basic transplantation reaction joseph.pptx

8/14/2019 basic transplantation reaction JOSEPH.pptx

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ASIC TRANSPLANTATION ASIC TRANSPLANTATIONREACTIONEACTION

mmunology and Serolog mmunology and Serolog

#Group 8

#Group 8

,Guevarra Sonny,Guevarra Sonny,Mungcal Lilibeth,Mungcal Lilibeth

,Obah Aiko Marie,Obah Aiko Marie,Sarmiento Norilie Mae,Sarmiento Norilie Mae

,Tayag Joseph,Tayag Joseph



finit ion of terms finit ion of terms

Autograft –tissue grafted back on the original donor

Isograft –graft between syngeneic individuals such as identical twins

l lograf t – graft between allogeneic individuals

such as human to human enograft – graft between xenogeneic individuals such

as human to pig





echanism of Graf t Reject ion echanism of Graf t Reject ion.. - cell Reaction cell Reaction

. 1 Direct pathway 1 Direct pathway

. 2 Indirect pathway 2 Indirect pathway

. Humoral Antibody Reaction Humoral Antibody Reaction. 1 hyperacute rejection 1 hyperacute rejection. 2 acute early rejection 2 acute early rejection. 3 acute late rejection 3 acute late rejection. 4 insidious and late reject ion 4 insidious and late reject ion



chanism of Graft Rejection chanism of Graft Rejection

. - cell Reaction cell Reaction


ir ect Pathway - -the host T cell receptors recognize-foreign MHC peptide combination presented by donor antigen

( ).presenting cells APCs The T cell is able to recognize and respond to the foreign MHC molecule and is able to- .determine that the MHC molecule is non self




chanism of Graft Rejection chanism of Graft Rejection

. - cell Reaction cell Reaction nd ir ec t P at hw ay - is the mechanism in which recipient

( )antigen presenting cells APCs are able to process the donor

-antigens and present the resulting foreign peptides to T cells- .using self MHC molecules The host APCs digest the foreign.antigens through phagocytosis The peptides from the digested

+complex are presented by host MHC molecules to either CD4 or+ - .CD8 T cells




. Humoral Antibody Humoral Antibody

yper acutereject ion

–within minutes of

transplantation characterized by

sludging of red cells and

microthrombi,occurs in

individuals with-pre existing

humoral antibodies

Steps





–cute early reject ion occurring up to 10 days or so after the transplantation and is characterized by

dense cellular infiltration and rupture of the peritubularcapillaries and appears to be a

-hypersensitivity reaction to t lymphocytes

–cute late reject ion ,occurs 11 days onwards due

to breakthrough of immunosupression by the immune

response or can be caused by the binding of immunoglobulin and complement to the arterioles and

glomerular capillaries





–nsidious and late rejection associated with subendothelial deposits of C3 on the glomerular

basement membranes which may sometimes be an expression of underlying immune complex disorder or complex

formation with soluble antigens derived from the grafted kidney




-t ion of graft reject ion immunosuppressive-t ion of graft rejection immunosuppressive

–zathioprine inhibi ts nucleic acid synthesis- -nd has a preferent ial effect on T cell

e dia te d re ac tio ns

- ,ethotrexate fol ic acid antagonist inhibits ucleic acid synthesis

–yclosphamide at tacks DNA b alkylat ion and,ross l inking preventing correct duplication

– -yclosporine blocks transcipt ion of IL 2 in-ct ivated T cel ls

– -acrol imus blocks various T cells and endri t ic cel l activi ty

basic transplantation reaction joseph.pptx

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