivity: PTC-209 is a specific inhibitor with an of 0.5BMI-1 IC50μM.

Bioactivity: PTC-209 hydrobromide is a specific inhibitor withBMI-1 of 0.5 μM in both GEMS reporter and ELISA assays.IC50

Bioactivity: Pterostilbene is a stilbenoid isolated from blueberries and . Shows anti-oxidant,Pterocarpus marsupium [1]

anti-inflammatory, anti-carcinogenic, anti-diabetic andanti-obesity properties . Pterostilbene blocks …[1] [4]

Pregnenolone (Arthenolone; 3β-Hydroxy-5-pregnen-20-one) Cat. No.: HY-B0151

Pregnenolone monosulfate (Pregn-5-en-20-on-3β-yl sulfuric acid) Cat. No.: HY-B1739

PRIMA-1 (NSC-281668) Cat. No.: HY-19980A

PRIMA-1Met (APR-246) Cat. No.: HY-19980

Procainamide hydrochloride Cat. No.: HY-A0084

Proflavine hemisulfate (Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate) Cat. No.: HY-B0883

Propranolol hydrochloride Cat. No.: HY-B0573

PTC-209 Cat. No.: HY-15888

PTC-209 hydrobromide Cat. No.: HY-15888A

Pterostilbene Cat. No.: HY-N0828

https://www.MedChemExpress.com/Pregnenolone.html

https://www.MedChemExpress.com/Pregnenolone_monosulfate.html

https://www.MedChemExpress.com/PRIMA-1.html

https://www.MedChemExpress.com/PRIMA-1Met.html

https://www.MedChemExpress.com/Procainamide-hydrochloride.html

https://www.MedChemExpress.com/Proflavine-hemisulfate.html

https://www.MedChemExpress.com/Propranolol-hydrochloride.html

https://www.MedChemExpress.com/PTC-209.html

https://www.MedChemExpress.com/PTC-209-hydrobromide.html

https://www.MedChemExpress.com/Pterostilbene.html


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg


100 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg


1 g, 5 g


5 g


10 g, 50 g


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg

Bioactivity: Purmorphamine is a agonist with ansmoothened receptor of 1 μM.EC50

Bioactivity: Purvalanol A is a potent inhibitor, which inhibitsCDKcdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1,and cdk5-p35 with s of 4, 70, 35, 850, 75 nM,IC50resepctively.

Bioactivity: PX-478 is an antitumor inhibitor of hypoxia-induciblefactor-1α ( ).HIF-1α

Bioactivity: Pyrazinamide is a pyrazine that is used therapeutically as anantitubercular agent. Target: Antibacterial Pyrazinamide is aprodrug that stops the growth of Mycobacterium tuberculosis.Pyrazinoic acid was thought to inhibit the enzyme fatty acidsynthase (FAS) I, which is required by the bacterium to…

Bioactivity: Pyriproxyfen is a juvenile hormone analog, preventing larvaefrom developing into adulthood and thus rendering them unableto reproduce. Pyriproxyfen is a pyridine-based pesticide whichis found to be effective against a variety of arthropoda.

Bioactivity: Quercetin, a natural flavonoid, is a stimulator of recombinant and also a inhibitor with of 2.4±0.6 μM, 3.0±0.0SIRT1 PI3K IC50

μM and 5.4±0.3 μM for PI3K γ, PI3K δ and PI3K β, respectively.

Bioactivity: Quercitrin is a natural compound found in Tartary buckwheatwith a potential anti-inflammation effect that is used totreat heart and vascular conditions. IC50 value: Target: Invitro: There were significant increases in caspase-3 activity,loss of MMP, and increases in the apoptotic cell population in…

Bioactivity: Quinacrine is a fluorescent probe for the conformationaltransitions of the cholinergic receptor protein. Quinacrineshows activity in the low μM range with a mean IC50 of 2.30 μMIn the patient AML cells. IC50 value: 2.30 μM (for AML cells)Target: in vitro: Quinacrine is a fluorescent probe for the…

Bioactivity: Quizartinib (AC220) is a potent tyrosine kinase inhibitorFlt3with a of 1.6±0.7 nM.Kd

Bioactivity: Rabusertib (LY2603618) is a potent and selective inhibitor of with an of 7 nM.Chk1 IC50


Purmorphamine (Shh Signaling Antagonist VI) Cat. No.: HY-15108

Purvalanol A (NG-60) Cat. No.: HY-18299A

PX-478 Cat. No.: HY-10231

Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) Cat. No.: HY-B0271

Pyriproxyfen (S-31183) Cat. No.: HY-B2031

Quercetin Cat. No.: HY-18085

Quercitrin (Quercetin 3-rhamnoside) Cat. No.: HY-N0418

Quinacrine dihydrochloride (Mepacrine dihydrochloride; SN-390) Cat. No.: HY-13735A

Quizartinib (AC220) Cat. No.: HY-13001

Rabusertib (LY2603618; IC-83) Cat. No.: HY-14720

https://www.MedChemExpress.com/Purmorphamine.html

https://www.MedChemExpress.com/Purvalanol-A.html

https://www.MedChemExpress.com/PX-478.html

https://www.MedChemExpress.com/pyrazinamide.html

https://www.MedChemExpress.com/Pyriproxyfen.html

https://www.MedChemExpress.com/Quercetin.html

https://www.MedChemExpress.com/Quercitrin.html

https://www.MedChemExpress.com/Quinacrine-dihydrochloride.html

https://www.MedChemExpress.com/Quizartinib.html




100 mg


5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg


50 mg, 100 mg

Purity: 99.93%Clinical Data: LaunchedSize: 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 2 g, 5 g


100 mg, 200 mg, 500 mg, 1 g, 5 g


50 mg, 100 mg


5 mg, 10 mg, 50 mg

Bioactivity: RAF265 is a potent / inhibitor.RAF VEGFR2 Bioactivity: Raloxifene hydrochloride(LY156758 hydrochloride) is a secondgeneration selective estrogen receptor antagonist. Target:Estrogen receptor Approved: September 14, 2007 Raloxifeneactivates TGF beta 3 promoter as a full agonist at nanomolarconcentrations, and raloxifene inhibits the estrogen response…

Bioactivity: Ranolazine dihydrochloride (RS-43285) is an antianginal agentwith antiarrhythmic properties that achieves its effects via anovel mechanism of action (inhibition of the late phase of theinward sodium current), without affecting heart rate or bloodpressure (BP). IC50 value: Target: sodium-dependent calcium…

Bioactivity: Rapamycin (Sirolimus; AY 22989) is a potent and specific inhibitor with an of 0.1 nM in HEK293 cells.mTOR IC50

Rapamycin binds to FKBP12 and specifically acts as anallosteric inhibitor of . Rapamycin is…mTORC1 [1]

Bioactivity: Rasagiline Mesylate is a new MAO-B inhibitor for the treatmentof idiopathic Parkinson's disease. Target: Monoamine Oxidase(MAO)-B Rasagiline (N-propargyl-1-(R)-aminoindan) is a novel,highly potent irreversible monoamine oxidase (MAO)-Binhibitor, anti-Parkinsonian drug. Rasagiline is effective as…

Bioactivity: Regorafenib (BAY 73-4506) is a multi-targeted receptortyrosine kinase inhibitor with s of 13/4.2/46, 22, 7, 1.5IC50and 2.5 nM for , , , and ,VEGFR1/2/3 PDGFRβ Kit RET Raf-1respectively.

Bioactivity: Regorafenib Hydrochloride is a multi-target inhibitor for, , , and with s ofVEGFR1/2/3 PDGFRβ Kit RET Raf-1 IC50

13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

Bioactivity: Regorafenib monohydrate is a multi-target inhibitor for, , , and with s ofVEGFR1/2/3 PDGFRβ Kit RET Raf-1 IC50

13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

Bioactivity: Resatorvid (TAK-242) is a potent signaling inhibitorTLR4which selectively inhibits the TLR4-mediated production ofcytokines and nitric oxide.

