axsun technologies inc. swept laser engines for oct imaging · 2018-08-30 · axsun technologies...
TRANSCRIPT
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Bill Ahern
Director of Marketing- Axsun
BioOpto Japan
September 26, 2012
Axsun Technologies Inc.
Swept Laser Engines for OCT Imaging
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Outline
• Axsun Overview
• Axsun Technology and Manufacturing
• Clinical Benefits of SSOCT
• Axsun Swept Laser Engine products
• SSOCT Future Directions
• Axsun OCT Images
• Conclusion
• Topcon Eye Care Presentation
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Axsun Technologies Inc.
• A wholly owned subsidiary of Volcano
Corporation (Nasdaq: VOLC)
• Founded in 1998, located in Billerica, MA
• Producing more than ten thousand
optical engines annually into Telecom,
Industrial Spectroscopy and Medical
Imaging applications
• Unique tunable MEMS and optical
integration technology
• Telecom and Industrial products have
strong synergy with Medical Imaging
• 115 employees
• 110 Issued Patents
AXSUN MODULE ASSEMBLY FACILITY
Optical Engine
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4
MEMs Technology and
Manufacturing Platform
High Capacity, Automated
Manufacturing
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The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices Optical Bench Optical Engine
Module
Complete Subsystem
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The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices Optical Bench Optical Engine
Module
Complete Subsystem
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The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices Optical Bench Optical Engine
Module
Complete Subsystem
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The Axsun Platform – Unique Devices,
Assembly, and Products
Unique Devices Optical Bench Optical Engine
Module
Complete Subsystem
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9
Swept Source OCT
Advantages
Axsun Swept Laser Technology
and Performance
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Optical Coherence Tomography OCT Techniques
1. Time-domain OCT
2. Frequency-domain OCT • Spectral-domain OCT
• Swept-source OCT
Swept-Source OCT advantages
– Enables balanced and polarization diverse detection
schemes
– Longer Wavelengths, such as 1060 and 1300 nm, enable
deeper penetration into tissue
– Increased imaging depth range from slower signal roll-off
– High SNR and Resolution in a compact, rugged package
#10
SSOCT
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SSOCT Current and Future Capabilities enable
dramatic benefits to patients
11
Market
Need Clinical Benefits
SSOCT
Current
Capability
SSOCT Future
Capability
Advance over
current systems
Imaging
Speed
Fewer movement artifacts, Larger # of
averaged images Faster 3D imaging
Better image quality in less time
More accurate diagnosis
100 kHz 200kHz+ 4X+
Imaging
Resolution
Ability to view sub retinal vasculature and
individual blood vessels. Distinguish
cancer from Dysplasia. More accurate
diagnosis
7-16 Microns 5-10 Microns
Equivalent
resolution at 4-8X
speed
Imaging
depth range
Increases the potential patient population
and range of the instrument (able to
image diseased eyes completely),
possibility of whole eye imaging
4 to 8mm 4 to 40 mm 2-8x at higher
speed
Deeper
Tissue
Penetration
Makes the instrument more versatile,
enabling choroidal thickness maps and
quality retinal images in the presence of
cataracts
Into Sclera
Into sclera with
wider DOF
2X
Size and
cost
Enables widespread deployment of
SSOCT at a reasonable system cost.