Bioactivity: Reserpine is an inhibitor of the vesicular monoamine ( ).transporter 2 VMAT2

RAF265 (CHIR-265) Cat. No.: HY-10248

Raloxifene hydrochloride (LY156758 hydrochloride; LY139481 hydrochloride) Cat. No.: HY-13738A

Ranolazine dihydrochloride (CVT 303 (dihydrochloride); RS 43285) Cat. No.: HY-17401

Rapamycin (Sirolimus; AY 22989) Cat. No.: HY-10219

Rasagiline mesylate (AGN1135 (mesylate); TVP1012 (mesylate)) Cat. No.: HY-14605

Regorafenib (BAY 73-4506) Cat. No.: HY-10331

Regorafenib Hydrochloride (BAY73-4506 hydrochloride) Cat. No.: HY-13308

Regorafenib monohydrate (BAY 73-4506 monohydrate) Cat. No.: HY-10331A

Resatorvid (TAK-242; CLI-095) Cat. No.: HY-11109

Reserpine Cat. No.: HY-N0480

https://www.MedChemExpress.com/RAF265.html

https://www.MedChemExpress.com/raloxifene-hydrochloride.html

https://www.MedChemExpress.com/ranolazine-dihydrochloride.html

https://www.MedChemExpress.com/Rapamycin.html

https://www.MedChemExpress.com/rasagiline-mesylate.html

https://www.MedChemExpress.com/Regorafenib.html

https://www.MedChemExpress.com/Regorafenib-Hydrochloride.html

https://www.MedChemExpress.com/Regorafenib-monohydrate.html

https://www.MedChemExpress.com/TAK-242.html

https://www.MedChemExpress.com/Reserpine.html


100 mg, 500 mg



1 g, 5 g


10 mg, 50 mg, 100 mg, 200 mg



50 mg, 200 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg


100 mg, 200 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: Reversine is a novel class of ATP-competitive Aurora kinaseinhibitor with s of 400, 500 and 400 nM for ,IC50 Aurora A

and , respectively.Aurora B Aurora C

Bioactivity: Rhein is a lipophilic anthraquinone extensively found inmedicinal herbs, and has many pharmacological effects,including epatoprotective, nephroprotective,anti-inflammatory, antioxidant, anticancer, and antimicrobialactivities. IC50 value: Target: In vitro: Rhein (0.1 and 1…

Bioactivity: RITA is an inhibitor of , binds top53-HDM-2 interactionp53dN, with a of 1.5 nM, and also induces Kd DNA-DNA

.cross-links

Bioactivity: ROC-325 is a novel inhibitor of .autophagy

Bioactivity: Rosiglitazone (BRL49653) is a selective agonist withPPARγs of 30 nM, 100 nM and 60 nM for , , andEC50 PPARγ1 PPARγ2

, respectively.PPARγ

Bioactivity: Rosiglitazone maleate is a potent and selective activator of, with s of 30 nM, 100 nM and 60 nM for ,PPARγ EC50 PPARγ1

, and , respectively, and a of appr 40 nMPPARγ2 PPARγ Kdfor ; Rosiglitazone maleate is also an modulator of PPARγ …

Bioactivity: Rosuvastatin Calcium is a competitive inhibitor of HMG-CoAreductase with IC50 of 11 nM. IC50 Value: 11 nM [1] Target:HMG-CoA reductase in vitro: Rosuvastatin is relativelyhydrophilic and is highly selective for hepatic cells; itsuptake is mediated by the liver-specific organic anion…

Bioactivity: Rotenone is an mitochondrial electron transport chain inhibitor.complex I

Bioactivity: Rottlerin, a natural product purified from Mallotus, is a specific inhibitor, with valuesPhilippinensis PKC IC50

for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100μM. Rottlerin acts as a direct mitochondrial uncoupler, andstimulates autophagy by targeting a signaling cascade upstream…

Bioactivity: Rupatadine Fumarate (UR-12592 Fumarate) is a potent dualPAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit plateletmembranes/guinea pig cerebellum membranes). IC50 value:Target: PAF/H1 antagonist in vitro: Rupatadine competitivelyinhibited histamine-induced guinea pig ileum contraction (pA2…


Reversine Cat. No.: HY-14711

Rhein (Rheic Acid; Rhubarb yellow; Monorhein) Cat. No.: HY-N0105

RITA (NSC 652287) Cat. No.: HY-13424

ROC-325 Cat. No.: HY-103706

Rosiglitazone (BRL49653) Cat. No.: HY-17386

Rosiglitazone maleate (BRL 49653C) Cat. No.: HY-14600

Rosuvastatin Calcium (Rosuvastatin hemicalcium; ZD 4522 Calcium) Cat. No.: HY-17504

Rotenone Cat. No.: HY-B1756

Rottlerin (Mallotoxin; NSC 56346; NSC 94525) Cat. No.: HY-18980

Rupatadine Fumarate (UR-12592 (Fumarate)) Cat. No.: HY-13511A

https://www.MedChemExpress.com/reversine.html

https://www.MedChemExpress.com/Rhein.html

https://www.MedChemExpress.com/rita.html

https://www.MedChemExpress.com/ROC-325.html

https://www.MedChemExpress.com/Rosiglitazone.html

https://www.MedChemExpress.com/rosiglitazone-maleate.html

https://www.MedChemExpress.com/Rosuvastatin-Calcium.html

https://www.MedChemExpress.com/Rotenone.html

https://www.MedChemExpress.com/Rottlerin.html

https://www.MedChemExpress.com/Rupatadine-Fumarate.html



10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg


10 g, 50 g


100 mg, 500 mg




1 mg, 5 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g


5 g, 10 g

Bioactivity: Rutin, a naturally occurring flavonoid glycoside, hasantioxidant, anti-inflammatory, anti-allergic, anti-angiogenicand antiviral properties.

Bioactivity: Ruxolitinib is a potent and selective inhibitor withJAK1/2s of 3.3 nM and 2.8 nM in cell-free assays, and hasIC50

130-fold selectivity for JAK1/2 over JAK3.

Bioactivity: Ruxolitinib phosphate is a potent inhibitor with sJAK1/2 IC50of 3.3 nM/2.8 nM, respectively, showing more than 130-foldselectivity over JAK3.

Bioactivity: Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib.Ruxolitinib is the first potent, selective inhibitorJAK1/2to enter the clinic with of 3.3 nM/2.8 nM in cell-freeIC50assays.

Bioactivity: Ruxolitinib sulfate is the first potent, selective JAK1/2inhibitor to enter the clinic with s of 3.3 nM/2.8 nM, andIC50has > 130-fold selectivity for JAK1/2 versus JAK3.

Bioactivity: S130 is a high affinity, selective inhibitor of (aATG4Bmajor cysteine protease) with an of 3.24 µM. S130IC50

suppresses autophagy flux .[1]

Bioactivity: Salbutamol Hemisulfate is a short-acting β2 adrenergicreceptor agonist Target: β2 Adrenergic Receptor Salbutamol isa short-acting, selective beta2-adrenergic receptor agonistused in the treatment of asthma and COPD. All the effects ofR,S-salbutamol on guinea-pig skeletal muscles are due to the…

Bioactivity: Salicylic acid inhibits cyclo-oxygenase-2 ( ) activityCOX-2independently of transcription factor (NF-κB) activation.

Bioactivity: Salinomycin is an anticoccidial drug with potent anti-bacterialactivity and an novel anticancer agent targeting human cancerstem cells.

Bioactivity: Salirasib is a inhibitor that inhibits specifically bothRasoncogenically activated Ras and growth factorreceptor-mediated Ras activation, resulting in the inhibitionof Ras-dependent tumor growth.

Rutin (Rutoside; Quercetin 3-O-rutinoside) Cat. No.: HY-N0148

Ruxolitinib (INCB018424) Cat. No.: HY-50856

Ruxolitinib phosphate (INCB018424 phosphate) Cat. No.: HY-50858

Ruxolitinib S enantiomer (S-Ruxolitinib; INCB18424) Cat. No.: HY-50856A

Ruxolitinib sulfate (INCB018424 sulfate) Cat. No.: HY-50859

S130 Cat. No.: HY-112818

Salbutamol hemisulfate (Albuterol (hemisulfate); AH-3365 (hemisulfate)) Cat. No.: HY-B0436

Salicylic acid (2-Hydroxybenzoic acid) Cat. No.: HY-B0167

Salinomycin (Procoxacin) Cat. No.: HY-15597

Salirasib (S-Farnesylthiosalicylic acid; Farnesyl

Thiosalicylic Acid; FTS) Cat. No.: HY-14754

https://www.MedChemExpress.com/Rutin.html

https://www.MedChemExpress.com/Ruxolitinib.html

https://www.MedChemExpress.com/Ruxolitinib-phosphate.html

https://www.MedChemExpress.com/ruxolitinib-s-enantiomer.html

https://www.MedChemExpress.com/ruxolitinib-sulfate.html

https://www.MedChemExpress.com/s130.html

https://www.MedChemExpress.com/Salbutamol-hemisulfate.html

https://www.MedChemExpress.com/Salicylic-acid.html

https://www.MedChemExpress.com/Salinomycin.html

https://www.MedChemExpress.com/Salirasib.html


10 mg, 50 mg, 100 mg, 200 mg


50 mg, 100 mg, 200 mg


10 mg, 50 mg, 100 mg


2 mg, 5 mg, 10 mg, 25 mg, 50 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg




5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Bioactivity: Salubrinal is a cell-permeable and selective inhibitor of eIF2α.dephosphorylation

Bioactivity: Salvianolic acid B is an active ingredient of Salviamiltiorrhiza, which has been widely applied in China for themanagement of various microcirculation-related disorders, suchas cardiovascular disease, cerebrovascular disease, anddiabetic vascular complication. IC50 value: Target: In vitro:…

Bioactivity: Sanguinarine, a benzophenanthridine alkaloid derived from theroot of , can stimulate viaSanguinaria Canadensis apoptosisactivating the production of reactive oxygen species (ROS).Sanguinarine-induced apoptosis is associated with theactivation of JNK and NF-κB.

Bioactivity: Sanguinarine chloride, a benzophenanthridine alkaloid derivedfrom the root of , can stimulate Sanguinaria Canadensis apoptosisvia activating the production of reactive oxygen species(ROS). Sanguinarine-induced apoptosis is associated with theactivation of JNK and NF-κB.

Bioactivity: Sapanisertib (INK-128) is an orally available, ATP-dependent inhibitor with an of 1 nM for mTOR kinase.mTOR1/2 IC50

Bioactivity: Saquinavir mesylate is an HIV Protease Inhibitor used inantiretroviral therapy. IC50 Value: Target: HIV ProteaseSaquinavir is a protease inhibitor. Proteases are enzymes thatcleave protein molecules into smaller fragments. HIV proteaseis vital for both viral replication within the cell and…

Bioactivity: SAR405 is a / inhibitor with an of 1.2 nM.PIK3C3 Vps34 IC50SAR405 prevents autophagy and synergizes with MTOR inhibitionin tumor cells.

Bioactivity: Saracatinib (AZD0530) is a potent family inhibitor withSrcs of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr,IC50

and Blk and shows high selectivity over other tyrosinekinases.

Bioactivity: SB 202190 is a cell-permeable inhibitor withp38 MAP kinases of 50 nM and 100 nM for p38 and p38β2, respectively.IC50

Bioactivity: SB 203580 (RWJ 64809) is a widely used inhibitorp38 MAPKwith an of 0.3-0.5 μM. SB 203580 (RWJ 64809) shows moreIC50than 100-fold selectivity over Akt (PKB), LCK, and GSK-3β.


Salubrinal Cat. No.: HY-15486

Salvianolic acid B (Dan Shen Suan B; Lithospermic acid B) Cat. No.: HY-N1362

Sanguinarine (Pseudochelerythrine; Sanguinarin) Cat. No.: HY-N0052

Sanguinarine chloride (Pseudochelerythrine chloride; Sanguinarium chloride) Cat. No.: HY-N0052A

Sapanisertib (INK-128; MLN0128) Cat. No.: HY-13328

Saquinavir Mesylate (Ro 31-8959/003) Cat. No.: HY-17003

SAR405 Cat. No.: HY-12481

Saracatinib (AZD0530) Cat. No.: HY-10234

SB 202190 Cat. No.: HY-10295

SB 203580 (RWJ 64809) Cat. No.: HY-10256

https://www.MedChemExpress.com/Salubrinal.html

https://www.MedChemExpress.com/Salvianolic-acid-B.html

https://www.MedChemExpress.com/Sanguinarine.html

https://www.MedChemExpress.com/Sanguinarine-chloride.html

https://www.MedChemExpress.com/INK-128.html

https://www.MedChemExpress.com/saquinavir-mesylate.html

https://www.MedChemExpress.com/SAR405.html

https://www.MedChemExpress.com/Saracatinib.html

https://www.MedChemExpress.com/SB-202190.html




10 mg, 50 mg


10 mg


10 mg, 50 mg


10 mg



10 mg, 50 mg



5 mg, 10 mg, 50 mg, 100 mg



10 mg, 50 mg, 100 mg, 200 mg

Bioactivity: SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a widelyused inhibitor with an of 0.3-0.5 μM. SBp38 MAPK IC50203580 hydrochloride shows more than 100-fold selectivity overAkt (PKB), LCK, and GSK-3β.

Bioactivity: SB 216763 is potent, selective and ATP-competitive GSK-3inhibitor with s of 34.3 nM for both GSK-3α and GSK-3β.IC50

Bioactivity: SBC-115076 is an anti-proprotein convertase subtilisin kexintype 9 (anti-PCSK9) compounds, for the treatment and/orprevention of cardiovascular diseases. Target: PCSK9 in vivo:SBC-115076 lowers cholesterol levels in mice that are fed highfat diet.

Bioactivity: SBE13 is a potent and selective inhibitor, with an ofPlk1 IC50200 pM; SBE13 poorly inhibits Plk2 (IC >66 μM) or Plk350(IC =875 nM).50

Bioactivity: SBE13 Hydrochloride is a potent and selective inhibitor,Plk1with an of 200 pM; SBE13 Hydrochloride poorly inhibitsIC50Plk2 (IC >66 μM) or Plk3 (IC =875 nM).50 50

Bioactivity: Schisandrin has various therapeutic effects on a range ofmedical conditions such as anti-asthmatic, anti-cancer, andanti-inflammatory effects. IC50 value: Target: in vitro: Schinhibited the pro-fibrotic activity of TGF-β1 in AML12 cells;thus, it suppressed the accumulation of ECM proteins. Also,…

Bioactivity: Schisandrin A inhibits activity with an of 6.60 μMCYP3A IC50and of 5.83 μM, respectively.Ki

Bioactivity: Schisandrin B(Wuweizisu-B) is a dibenzocyclooctadienederivative isolated from Fructus Schisandrae, has been shownto produce antioxidant effect on rodent liver and heart. IC50value: Target: in vitro: Schisandrin B exhibitsanti-inflammatory activity through modulation of the…

Bioactivity: Schisandrol B (Gomisin-A;TJN-101;Wuweizi alcohol-B) is one ofits major active constituents of traditional hepato-protectiveChinese medicine, Schisandra sphenanthera.

Bioactivity: Scriptaid is a potent inhibitor,histone deacetylase (HDAC)used in cancer research.

SB 203580 hydrochloride (RWJ 64809 hydrochloride) Cat. No.: HY-10256A

SB 216763 Cat. No.: HY-12012

SBC-115076 Cat. No.: HY-12402

SBE13 Cat. No.: HY-15158A

SBE13 Hydrochloride Cat. No.: HY-15158

Schisandrin (Schizandrol; Schizandrol-A; Wuweizi alcohol-A;

Wuweizichun-A) Cat. No.: HY-N0691

Schisandrin A (Schizandrin-A; Wuweizisu-A; Deoxyschizandrin) Cat. No.: HY-N0693

Schisandrin B (Schizandrin-B; Wuweizisu-B; gamma-Schisandrin) Cat. No.: HY-N0089

Schisandrol B (Gomisin-A; TJN-101; Wuweizi alcohol-B) Cat. No.: HY-N0692

Scriptaid (Scriptide; GCK1026) Cat. No.: HY-15489

https://www.MedChemExpress.com/SB-203580-hydrochloride.html


https://www.MedChemExpress.com/SBC-115076.html

https://www.MedChemExpress.com/SBE13.html

https://www.MedChemExpress.com/SBE13-Hydrochloride.html

https://www.MedChemExpress.com/Schisandrin.html

https://www.MedChemExpress.com/Schisandrin-A.html

https://www.MedChemExpress.com/Schisandrin-B.html

https://www.MedChemExpress.com/Schisandrol-B.html

https://www.MedChemExpress.com/Scriptaid.html


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg, 100 mg


100 mg, 500 mg


50 mg, 100 mg, 200 mg, 500 mg


50 mg, 100 mg, 200 mg


5 mg, 10 mg, 25 mg


5 mg, 10 mg, 50 mg


10 mg, 50 mg


100 mg, 500 mg


2 mg, 5 mg, 10 mg, 25 mg, 50 mg

Bioactivity: Scutellarin, a main active ingredient extracted from Erigeronbreviscapus (Vant.) Hand-Mazz., has been wildly used to treatacute cerebral infarction and paralysis induced bycerebrovascular diseases.

Bioactivity: Selenomethionine is a naturally occurring amino acidcontaining selenium, is a common natural food source ofselenium.

Bioactivity: Sertindole, a neuroleptic, is one of the newer antipsychoticmedications available. Target: Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic receptors.Sertindole offers an alternative treatment option for…

Bioactivity: SGI-1776 is an inhibitor of kinases, with s of 7Pim IC50nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.

Bioactivity: 6-shogaol, an active compound isolated from Ginger ( Zingiber Rosc), exhibits a variety of biological activitiesofficinale

including anticancer, anti-inflammation, and anti-oxidation.

Bioactivity: Sildenafil is a potent phosphodiesterase type 5 ( )PDE5inhibitor with of 5.22 nM.IC50

Bioactivity: Sildenafil citrate is a potent phosphodiesterase type 5 () inhibitor with of 5.22 nM.PDE5 IC50

Bioactivity: Silibinin, an effective anti-cancer and chemopreventive agent,has been shown to exert multiple effects on cancer cells,including inhibition of both cell proliferation and migration.IC50 value: Target: anticancer in vitro: silibininsignificantly induced the expression of the non-steroidal…

Bioactivity: Silmitasertib (CX-4945) is an orally bioavailable, highlyselective and potent inhibitor, with values of 1 nMCK2 IC50against CK2α and CK2α'.

Bioactivity: Silmitasertib sodium salt is an orally bioavailable, highlyselective and potent inhibitor, with values of 1 nMCK2 IC50against CK2α and CK2α'.