Smaller size enables portable and
handheld imaging instruments
Existing
diagnostic
system
footprint
Volume drives
smaller size and
low cost
Smaller and lower
cost for
widespread
deployment
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#12
Axsun MEMs External Cavity Tunable Laser
14 mm
SOA
Tunable FP Filter
Laser Cavity
Gain Output
Optical
Fiber
Fiber
Reflector
Lens Lens
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Micro-Electro-Mechanical System
(MEMS) Tunable Filter
Tethered
Membrane
Filter Assembly
Wafer Scale Processing
HR Coated
Flat Mirror
Electrode Gap
Optical Cavity
HR Coated Curved
Mirror on Tethered
Membrane
Si
#13
MEMS Fabry-Perot Filter Structure
V
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Micro-Optical Bench Packaging Platform
#14
SOA gain chip
Output Fiber pigtail
LIGA alignment structure
Si micro lens
MEMS tunable filter
Micro-optical bench
x
y
z
Micro-
lens
fiber
Enables the most compact, highest
speed tunable laser for OCT
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Axsun Swept Laser
Performance
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Axsun Laser Tuning Range (Bandwidth)
#16
BW > 110 nm BW > 100 nm
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Axsun Laser Coherence Length
0 2 4 6 8 10 12 14 16 18 20 22-60
-55
-50
-45
-40
-35
-30
-25
-20
-15
-10
-5
0
5
Full Length (mm)
Sig
nal F
FT
(dB
=20*l
og10)
<Down Tune Wavelength> <oct 0243 CohLen 1mm.dat>
Coherence Length = 13.5 mm
#17
Operating conditions:
– l ~ 1060 nm
– 110 nm tuning
range
– 100 kHz scan rate
Axsun’s slow signal rolloff enables longer imaging depth
range than competitive swept lasers and Spectral Domain
OCT systems
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SNR over Imaging Depth
#18
Slow SNR rolloff enables
longer imaging depth
range
Ref:
Benjamin Potsaid, Bernhard Baumann,
David Huang, Scott Barry, Alex E. Cable,
Joel S. Schuman, Jay S. Duker, and
James G. Fujimoto, "Ultrahigh speed
1050nm swept source / Fourier domain
OCT retinal and anterior segment imaging
at 100,000 to 400,000 axial scans per
second," Opt. Express 18, 20029-20048
(2010)
1060 47kHz
InGaAs Camera 850nm 91kHz
CMOS Camera Axsun 1060nm
100kHz Engine
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Axsun OCT Engine
products
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Axsun OCT products
#21
Axsun Swept Laser OEM Engine Axsun Camera Link DAQ Board
Axsun Swept Laser Benchtop
Engine Axsun Swept Laser Engine with
integrated DAQ
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OCT system with Axsun SS Laser +
Axsun Data Acquisition Board
#22
Swept Laser
20
80
50
50
Balanced
Receiver
Variable Delay
10
90
Clock
Clock interferometerDAQ Board
Sweep
Trigger
Signal
1060 nm OCT “Engine”
Probe
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OCT System (Systems Engineering)
• Based on Axsun
1310nm SSOCT Engine
– Includes stage mount or
handheld probe
– Reference and sample
interferometers
– High Speed Data
acquisition card
– 2 axis scanning for 2D or
optional 3D OCT imaging
– Integrated control and
image display software
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Axsun OCT Future
Directions
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Product Plans
• Axsun’s Core Technology provides distinct advantages in
size, speed, imaging depth range and reliability for our OCT
Engine Products
• In 2012 and beyond, Axsun will build on our technology lead
in Swept Laser Subsystems
– Higher speed, wider bandwidth Swept Laser Engines
– Data Acquisition/Image Processing
• Our value added subsystem products will speed TTM and
allow our OEM customers to focus on their applications
25
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OCT Product Roadmap – Next Gen Lasers
• 140nm 100kHz 1310nm Engine
– High resolution Anterior segment imaging
– Endoscopic cancer detection
– Enables higher resolution and
speed
– Targeting similar coherence length
to our 100nm 50kHz 1310 laser (12-
15mm) – We can provide equivalent resolution
at 4X speed and 3x Imaging depth of
our competitors
– Available early 2013
26
Wider Tuning BW
100nm
150nm
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OCT Product Roadmap- System Capabilities
• 2 Channel PCIe based DAQ Board – Specifically designed to work seamlessly
with Axsun 100 and future 200kHz sources
– 2 Channel 500MSPS 12-bit DAQ – 1024-2048 samples per A scan
– Xlinx Virtex 6 FPGA gives added signal
processing capability – Image processing (FFT, Pol. Mixing Windowing)
– Image compression
– Multiple high speed data interfaces – Ethernet, GBE, RS232, PCI
– In house expertise to provide custom
algorithms
– Quick turn customization capability will be
a differentiator and speed TTM for our
customers
27
500MSPS PCI DAQ
x8 PCIe
Bra
cket
Cut
out
regi
on (