Scutellarein (6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone) Cat. No.: HY-N0752

Selenomethionine (Seleno-DL-methionine; DL-Selenomethionine) Cat. No.: HY-B1000

Sertindole (Lu 23-174) Cat. No.: HY-14543

SGI-1776 Cat. No.: HY-13287

Shogaol ([6]-Shogaol; 6-Shogaol) Cat. No.: HY-14616

Sildenafil (UK-92480) Cat. No.: HY-15025

Sildenafil citrate (UK-92480 citrate) Cat. No.: HY-15025A

Silibinin (Silybin; Silibinin A; Silymarin I) Cat. No.: HY-13748

Silmitasertib (CX-4945) Cat. No.: HY-50855

Silmitasertib sodium salt (CX-4945 (sodium salt)) Cat. No.: HY-50855B

https://www.MedChemExpress.com/Scutellarein.html

https://www.MedChemExpress.com/Selenomethionine.html

https://www.MedChemExpress.com/Sertindole.html

https://www.MedChemExpress.com/SGI-1776.html

https://www.MedChemExpress.com/Shogaol.html

https://www.MedChemExpress.com/Sildenafil.html

https://www.MedChemExpress.com/Sildenafil-citrate.html

https://www.MedChemExpress.com/silibinin.html

https://www.MedChemExpress.com/CX-4945.html

https://www.MedChemExpress.com/CX-4945-sodium-salt.html



5 mg, 10 mg, 50 mg, 100 mg



5 mg, 10 mg, 50 mg, 100 mg, 200 mg


100 mg, 200 mg



100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg


100 mg


50 mg, 100 mg, 200 mg, 500 mg


1 mg, 2 mg

Bioactivity: Silvestrol is a eukaryotic translation initiation factor 4A () inhibitor isolated from the fruits and twigs of eIF4A Aglaia

.foveolata

Bioactivity: Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA with a of 0.2 nM.reductase Ki

Bioactivity: Sinomenine hydrochloride is a blocker of the activationNF-κBand also an activator of .μ-opioid receptor

Bioactivity: Sirtinol is a inhibitor, with s of 48 μM, 57.7 μMsirtuin IC50and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.

Bioactivity: Sitagliptin is a potent inhibitor of with of 19 nMDPP4 IC50in Caco-2 cell extracts.

Bioactivity: Sitagliptin phosphate is a potent inhibitor of with DPP4 IC50of 19 nM in Caco-2 cell extracts.

Bioactivity: Sitagliptin phosphate monohydrate is a potent inhibitor of with of 19 nM in Caco-2 cell extracts.DPP4 IC50

Bioactivity: SKF-96365 hydrochloride is a non-selective TRP Channelblocker.

Bioactivity: SLLN-15 is an oral active, selective and potent enhancer of that activates cytostatic macroautophagy/autophagyautophagy

in triple-negative breast cancer (TNBC) .[1]

Bioactivity: SMER18 is a small molecule enhancer of rapamycin which act asa mTOR-independent autophagy inducer.

Silvestrol ((-)-Silvestrol) Cat. No.: HY-13251

Simvastatin (MK 733) Cat. No.: HY-17502

Sinomenine hydrochloride (Cucoline hydrochloride) Cat. No.: HY-15122A

Sirtinol Cat. No.: HY-13515

Sitagliptin (MK0431) Cat. No.: HY-13749

Sitagliptin phosphate (MK0431 phosphate) Cat. No.: HY-13749A

Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) Cat. No.: HY-13749B

SKF-96365 hydrochloride Cat. No.: HY-100001

SLLN-15 Cat. No.: HY-125465

SMER18 Cat. No.: HY-18672

https://www.MedChemExpress.com/Silvestrol.html

https://www.MedChemExpress.com/Simvastatin.html

https://www.MedChemExpress.com/Sinomenine_hydrochloride.html

https://www.MedChemExpress.com/Sirtinol.html

https://www.MedChemExpress.com/Sitagliptin.html

https://www.MedChemExpress.com/sitagliptin-phosphate.html

https://www.MedChemExpress.com/Sitagliptin-phosphate-monohydrate.html

https://www.MedChemExpress.com/SKF-96365-hydrochloride.html

https://www.MedChemExpress.com/SLLN-15.html

https://www.MedChemExpress.com/SMER18.html


5 mg, 10 mg, 50 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


100 mg, 500 mg


100 mg, 500 mg


100 mg, 500 mg, 1 g, 5 g


10 g, 50 g


100 mg, 200 mg


1 g, 5 g, 500 g


50 mg, 100 mg, 200 mg, 500 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg

Bioactivity: SMER28 is a positive regulator of acting via anautophagymTOR-independent mechanism. SMER28 prevents the accumulationof amyloid beta peptide.

Bioactivity: SN-38 (NK012) is an active metabolite of the Topoisomerase Iinhibitor Irinotecan. SN-38 (NK012) inhibits and DNA RNA

with s of 0.077 and 1.3 μM, respectively.synthesis IC50

Bioactivity: Butyric acid is a inhibitor, withhistone deacetylase (HDAC)anti-tumor effects in several cancers.

Bioactivity: Sodium phenylbutyrate is an inhibitor of and endoplasmicHDACreticulum stress, used in cancer and infection research.(ER)

Bioactivity: Sodium Salicylate inhibits cyclo-oxygenase-2 ( )COX-2activity independently of transcription factor (NF-κB)activation.

Bioactivity: Sofalcone, a gastric agent in clinical use, is knownantiulcerto induce the expression of ( ) inHeme oxygenase-1 HO-1gastric epithelium.

Bioactivity: Sorafenib (Bay 43-9006) is a potent multikinase inhibitor withs of 6 nM, 20 nM, and 22 nM for , , andIC50 Raf-1 B-Raf

, respectively.VEGFR-3

Bioactivity: Sorafenib Tosylate (Bay 43-9006 Tosylate) is a potentmultikinase inhibitor, with s of 6 nM, 20 nM, and 22 nMIC50for , , and , respectively.Raf-1 B-Raf VEGFR-3

Bioactivity: SP600125 is a reversible and ATP-competitive inhibitorJNKwith s of 40, 40 and 90 nM for , and ,IC50 JNK1 JNK2 JNK3

respectively.

Bioactivity: Spautin-1 is a specific and potent inhibitor whichautophagyinhibits ubiquitin-specific peptidases, USP10 and USP13 with

s of 0.6-0.7 μM.IC50


SMER28 Cat. No.: HY-100200

SN-38 (NK012) Cat. No.: HY-13704

Sodium Butyrate (Butanoic acid sodium salt) Cat. No.: HY-B0350A

Sodium phenylbutyrate (Sodium 4-phenylbutyrate; TriButyrate) Cat. No.: HY-15654

Sodium Salicylate (Salicylic acid sodium salt;

2-Hydroxybenzoic acid sodium salt) Cat. No.: HY-B0167A

Sofalcone Cat. No.: HY-B2184

Sorafenib (Bay 43-9006) Cat. No.: HY-10201

Sorafenib Tosylate (Bay 43-9006 (Tosylate)) Cat. No.: HY-10201A

SP600125 Cat. No.: HY-12041

Spautin-1 Cat. No.: HY-12990

https://www.MedChemExpress.com/SMER28.html

https://www.MedChemExpress.com/SN-38.html

https://www.MedChemExpress.com/Sodium-Butyrate.html

https://www.MedChemExpress.com/Sodium-phenylbutyrate.html

https://www.MedChemExpress.com/Sodium-Salicylate.html

https://www.MedChemExpress.com/Sofalcone.html

https://www.MedChemExpress.com/Sorafenib.html

https://www.MedChemExpress.com/Sorafenib-Tosylate.html

https://www.MedChemExpress.com/SP600125.html

https://www.MedChemExpress.com/Spautin-1.html




10 mg, 25 mg, 50 mg


10 mg, 50 mg


100 mg, 500 mg



2 mg, 5 mg, 10 mg, 50 mg, 100 mg


2 mg, 5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


1 g, 5 g

Bioactivity: Spironolactone is a potent antagonist of the androgenreceptor. Target: Androgen Receptor Spironolactone is apotassium sparing diuretic that acts by antagonism ofaldosterone in the distal renal tubules. It is used mainly inthe treatment of refractory edema in patients with congestive…

Bioactivity: SR-3677 is a potent and selective inhibitor with anROCK-II of ~3 nM.IC50

Bioactivity: SR9009 is a agonist with s of 670 nM and 800REV-ERBα/β IC50nM for REV-ERBα and REV-ERBβ, respectively.

Bioactivity: SR9011 is a / agonist with s of 790 nM and 560REV-ERBα β IC50nM for REV-ERBα and REV-ERBβ, respectively.

Bioactivity: SR9011 hydrochloride is a / agonist with s ofREV-ERBα β IC50790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.

Bioactivity: SRT 1720 Hydrochloride is a selective activator of withSIRT1an of 0.16 μM, and shows less potent activities onEC1.5SIRT2 and SIRT3 with EC s of 37 μM and 300 μM,1.5respectively.

Bioactivity: Stavudine is a nucleoside analog that inhibits reversetranscriptase and has in vitro activity against HIV. Target:HIV RT; NRTIs Stavudine is a dideoxynucleoside analog thatinhibits reverse transcriptase and has in vitro activityagainst HIV. Stavudine is an analog of thymidine. It is…

Bioactivity: STF-31 is an inhibitor of glucose transporter 1 (GLUT1, IC50 =1 μM). IC50 value: 1 μM Target: GLUT1 in vitro: STF 31 is aglucose uptake inhibitor in RCC (renal cell carcinoma) 4cells. By limiting glucose uptake in cancer cells, the immenseenergy requirements for the cancer cell is not met and the…

Bioactivity: STF-62247 is TGN inhibitor with IC50 of 0.625μM and 16μM inRCC4 and RCC4/VHL cells,respectively.It specifically inducesautophagic cell death in cells that have lost VHL, anessential mutation in the development of RCC. IC50: 0.625/16μMin RCC4 and RCC4/VHL cells,respectively.[1] In vitro:…

Bioactivity: Streptozocin is a potent agent, with sDNA-methylating IC50of 11.7, 904 and 1024 μg/mL in HL60, K562 and C1498 cellsrespectively.

Spironolactone (SC9420) Cat. No.: HY-B0561

SR-3677 Cat. No.: HY-13300

SR9009 Cat. No.: HY-16989

SR9011 Cat. No.: HY-16988

SR9011 hydrochloride Cat. No.: HY-16988A

SRT 1720 Hydrochloride Cat. No.: HY-15145

Stavudine (d4T) Cat. No.: HY-B0116

STF-31 Cat. No.: HY-18728

STF-62247 (STF62247; STF 62247) Cat. No.: HY-100746

Streptozocin (Streptozotocin; U 9889) Cat. No.: HY-13753

https://www.MedChemExpress.com/spironolactone.html

https://www.MedChemExpress.com/SR-3677.html

https://www.MedChemExpress.com/SR9009.html

https://www.MedChemExpress.com/SR9011.html

https://www.MedChemExpress.com/SR9011-hydrochloride.html

https://www.MedChemExpress.com/SRT-1720-Hydrochloride.html

https://www.MedChemExpress.com/stavudine.html

https://www.MedChemExpress.com/STF-31.html

https://www.MedChemExpress.com/STF-62247.html

https://www.MedChemExpress.com/Streptozocin.html


500 mg, 1 g, 5 g


500 mg, 1 g, 5 g


5 mg, 10 mg, 50 mg

Purity: 98.46%Clinical Data: LaunchedSize: 10 mg, 50 mg, 100 mg, 200 mg, 500 mg


100 mg, 200 mg, 500 mg


100 mg, 500 mg


1 g, 5 g


500 mg


5 mg, 10 mg, 50 mg


10 mg, 50 mg, 100 mg

Bioactivity: SU11274 is a selective inhibitor with of 10 nM,Met IC50but has no effects on PGDFRβ, EGFR or Tie2.

Bioactivity: SU9516 is a potent inhibitor, with an of 22 nM, andCDK2 IC50also shows inhibitory effects on CDK1 and CDK4, with s ofIC5040, 200 nM, respectively.

Bioactivity: Sulfabenzamide is a intermediate in the synthesis of organicand pharmaceutical.

Bioactivity: Sulfasalazine is a drug for the treatment of rheumatoidarthritis and ulcerative colitis. Sulfasalazine is reported tosuppress activity.NF-κB

Bioactivity: Sulindac (MK-231) is a non-steroidal antiinflammatory agent,acts as a inhibitor, and inhibits overexpression ofCOX-2COX-2.

Bioactivity: Sunitinib (SU 11248) is a multi-targeted receptor tyrosinekinase inhibitor with s of 80 nM and 2 nM for andIC50 VEGFR2

, respectively.PDGFRβ

Bioactivity: Tacrolimus (FK506; Fujimycin) is a macrocyclic lactone withpotent immunosuppressive properties. Tacrolimus binds to

to form a complex and inhibitsFK506 binding protein (FKBP).calcineurin phosphatase

Bioactivity: Tacrolimus monohydrate (FK506 monohydrate; Fujimycinmonohydrate) binds to ( ). ThisFK506 binding protein FKBPcomplex inhibits calcineurin phosphatase (PP2B). Tacrolimusmonohydrate is a mTOR-independent inducer.autophagy

Bioactivity: Tamoxifen is a selective estrogen receptor modulator () which blocks estrogen action in breast cells and canSERM

activate estrogen activity in other cells, such as bone,liver, and uterine cells.

Bioactivity: Tamoxifen Citrate is a selective estrogen receptor modulator ().SERM


SU11274 (PKI-SU11274) Cat. No.: HY-12014

SU9516 Cat. No.: HY-18629

Sulfabenzamide (N-Sulfanilylbenzamide) Cat. No.: HY-B0960

Sulfasalazine (NSC 667219) Cat. No.: HY-14655

Sulindac (MK-231) Cat. No.: HY-B0008

Sunitinib (SU 11248) Cat. No.: HY-10255A

Tacrolimus (FK506; Fujimycin; FR900506) Cat. No.: HY-13756

Tacrolimus monohydrate (FK506 (monohydrate); Fujimycin

(monohydrate); FR900506 (monohydrate)) Cat. No.: HY-13756A

Tamoxifen (ICI47699; Z-Tamoxifen; trans-Tamoxifen) Cat. No.: HY-13757A

Tamoxifen Citrate (ICI 46474) Cat. No.: HY-13757

https://www.MedChemExpress.com/SU11274.html

https://www.MedChemExpress.com/SU9516.html

https://www.MedChemExpress.com/Sulfabenzamide.html

https://www.MedChemExpress.com/Sulfasalazine.html

https://www.MedChemExpress.com/Sulindac.html

https://www.MedChemExpress.com/Sunitinib.html

https://www.MedChemExpress.com/Tacrolimus.html

https://www.MedChemExpress.com/tacrolimus-monohydrate.html

https://www.MedChemExpress.com/Tamoxifen.html

https://www.MedChemExpress.com/Tamoxifen-Citrate.html



10 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 100 mg


200 mg, 1 g


10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g


50 mg, 100 mg, 500 mg, 1 g


5 mg, 10 mg, 50 mg, 100 mg


1 g


50 mg, 100 mg


1 g, 5 g


10 mg, 25 mg, 100 mg, 200 mg

Bioactivity: Tanespimycin (17-AAG) is a potent inhibitor with anHSP90 of 5 nM, having a 100-fold higher binding affinity forIC50

tumour cell derived HSP90 than normal cell derived HSP90.

Bioactivity: Taurine is an organic acid widely distributed in animaltissues. Target: Others Taurine is a major constituent of bileand can be found in the large intestine and accounts forapproximately 0.1% of total human body weight [1]. Taurine ispresent in high concentration in algae and in the animals…

Bioactivity: Taxifolin ((+)-Dihydroquercetin) exhibits important anti- activity. Taxifolin exhibits significant inhibitorytyrosinase

activity against with an value of 193.3 μM.collagenase IC50

Bioactivity: TBHQ is an antioxidant that activates .Nrf2

Bioactivity: Telaglenastat (CB-839) is a potent and selective inhibitor ofglutaminase with an of less than 50 nM.IC50

Bioactivity: Telmisartan is a potent, long lasting antagonist of angiotensin, selectively inhibiting the bindingII type 1 receptor (AT1)

of I-AngII to AT1 receptors with of 9.2 nM.125 IC50

Bioactivity: Temozolomide (NSC 362856; CCRG 81045) is an oral DNA agent used to treat some brain cancers.alkylating

Bioactivity: Tempol is a general superoxide dismutase (SOD)-mimetic drugthat efficiently neutralizes reactive oxygen species (ROS).

Bioactivity: Temsirolimus is an inhibitor of with an of 1.76mTOR IC50μM.

Bioactivity: Tenovin-1 is an inhibitor of and , ansirtuin 1 sirtuin 2activator of and may have potential in the management ofp53cancer.

Tanespimycin (17-AAG; NSC 330507; CP 127374) Cat. No.: HY-10211

Taurine (2-Aminoethanesulfonic acid) Cat. No.: HY-B0351

Taxifolin ((+)-Dihydroquercetin; (+)-Taxifolin) Cat. No.: HY-N0136

TBHQ (tert-Butylhydroquinone) Cat. No.: HY-100489

Telaglenastat (CB-839) Cat. No.: HY-12248

Telmisartan (BIBR 277) Cat. No.: HY-13955

Temozolomide (NSC 362856; CCRG 81045; TMZ) Cat. No.: HY-17364

Tempol (4-Hydroxy-TEMPO) Cat. No.: HY-100561

Temsirolimus (CCI-779) Cat. No.: HY-50910

Tenovin-1 Cat. No.: HY-13423

https://www.MedChemExpress.com/17-AAG.html

https://www.MedChemExpress.com/taurine.html

https://www.MedChemExpress.com/Taxifolin.html

https://www.MedChemExpress.com/TBHQ.html

https://www.MedChemExpress.com/CB-839.html

https://www.MedChemExpress.com/telmisartan.html

https://www.MedChemExpress.com/Temozolomide.html

https://www.MedChemExpress.com/Tempol.html

https://www.MedChemExpress.com/Temsirolimus.html

https://www.MedChemExpress.com/Tenovin-1.html


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


100 mg, 500 mg


5 mg, 10 mg, 25 mg, 50 mg


5 g


200 mg, 500 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg


5 mg, 10 mg, 50 mg, 100 mg


2 mg, 5 mg, 10 mg, 50 mg, 100 mg


2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: Tenovin-6 is an inhibitor of and , slightly inhibitsSIRT1 SIRT2, and is also a potent activator of , with s ofHDAC8 p53 IC50

21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3,respectively.