end
view
)
4GTXs
8 GTXs
DSP
TI ADC
TI ADC
BracketMtg Hole
MaximADC
Virtex-6Xilinx
XC6VLX130T-1FFG784C
+ Aavid374324B60023G(27x27x10mm)
spring-clip
anchor
Flash
FRAM
LED
StandoffMtg Hole
(on Engineand heatsink)
Engine PCB Outline
PHY
1Gb
PHY
PHY
JTAG1 J6
QSFP cageMolex 0747500021
Module
AvagoAFBR-79Q4Z
PCB Bracket
Strut
Mtg HoleStrut
CLOCK LOGIC
12V SUPPLY FILTER,
DIGITAL VOLTAGE REGULATORS
(5VD, 3.3VD, 2.5V, 1V)
ANALOGVOLTAGE
REGULATORS(6V, 5VA, 3.3VA
-5V)
SATA
J1
SATAJ2
PowerJ3
USBJ4
MBJ5
0.124
SDRAM
SMA J10
Hand-pieceJ11
RJ-45J9
(R/A)
COMJ7
7.000”
4.376”
FAN J16
AUX
J15
F/O
J8
JTAG J12J14
J13
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Axsun OCT Markets
and Real World
Imaging Examples
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Expanding Axsun Opportunities
Lung Image Source U. Illinois Urbana
Pulmonology
GI Image Source – Nature Medicine
Retinal Image Courtesy of Topcon
Molar with Composite Filling
Renal Artery
Abdominal Aortic Aneurysm
Hip Arthroscopy
Superficial Femoral Artery
Carotid Artery
IVC Filter Placement
Neurology
Structural Heart
Shoulder Arthroscopy
MIS Spine
Below the Knee
Dental
Ophthalmology
Gastrointestinal
Skin
Image Guided Therapy, Diagnosis & Guidance
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30
Ophthalmic OCT Today – Diagnostic
Age Related Macular Degeneration (AMD)
Causes 9% of blindness WW
Diabetic Retinopathy
Causes 5% of blindness WW
Cataracts
Causes 47% of blindness WW
Glaucoma
Causes 12% of blindness WW
Source: National Eye Institute and World Health Organization
OCT is primarily used today to diagnose age related eye disease
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31
Ophthalmic OCT – Future Directions
• 18 Million cataract surgeries performed in 2010
• Current method for Cataract Surgery
– Manual scalpel incisions
– Outcome is highly dependent on the
surgeon’s skill
– Not precise enough for new IOL technology
• Laser Cataract Surgery with OCT guidance
– More precise self-healing incisions
• Faster patient recovery
– Lower risk of adverse events
– Consistently better surgical outcomes
• OCT Expected to penetrate the $800M
Cataract Surgery Equipment market
rapidly over the next several years
Laser Corneal
Incision
Laser Fragmented
Lens
Source: Marketscope 2009 Cataract Surgical Market Report
OCT will be used to guide sight-restoring laser surgery
Image Source: Optimedica
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Anterior Segment Imaging at 1050 nm
#32
High resolution images of
Corneo-Scleral Region
showing Cornea, Iris,
Schlemm’s Canal, Cilliary
Body and Ora Serrata
3D Reconstruction of
Limbus, En Face
projections of Scleral
Vasculature
I. Grulkowski et al PHOTONICS LETTERS OF POLAND, VOL. 3 (4), 132-134 (2011)
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Retinal Measurements with 1060nm
Axsun Swept Laser Engine
#33
Torzicky et al 26 March 2012 / Vol. 20, No. 7 / OPTICS EXPRESS 7565
Automated measurement
of choroidal thickness in
the Human Eye with
PSOCT- Medical
University of Vienna
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Blood Flow Measurement with SSOCT
• ONH blood flow with OCT Eye Angiography(1) – Uses an amplitude
decorrelation method as an alternative to Doppler OCT
• Doppler and PSOCT measurement of ONH flow(2)
34
Huang SSOCT Angiography in the Eye – ARVO 2012
1. ARVO Presentation May 2012
2. OPTICS LETTERS / Vol. 37, No. 11 / June 1, 2012 Yasuno et al – Doppler and PSOCT
Measurement of ONH Blood flow
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Speed of SSOCT Enables Dynamic
Measurement
• OCT Doppler Imaging of
Vibrating porcine Vocal
Chords – UC Irvine (1)
35
1. June 2011 / Vol. 19, No. 12 / OPTICS
EXPRESS 2010
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Novel imaging using properties
of SSOCT
#36
• Simultaneous imaging of
Anterior and Posterior
Eye Segments with
SSOCT
– Dhalla et al at Duke
University
1. SPIE 2012 Conference Proceedings
Both images obtained in 200mSec with Axsun 1060
Swept source
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World Class Retinal Imaging
Image Courtesy of
Topcon
(Healthy Subject)
#37
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Summary
• Axsun’s Core Technology provides distinct
advantages in size, speed, imaging depth range
and reliability for our OCT Engine Products
• Swept Laser OCT provides many clinical benefits
to patients and will grow quickly over the next
several years
• Researchers and OEMs are building a large body
of impressive clinical data showing advantages
from the use of Swept Laser OCT
• Axsun’s Swept Laser OCT Engine products are
leading the way in the next generation of OCT
imaging systems
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Systems Engineering Stand B-192
Thank you for your Attention