Bioactivity: Tenovin-6 Hydrochloride is an inhibitor of and ,SIRT1 SIRT2slightly inhibits , and is also a potent activator ofHDAC8

, with s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2,p53 IC50and SirT3, respectively.

Bioactivity: Tepotinib (EMD-1214063) is a potent and selective c-Metinhibitor with IC50 of 4 nM, >200-fold selective for c-Metthan IRAK4, TrkA, Axl, IRAK1, and Mer.

Bioactivity: Tetrahydrocurcumin is a Curcuminoid found in turmeric () that is produced by the reduction ofCurcuma longa

Curcumin. Tetrahydrocurcumin inhibit and .CYP2C9 CYP3A4

Bioactivity: TG101209 is a selective inhibitor with of 6 nM,JAK2 IC50less potent to and with of 25 nM and 17 nM, apprFlt3 RET IC5030-fold selective for JAK2 than JAK3, and sensitive toJAK2V617F and MPLW515L/K mutations.

Bioactivity: Thalidomide is initially promoted as a sedative, inhibitsereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligasecomplex CUL4-RBX1-DDB1, with a of 250 nM, and hasKdimmunomodulatory, anti-inflammatory and anti-angiogenic cancerproperties.

Bioactivity: Theophylline is a nonselective phosphodiesterase (PDE)inhibitor, blocker, and adenosine receptor histone deacetylase

activator.(HDAC)

Bioactivity: Thiamet G is a potent and selective inhibitor of O-GlcNAcase, which acts to remove O-GlcNAc from modified proteins,(OGA)

with of 20 nM for human OGA.Ki

Bioactivity: Thioridazine is an antipsychotic drug, used in the treatmentof schizophrenia and psychosis, shows D4 selectivity orserotonin antagonism.

Bioactivity: Tigecycline (GAR-936) is a broad-spectrum glycylcyclineantibiotic. The mean inhibitory concentration (MIC) ofTigecycline for (MG1655 strain) is approximately 125E. coling/mL . MIC and MIC are 1 and 2 mg/L for[1]

50 90 ( ), respectively…Acinetobacter baumannii A. baumannii


Tenovin-6 Cat. No.: HY-15510

Tenovin-6 Hydrochloride Cat. No.: HY-15510B

Tepotinib (EMD-1214063) Cat. No.: HY-14721

Tetrahydrocurcumin (HZIV 81-2) Cat. No.: HY-N0893

TG101209 Cat. No.: HY-10410

Thalidomide Cat. No.: HY-14658

Theophylline (1,3-Dimethylxanthine; Theo-24) Cat. No.: HY-B0809

Thiamet G Cat. No.: HY-12588

Thioridazine hydrochloride Cat. No.: HY-B0965

Tigecycline (GAR-936) Cat. No.: HY-B0117

https://www.MedChemExpress.com/Tenovin-6.html

https://www.MedChemExpress.com/Tenovin-6-Hydrochloride.html

https://www.MedChemExpress.com/EMD-1214063.html

https://www.MedChemExpress.com/Tetrahydrocurcumin.html

https://www.MedChemExpress.com/TG101209.html

https://www.MedChemExpress.com/thalidomide.html

https://www.MedChemExpress.com/Theophylline.html

https://www.MedChemExpress.com/Thiamet-G.html

https://www.MedChemExpress.com/Thioridazine-hydrochloride.html

https://www.MedChemExpress.com/Tigecycline.html



5 mg, 10 mg, 50 mg, 100 mg, 200 mg



10 mg, 50 mg, 100 mg



10 mg, 50 mg


1 g, 5 g


10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg

Purity: >98%Clinical Data: LaunchedSize: 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Purity: >98%Clinical Data: LaunchedSize: 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Bioactivity: Tigecycline hydrochloride (GAR-936 hydrochloride) is abroad-spectrum glycylcycline antibiotic. The mean inhibitoryconcentration (MIC) of Tigecycline for (MG1655 strain)E. coliis approximately 125 ng/mL . MIC and MIC are 1 and[1]

50 902 mg/L for ( ),…Acinetobacter baumannii A. baumannii

Bioactivity: Tigecycline mesylate (GAR-936 mesylate) is a broad-spectrumglycylcycline antibiotic. The mean inhibitory concentration(MIC) of Tigecycline for (MG1655 strain) isE. coliapproximately 125 ng/mL . MIC and MIC are 1 and 2[1]

50 90mg/L for ( ),…Acinetobacter baumannii A. baumannii

Bioactivity: Tigecycline tetramesylate (GAR-936 tetramesylate) is abroad-spectrum glycylcycline antibiotic. The mean inhibitoryconcentration (MIC) of Tigecycline for (MG1655 strain)E. coliis approximately 125 ng/mL . MIC and MIC are 1 and[1]

50 902 mg/L for ( ),…Acinetobacter baumannii A. baumannii

Bioactivity: Tizoxanide is the active metabolite of Nitazoxanide, which isa thiazolide anti-infective compound against anaerobicbacteria, protozoa, and a range of viruses. IC50 value:Target: Antiviral agent in vitro: Tizoxanide inhibited virusreplication of all CIVs with 50% and 90% inhibitory…

Bioactivity: Tolbutamide is a first generation potassium channel blocker,sulfonylurea oral hypoglycemic drug. Target: Potassium ChannelTolbutamide is an oral antihyperglycemic agent used for thetreatment of non-insulin-dependent diabetes mellitus (NIDDM).Tolbutamide act by stimulating β cells of the pancreas to…

Bioactivity: Tolvaptan is a selective, competitive arginine vasopressinreceptor 2 antagonist with an IC50 of 1.28μM for theinhibition of AVP-induced platelet aggregation. IC50 value:1.28 uM (inhibition of AVP-induced platelet aggregation)Target: vasopressin receptor 2 Tolvaptan (OPC-41061) is a…

Bioactivity: Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase Iinhibitor. The values of Topotecan at 24 h are 2.73±0.25IC50μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM ofGSCs-U251 and 5.95±0.24 μM of GSCs-U87.

Bioactivity: Topotecan Hydrochloride (SKF 104864A Hydrochloride; NSC 609669Hydrochloride) is a inhibitor with potentTopoisomerase Iantineoplastic activities.

Bioactivity: Torin 1 is a potent inhibitor of with an of 3 nM.mTOR IC50Torin 1 inhibits both / complexes with valuesmTORC1 2 IC50between 2 and 10 nM.

Bioactivity: Torin 2 is an inhibitor with of 0.25 nM formTOR EC50inhibiting cellular mTOR activity, and exhibits 800-foldselectivity over PI3K (EC : 200 nM). Torin 2 also inhibits50

with an of 0.5 nM in the cell free assay. Tori…DNA-PK IC50

Tigecycline hydrochloride (GAR-936 hydrochloride) Cat. No.: HY-B0117A

Tigecycline mesylate (GAR-936 mesylate) Cat. No.: HY-B0117B

Tigecycline tetramesylate (GAR-936 tetramesylate) Cat. No.: HY-B0117C

Tizoxanide (TIZ) Cat. No.: HY-12687

Tolbutamide Cat. No.: HY-B0401

Tolvaptan (OPC-41061) Cat. No.: HY-17000

Topotecan (SKF 104864A; NSC 609669) Cat. No.: HY-13768

Topotecan Hydrochloride (SKF 104864A (Hydrochloride); NSC 609669 (Hydrochloride)) Cat. No.: HY-13768A

Torin 1 Cat. No.: HY-13003

Torin 2 Cat. No.: HY-13002

https://www.MedChemExpress.com/Tigecycline-hydrochloride.html

https://www.MedChemExpress.com/tigecycline-mesylate.html

https://www.MedChemExpress.com/Tigecycline_tetramesylate.html

https://www.MedChemExpress.com/Tizoxanide.html

https://www.MedChemExpress.com/Tolbutamide.html

https://www.MedChemExpress.com/Tolvaptan.html

https://www.MedChemExpress.com/topotecan.html

https://www.MedChemExpress.com/Topotecan-Hydrochloride.html

https://www.MedChemExpress.com/Torin-1.html

https://www.MedChemExpress.com/Torin-2.html


10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


10 mg, 50 mg


100 mg


100 mg, 500 mg


100 mg


10 mg, 50 mg, 100 mg


50 mg, 100 mg, 200 mg


50 mg, 100 mg, 250 mg


5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: Torkinib (PP 242) is a selective and ATP-competitive mTORinhibitor with an of 8 nM. PP242 inhibits both IC50 mTORC1

and with s of 30 nM and 58 nM, respectively.mTORC2 IC50

Bioactivity: Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C with s of 0.6, 18, 4.6 nM, respectively.kinases Ki

Bioactivity: TPEN is a specific cell-permeable heavy metal chelator. Bioactivity: Trametinib is a potent inhibitor that inhibits MEK1 andMEKMEK2 with s of about 2 nM. Due to the poor solubility ofIC50Trametinib, Trametinib DMSO solvate (Cat. No.: HY-10999A)is recommeded.

Bioactivity: Triclosan is an antibacterial and antifungal agent found inconsumer products, including soaps, detergents, toys, andsurgical cleaning treatments.

Bioactivity: Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemetic.Target: Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic. Trifluoperazine inhibited in…

Bioactivity: Triflupromazine hydrochloride is an antipsychotic medication,which are Dopamine D1/D2 receptor antagonists.

Bioactivity: Trimetazidine dihydrochloride is a drug for angina pectoris.Trimetazidine is the first cytoprotective anti-ischemic agent, which improves myocardial glucose utilization throughinhibition of fatty acid metabolism.

Bioactivity: Tripterin (Celastrol) is a inhibitor whichproteasomepotently and preferentially inhibits the chymotrypsin-likeactivity of a purified with of 2.5 μM.20S proteasome IC50

Bioactivity: Troglitazone is a agonist, with s of 550 nM andPPARγ EC50780 nM for human and murinePPARγ receptor, respectively.


Torkinib (PP 242) Cat. No.: HY-10474

Tozasertib (VX 680; MK-0457) Cat. No.: HY-10161

TPEN (TPEDA) Cat. No.: HY-100202

Trametinib (GSK1120212; JTP-74057) Cat. No.: HY-10999

Triclosan Cat. No.: HY-B1119

Trifluoperazine dihydrochloride (TFP; SKF5019) Cat. No.: HY-B0532A

Triflupromazine hydrochloride Cat. No.: HY-B0909

Trimetazidine dihydrochloride Cat. No.: HY-B0968

Tripterin (Celastrol) Cat. No.: HY-13067

Troglitazone (CS-045) Cat. No.: HY-50935

https://www.MedChemExpress.com/PP-242.html

https://www.MedChemExpress.com/Tozasertib.html

https://www.MedChemExpress.com/TPEN.html

https://www.MedChemExpress.com/Trametinib.html

https://www.MedChemExpress.com/Triclosan.html

https://www.MedChemExpress.com/trifluoperazine-dihydrochloride.html

https://www.MedChemExpress.com/Triflupromazine-hydrochloride.html

https://www.MedChemExpress.com/Trimetazidine-dihydrochloride.html

https://www.MedChemExpress.com/Celastrol.html

https://www.MedChemExpress.com/troglitazone.html



5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg


10 mg, 50 mg, 100 mg


10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Bioactivity: Tubastatin A (Hydrochloride) is a potent and selective inhibitor with of 15 nM in aHDAC6 IC50

cell-free assay, and is selective (1000-fold more) against allother isozymes except HDAC8 (57-fold more).

Bioactivity: Tubastatin-A is a potent and selective inhibitor with of 15 nM in aHDAC6 IC50

cell-free assay, and is selective (1000-fold more) against allother isozymes except HDAC8 (57-fold more).

Bioactivity: TWS119 is a specific inhibitor of , with an of 30GSK-3β IC50nM, and activates the wnt/β-catenin pathway.

Bioactivity: U0126 is a potent and non-ATP competitive and MEK1 MEK2inhibitor, with s of 70 nM and 60 nM, respectively.IC50

Bioactivity: UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6)activator, inducing autophagy in human tumor cells, with an

of 38 μM .EC50[1]

Bioactivity: UNBS5162 is a pan-antagonist of expression,CXCL chemokinewith anti-tumor activity.

Bioactivity: UNC0638 selectively inhibits and G9a GLP histone activity with s of less than 15 nMmethyltransferase IC50

and 19 nM, respectively.

Bioactivity: UNC1999 is a SAM-competitive, potent and selective inhibitorof with s of 10 nM and 45 nM, repectively.EZH1/2 IC50

Bioactivity: URB597 is a potent, orally bioavailable FAAH inhibitor withIC50 of 4.6 nM, with no activity on other cannabinoid-relatedtargets. IC50 value: 4.6 nM [1] Target: FAAH in vitro: URB597binds in the hydrophobic pocket and catalytic core of FAAHthat connects the active site residues to the membrane surface…

Bioactivity: URMC-099 is an orally bioavailable and potent mixed lineagekinase type 3 ( ) ( =14 nM) inhibitor with withMLK3 IC50excellent blood-brain barrier penetration properties.

Tubastatin A Hydrochloride (Tubastatin A HCl; TSA HCl) Cat. No.: HY-13271

Tubastatin-A Cat. No.: HY-13271A

TWS119 Cat. No.: HY-10590

U0126 (U0126-EtOH) Cat. No.: HY-12031

UBCS039 Cat. No.: HY-115453

UNBS5162 Cat. No.: HY-16509

UNC0638 Cat. No.: HY-15273

UNC1999 Cat. No.: HY-15646

URB-597 (KDS-4103) Cat. No.: HY-10864

URMC-099 Cat. No.: HY-12599

https://www.MedChemExpress.com/Tubastatin-A-Hydrochloride.html

https://www.MedChemExpress.com/Tubastatin-A.html

https://www.MedChemExpress.com/TWS119.html

https://www.MedChemExpress.com/U0126.html

https://www.MedChemExpress.com/ubcs039.html

https://www.MedChemExpress.com/UNBS5162.html

https://www.MedChemExpress.com/UNC0638.html

https://www.MedChemExpress.com/UNC1999.html

https://www.MedChemExpress.com/URB-597.html

https://www.MedChemExpress.com/URMC-099.html


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg




25 mg, 50 mg, 100 mg, 500 mg


250 mg, 1 g, 5 g


1 g, 5 g, 25 g


1 g, 5 g, 25 g


5 mg, 10 mg


5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Bioactivity: Urolithin A is an intestinal metabolite of ellagic acid withantioxidant and antiproliferative effects; inhibits T24 andCaco-2 cell growth with values of 43.9 and 49 μM,IC50respectively.

Bioactivity: Ursolic acid (Prunol) is a natural pentacyclic triterpenoidcarboxylic acid, exerts anti-tumor effects and is an effectivecompound for cancer prevention and therapy.

Bioactivity: Valproic acid is an inhibitor, with in the range ofHDAC IC500.5 and 2 mM, also inhibits ( , 400 μM), andHDAC1 IC50induces proteasomal degradation of ; Valproic acidHDAC2sodium salt is used in the treatment of epilepsy, bipo…

Bioactivity: Valproic acid sodium salt is an anticonvulsants used to treatepilepsy, bipolar disorder and migraines. Valproic acidinhibits with an of 0.4 mM.histone deacetylase 1 (HDAC1) IC50

Bioactivity: Vancomycin hydrochloride is an antibiotic for the treatment of infections. It acts by inhibiting the second stage ofbacterial

cell wall synthesis of susceptible bacteria. Vancomycin alsoalters the permeability of the cell membrane and selectivelyinhibits ribonucleic acid synthesis.

Bioactivity: Vandetanib is a potent inhibitor of with an of 40VEGFR2 IC50nM.

Bioactivity: Vandetanib hydrochloride is a potent inhibitor of withVEGFR2 of 40 nM.IC50

Bioactivity: Vandetanib trifluoroacetate is a potent inhibitor of VEGFR2with of 40 nM.IC50

Bioactivity: Veliparib is a potent inhibitor, inhibiting andPARP PARP1 with s of 5.2 and 2.9 nM, respectively.PARP2 Ki

Bioactivity: Veliparib (dihydrochloride) is a potent inhibitor of and with s of 5.2PARP1 PARP2 Ki

nM and 2.9 nM in cell-free assays, respectively.


Urolithin A Cat. No.: HY-100599

Ursolic acid (Prunol; Urson; Malol) Cat. No.: HY-N0140

Valproic acid (VPA; 2-Propylpentanoic Acid) Cat. No.: HY-10585

Valproic acid sodium salt (Sodium Valproate) Cat. No.: HY-10585A

Vancomycin hydrochloride Cat. No.: HY-17362

Vandetanib (ZD6474) Cat. No.: HY-10260

Vandetanib hydrochloride (ZD6474 hydrochloride) Cat. No.: HY-10260B

Vandetanib trifluoroacetate (ZD6474 trifluoroacetate) Cat. No.: HY-10260A

Veliparib (ABT-888) Cat. No.: HY-10129

Veliparib dihydrochloride (ABT-888 dihydrochloride) Cat. No.: HY-10130

https://www.MedChemExpress.com/Urolithin-A.html

https://www.MedChemExpress.com/Ursolic-acid.html

https://www.MedChemExpress.com/valproic-acid.html

https://www.MedChemExpress.com/Valproic-acid-sodium-salt.html

https://www.MedChemExpress.com/Vancomycin-hydrochloride.html

https://www.MedChemExpress.com/Vandetanib.html

https://www.MedChemExpress.com/vandetanib-hydrochloride.html

https://www.MedChemExpress.com/vandetanib-trifluoroacetate.html

https://www.MedChemExpress.com/Veliparib.html

https://www.MedChemExpress.com/Veliparib-dihydrochloride.html



250 mg, 500 mg, 1 g, 5 g


5 mg, 10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg, 100 mg, 200 mg


10 mg, 50 mg



5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg


10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g

Bioactivity: Vemurafenib (PLX4032; RG7204) is a novel and potent inhibitorof kinase, with s of 31 and 48 nM for RAF B-RAF IC50

V600E

and c-RAF-1, respectively.

Bioactivity: Venetoclax (ABT-199; GDC-0199) is a highly potent, selectiveand orally bioavailable inhibitor with a of less thanBcl-2 Ki0.01 nM.

Bioactivity: VER-155008 is an inhibitor of , with s of 0.5 μM,Hsp70 IC502.6 μM, and 2.6 μM for , Hsc70 and Grp7, respectively,Hsp70and with a of 0.3 μM for .Kd Hsp70

Bioactivity: Verteporfin is a photosensitizer for photodynamic therapy toeliminate the abnormal blood vessels in the eye associatedwith conditions such as age-related macular degeneration.Verteporfin is a inhibitor which disrupts YAP-TEADYAPinteractions.

Bioactivity: Vinblastine sulfate is a cytotoxic alkaloid used againstvarious cancer types. Vinblastine sulfate inhibits theformation of microtubule and suppresses nAChR with an ofIC508.9 μM.

Bioactivity: Vinorelbine is an anti-mitotic agent which inhibits theproliferation of Hela cells with IC of 1.25 nM.50

Bioactivity: Vinorelbine (ditartrate) is an anti-mitotic agent whichinhibits the proliferation of Hela cells with IC of 1.2550nM.

Bioactivity: Vismodegib (GDC-0449) is an orally active pathwayhedgehoginhibitor with an of 3 nM. It also inhibits P-gp, ABCG2IC50with IC values of 3.0 μM and 1.4 μM, respectively.50

Bioactivity: Vistusertib (AZD2014) is an ATP competitive inhibitormTORwith an of 2.81 nM. AZD2014 inhibits both andIC50 mTORC1

complexes.mTORC2

Bioactivity: Vorinostat is a potent and orally available inhibitor of, and , andHDAC1 HDAC2 HDAC3 (Class I) HDAC7 (Class II)

, with values of 10 nM and 20 nM forHDAC11 (Class IV ) ID50HDAC1 and HDAC3, respectively.

Vemurafenib (PLX4032; RG7204; RO5185426) Cat. No.: HY-12057

Venetoclax (ABT-199; GDC-0199) Cat. No.: HY-15531

VER-155008 Cat. No.: HY-10941

Verteporfin (CL 318952) Cat. No.: HY-B0146

Vinblastine sulfate (Vincaleukoblastine sulfate salt) Cat. No.: HY-13780

Vinorelbine (KW-2307 base) Cat. No.: HY-12053

Vinorelbine ditartrate (KW-2307; Nor-5'-anhydrovinblastine ditartrate) Cat. No.: HY-12053A

Vismodegib (GDC-0449) Cat. No.: HY-10440

Vistusertib (AZD2014) Cat. No.: HY-15247

Vorinostat (SAHA) Cat. No.: HY-10221

https://www.MedChemExpress.com/Vemurafenib.html

https://www.MedChemExpress.com/ABT-199.html

https://www.MedChemExpress.com/VER-155008.html

https://www.MedChemExpress.com/Verteporfin.html

https://www.MedChemExpress.com/Vinblastine-sulfate.html

https://www.MedChemExpress.com/vinorelbine.html

https://www.MedChemExpress.com/Vinorelbine-ditartrate.html

https://www.MedChemExpress.com/Vismodegib.html


https://www.MedChemExpress.com/Vorinostat.html



5 mg, 10 mg, 50 mg, 100 mg



1 g, 5 g


5 mg, 10 mg, 50 mg, 100 mg


5 mg, 10 mg, 50 mg, 100 mg


10 mg, 50 mg


5 mg, 10 mg, 50 mg


5 mg, 10 mg, 50 mg


2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Bioactivity: Vps34-PIK-III is a potent and selective inhibitor of VPS34with an of 18 nM.IC50

Bioactivity: Wogonin is a naturally occurring mono-flavonoid, can inhibitthe activity of and , and exhibitsCDK8 Wntanti-inflammatory and anti-tumor effects.

Bioactivity: WYE-354 is an ATP-competitive inhibitor with an mTOR IC50of 5 nM. WYE-354 also inhibits and with s ofPI3Kα PI3Kγ IC501.89 μM and 7.37 μM, respectively. WYE-354 inhibits both

and .mTORC1 mTORC2

Bioactivity: XCT-790 is a potent, selective and inverse agonist ofestrogen-related receptor alpha(ERRα); induces cell death inchemotherapeutic resistant cancer cells. IC50 value: Target:ERRα ERRalpha inverse agonist XCT-790 induced cell death inHepG2 hepatocarcinoma and its multi-drug resistance (MDR)…

Bioactivity: XL388 is a highly potent and ATP-competitive inhibitormTORwith an of 9.9 nM. XL388 simultaneously inhibits bothIC50

and .mTORC1 mTORC2

Bioactivity: XRK3F2 is an inhibitor of domain.p62 (Sequestosome-1)-ZZ/

Bioactivity: Xylitol is a chemical categorized as a polyalcohol or sugaralcohol. Target: Others Xylitol is a chemical categorized as apolyalcohol or sugar alcohol (alditol). Xylitol has theformula (CHOH)3(CH2OH)2 and is an achiral isomer ofpentane-1,2,3,4,5-pentol. Xylitol is used as a diabetic…

Bioactivity: Yangonin exhibits affinity for the human recombinantcannabinoid with an and a of 1.79 ±CB1 receptor IC50 Ki0.53 μM and 0.72±0.21 μM, respectively.

Bioactivity: YM-155 is a inhibitor with an of 0.54 nM.survivin IC50 Bioactivity: YM-155 hydrochloride is a novel suppressant with ansurvivin of 0.54 nM for the inhibition of survivin promoterIC50

activity.


Vps34-PIK-III Cat. No.: HY-12794

Wogonin Cat. No.: HY-N0400

WYE-354 Cat. No.: HY-12034

XCT790 Cat. No.: HY-10426

XL388 Cat. No.: HY-13806

XRK3F2 Cat. No.: HY-112904

Xylitol (Xylite) Cat. No.: HY-N0538

Yangonin Cat. No.: HY-N0919

YM-155 (Sepantronium bromide) Cat. No.: HY-10194

YM-155 hydrochloride Cat. No.: HY-10194A

https://www.MedChemExpress.com/Vps34-PIK-III.html

https://www.MedChemExpress.com/Wogonin.html

https://www.MedChemExpress.com/WYE-354.html

https://www.MedChemExpress.com/XCT790.html

https://www.MedChemExpress.com/xl388.html

https://www.MedChemExpress.com/XRK3F2.html

https://www.MedChemExpress.com/xylitol.html

https://www.MedChemExpress.com/Yangonin.html

https://www.MedChemExpress.com/YM-155.html

https://www.MedChemExpress.com/ym-155-hydrochloride.html



10 mg, 50 mg, 100 mg



50 mg, 100 mg



10 mg, 50 mg


2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Bioactivity: YM-201636 is a potent and selective inhibitor with anPIKfyve of 33 nM. YM-201636 also inhibits p110α with IC ofIC50 50

3.3 μM.

Bioactivity: Zebularine (NSC309132; 4-Deoxyuridine) is a DNA inhibitor. Zebularine also inhibitsmethyltransferase

with a of 0.95 μM.cytidine deaminase Ki

Bioactivity: Zoledronic Acid is a third-generation, nitrogen-containingbisphosphonate, inhibits osteoclast-mediated bone resorption,and also has antitumor activity.

Bioactivity: Zoledronic acid monohydrate is a third-generation,nitrogen-containing bisphosphonate, inhibitsosteoclast-mediated bone resorption, and also has antitumoractivity.

Bioactivity: ZSTK474 is an ATP-competitive pan-class I inhibitor withPI3Ks of16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3KδIC50

and PI3Kγ, respectively.

Bioactivity: β-Lapachone is a naturally occurring O-naphthoquinone, acts asa inhibitor, and induces apoptosis bytopoisomerase Iinhibiting cell cycle progression.

YM-201636 Cat. No.: HY-13228

Zebularine (NSC309132; 4-Deoxyuridine) Cat. No.: HY-13420

Zoledronic Acid (Zoledronate; CGP 42446; CGP42446A; ZOL 446) Cat. No.: HY-13777

Zoledronic acid monohydrate (Zoledronate monohydrate; CGP

42446 monohydrate; CGP42446A monohydrate; …) Cat. No.: HY-13777A

ZSTK474 Cat. No.: HY-50847

β-Lapachone (ARQ-501; NSC-26326) Cat. No.: HY-13555

https://www.MedChemExpress.com/ym-201636.html

https://www.MedChemExpress.com/Zebularine.html

https://www.MedChemExpress.com/zoledronic-acid.html

https://www.MedChemExpress.com/zoledronic-acid-monohydrate.html

https://www.MedChemExpress.com/zstk474.html

https://www.MedChemExpress.com/_beta_-Lapachone.html

autophagy - medchemexpress.com...catabolism with another key protein degradation pathway, the...

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